{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:20:40Z","timestamp":1787818840740,"version":"build-2784847793"},"reference-count":198,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304395"],"award-info":[{"award-number":["82304395"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82504700"],"award-info":[{"award-number":["82504700"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["82304395"],"award-info":[{"award-number":["82304395"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"award":["82504700"],"award-info":[{"award-number":["82504700"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Nanodrug delivery systems have shown great promise against tumors, inflammatory diseases and central nervous system disorders. However, several limitations still exist before further clinical application. The unsatisfactory circulation time in vivo, rapid clearance by the mononuclear phagocyte system, insufficient tissue penetration and low targeting efficiency all hinder the clinical translation of nanomedicines. Cells are the fundamental functional units of the body and their intrinsic biological properties make them promising drug delivery vehicles for targeted therapy. Conjugating cells with nanomedicines combines the carrier functions of living cells with the therapeutic effects of nanodrugs, offering an effective strategy to improve targeted drug delivery. Compared with the existing literature, this review specifically summarizes the biological properties and major applications of six types of living cell carriers. The recent strategies for constructing cell\u2013nanomedicine conjugates are also discussed. Finally, we highlight the current challenges for clinical translation and discuss future directions for the development of cell\u2013nanomedicine delivery systems.<\/jats:p>","DOI":"10.3390\/pharmaceutics18091070","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:02:27Z","timestamp":1787817747000},"page":"1070","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advances in Living Cell-Mediated Nanodrug Delivery Systems: Construction Strategies, Applications and Challenges"],"prefix":"10.3390","volume":"18","author":[{"given":"Huaying","family":"Pan","sequence":"first","affiliation":[{"name":"Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug, West China School of Pharmacy, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Fu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug, West China School of Pharmacy, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenao","family":"Yan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug, West China School of Pharmacy, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Yan","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China"},{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug, West China School of Pharmacy, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6201-9338","authenticated-orcid":false,"given":"Yining","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minglu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug, West China School of Pharmacy, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2496-7141","authenticated-orcid":false,"given":"Yucheng","family":"Xiang","sequence":"additional","affiliation":[{"name":"Sichuan Higher Education Institute Key Laboratory of Structure-Specific Small Molecule Drugs, Institute of Materia Medica, School of Pharmacy, Chengdu Medical College, Chengdu 610500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41392-023-01536-y","article-title":"Nanomedicine in Cancer Therapy","volume":"8","author":"Fan","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"113919","DOI":"10.1016\/j.jconrel.2025.113919","article-title":"Monocyte Membrane-Coated Drug Nanocrystals for Enhanced Targeted Therapy of Rheumatoid Arthritis","volume":"384","author":"Shi","year":"2025","journal-title":"J. Control. Release"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.apsb.2023.10.006","article-title":"Dual-Responsive Supramolecular Photodynamic Nanomedicine with Activatable Immunomodulation for Enhanced Antitumor Therapy","volume":"14","author":"He","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e2307261","DOI":"10.1002\/smll.202307261","article-title":"A Less-Is-More Strategy for Mitochondria-Targeted Photodynamic Therapy of Rheumatoid Arthritis","volume":"20","author":"Zuo","year":"2024","journal-title":"Small"},{"key":"ref_5","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Pardridge, W.M. (2019). Blood-Brain Barrier and Delivery of Protein and Gene Therapeutics to Brain. Front. Aging Neurosci., 11.","DOI":"10.3389\/fnagi.2019.00373"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e2417869","DOI":"10.1002\/adma.202417869","article-title":"Microglial-Biomimetic Memantine-Loaded Polydopamine Nanomedicines for Alleviating Depression","volume":"37","author":"Jiang","year":"2025","journal-title":"Adv. Mater."