{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T12:31:19Z","timestamp":1787056279110,"version":"build-2736575974"},"reference-count":83,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Background\/Objectives: Combining chemotherapy with local magnetic hyperthermia (MHT) is promising because heating tumor tissue can increase cell damage, sensitize cells to cytostatic drugs, impair DNA repair, and change tumor microenvironment permeability. This creates conditions for enhancing the antitumor efficacy of chemotherapy while potentially reducing systemic toxicity. The aim of this study was to evaluate the efficacy of MHT with Zn0.2Mn0.8Fe2O4@OA nanoparticles alone and in combination with cisplatin in a Lewis lung carcinoma model. Methods: Four types of magnetic nanoparticles were synthesized and characterized: Fe3O4 and Zn0.2Mn0.8Fe2O4 coated with oleic acid (OA) or SiO2-NH2. Their physicochemical and magnetothermal properties, cytotoxicity, reactive oxygen species generation, and biodegradation in vivo were evaluated. Antitumor efficacy was studied in C57Bl\/6 mice with LLC tumors after intratumoral administration of nanoparticles and two MHT sessions (100 kHz, 8 kA\/m, 30 min). In combination therapy, ZnMn@OA and cisplatin at doses of 9 or 18 mg\/kg were used. Results\/Conclusions: Zn0.2Mn0.8Fe2O4@OA combined efficient heating, biodegradation, and the most pronounced effect among the MHT-alone groups, although MHT without chemotherapy did not provide sustained inhibition of tumor growth or a significant increase in survival. The combination of Zn0.2Mn0.8Fe2O4@OA-MHT with cisplatin 9 mg\/kg produced the best therapeutic outcome: median survival increased significantly by two fold compared with the control group and by 1.8-fold compared with the chemotherapy-alone group at the comparable cisplatin dose. This regimen also stabilized body weight, reduced systemic toxicity, and restored RBC, HGB, and HCT parameters to the level of healthy animals by day 7 of the experiment. These data confirm the potential of MHT as a chemosensitizing approach that improves the efficacy and tolerability of cisplatin therapy.<\/jats:p>","DOI":"10.3390\/pharmaceutics18081021","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:35:08Z","timestamp":1786984508000},"page":"1021","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Magnetic Hyperthermia via Zn0.2Mn0.8Fe2O4 Oleic Acid Nanoparticles Enhances Chemotherapy Efficacy in a Lewis Lung Carcinoma Model"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7675-0823","authenticated-orcid":false,"given":"Denis E.","family":"Yakobson","sequence":"first","affiliation":[{"name":"Federal Center for Biotechnology and Medicine Advancement, National Research Ogarev Mordovia State University (MRSU), Bolshevistskaya Str. 68, 430005 Saransk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8272-1973","authenticated-orcid":false,"given":"Mikhail N.","family":"Zharkov","sequence":"additional","affiliation":[{"name":"Federal Center for Biotechnology and Medicine Advancement, National Research Ogarev Mordovia State University (MRSU), Bolshevistskaya Str. 68, 430005 Saransk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0739-3981","authenticated-orcid":false,"given":"Oleg A.","family":"Kulikov","sequence":"additional","affiliation":[{"name":"Federal Center for Biotechnology and Medicine Advancement, National Research Ogarev Mordovia State University (MRSU), Bolshevistskaya Str. 68, 430005 Saransk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5248-0136","authenticated-orcid":false,"given":"Vasilisa I.","family":"Kulikova","sequence":"additional","affiliation":[{"name":"Federal Center for Biotechnology and Medicine Advancement, National Research Ogarev Mordovia State University (MRSU), Bolshevistskaya Str. 68, 430005 Saransk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0478-3634","authenticated-orcid":false,"given":"Vladislav S.","family":"Bobrov","sequence":"additional","affiliation":[{"name":"Federal Center for Biotechnology and Medicine Advancement, National Research Ogarev Mordovia State University (MRSU), Bolshevistskaya Str. 68, 430005 Saransk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksey O.","family":"Makarov","sequence":"additional","affiliation":[{"name":"Federal