{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:25:51Z","timestamp":1790641551139,"version":"4.1.0"},"reference-count":50,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51703245"],"award-info":[{"award-number":["51703245"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["51703245"],"award-info":[{"award-number":["51703245"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"crossref","award":["2024J01499"],"award-info":[{"award-number":["2024J01499"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"crossref","award":["2023J011526"],"award-info":[{"award-number":["2023J011526"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"crossref","award":["2023J01711"],"award-info":[{"award-number":["2023J01711"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fujian Science and Technology Innovation Joint Found Project","award":["2024Y9097"],"award-info":[{"award-number":["2024Y9097"]}]},{"name":"Project of Fuzhou Science and Technology","award":["2023-S-010"],"award-info":[{"award-number":["2023-S-010"]}]},{"name":"Clinical Medicine and Basic Medicine Integrative Development Joint Fund of Fujian Medical University","award":["2025RH029"],"award-info":[{"award-number":["2025RH029"]}]},{"award":["2025RH029"],"award-info":[{"award-number":["2025RH029"]}],"id":[{"id":"https:\/\/ror.org\/050s6ns64","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair","award":["GXLIRMMKL-K202403"],"award-info":[{"award-number":["GXLIRMMKL-K202403"]}]},{"name":"Fujian Provincial Clinical Medical Research Center for First Aid and Rehabilitation in Orthopaedic Trauma","award":["2020Y2014"],"award-info":[{"award-number":["2020Y2014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Background: Hepatocellular carcinoma (HCC) remains challenging to treat because of the limited therapeutic efficacy and insufficient selectivity of conventional therapies. To overcome these limitations, multifunctional nanoplatforms integrating biomimetic strategies and combination therapy have attracted increasing attention. Single-modality therapies are often limited by insufficient therapeutic efficacy and restricted mechanisms of action, highlighting the need for biomimetic nanoplatforms that integrate combination therapeutic strategies for enhanced antitumor performance. Methods: Herein, a biomimetic strategy-based nanoplatform (DI-ZM) was constructed via a combination of ZIF-8 biomineralization, physical adsorption of dihydroartemisinin (DHA) and indocyanine green (ICG), followed by HepG2 cell membrane coating to achieve homologous interaction. This design enables integrated chemotherapy, photothermal therapy (PTT), and photodynamic therapy (PDT) within a single system. Results: The resulting DI-ZM nanoparticles exhibited a hydrodynamic diameter of approximately ~200 nm with good colloidal stability and high drug-loading capacity. Under 808 nm laser irradiation, DI-ZM achieved a temperature elevation to ~66 \u00b0C within 5 min, together with efficient ROS generation. Compared with uncoated nanoparticles, the biomimetic membrane coating significantly enhanced cellular uptake and homologous targeting ability, as confirmed by CLSM and flow cytometry analysis. Benefiting from the biomimetic membrane coating, DI-ZM further exhibited improved homologous targeting and cellular uptake, which contributed to enhanced intracellular ROS generation. This was accompanied by significant mitochondrial membrane depolarization and apoptosis rates exceeding 80% in HepG2 cells under laser irradiation, ultimately resulting in markedly enhanced cytotoxicity. In addition, the biomimetic membrane coating also enabled efficient penetration of DI-ZM into multicellular tumor spheroids, indicating its improved tumor-penetration capability. In vivo antitumor studies further revealed effective tumor suppression with a tumor inhibition rate of approximately 97%, along with acceptable systemic tolerance in HepG2 tumor-bearing mice. Conclusion: The biomimetic membrane-coated ZIF-8 nanoplatform integrating chemotherapy with ICG-mediated phototherapy (photothermal and photodynamic therapy) provides an effective strategy for the combination therapy against HCC.<\/jats:p>","DOI":"10.3390\/pharmaceutics18081000","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T12:47:11Z","timestamp":1786625231000},"page":"1000","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Biomimetic ZIF-8 Nanoplatform for Enhanced Therapeutic Efficacy of Combined Phototherapy and Chemotherapy Against Hepatocellular Carcinoma"],"prefix":"10.3390","volume":"18","author":[{"given":"Xinlei","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery, Fuzhou Second General Hospital, Fuzhou 350007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoteng","family":"Huang","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, School of Pharmacy, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Zheng","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Natural Medicine Pharmacology, Department of Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Yao","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, School of Pharmacy, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, School of Pharmacy, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Tu","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, School of