{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T08:22:01Z","timestamp":1787559721356,"version":"build-2736575974"},"reference-count":64,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006334","name":"Jan Kochanowski University","doi-asserted-by":"publisher","award":["SUPB.RN.25.019"],"award-info":[{"award-number":["SUPB.RN.25.019"]}],"id":[{"id":"10.13039\/501100006334","id-type":"DOI","asserted-by":"publisher"}]},{"award":["SUPB.RN.25.019"],"award-info":[{"award-number":["SUPB.RN.25.019"]}],"id":[{"id":"https:\/\/ror.org\/00krbh354","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Background: Plants have been traditionally used for centuries to treat wounds and, over time, have been tested for their healing properties. There is a constant search for new natural resources that could be used to develop various topical wound care products. Methods: A comprehensive search of the literature was conducted in PubMed\/MEDLINE, Scopus, and Web of Science databases (2022\u20132026) in accordance with the PRISMA 2020 guidelines. Included studies focused on current in vitro and in vivo research on hydrogels containing plant extracts from the Asteraceae and Lamiaceae families and their potential application in wound healing and skin regeneration. Results: An analysis of 24 included studies confirms that both families include interesting and valuable plants with antioxidant, antimicrobial and anti-inflammatory properties; these plants also influence collagen deposition, fibroblast proliferation, and epithelialization, and reduce the risk of infection, thereby contributing to faster wound healing. The most frequently tested phytoextract in this respect was Calendula officinalis (Asteraceae) incorporated into a hydrogel. A variety of materials, including natural, semi-synthetic, and synthetic polymers, as well as hybrid matrix, but also diverse formulation strategies, from simple solutions to more advanced and modern methods, have been used to produce hydrogels. Conclusions: This systematic review summarizes the current evidence, highlights directions and possibilities for the use of phytoextract-based hydrogels, and discusses limitations and future perspectives in the development of effective externally applied formulations to support wound healing.<\/jats:p>","DOI":"10.3390\/pharmaceutics18091047","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T08:03:41Z","timestamp":1787558621000},"page":"1047","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Systematic Review of Recent Developments in Wound Healing and Skin Regeneration Properties of Plant-Extract-Based Hydrogels for Skin Delivery: A Focus on Asteraceae and Lamiaceae Families"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0471-3561","authenticated-orcid":false,"given":"Monika","family":"Michalak","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Collegium Medicum, Jan Kochanowski University, IX Wiek\u00f3w Kielc 19, 25-369 Kielce, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,23]]},"reference":[{"key":"ref_1","first-page":"2","article-title":"Medicinal plants and bioactive compounds: Traditional and modern approaches to wound healing","volume":"11","author":"Alimyar","year":"2025","journal-title":"Int. J. Med. Sci. Drug Res."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Albahri, G., Badran, A., Hijazi, A., Daou, A., Baydoun, E., Nasser, M., and Merah, O. (2023). The Therapeutic Wound Healing Bioactivities of Various Medicinal Plants. Life, 13.","DOI":"10.3390\/life13020317"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Michalak, M. (2023). Plant Extracts as Skin Care and Therapeutic Agents. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242015444"},{"key":"ref_4","first-page":"247","article-title":"Novel Approaches for Herbal Drug Delivery in Wound Healing: A Review","volume":"84","author":"Khan","year":"2022","journal-title":"Indian J. Pharm. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Marchioni, I., Najar, B., Ruini, B., Copetta, A., Pistelli, L., and Pistelli, L. (2020). Bioactive Compounds and Aroma Profile of Some Lamiaceae Edible Flowers. Plants, 9.","DOI":"10.3390\/plants9060691"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Kowalczyk, T., Merecz-Sadowska, A., Ghorbanpour, M., Szemraj, J., Piekarski, J., Bijak, M., \u015aliwi\u0144ski, T., Zajdel, R., and Sitarek, P. (2023). Enhanced Natural Strength: Lamiaceae Essential Oils and Nanotechnology in In Vitro and In Vivo Medical Research. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242015279"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Rolnik, A., and Olas, B. (2021). The Plants of the Asteraceae Family as Agents in the Protection of Human Health. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22063009"},{"key":"ref_8","first-page":"187","article-title":"Chemical composition, biological activities, and nutritional application of Asteraceae family herbs: A systematic review","volume":"6","author":"Kazeminia","year":"2022","journal-title":"Trends Phytochem. Res."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Marques, M.P., Mendon\u00e7a, L., Neves, B.G., Varela, C., Oliveira, P., and Cabral, C. (2023). Exploring Iberian Peninsula Lamiaceae as Potential Therapeutic Approaches in Wound Healing. Pharmaceuticals, 16.","DOI":"10.3390\/ph16030347"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.2174\/0115680266319052240819104310","article-title":"Phytochemical Profile and Antioxidant and Protective Activities of Various Types of Extracts from Hyssopus officinalis L. and Grindelia robusta Nutt. Herb Grown in Poland","volume":"24","author":"Michalak","year":"2024","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Michalak, M., Stryjecka, M., \u017barnowiec, P., Zag\u00f3rska-Dziok, M., and Kie\u0142tyka-Dadasiewicz, A. (2024). Chemical Composition of Extracts from Various Parts of Feverfew (Tanacetum parthenium L.) and Their Antioxidant, Protective, and Antimicrobial Activities. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252212179"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Michalak, M., Zag\u00f3rska-Dziok, M., \u017barnowiec, P., Ostro\u017cka-Cie\u015blik, A., Bocho-Janiszewska, A., Stryjecka, M., Dobro\u015b, N., Kostrzewa, D., and Paradowska, K. (2025). Evaluation of Salvia yangii Extract as a Promising Protective Raw Material Applied Topically to the Skin. Molecules, 30.","DOI":"10.3390\/molecules30173505"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Michalak, M., Stryjecka, M., Zag\u00f3rska-Dziok, M., and \u017barnowiec, P. (2024). Biological Activity of Horehound (Marrubium vulgare L.) Herb Grown in Poland and Its Phytochemical Composition. Pharmaceuticals, 17.","DOI":"10.3390\/ph17060780"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"107260","DOI":"10.1016\/j.burns.2024.08.026","article-title":"Recent advances in the use of essential oils and their nanoformulations for wound treatment","volume":"51","author":"Mssillou","year":"2025","journal-title":"Burns"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Carvalho, A.R., Diniz, R.M., Suarez, M.A.M., Figueiredo, C.S.S.e.S., Zagmignan, A., Grisotto, M.A.G., Fernandes, E.S., and da Silva, L.C.N. (2018). Use of Some Asteraceae Plants for the Treatment of Wounds: From Ethnopharmacological Studies to Scientific Evidences. Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.00784"},{"key":"ref_16","first-page":"21","article-title":"The Medicinal Value of Asteraceae Family Plants in Terms of Wound Healing Activity","volume":"39","author":"Suntar","year":"2014","journal-title":"FABAD J. Pharm. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Bonnici, L., Suleiman, S., Schembri-Wismaye, P., and Cassar, A. (2024). Targeting Signalling Pathways in Chronic Wound Healing. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25010050"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"197","DOI":"10.18794\/aams\/173203","article-title":"Wound healing\u2014Characteristics of the ideal dressing","volume":"77","author":"Olczyk","year":"2023","journal-title":"Ann. Acad. Med. Siles."},{"key":"ref_19","first-page":"146764","article-title":"Complements and the Wound Healing Cascade: An Updated Review","volume":"2013","author":"Sinno","year":"2013","journal-title":"Plast. Surg. Int."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Herman, A., Leska, A., Wi\u0144ska, P., and Herman, A.P. (2025). Plant Extracts as Modulators of the Wound Healing Process\u2014Preliminary Study. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26157490"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s10787-023-01157-5","article-title":"The wound healing effect of botanicals and pure natural substances used in in vivo models","volume":"31","author":"Negm","year":"2023","journal-title":"Inflammopharmacology"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Comino-Sanz, I.M., L\u00f3pez-Franco, M.D., Castro, B., and Pancorbo-Hidalgo, P.L. (2021). The Role of Antioxidants on Wound Healing: A Review of the Current Evidence. J. Clin. Med., 10.","DOI":"10.20944\/preprints202107.0361.v1"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Michalak, M. (2022). Plant-Derived Antioxidants: Significance in Skin Health and the Ageing Process. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23020585"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/efd2.160","article-title":"Guidelines for the in vitro Determination of Anti-Inflammatory Activity","volume":"5","author":"Huang","year":"2024","journal-title":"eFood"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Michalak, M., Zag\u00f3rska-Dziok, M., Klimek-Szczykutowicz, M., and Szopa, A. (2023). Phenolic Profile and Comparison of the Antioxidant, Anti-Ageing, Anti-Inflammatory, and Protective Activities of Borago officinalis Extracts on Skin Cells. Molecules, 28.","DOI":"10.3390\/molecules28020868"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Balestrin, L.A., Back, P.I., Marques, M.S., Ara\u00fajo, G.M.S., Carrasco, M.C.F., Batista, M.M., Silveira, T., Rodrigues, J.L., Fachel, F.N.S., and Koester, L.S. (2022). Effect of Hydrogel Containing Achyrocline satureioides (Asteraceae) Extract\u2013Loaded Nanoemulsions on Wound Healing Activity. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14122726"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Lee, S.G., Lee, E.B., Nam, T.S., You, S., Im, D., Kim, K., Gu, B., Nam, G.-y., Lee, H., and Kwon, S.J. (2025). Anti-Inflammatory and Pain-Relieving Effects of Arnica Extract Hydrogel Patch in Carrageenan-Induced Inflammation and Hot Plate Pain Models. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17020171"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00403-014-1474-6","article-title":"Medicinal plants and their natural components as future drugs for the treatment of burn wounds: An integrative review","volume":"306","author":"Bahramsoltani","year":"2014","journal-title":"Arch. Dermatol. Res."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Michalak, M., Zagorska-Dziok, M., \u017barnowiec, P., Bocho-Janiszewska, A., Stryjecka, M., Kostrzewa, D., Dobro\u015b, N., and Paradowska, K. (2025). Evaluation of Achillea millefolium var. Paprika Extract with Antioxidant, Antimicrobial, and Skin Protection Potential in Topical Application. Appl. Sci., 15.","DOI":"10.3390\/app15094631"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"399724","DOI":"10.1590\/acb399724","article-title":"Calendula Glycolic Extract Enhances Wound Healing of Alginate Hydrogel","volume":"39","author":"Possa","year":"2024","journal-title":"Acta Cir. Bras."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Paczkowska-Walendowska, M., Koumentakou, I., Lazaridou, M., Bikiaris, D., Miklaszewski, A., Plech, T., and Cielecka-Piontek, J. (2024). 3D-Printed Chitosan-Based Scaffolds with Scutellaria baicalensis Extract for Dental Applications. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16030359"},{"key":"ref_32","first-page":"824","article-title":"Fabrication and Evaluation of 3D-Printed Dittany-Infused Patches for Anti-Inflammatory Dermatological Applications","volume":"92","author":"Paloukopoulou","year":"2025","journal-title":"Planta Med."},{"key":"ref_33","first-page":"19","article-title":"Healing of Wounds Treated with Chitosan Hydrogels with Extracts from Aloe vera and Calendula officinalis","volume":"43","year":"2022","journal-title":"Rev. Mex. Ing. Biom\u00e9dica"},{"key":"ref_34","first-page":"54","article-title":"Treatment of Burn Wounds with a Chitosan-Based Hydrogel Dressing Containing Artemisia absinthium L.: A Comprehensive In Vivo Study","volume":"5","author":"Aydin","year":"2024","journal-title":"Int. J. Tradit. Complement. Med. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s43939-025-00178-x","article-title":"Progress in hydrogel toughening: Addressing structural and crosslinking challenges for biomedical applications","volume":"5","author":"Rumon","year":"2025","journal-title":"Discov. Mat."