Center for Biotechnology and Medicine Advancement, National Research Ogarev Mordovia State University (MRSU), Bolshevistskaya Str. 68, 430005 Saransk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina P.","family":"Brodovskaya","sequence":"additional","affiliation":[{"name":"Federal Center for Biotechnology and Medicine Advancement, National Research Ogarev Mordovia State University (MRSU), Bolshevistskaya Str. 68, 430005 Saransk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa A.","family":"Balykova","sequence":"additional","affiliation":[{"name":"Federal Center for Biotechnology and Medicine Advancement, National Research Ogarev Mordovia State University (MRSU), Bolshevistskaya Str. 68, 430005 Saransk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0052-4958","authenticated-orcid":false,"given":"Ran","family":"Yan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9688-7640","authenticated-orcid":false,"given":"Nikolay A.","family":"Pyataev","sequence":"additional","affiliation":[{"name":"Federal Center for Biotechnology and Medicine Advancement, National Research Ogarev Mordovia State University (MRSU), Bolshevistskaya Str. 68, 430005 Saransk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Bukhari, S.N.A. (2022). Emerging Nanotherapeutic Approaches to Overcome Drug Resistance in Cancers with Update on Clinical Trials. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14040866"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Luiz, M.T., Dutra, J.A.P., Viegas, J.S.R., De Ara\u00fajo, J.T.C., Tavares Junior, A.G., and Chorilli, M. (2023). Hybrid Magnetic Lipid-Based Nanoparticles for Cancer Therapy. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15030751"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Oliveira, R.R., Cintra, E.R., Sousa-Junior, A.A., Moreira, L.C., Da Silva, A.C.G., De Souza, A.L.R., Valadares, M.C., Carri\u00e3o, M.S., Bakuzis, A.F., and Lima, E.M. (2023). Paclitaxel-Loaded Lipid-Coated Magnetic Nanoparticles for Dual Chemo-Magnetic Hyperthermia Therapy of Melanoma. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15030818"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"152202","DOI":"10.1016\/j.bbrc.2025.152202","article-title":"Study of Antitumor Efficacy and Pharmacokinetics of a Photosensitizer Based on Natural Furanocoumarins and Upconversion Rare Earth Metal Particles in Mice with Lewis Lung Carcinoma and B16 Melanoma","volume":"776","author":"Shlyapkina","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"16055","DOI":"10.1038\/s41598-022-20558-0","article-title":"The Heating Efficiency of Magnetic Nanoparticles under an Alternating Magnetic Field","volume":"12","author":"Yu","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Sharma, A., Cressman, E., Attaluri, A., Kraitchman, D.L., and Ivkov, R. (2022). Current Challenges in Image-Guided Magnetic Hyperthermia Therapy for Liver Cancer. Nanomaterials, 12.","DOI":"10.3390\/nano12162768"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Albarqi, H.A., Demessie, A.A., Sabei, F.Y., Moses, A.S., Hansen, M.N., Dhagat, P., Taratula, O.R., and Taratula, O. (2020). Systemically Delivered Magnetic Hyperthermia for Prostate Cancer Treatment. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12111020"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"909","DOI":"10.3109\/02656736.2015.1075072","article-title":"Magnetic Nanoparticle-Mediated Hyperthermia Therapy Induces Tumour Growth Inhibition by Apoptosis and Hsp90\/AKT Modulation","volume":"31","author":"Shetake","year":"2015","journal-title":"Int. J. Hyperth."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jcis.2024.05.046","article-title":"Multicore Iron Oxide Nanoparticles for Magnetic Hyperthermia and Combination Therapy against Cancer Cells","volume":"670","author":"Somoza","year":"2024","journal-title":"J. Colloid Interface Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"11614","DOI":"10.1039\/D1CS00427A","article-title":"Magnetic Nanoparticles and Clusters for Magnetic Hyperthermia: Optimizing Their Heat Performance and Developing Combinatorial Therapies to Tackle Cancer","volume":"50","author":"Avugadda","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Szwed, M., and Marczak, A. (2024). Application of Nanoparticles