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jconrel.2021.04.029","article-title":"Improving Anti-PD-L1 Therapy in Triple Negative Breast Cancer by Polymer-Enhanced Immunogenic Cell Death and CXCR4 Blockade","volume":"334","author":"Zhou","year":"2021","journal-title":"J. Control. Release"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41392-023-01499-0","article-title":"Metabolic Reprogramming of Proinflammatory Macrophages by Target Delivered Roburic Acid Effectively Ameliorates Rheumatoid Arthritis Symptoms","volume":"8","author":"Jia","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jconrel.2022.05.011","article-title":"Split Bullets Loaded Nanoparticles for Amplified Immunotherapy","volume":"347","author":"Liu","year":"2022","journal-title":"J. Control. Release"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.jconrel.2022.11.006","article-title":"Peritumoral Scaffold Neutralizes Tumor pH for Chemotherapy Sensitization and Metastasis Inhibition","volume":"352","author":"Yan","year":"2022","journal-title":"J. Control. Release"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.jconrel.2024.01.069","article-title":"A Nano-Platform Combats the \u201cAttack\u201d and \u201cDefense\u201d of Cytoskeleton to Block Cascading Tumor Metastasis","volume":"367","author":"Tao","year":"2024","journal-title":"J. Control. Release"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1038\/s41467-024-47111-z","article-title":"Cell Surface Patching via CXCR4-Targeted Nanothreads for Cancer Metastasis Inhibition","volume":"15","author":"Zhou","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e000573","DOI":"10.1136\/bmjonc-2024-000573","article-title":"Thirty Years from FDA Approval of Pegylated Liposomal Doxorubicin (Doxil\/Caelyx): An Updated Analysis and Future Perspective","volume":"4","author":"Gabizon","year":"2025","journal-title":"BMJ Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Kadri, H., Alshatfa, M., Alsalloum, F.Z., Elhissi, A., Daou, A., and Khoder, M. (2025). Albumin Nanoparticles in Cancer Therapeutics: Clinical Status, Challenges, and Future Directions. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17101290"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1716153","article-title":"Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis","volume":"379","author":"Adams","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"6389","DOI":"10.1038\/s41467-025-61543-1","article-title":"Targeting Modulation of the Choroid Plexus Blood-CSF Barrier and CSF Hypersecretion via Lipid Nanoparticle-Mediated Co-Delivery of siRNA and Resveratrol","volume":"16","author":"Wang","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e2203182","DOI":"10.1002\/smll.202203182","article-title":"Intranasal Delivery of BACE1 siRNA and Rapamycin by Dual Targets Modified Nanoparticles for Alzheimer\u2019s Disease Therapy","volume":"18","author":"Yang","year":"2022","journal-title":"Small"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1021\/acsnano.1c06022","article-title":"Targeted Inhibition of Tumor Inflammation and Tumor-Platelet Crosstalk by Nanoparticle-Mediated Drug Delivery Mitigates Cancer Metastasis","volume":"16","author":"Li","year":"2022","journal-title":"ACS Nano"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1016\/j.apsb.2023.02.009","article-title":"Sequential Delivery of PD-1\/PD-L1 Blockade Peptide and IDO Inhibitor for Immunosuppressive Microenvironment Remodeling via an MMP-2 Responsive Dual-Targeting Liposome","volume":"13","author":"Hu","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jconrel.2022.09.027","article-title":"A Cell-Laden Hydrogel as Prophylactic Vaccine and Anti-PD-L1 Amplifier against Autologous Tumors","volume":"351","author":"Li","year":"2022","journal-title":"J. Control. Release"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/s41392-025-02453-y","article-title":"Microglia-Derived Nanovesicles Synchronize Macroautophagy and Chaperone-Mediated Autophagy for Alzheimer\u2019s Disease Therapy","volume":"10","author":"Li","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"113820","DOI":"10.1016\/j.jconrel.2025.113820","article-title":"Dual-Action Membrane-Chimeric Liposomes with Self-Reinforcing Targeting for Acute Lung Injury Treatment","volume":"383","author":"Bai","year":"2025","journal-title":"J. Control. Release"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.jconrel.2023.11.050","article-title":"Co-Delivery of Oxaliplatin Prodrug Liposomes with Bacillus Calmette-Gu\u00e9rin for Chemo-Immunotherapy of Orthotopic Bladder Cancer","volume":"365","author":"Ma","year":"2024","journal-title":"J. Control. Release"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1016\/j.apsb.2021.12.015","article-title":"Milk-Derived Exosomes Exhibit Versatile Effects for Improved Oral Drug Delivery","volume":"12","author":"Wu","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"114614","DOI":"10.1016\/j.addr.2022.114614","article-title":"The Tumor EPR Effect for Cancer Drug Delivery: Current Status, Limitations, and Alternatives","volume":"191","author":"Sun","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41392-021-00631-2","article-title":"Recent Progress in Targeted Delivery Vectors Based on Biomimetic