Pharmacy, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longhua","family":"Shen","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, School of Pharmacy, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Fujian Medical University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Fujian Medical University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7779-6957","authenticated-orcid":false,"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, School of Pharmacy, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyang","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, School of Pharmacy, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Fuzhou Second General Hospital, Fuzhou 350007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4485-998X","authenticated-orcid":false,"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, School of Pharmacy, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"166321","DOI":"10.1016\/j.cej.2025.166321","article-title":"TRPV2 ion channel modulation via photothermally active nanoparticles with enhanced cellular internalization for liver cancer stemness suppression","volume":"520","author":"Shao","year":"2025","journal-title":"Chem. Eng. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e2204937","DOI":"10.1002\/advs.202204937","article-title":"Modulating Nanozyme-Based Nanomachines via Microenvironmental Feedback for Differential Photothermal Therapy of Orthotopic Gliomas","volume":"10","author":"Yin","year":"2023","journal-title":"Adv. Sci."},{"key":"ref_3","first-page":"127874","article-title":"Cerium-doped TiO2 photocatalyst for the degradation of methyl ethyl ketone in a continuous-flow reactor: The role of surface fluorination and residence time","volume":"421","author":"Lee","year":"2021","journal-title":"Chem. Eng. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s11658-025-00710-0","article-title":"Old drugs, new challenges: Reassigning drugs for cancer therapies","volume":"30","author":"Czechowicz","year":"2025","journal-title":"Cell. Mol. Biol. Lett."},{"key":"ref_5","first-page":"475","article-title":"Development of nanoscale drug delivery systems of dihydroartemisinin for cancer therapy: A review","volume":"17","author":"Wong","year":"2022","journal-title":"Asian J. Pharm. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2422241","DOI":"10.1002\/adfm.202422241","article-title":"Convertible ROS Nanogenerator\/Eliminator for Enhanced Tumor Photothermal Therapy with Reduced Inflammatory Response","volume":"35","author":"Zhou","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"124196","DOI":"10.1016\/j.biomaterials.2026.124196","article-title":"Self-amplifying nanomedicine reprograms redox metabolism to trigger immunogenic ferroptosis in colon cancer: Multiomics identifies AMPD3 as a novel regulator","volume":"333","author":"Huang","year":"2026","journal-title":"Biomaterials"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"rbad048","DOI":"10.1093\/rb\/rbad048","article-title":"Codelivery of dihydroartemisinin and chlorin e6 by copolymer nanoparticles enables boosting photodynamic therapy of breast cancer with low-power irradiation","volume":"10","author":"Jia","year":"2023","journal-title":"Regen. Biomater."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Xu, R., Wang, S., Guo, Q., Zhong, R., Chen, X., and Xia, X. (2025). Anti-tumor strategies of photothermal therapy combined with other therapies using nanoplatforms. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17030306"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e22226","DOI":"10.1002\/advs.202522226","article-title":"A mitochondria-specific nanomedicine for synergistic chemo-photothermal therapy and immunogenic activation against breast cancer","volume":"13","author":"Li","year":"2026","journal-title":"Adv. Sci."},{"key":"ref_11","first-page":"2001850","article-title":"A light-controlled nanoplatform for enhanced photodynamic therapy and anti-angiogenic gene silencing against cancer metastasis","volume":"10","author":"Dong","year":"2021","journal-title":"Adv. Healthc. Mater."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s42114-024-01158-0","article-title":"Genistein and chlorin E6-loaded versatile nanoformulation for remodeling the hypoxia-related tumor microenvironment and boosting photodynamic therapy in nasopharyngeal carcinoma treatment","volume":"8","author":"Zhou","year":"2025","journal-title":"Adv. Compos. Hybrid. Mater."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"0583","DOI":"10.34133\/research.0583","article-title":"Recent advances in indocyanine green-based probes for second near-infrared fluorescence imaging and therapy","volume":"8","author":"Hu","year":"2025","journal-title":"Research"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e2417440","DOI":"10.1002\/adma.202417440","article-title":"NIR-II fluorescent thermophoretic nanomotors for superficial tumor photothermal therapy","volume":"37","author":"Jiang","year":"2025","journal-title":"Adv. Mater."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Chen, Y., Wang, B., Chen, W., Wang, T., Li, M., Shen, Z., Wang, F., Jia, J., Li, F., and Huang, X. (2022). Co-delivery of dihydroartemisinin and indocyanine green by metal-organic framework-based vehicles for combination treatment of hepatic carcinoma. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14102047"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"0672","DOI":"10.34133\/research.0672","article-title":"Gas-generating photocatalytic agents for bacterial Infection treatment","volume":"8","author":"Hu","year":"2025","journal-title":"Research"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"123387","DOI":"10.1016\/j.biomaterials.2025.123387","article-title":"Tumor microenvironment responsive nano-PROTAC for BRD4 degradation enhanced cancer photo-immunotherapy","volume":"322","author":"Li","year":"2025","journal-title":"Biomaterials"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"26980","DOI":"10.1021\/acsnano.5c09310","article-title":"Immuno-initiator rectifies immunodeficiency to restore immune function and potentiate immunotherapy against IDH mutant glioma","volume":"19","author":"Zhou","year":"2025","journal-title":"ACS Nano"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.7150\/thno.108471","article-title":"Hybrid NIR-responsive liposome\/hydrogel platform mediating chemo-photothermal therapy of retinoblastoma enhanced by quercetin as an adjuvant","volume":"15","author":"Lin","year":"2025","journal-title":"Theranostics"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e06051","DOI":"10.1002\/advs.202506051","article-title":"GSH-Responsive nanoparticles enhance hepatocellular carcinoma immunotherapy through synergistic effects of cuproptosis and PI3K inhibitor combination","volume":"13","author":"Wu","year":"2026","journal-title":"Adv. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e12376","DOI":"10.1002\/adma.202412376","article-title":"A hypoxia-activatable prodrug for targeted combination therapy of hepatoma","volume":"38","author":"Wang","year":"2026","journal-title":"Adv. Mater."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e19473","DOI":"10.1002\/adma.202519473","article-title":"Optimized lipid nanoparticles for co-delivery of mRNA and siRNA therapeutics in refractory liver cancer","volume":"38","author":"Liao","year":"2026","journal-title":"Adv. Mater."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"122480","DOI":"10.1016\/j.biomaterials.2024.122480","article-title":"Hypoxia-activated cascade nanovaccine for synergistic chemoembolization-immune therapy of hepatocellular carcinoma","volume":"306","author":"Shi","year":"2024","journal-title":"Biomaterials"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"216746","DOI":"10.1016\/j.ccr.2025.216746","article-title":"Integrative gas-based therapeutics for cancer treatment: Recent advances and multi-therapy innovations","volume":"539","author":"Zhang","year":"2025","journal-title":"Coord. Chem. Rev."},{"key":"ref_25","first-page":"3581","article-title":"Polyethylene glycol-poly(\u03b5-benzyloxycarbonyl-L-lysine)-conjugated VEGF siRNA for antiangiogenic gene therapy in hepatocellular carcinoma","volume":"12","author":"Wang","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Liu, Y., Yu, T., Zhang, C., Yang, Z., Yu, D., He, B., and Liang, Y. (2025). Nanostructured delivery systems for curcumin: Improving bioavailability and plaque-targeting efficacy in atherosclerosis. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17111465"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"rbae122","DOI":"10.1093\/rb\/rbae122","article-title":"Curcumin-incorporated EGCG-based nano-antioxidants alleviate colon and kidney inflammation via antioxidant and anti-inflammatory therapy","volume":"11","author":"Pan","year":"2024","journal-title":"Regen. Biomater."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"46090","DOI":"10.1021\/acsami.4c09901","article-title":"Acid-resistant nano-antioxidants based on epigallocatechin gallate alleviate acute intestinal and kidney inflammation","volume":"16","author":"Pan","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"6340","DOI":"10.1021\/acs.biomac.5c01439","article-title":"Multifunctional D-type peptide dendrimer-based nanocarriers enabling inherent autophagy modulation and lysosomal escape for breast tumor therapy","volume":"26","author":"Huang","year":"2025","journal-title":"Biomacromolecules"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e02349","DOI":"10.1002\/adhm.202502349","article-title":"Injectable ROS\/pH-responsive hydrogel for synergistic chemo-photodynamic tumor therapy and enhanced wound healing","volume":"15","author":"Yi","year":"2026","journal-title":"Adv. Healthc. Mater."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"100076","DOI":"10.1016\/j.ntm.2025.100076","article-title":"Bio-nanomaterials: Promising anticancer properties and treatment strategies","volume":"4","author":"Elemike","year":"2025","journal-title":"Nano TransMed"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"100119","DOI":"10.1016\/j.ntm.2026.100119","article-title":"A hyaluronic acid-based microneedle platform for enhanced ferroptosis-induced tumor therapy and antibacterial applications","volume":"5","author":"Shangguan","year":"2026","journal-title":"Nano TransMed"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"63","DOI":"10.22203\/eCM.v055a05","article-title":"Microneedle-mediated delivery of an NIR-triggered nanoagent for synergistic anti-biofilm infection therapy","volume":"55","author":"Chen","year":"2026","journal-title":"Eur. Cells Mater."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"159380","DOI":"10.1016\/j.cej.2025.159380","article-title":"Butterfly-shaped dendrimers with photosensitizer recruitment function for enhanced light-controlled precise cascaded ROS and NO release in multimodal diabetic foot ulcers infections treatment","volume":"505","author":"Huang","year":"2025","journal-title":"Chem. Eng. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"102806","DOI":"10.1016\/j.mtbio.2026.102806","article-title":"pH-Responsive ZIF-8@quercetin nanoparticles induce pyroptosis for targeted gastric cancer therapy","volume":"37","author":"Xu","year":"2026","journal-title":"Mater. Today Bio"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"101912","DOI":"10.1016\/j.mtbio.2025.101912","article-title":"A nitric oxide and hydroxyl radical synergistic releasing nanozyme for bacterial ferroptosis-like death and wound healing","volume":"32","author":"Liu","year":"2025","journal-title":"Mater. Today Bio"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"23491","DOI":"10.1021\/acsnano.5c04836","article-title":"Nanomedicine and spleen-targeting strategies for precision immunomodulation: Advances, challenges, and future perspectives","volume":"19","author":"Oh","year":"2025","journal-title":"ACS Nano"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"113835","DOI":"10.1016\/j.jconrel.2025.113835","article-title":"Multivalent assembly of nucleolin-targeted F3 peptide potentiates TRAIL\u2019s tumor penetration and antitumor effects","volume":"383","author":"Tao","year":"2025","journal-title":"J. Control. Release"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e13548","DOI":"10.1002\/smll.202513548","article-title":"Selective membrane protein enrichment enables defined biomimetic nanoparticles for endothelial targeting","volume":"22","author":"Raviv","year":"2026","journal-title":"Small"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nnano.2017.54","article-title":"Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence","volume":"12","author":"Xue","year":"2017","journal-title":"Nat. Nanotechnol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"114297","DOI":"10.1016\/j.jconrel.2025.114297","article-title":"Biomimetic immortalized mesenchymal stem cell-based nanoparticles suppress orthotopic postsurgical glioma via CD73 targeting and chemotherapy","volume":"388","author":"Zhang","year":"2025","journal-title":"J. Control. Release"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"7001","DOI":"10.1021\/acsnano.5c18774","article-title":"Drug-free immunotherapeutic biomimetic nanoparticles for treating triple-negative breast cancer","volume":"20","author":"Vizenblit","year":"2026","journal-title":"ACS Nano"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Wang, F., Deng, Y., Yu, L., Zhou, A., Wang, J., Jia, J., Li, N., Ding, F., Lian, W., and Liu, Q. (2022). A macrophage membrane-polymer hybrid biomimetic nanoplatform for therapeutic delivery of somatostatin peptide to chronic pancreatitis. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14112341"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41571-022-00699-x","article-title":"Targeting drugs to tumours using cell membrane-coated nanoparticles","volume":"20","author":"Fang","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jconrel.2024.10.004","article-title":"Brain targeted biomimetic siRNA nanoparticles for drug resistance glioblastoma treatment","volume":"376","author":"Li","year":"2024","journal-title":"J. Control. Release"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"23276","DOI":"10.1021\/acsnano.5c06202","article-title":"Cancer cell membrane-coated homodimer prodrug nanoassemblies to simultaneously deliver prodrugs and immune adjuvants for combined chemo-immunotherapy","volume":"19","author":"Zhao","year":"2025","journal-title":"ACS Nano"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"28813","DOI":"10.1021\/acsnano.5c08820","article-title":"Cascade nanoreactors for in-situ peroxynitrite generation via pyrrole-bridged NIR-II type-I photosensitizers to enhance tumor phototherapy","volume":"19","author":"Xin","year":"2025","journal-title":"ACS Nano"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e16225","DOI":"10.1002\/adma.202516225","article-title":"Construction of diverse calcium-based nanomaterials through a microemulsion method for pyroptosis-initiated antitumor immunotherapy","volume":"38","author":"Li","year":"2026","journal-title":"Adv. Mater."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"115682","DOI":"10.1016\/j.colsurfb.2026.115682","article-title":"Zwitterionic peptide dendrimer-based nanocarriers with enhanced stability and biocompatibility for cancer therapy","volume":"265","author":"Dong","year":"2026","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"14337","DOI":"10.1021\/acs.nanolett.4c04026","article-title":"Mucin-triggered osmium nanoclusters as protein-corona-like nanozymes with photothermal-enhanced peroxidase-like activity for tumor-specific therapy","volume":"24","author":"He","year":"2024","journal-title":"Nano Lett."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/18\/8\/1000\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T04:34:48Z","timestamp":1786768488000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/18\/8\/1000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":50,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["pharmaceutics18081000"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics18081000","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]}}}