for Magnetic Hyperthermia for Cancer Treatment\u2014The Current State of Knowledge. Cancers, 16.","DOI":"10.3390\/cancers16061156"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.2147\/IJN.S108577","article-title":"Nanoparticle-Based Hyperthermia Distinctly Impacts Production of ROS, Expression of Ki-67, TOP2A, and TPX2, and Induction of Apoptosis in Pancreatic Cancer","volume":"12","author":"Ludwig","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/02656730701769841","article-title":"Cellular Responses to Hyperthermia (40\u201346 \u00b0C): Cell Killing and Molecular Events","volume":"24","year":"2008","journal-title":"Int. J. Hyperth."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s13014-015-0462-0","article-title":"Effects of Hyperthermia on DNA Repair Pathways: One Treatment to Inhibit Them All","volume":"10","author":"Oei","year":"2015","journal-title":"Radiat. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Maurici, C.E., Colenbier, R., Wylleman, B., Brancato, L., Van Zwol, E., Van Den Bossche, J., Timmermans, J.-P., Giovannetti, E., Mori Da Cunha, M.G.M.C., and Bogers, J. (2022). Hyperthermia Enhances Efficacy of Chemotherapeutic Agents in Pancreatic Cancer Cell Lines. Biomolecules, 12.","DOI":"10.3390\/biom12050651"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"463","DOI":"10.21037\/atm-22-955","article-title":"Hyperthermia Enhances the Efficacy of Chemotherapeutic Drugs in Heat-Sensitive Cells Through Interfering with DNA Damage Repair","volume":"10","author":"Ni","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.addr.2020.07.007","article-title":"Hyperthermia Can Alter Tumor Physiology and Improve Chemo- and Radio-Therapy Efficacy","volume":"163\u2013164","author":"Dunne","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Fatima, H., Charinpanitkul, T., and Kim, K.-S. (2021). Fundamentals to Apply Magnetic Nanoparticles for Hyperthermia Therapy. Nanomaterials, 11.","DOI":"10.3390\/nano11051203"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Zhang, J., Zhang, T., and Gao, J. (2022). Biocompatible Iron Oxide Nanoparticles for Targeted Cancer Gene Therapy: A Review. Nanomaterials, 12.","DOI":"10.3390\/nano12193323"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1039\/D1BM01963E","article-title":"Superparamagnetic Iron Oxide Nanoparticles for Magnetic Hyperthermia: Recent Advancements, Molecular Effects, and Future Directions in the Omics Era","volume":"10","author":"Pucci","year":"2022","journal-title":"Biomater. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.jmmm.2009.02.075","article-title":"Suitability of Commercial Colloids for Magnetic Hyperthermia","volume":"321","author":"Kallumadil","year":"2009","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"126117","DOI":"10.1016\/j.matchemphys.2022.126117","article-title":"A Mini-Review on AFe2O4 (A = Zn, Mg, Mn, Co, Cu, and Ni) Nanoparticles: Photocatalytic, Magnetic Hyperthermia and Cytotoxicity Study","volume":"286","author":"Manohar","year":"2022","journal-title":"Mater. Chem. Phys."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"102403","DOI":"10.1063\/5.0082857","article-title":"Optimization of Zn\u2013Mn Ferrite Nanoparticles for Low Frequency Hyperthermia: Exploiting the Potential of Superquadratic Field Dependence of Magnetothermal Response","volume":"120","author":"Liu","year":"2022","journal-title":"Appl. Phys. Lett."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"169379","DOI":"10.1016\/j.jmmm.2022.169379","article-title":"The \u201cField or Frequency\u201d Dilemma in Magnetic Hyperthermia: The Case of Zn Mn Ferrite Nanoparticles","volume":"555","author":"Liu","year":"2022","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Liu, N.N., Alekhina, Y.A., Pyatakov, A.P., Zharkov, M.N., Yakobson, D.E., Pyataev, N.A., Sukhorukov, G.B., Perov, N.S., and Tishin, A.M. (2023). Impact of Colloidal Stabilization of MnZn-Ferrite Nanoparticles by Oleic Acid on Their Magnetothermal Properties. Front. Therm. Eng., 3.","DOI":"10.3389\/fther.2023.1195740"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1080\/02656730500158360","article-title":"Clinical Hyperthermia of Prostate Cancer Using Magnetic Nanoparticles: Presentation of a New Interstitial Technique","volume":"21","author":"Johannsen","year":"2005","journal-title":"Int. J. Hyperth."