Nanoparticles","volume":"6","author":"Chen","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.1038\/s41467-023-40814-9","article-title":"Cholesterol Removal Improves Performance of a Model Biomimetic System to Co-Deliver a Photothermal Agent and a STING Agonist for Cancer Immunotherapy","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"9847612","DOI":"10.34133\/2022\/9847612","article-title":"Glymphatic System and Subsidiary Pathways Drive Nanoparticles Away from the Brain","volume":"2022","author":"Liu","year":"2022","journal-title":"Research"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"5241","DOI":"10.1021\/acsnano.7b08355","article-title":"Erythrocyte-Cancer Hybrid Membrane Camouflaged Hollow Copper Sulfide Nanoparticles for Prolonged Circulation Life and Homotypic-Targeting Photothermal\/Chemotherapy of Melanoma","volume":"12","author":"Wang","year":"2018","journal-title":"ACS Nano"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"120159","DOI":"10.1016\/j.biomaterials.2020.120159","article-title":"Phagocyte-Membrane-Coated and Laser-Responsive Nanoparticles Control Primary and Metastatic Cancer by Inducing Anti-Tumor Immunity","volume":"255","author":"Hu","year":"2020","journal-title":"Biomaterials"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.actbio.2022.05.045","article-title":"Metabolic Reprogramming by Dual-Targeting Biomimetic Nanoparticles for Enhanced Tumor Chemo-Immunotherapy","volume":"148","author":"Zang","year":"2022","journal-title":"Acta Biomater."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1039\/C9BM01444F","article-title":"Biomimetic Cell-Derived Nanocarriers for Modulating Immune Responses","volume":"8","author":"Qin","year":"2020","journal-title":"Biomater. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"167539","DOI":"10.1016\/j.jmb.2022.167539","article-title":"Probing the Interaction Between Supercarrier RBC Membrane and Nanoparticles for Optimal Drug Delivery","volume":"435","author":"Wang","year":"2023","journal-title":"J. Mol. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1039\/D2LC00799A","article-title":"Nanoparticle Protein Corona: From Structure and Function to Therapeutic Targeting","volume":"23","author":"Bashiri","year":"2023","journal-title":"Lab Chip"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.jcis.2023.06.015","article-title":"Fusogenic Cell-Derived Nanocarriers for Cytosolic Delivery of Cargo inside Living Cells","volume":"648","author":"Soprano","year":"2023","journal-title":"J. Colloid Interface Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e2207787","DOI":"10.1002\/adma.202207787","article-title":"Living Leukocyte-Based Drug Delivery Systems","volume":"35","author":"Chen","year":"2023","journal-title":"Adv. Mater."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"114827","DOI":"10.1016\/j.addr.2023.114827","article-title":"Myeloid Cell-Mediated Drug Delivery: From Nanomedicine to Cell Therapy","volume":"197","author":"Zhang","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"eabn1805","DOI":"10.1126\/sciadv.abn1805","article-title":"In Vivo Hitchhiking of Immune Cells by Intracellular Self-Assembly of Bacteria-Mimetic Nanomedicine for Targeted Therapy of Melanoma","volume":"8","author":"Gao","year":"2022","journal-title":"Sci. Adv."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev-cellbio-120420-104341","article-title":"Hitchhiking Across Kingdoms: Cotransport of Cargos in Fungal, Animal, and Plant Cells","volume":"38","author":"Christensen","year":"2022","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1038\/s41401-020-00606-z","article-title":"Surface Loading of Nanoparticles on Engineered or Natural Erythrocytes for Prolonged Circulation Time: Strategies and Applications","volume":"42","author":"Zhang","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"11129","DOI":"10.1021\/nn404853z","article-title":"Delivering Nanoparticles to Lungs While Avoiding Liver and Spleen through Adsorption on Red Blood Cells","volume":"7","author":"Anselmo","year":"2013","journal-title":"ACS Nano"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1038\/s41467-018-05079-7","article-title":"Red Blood Cell-Hitchhiking Boosts Delivery of Nanocarriers to Chosen Organs by Orders of Magnitude","volume":"9","author":"Brenner","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"5205","DOI":"10.1007\/s12274-022-4105-0","article-title":"Glucose-Responsive Erythrocyte-Bound Nanoparticles for Continuously Modulated Insulin Release","volume":"15","author":"Xu","year":"2022","journal-title":"Nano Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"122505","DOI":"10.1016\/j.carbpol.2024.122505","article-title":"Drug Delivery under Cover of Erythrocytes Extends Drug Half-Life: A Thrombolytic Targeting Therapy Utilizing Microenvironment-Responsive Artificial Polysaccharide Microvesicles","volume":"343","author":"Shan","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2201481","DOI":"10.1002\/advs.202201481","article-title":"Cyclic Mechanical Stresses Alter Erythrocyte Membrane Composition and Microstructure and Trigger Macrophage Phagocytosis","volume":"9","author":"Yeh","year":"2022","journal-title":"Adv. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"eaed3138","DOI":"10.1126\/sciadv.aed3138","article-title":"Erythrocyte Patch for Enhanced B Cell Depletion Therapy","volume":"12","author":"Liu","year":"2026","journal-title":"Sci. Adv."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"517","DOI":"10.26502\/jbb.2642-91280175","article-title":"Revolutionary Advances in Red Blood Cell-Based Nano carrier Drug Delivery Systems for Specific Tumor Therapy: Progresses, Challenges, and Research Directions","volume":"7","author":"Ullah","year":"2024","journal-title":"J. Biotechnol. Biomed."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jconrel.2011.09.084","article-title":"E-Selectin as a Target for Drug Delivery and Molecular Imaging","volume":"158","author":"Jubeli","year":"2012","journal-title":"J. Control. Release"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.apsb.2021.05.012","article-title":"Fucoidan-Functionalized Activated Platelet-Hitchhiking Micelles Simultaneously Track Tumor Cells and Remodel the Immunosuppressive Microenvironment for Efficient Metastatic Cancer Treatment","volume":"12","author":"Guo","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1161\/CIRCRESAHA.117.310795","article-title":"Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis","volume":"122","author":"Koupenova","year":"2018","journal-title":"Circ. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.actbio.2025.02.014","article-title":"In Situ Dual-Targeted Drug Delivery System for Alleviating Imaging and Pathological Damage in Septic Arthritis","volume":"195","author":"Wang","year":"2025","journal-title":"Acta Biomater."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"122478","DOI":"10.1016\/j.biomaterials.2024.122478","article-title":"Platelet-Derived Drug Delivery Systems: Pioneering Treatment for Cancer, Cardiovascular Diseases, Infectious Diseases, and Beyond","volume":"306","author":"Zhu","year":"2024","journal-title":"Biomaterials"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/s12935-025-03877-w","article-title":"The Role of Platelets in Tumor Immune Evasion and Metastasis: Mechanisms and Therapeutic Implications","volume":"25","author":"Gan","year":"2025","journal-title":"Cancer Cell Int."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Elaskalani, O., Berndt, M.C., Falasca, M., and Metharom, P. (2017). Targeting Platelets for the Treatment of Cancer. Cancers, 9.","DOI":"10.3390\/cancers9070094"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1186\/s40001-023-01342-w","article-title":"The Critical Role of Platelet in Cancer Progression and Metastasis","volume":"28","author":"Zhou","year":"2023","journal-title":"Eur. J. Med. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12935-023-02927-5","article-title":"Tumor Educated Platelet: The Novel BioSource for Cancer Detection","volume":"23","author":"Ding","year":"2023","journal-title":"Cancer Cell Int."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Jansen, E.E., Braun, A., Jansen, P., and Hartmann, M. (2021). Platelet-Therapeutics to Improve Tissue Regeneration and Wound Healing-Physiological Background and Methods of Preparation. Biomedicines, 9.","DOI":"10.3390\/biomedicines9080869"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e13474","DOI":"10.1002\/advs.202513474","article-title":"A Conjugation Delivery System of Macrophages and Platelet Pharmacytes Promotes Regeneration After Spinal Cord Injury","volume":"13","author":"Wang","year":"2025","journal-title":"Adv. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41392-025-02124-y","article-title":"Tissue Macrophages: Origin, Heterogenity, Biological Functions, Diseases and Therapeutic Targets","volume":"10","author":"Guan","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"123601","DOI":"10.1016\/j.lfs.2025.123601","article-title":"Reprogram to Heal: Macrophage Phenotypes as Living Therapeutics","volume":"371","author":"Ghamangiz","year":"2025","journal-title":"Life Sci."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Xiao, M., and Li, X. (2025). The Impact of the Tumor Microenvironment on Macrophages. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1572764"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12943-020-01165-x","article-title":"CCL2-CCR2 Axis Recruits Tumor Associated Macrophages to Induce Immune Evasion through PD-1 Signaling in Esophageal Carcinogenesis","volume":"19","author":"Yang","year":"2020","journal-title":"Mol. Cancer"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"11283","DOI":"10.18632\/oncotarget.2207","article-title":"Multiple Myeloma Cells Recruit Tumor-Supportive Macrophages through the CXCR4\/CXCL12 Axis and Promote Their Polarization toward the M2 Phenotype","volume":"5","author":"Beider","year":"2014","journal-title":"Oncotarget"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41568-023-00635-w","article-title":"How Chemokines Organize the Tumour Microenvironment","volume":"24","author":"Mempel","year":"2024","journal-title":"Nat. Rev. Cancer"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"14441","DOI":"10.1021\/acsnano.4c01120","article-title":"Pluronic-Based