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Alberts, A., Moldoveanu, E.-T., Niculescu, A.-G., and Grumezescu, A.M. (2025). Hydrogels for Wound Dressings: Applications in Burn Treatment and Chronic Wound Care. J. Compos. Sci., 9.","DOI":"10.3390\/jcs9030133"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Gounden, V., and Singh, M. (2024). Hydrogels and Wound Healing: Current and Future Prospects. Gels, 10.","DOI":"10.3390\/gels10010043"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"47738","DOI":"10.1002\/app.47738","article-title":"Wound dressings: Current advances and future directions","volume":"136","author":"Ghomi","year":"2019","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Pintilei, P.S., Binaymotlagh, R., Chronopoulou, L., and Palocci, C. (2025). The Role of Natural Hydrogels in Enhancing Wound Healing: From Biomaterials to Bioactive Therapies. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17101243"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Chelu, M., and Musuc, A.M. (2023). Polymer Gels: Classification and Recent Developments in Biomedical Applications. Gels, 9.","DOI":"10.3390\/gels9020161"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Maeso, L., Antezana, P.E., Hvozda Arana, A.G., Evelson, P.A., Orive, G., and Desimone, M.F. (2024). Progress in the Use of Hydrogels for Antioxidant Delivery in Skin Wounds. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16040524"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"114719","DOI":"10.1016\/j.jconrel.2026.114719","article-title":"Hybrid hydrogels for biomedical applications: Addressing challenges in drug delivery through advanced crosslinking and nanocarrier integration","volume":"392","author":"Anwar","year":"2026","journal-title":"J. Control. Release"},{"key":"ref_43","first-page":"1257","article-title":"Herbal-Based Hydrogels for Topical Applications: A Comprehensive Review of Formulation, Properties, and Therapeutic Potential","volume":"11","author":"Verma","year":"2026","journal-title":"Int. J. Pharm. Res. Appl."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"100161","DOI":"10.1016\/j.plana.2025.100161","article-title":"Nanomaterials for delivery of medicinal plant extracts and phytochemicals: Potential applications and future perspectives","volume":"12","author":"Ghosh","year":"2025","journal-title":"Plant Nano Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1007\/s12010-026-05594-0","article-title":"Plasticization of an Ageratum conyzoides Natural Extract in Crosslinked Hydrogel: A Promising Material for Combating Wound Infection","volume":"198","author":"Kantesaria","year":"2026","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Papp, B., Szucs, Z., Gonda, S., Cziaky, Z., Kajtar, R., Lekli, I., Haimhoffer, A., Klusoczki, A., Jozsa, L., and Pet\u0151, \u00c1. (2026). Preparation and Investigation of Artemisia annua L.-Loaded Alginate Hydrogels with Excipients. Pharmaceuticals, 19.","DOI":"10.3390\/ph19030424"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Dogra, S., Koul, B., Singh, J., Mishra, M., and Rabbee, M.F. (2024). Formulation and In Vitro Assessment of Tragacanth Gum-Based Hydrogel Loaded with Artemisia vestita Leaf Extract for Wound Healing. Processes, 12.","DOI":"10.3390\/pr12122750"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Ferreira, L.M.d.M.C., Bandeira, E.d.S., Gomes, M.F., Lynch, D.G., Bastos, G.N.T., Silva-J\u00fanior, J.O.C., and Ribeiro-Costa, R.M. (2023). Polyacrylamide Hydrogel Containing Calendula Extract as aWound Healing Bandage: In Vivo Test. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043806"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jtv.2021.10.004","article-title":"Chronic wound healing by controlled release of chitosan hydrogels loaded with silver nanoparticles and calendula extract","volume":"31","year":"2022","journal-title":"J. Tissue Viability"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Pelin, I.M., Silion, M., Popescu, I., R\u00eembu, C.M., Fundueanu, G., and Constantin, M. (2023). Pullulan\/Poly(vinyl alcohol) Hydrogels Loaded with Calendula officinalis Extract: Design and In Vitro Evaluation for Wound Healing Applications. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15061674"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Chanaj-Kaczmarek, J., Paczkowska, M., Osma\u0142ek, T., Kapro\u0144, B., Plech, T., Szymanowska, D., Kara\u017aniewicz-\u0141ada, M., Kobus-Cisowska, J., and Cielecka-Piontek, J. (2020). Hydrogel Delivery System Containing Calendulae flos Lyophilized Extract with Chitosan as a Supporting Strategy for Wound Healing Applications. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12070634"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14715\/cmb\/2022.68.11.1","article-title":"Preparation of Liposomal Hydrogel Containing Calendula and Application as a Wound Dressing","volume":"68","author":"Naseriyeh","year":"2022","journal-title":"Cell. Mol. Biol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Zamora-Mendoza, L., Vispo, S.N., De Lima, L., Mora, J.R., Machado, A., and Alexis, F. (2023). Hydrogel for the Controlled Delivery of Bioactive Components from Extracts of Eupatorium glutinosum Lam. Leaves. Molecules, 28.","DOI":"10.3390\/molecules28041591"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"901","DOI":"10.2174\/1567201820666230328122504","article-title":"A Novel Phytotherapy Application: Preparation, Characterization, Antioxidant Activities and Determination of Anti-inflammatory Effects by In vivo HET-CAM Assay of Chitosan-based DDSs Containing Endemic Helichrysum pamphylicum P.H. Davis & Kupicha Methanolic Extract","volume":"21","author":"Ismailovi","year":"2024","journal-title":"Curr. Drug Deliv."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"135425","DOI":"10.1016\/j.ijbiomac.2024.135425","article-title":"A Multifunctional Polyacrylonitrile Fibers\/Alginate-Based Hydrogel Loaded with Chamomile Extract and Silver Sulfadiazine for Full-Thickness Wound Healing","volume":"279","author":"Moshfeghi","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"107700","DOI":"10.1016\/j.burns.2025.107700","article-title":"Accelerating Burn Wound Healing Using Alginate\/Carboxymethyl Cellulose Nanogel Containing Tussilago farfara and ZnO Nanoparticles","volume":"51","author":"Zamani","year":"2025","journal-title":"Burns"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"140186","DOI":"10.1016\/j.ijbiomac.2025.140186","article-title":"Xanthium strumarium\/Gelatin Methacryloyl-Based Hydrogels with Anti-Inflammatory and Antioxidant Properties for Diabetic Wound Healing via the Akt\/mTOR Pathway","volume":"300","author":"Zhao","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"4242","DOI":"10.1039\/D4BM00349G","article-title":"A Novel Chitosan\u2013PEG Hydrogel Embedded with In Situ Silver Nanoparticles of Clerodendrum glandulosum Lindl. Extract: Evaluation of Its In Vivo Diabetic Wound Healing Properties Using an Image-Guided Machine Learning Model","volume":"12","author":"Majie","year":"2024","journal-title":"Biomater. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1080\/14786419.2022.2108421","article-title":"LC-MS\/MS Metabolomics Profiling of Glechoma hederacea L. Methanolic Extract; In Vitro Antimicrobial and In Vivo with In Silico Wound Healing Studies on Staphylococcus aureus-Infected Rat Skin Wound","volume":"37","author":"Nohara","year":"2023","journal-title":"Nat. Prod. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41598-021-04025-w","article-title":"Sustainable Phyto-Fabrication of Silver Nanoparticles Using Gmelina arborea Exhibit Antimicrobial and Biofilm Inhibition Activity","volume":"12","author":"Chandrasekharan","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"21109","DOI":"10.1038\/s41598-024-71525-w","article-title":"Design of multiple-function matrix encapsulated with Marjoram extract to support cellular functions, stimulate collagen synthesis and decrease infection in wound","volume":"14","author":"Mohammadi","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Gavan, A., Colobatiu, L., Hanganu, D., Bogdan, C., Olah, N.K., Achim, M., and Mirel, S. (2022). Development and Evaluation of Hydrogel Wound Dressings Loaded with Herbal Extracts. Processes, 10.","DOI":"10.3390\/pr10020242"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Negut, I., Grumezescu, V., and Grumezescu, A.M. (2018). Treatment Strategies for Infected Wounds. 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