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0304-8853(99)00088-8","article-title":"Roland Felix Magnetic Fluid Hyperthermia (MFH): Cancer Treatment with AC Magnetic Field Induced Excitation of Biocompatible Superparamagnetic Nanoparticles","volume":"201","author":"Jordan","year":"1999","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s11060-010-0389-0","article-title":"Efficacy and Safety of Intratumoral Thermotherapy Using Magnetic Iron-Oxide Nanoparticles Combined with External Beam Radiotherapy on Patients with Recurrent Glioblastoma Multiforme","volume":"103","author":"Ulrich","year":"2011","journal-title":"J. Neurooncol"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11060-018-03005-x","article-title":"Combined Intracavitary Thermotherapy with Iron Oxide Nanoparticles and Radiotherapy as Local Treatment Modality in Recurrent Glioblastoma Patients","volume":"141","author":"Grauer","year":"2019","journal-title":"J. Neurooncol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Zhu, N., Ji, H., Yu, P., Niu, J., Farooq, M.U., Akram, M.W., Udego, I.O., Li, H., and Niu, X. (2018). Surface Modification of Magnetic Iron Oxide Nanoparticles. Nanomaterials, 8.","DOI":"10.3390\/nano8100810"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1021\/acs.langmuir.6b03360","article-title":"Large-Scale, Facile Transfer of Oleic Acid-Stabilized Iron Oxide Nanoparticles to the Aqueous Phase for Biological Applications","volume":"33","author":"Cai","year":"2017","journal-title":"Langmuir"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.apsusc.2016.04.181","article-title":"Iron Oxide Nanoparticles Stabilized with a Bilayer of Oleic Acid for Magnetic Hyperthermia and MRI Applications","volume":"383","author":"Soares","year":"2016","journal-title":"Appl. Surf. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1080\/02656736.2019.1628313","article-title":"Evaluation of Magnetic Nanoparticles for Magnetic Fluid Hyperthermia","volume":"36","author":"Lanier","year":"2019","journal-title":"Int. J. Hyperth."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Mamani, J.B., Souza, T.K.F., Nucci, M.P., Oliveira, F.A., Nucci, L.P., Alves, A.H., Rego, G.N.A., Marti, L., and Gamarra, L.F. (2021). In Vitro Evaluation of Hyperthermia Magnetic Technique Indicating the Best Strategy for Internalization of Magnetic Nanoparticles Applied in Glioblastoma Tumor Cells. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13081219"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"011303","DOI":"10.1063\/5.0073494","article-title":"Performance of Nanoparticles for Biomedical Applications: The in Vitro\/in Vivo Discrepancy","volume":"3","author":"Berger","year":"2022","journal-title":"Biophys. Rev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1038\/s41598-022-07062-1","article-title":"Towards Optimal Thermal Distribution in Magnetic Hyperthermia","volume":"12","author":"Rytov","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1038\/s41598-017-18162-8","article-title":"Magnetic Vortices as Efficient Nano Heaters in Magnetic Nanoparticle Hyperthermia","volume":"8","author":"Usov","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Kulikov, O.A., Zharkov, M.N., Ageev, V.P., Yakobson, D.E., Shlyapkina, V.I., Zaborovskiy, A.V., Inchina, V.I., Balykova, L.A., Tishin, A.M., and Sukhorukov, G.B. (2022). Magnetic Hyperthermia Nanoarchitectonics via Iron Oxide Nanoparticles Stabilised by Oleic Acid: Anti-Tumour Efficiency and Safety Evaluation in Animals with Transplanted Carcinoma. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23084234"},{"key":"ref_39","unstructured":"Waldoefner, N., and Jordan, A. (2016). Agglomerating Magnetic Alkoxysilane-Coated Nanoparticles. (US Patent 9,408,912)."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jphotochem.2006.01.017","article-title":"Photochemistry of Fe(III) and Sulfosalicylic Acid Aqueous Solutions","volume":"182","author":"Pozdnyakov","year":"2006","journal-title":"J. Photochem. Photobiol. A Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"454","DOI":"10.4028\/www.scientific.net\/SSP.215.454","article-title":"The Expeimental Setup for Measuring of Thermal Parameters of Magnetic Fluids in AC Magnetic Field","volume":"215","author":"Elkhova","year":"2014","journal-title":"Solid State Phenom."