{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:23:16Z","timestamp":1787732596806,"version":"build-2784847793"},"reference-count":18,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Polymeric drug delivery systems continue to play a pivotal role in modern pharmaceutical research, offering innovative solutions for overcoming limitations associated with conventional drug administration [...]<\/jats:p>","DOI":"10.3390\/pharmaceutics18091058","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:11:15Z","timestamp":1787731875000},"page":"1058","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advances in Polymeric Drug Delivery Systems"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0950-7409","authenticated-orcid":false,"given":"Barbara","family":"Zawidlak-W\u0119grzy\u0144ska","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Medicine in Zabrze, Academy of Silesia, 40-555 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3972-7074","authenticated-orcid":false,"given":"Joanna","family":"Rydz","sequence":"additional","affiliation":[{"name":"Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sk\u0142odowska 34, 41-819 Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Pathak, A., and Singh, S.P. (2025). Introduction to Drug Delivery System: Past, Present, and Future Perspectives. Next-Generation Drug Delivery Systems, Humana. Methods in Pharmacology and Toxicology.","DOI":"10.1007\/978-1-0716-4554-3"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1021\/acs.chemrev.5b00346","article-title":"Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release","volume":"116","author":"Kamaly","year":"2016","journal-title":"Chem. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"16071","DOI":"10.1038\/natrevmats.2016.71","article-title":"Designing Hydrogels for Controlled Drug Delivery","volume":"1","author":"Li","year":"2016","journal-title":"Nat. Rev. Mater."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40824-020-00190-7","article-title":"Recent Advances in Polymeric Drug Delivery Systems","volume":"24","author":"Sung","year":"2020","journal-title":"Biomater. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","article-title":"Engineering Precision Nanoparticles for Drug Delivery","volume":"20","author":"Mitchell","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/s41551-021-00698-w","article-title":"The Evolution of Commercial Drug Delivery Technologies","volume":"5","author":"Vargason","year":"2021","journal-title":"Nat. Biomed. Eng."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"100083","DOI":"10.1016\/j.ntm.2025.100083","article-title":"Nanoparticles for Drug Delivery: Insight into In Vitro and In Vivo Drug Release from Nanomedicines","volume":"4","author":"Ewii","year":"2025","journal-title":"Nano TransMed"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Negut, I., and Bita, B. (2023). Polymeric Micellar Systems\u2014A Special Emphasis on \u201cSmart\u201d Drug Delivery. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15030976"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Lee, H., Jeong, Y., Lee, N., Lee, I., and Lee, J.H. (2026). Recent Advances in Injectable Hydrogels for Biomedical and Aesthetic Applications: Focus on Rheological Characteristics. Gels, 12.","DOI":"10.3390\/gels12010011"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Milano, F., Masi, A., Madaghiele, M., Sannino, A., Salvatore, L., and Gallo, N. (2023). Current Trends in Gelatin-Based Drug Delivery Systems. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15051499"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Garcia, K.R., Beck, R.C.R., Brandalise, R.N., dos Santos, V., and Koester, L.S. (2024). Nanocellulose, the Green Biopolymer Trending in Pharmaceuticals: A Patent Review. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16010145"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Liu, J., Wu, W., Zhu, Q., and Zhu, H. (2023). Hydrogel-Based Therapeutics for Pancreatic Ductal Adenocarcinoma Treatment. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15102421"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Yu, Z., Shen, X., Yu, H., Tu, H., Chittasupho, C., and Zhao, Y. (2023). Smart Polymeric Nanoparticles in Cancer Immunotherapy. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15030775"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Rathi, R., Kumar, A., Vishvakarma, V., Huanbutta, K., Singh, I., and Sangnim, T. (2022). Advancements in Rectal Drug Delivery Systems: Clinical Trials and Patents Perspective. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14102210"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Zawidlak-W\u0119grzy\u0144ska, B., Rydz, J., Musio\u0142, M., and Radziwon-Balicka, A. (2024). Polymer\u2013Drug Anti-Thrombogenic and Hemocompatible Coatings as Surface Modifications. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16030432"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Domi\u0144ski, A., Konieczny, T., Godzierz, M., Musio\u0142, M., Janeczek, H., Fory\u015b, A., Domi\u0144ska, M., Pastuch-Gawo\u0142ek, G., Piotrowski, T., and Kurcok, P. (2022). Co-Delivery of 8-Hydroxyquinoline Glycoconjugates and Doxorubicin by Supramolecular Hydrogel Based on \u03b1-Cyclodextrin and pH-Responsive Micelles for Enhanced Tumor Treatment. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14112490"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Joiner, J.B., Prasher, A., Young, I.C., Kim, J., Shrivastava, R., Maturavongsadit, P., and Benhabbour, S.R. (2022). Effects of Drug Physicochemical Properties on In-Situ Forming Implant Polymer Degradation and Drug Release Kinetics. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14061188"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Gohn, A.M., Nolte, A., Ravotti, E., Forster, S.P., Giles, M., Rudd, N., and Mendis, G. (2022). Dissolution from Ethylene Vinyl Acetate Copolymer Long-Acting Implants: Effect of Model Active Ingredient Size and Shape. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14061139"}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/18\/9\/1058\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:15:48Z","timestamp":1787732148000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/18\/9\/1058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":18,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["pharmaceutics18091058"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics18091058","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,26]]}}}