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jssc.2018.01.001","article-title":"Threshold Heating Temperature for Magnetic Hyperthermia: Controlling the Heat Exchange with the Blocking Temperature of Magnetic Nanoparticles","volume":"260","author":"Pimentel","year":"2018","journal-title":"J. Solid State Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"43","DOI":"10.18413\/rrpharmacology.9.10055","article-title":"Polyelectrolyte Microcapsules as a Tool to Enhance Photosensitizing Effect of Chlorin E6","volume":"9","author":"Brodovskaya","year":"2023","journal-title":"Res. Results Pharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","article-title":"Cisplatin in Cancer Therapy: Molecular Mechanisms of Action","volume":"740","author":"Dasari","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"822","DOI":"10.3892\/ol.2014.2783","article-title":"Antitumor Effects of Different Administration Sequences of Cisplatin and Endostar on Lewis Lung Carcinoma","volume":"9","author":"Fan","year":"2015","journal-title":"Oncol. Lett."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3109\/02656736.2010.500645","article-title":"The Regimen of Gemcitabine and Cisplatin Combined with Radio Frequency Hyperthermia for Advanced Non-Small Cell Lung Cancer: A Phase II Study","volume":"27","author":"Shen","year":"2011","journal-title":"Int. J. Hyperth."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1756-9966-29-46","article-title":"Enhancement of Cisplatin Sensitivity in Lewis Lung Carcinoma by Liposome-Mediated Delivery of a Survivin Mutant","volume":"29","author":"Yu","year":"2010","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/S0022-5223(03)00707-4","article-title":"Cisplatin Augments Cytotoxic T-Lymphocyte\u2013Mediated Antitumor Immunity in Poorly Immunogenic Murine Lung Cancer","volume":"126","author":"Merritt","year":"2003","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/s41598-020-80853-6","article-title":"Combination Therapy of Cisplatin with Cilastatin Enables an Increased Dose of Cisplatin, Enhancing Its Antitumor Effect by Suppression of Nephrotoxicity","volume":"11","author":"Arita","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1007\/s12253-019-00773-3","article-title":"In Vivo Tumor Growth Inhibition and Antiangiogenic Effect of Cyclic NGR Peptide-Daunorubicin Conjugates Developed for Targeted Drug Delivery","volume":"26","author":"Tripodi","year":"2020","journal-title":"Pathol. Oncol. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"21018","DOI":"10.1074\/jbc.M211204200","article-title":"A Novel Lytic Peptide Composed of Dl-Amino Acids Selectively Kills Cancer Cells in Culture and in Mice","volume":"278","author":"Papo","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.1158\/1078-0432.CCR-04-2422","article-title":"Combined Dendritic Cell Cryotherapy of Tumor Induces Systemic Antimetastatic Immunity","volume":"11","author":"Machlenkin","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"ref_53","unstructured":"Khabriev, R.U. (2005). Methodological Guidelines for the Preclinical Study of Agents Capable of Inhibiting Metastasis and Increasing the Efficacy of Cytostatic Therapy of Malignant Tumors. Guidelines for Experimental (Preclinical) Study of New Pharmacological Substances, Meditsina."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Niu, P.-G., Zhang, Y.-X., Shi, D.-H., Liu, Y., Chen, Y.-Y., and Deng, J. (2015). Cardamonin Inhibits Metastasis of Lewis Lung Carcinoma Cells by Decreasing mTOR Activity. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0127778"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"7981","DOI":"10.1039\/D5MA00412H","article-title":"Engineered Mn\u2013Zn-Doped Ferrite Nanomaterials: Exploring Magnetothermal Effects for Cancer Treatment","volume":"6","author":"Fopase","year":"2025","journal-title":"Mater. Adv."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"7627","DOI":"10.1021\/acsnano.6b02876","article-title":"Massive Intracellular Biodegradation of Iron Oxide Nanoparticles Evidenced Magnetically at Single-Endosome and Tissue Levels","volume":"10","author":"Mazuel","year":"2016","journal-title":"ACS Nano"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"121365","DOI":"10.1016\/j.biomaterials.2022.121365","article-title":"The Surface Coating of Iron Oxide Nanoparticles Drives Their Intracellular Trafficking and Degradation in Endolysosomes Differently Depending on the Cell Type","volume":"281","author":"Portilla","year":"2022","journal-title":"Biomaterials"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1021\/acs.chemrestox.9b00118","article-title":"Iron Oxide Nanoparticle-Induced Neoplastic-Like Cell Transformation in Vitro Is Reduced with a Protective Amorphous Silica Coating","volume":"32","author":"Kornberg","year":"2019","journal-title":"Chem. Res. Toxicol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.1007\/s11095-014-1417-0","article-title":"High Therapeutic Efficiency of Magnetic Hyperthermia in Xenograft Models Achieved with Moderate Temperature Dosages in the Tumor Area","volume":"31","author":"Kossatz","year":"2014","journal-title":"Pharm. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.actbio.2017.05.047","article-title":"Time-Course Assessment of the Aggregation and Metabolization of Magnetic Nanoparticles","volume":"58","author":"Rojas","year":"2017","journal-title":"Acta Biomater."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"126100","DOI":"10.1016\/j.cej.2020.126100","article-title":"Coordination of Injectable Self-Healing Hydrogel with Mn-Zn Ferrite@mesoporous Silica Nanospheres for Tumor MR Imaging and Efficient Synergistic Magnetothermal-Chemo-Chemodynamic Therapy","volume":"401","author":"Wang","year":"2020","journal-title":"Chem. Eng. J."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"265102","DOI":"10.1088\/0957-4484\/22\/26\/265102","article-title":"Magnetic Multicore Nanoparticles for Hyperthermia\u2014Influence of Particle Immobilization in Tumour Tissue on Magnetic Properties","volume":"22","author":"Dutz","year":"2011","journal-title":"Nanotechnology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1021\/acsami.8b18451","article-title":"Cell-Promoted Nanoparticle Aggregation Decreases Nanoparticle-Induced Hyperthermia under an Alternating Magnetic Field Independently of Nanoparticle Coating, Core Size, and Subcellular Localization","volume":"11","author":"Talelli","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1038\/srep02887","article-title":"Effect of Magnetic Dipolar Interactions on Nanoparticle Heating Efficiency: Implications for Cancer Hyperthermia","volume":"3","author":"Branquinho","year":"2013","journal-title":"Sci. Rep."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.cis.2011.04.003","article-title":"Magnetic Fluid Hyperthermia: Focus on Superparamagnetic Iron Oxide Nanoparticles","volume":"166","author":"Laurent","year":"2011","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"170091","DOI":"10.1016\/j.jmmm.2022.170091","article-title":"Uniform Size PEGylated Iron Oxide Nanoparticles as a Potential Theranostic Agent Synthesized by a Simple Optimized Coprecipitation Route","volume":"564","author":"Arsalani","year":"2022","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Liu, Y., Wang, S., Wang, Q., Wang, L., Dong, J., and Zhang, B. (2024). Increasing the Particle Size and Magnetic Property of Iron Oxide Nanoparticles through a Segregated Nucleation and Growth Process. Nanomaterials, 14.","DOI":"10.2139\/ssrn.4762160"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Danaei, M., Dehghankhold, M., Ataei, S., Hasanzadeh Davarani, F., Javanmard, R., Dokhani, A., Khorasani, S., and Mozafari, M.R. (2018). Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems. Pharmaceutics, 10.","DOI":"10.3390\/pharmaceutics10020057"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jconrel.2019.02.030","article-title":"Measuring Particle Size Distribution of Nanoparticle Enabled Medicinal Products, the Joint View of EUNCL and NCI-NCL. A Step by Step Approach Combining Orthogonal Measurements with Increasing Complexity","volume":"299","author":"Caputo","year":"2019","journal-title":"J. Control. Release"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Li, L., Li, D., and Zhang, Z. (2022). Colloidal Stability of Magnetite Nanoparticles Coated by Oleic Acid and 3-(N,N-Dimethylmyristylammonio)Propanesulfonate in Solvents. Front. Mater., 9.","DOI":"10.3389\/fmats.2022.893072"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1039\/C3RA44644A","article-title":"Non-Aqueous to Aqueous Phase Transfer of Oleic Acid Coated Iron Oxide Nanoparticles for Hyperthermia Application","volume":"4","author":"Patil","year":"2014","journal-title":"RSC Adv."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Slavu, L.M., Rinaldi, R., and Di Corato, R. (2021). Application in Nanomedicine of Manganese-Zinc Ferrite Nanoparticles. Appl. Sci., 11.","DOI":"10.3390\/app112311183"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Malvindi, M.A., De Matteis, V., Galeone, A., Brunetti, V., Anyfantis, G.C., Athanassiou, A., Cingolani, R., and Pompa, P.P. (2014). Toxicity Assessment of Silica Coated Iron Oxide Nanoparticles and Biocompatibility Improvement by Surface Engineering. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0085835"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"5888","DOI":"10.1021\/la500903m","article-title":"Distinctive Interactions of Oleic Acid Covered Magnetic Nanoparticles with Saturated and Unsaturated Phospholipids in Langmuir Monolayers","volume":"30","author":"Matshaya","year":"2014","journal-title":"Langmuir"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"4847","DOI":"10.2147\/IJN.S68539","article-title":"Development of a Lauric Acid\/Albumin Hybrid Iron Oxide Nanoparticle System with Improved Biocompatibility","volume":"9","author":"Zaloga","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jcat.2022.09.010","article-title":"Influence of the Hydrodynamic Size and \u03b6 Potential of Manganese Ferrite Nanozymes as Peroxidase-Mimicking Catalysts at pH 4 in Different Buffers","volume":"414","author":"Naranjo","year":"2022","journal-title":"J. Catal."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3892\/br.2015.540","article-title":"Effect of Interleukin-2 Treatment Combined with Magnetic Fluid Hyperthermia on Lewis Lung Cancer-Bearing Mice","volume":"4","author":"Hu","year":"2016","journal-title":"Biomed. Rep."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1759-7714.2011.00075.x","article-title":"Higher Temperature Improves the Efficacy of Magnetic Fluid Hyperthermia for Lewis Lung Cancer in a Mouse Model","volume":"3","author":"Hu","year":"2012","journal-title":"Thorac. Cancer"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s13045-024-01601-1","article-title":"Heat Shock Proteins as Hallmarks of Cancer: Insights from Molecular Mechanisms to Therapeutic Strategies","volume":"17","author":"Zuo","year":"2024","journal-title":"J. Hematol. Oncol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1158\/0008-5472.CAN-15-2908","article-title":"Hyperthermia Synergizes with Chemotherapy by Inhibiting PARP1-Dependent DNA Replication Arrest","volume":"76","author":"Schaaf","year":"2016","journal-title":"Cancer Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s10863-019-09805-8","article-title":"Hyperthermia Potentiates Cisplatin Cytotoxicity and Negative Effects on Mitochondrial Functions in OVCAR-3 Cells","volume":"51","author":"Sukovas","year":"2019","journal-title":"J. Bioenerg. Biomembr."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Helderman, R.F.C.P.A., L\u00f6ke, D.R., Verhoeff, J., Rodermond, H.M., Van Bochove, G.G.W., Boon, M., Van Kesteren, S., Garcia Vallejo, J.J., Kok, H.P., and Tanis, P.J. (2020). The Temperature-Dependent Effectiveness of Platinum-Based Drugs Mitomycin-C and 5-FU during Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Colorectal Cancer Cell Lines. Cells, 9.","DOI":"10.3390\/cells9081775"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1023\/A:1024586630954","article-title":"Classification of Substances with Respect to Acute Toxicity for Parenteral Administration","volume":"37","author":"Berezovskaya","year":"2003","journal-title":"Pharm. Chem. J."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/18\/8\/1021\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T12:11:30Z","timestamp":1787055090000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/18\/8\/1021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":83,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["pharmaceutics18081021"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics18081021","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,17]]}}}