Nanoparticles for Delivery of Doxorubicin to the Tumor Microenvironment by Binding to Macrophages","volume":"18","author":"Hu","year":"2024","journal-title":"ACS Nano"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.ccell.2021.08.005","article-title":"Activating a Collaborative Innate-Adaptive Immune Response to Control Metastasis","volume":"39","author":"Sun","year":"2021","journal-title":"Cancer Cell"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cell.2010.03.014","article-title":"Macrophage Diversity Enhances Tumor Progression and Metastasis","volume":"141","author":"Qian","year":"2010","journal-title":"Cell"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"eadw7191","DOI":"10.1126\/sciadv.adw7191","article-title":"Macrophage Hitchhiking Nanomedicine for Enhanced \u03b2-Elemene Delivery and Tumor Therapy","volume":"11","author":"Chen","year":"2025","journal-title":"Sci. Adv."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"9799","DOI":"10.1021\/acsnano.2c03573","article-title":"Live Macrophage-Delivered Doxorubicin-Loaded Liposomes Effectively Treat Triple-Negative Breast Cancer","volume":"16","author":"LiYang","year":"2022","journal-title":"ACS Nano"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Lin, Z., Zou, S., and Wen, K. (2024). The Crosstalk of CD8+ T Cells and Ferroptosis in Cancer. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1255443"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s40824-021-00246-2","article-title":"Immune Cell Targeting Nanoparticles: A Review","volume":"25","author":"Lee","year":"2021","journal-title":"Biomater. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"291ra94","DOI":"10.1126\/scitranslmed.aaa5447","article-title":"Active Targeting of Chemotherapy to Disseminated Tumors Using Nanoparticle-Carrying T Cells","volume":"7","author":"Huang","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"7863","DOI":"10.1038\/s41467-024-51353-2","article-title":"Local Administration of Regulatory T Cells Promotes Tissue Healing","volume":"15","author":"Nayer","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"eadl4237","DOI":"10.1126\/science.adl4237","article-title":"Programming Tissue-Sensing T Cells That Deliver Therapies to the Brain","volume":"386","author":"Simic","year":"2024","journal-title":"Science"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41577-022-00732-1","article-title":"Roles of Natural Killer Cells in Immunity to Cancer, and Applications to Immunotherapy","volume":"23","author":"Wolf","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1126\/science.1198687","article-title":"Innate or Adaptive Immunity? The Example of Natural Killer Cells","volume":"331","author":"Vivier","year":"2011","journal-title":"Science"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.cell.2019.04.041","article-title":"Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity","volume":"177","author":"Gauthier","year":"2019","journal-title":"Cell"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1038\/s41591-025-03640-8","article-title":"Allogeneic NK Cells with a Bispecific Innate Cell Engager in Refractory Relapsed Lymphoma: A Phase 1 Trial","volume":"31","author":"Nieto","year":"2025","journal-title":"Nat. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41568-022-00491-0","article-title":"Natural Killer Cells in Antitumour Adoptive Cell Immunotherapy","volume":"22","author":"Laskowski","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"11317","DOI":"10.1021\/jacs.6c01128","article-title":"NIR-II Nanomedicine Engineered CAR-NK Cells for Precision Navigation and Potentiating Lung Cancer Immunotherapy by Remodeling Tumor Microenvironment","volume":"148","author":"Dai","year":"2026","journal-title":"J. Am. Chem. Soc."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Li, J., Huang, Y., Sun, H., and Yang, L. (2023). Mechanism of Mesenchymal Stem Cells and Exosomes in the Treatment of Age-Related Diseases. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1181308"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13287-016-0363-7","article-title":"Mechanisms of Mesenchymal Stem\/Stromal Cell Function","volume":"7","author":"Spees","year":"2016","journal-title":"Stem Cell Res. Ther."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e2426724122","DOI":"10.1073\/pnas.2426724122","article-title":"In Vivo Generation of CAR Macrophages via the Enucleated Mesenchymal Stem Cell Delivery System for Glioblastoma Therapy","volume":"122","author":"Zhou","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Li, D., Yang, Y., Zheng, G., Meng, L., Shang, L., Ren, J., Wang, L., and Bao, Y. (2024). The Potential of Cellular Homing Behavior in Tumor Immunotherapy: From Basic Discoveries to Clinical Applications of Immune, Mesenchymal Stem, and Cancer Cell Homing. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1495978"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11748-021-01696-0","article-title":"Modifying Strategies for SDF-1\/CXCR4 Interaction during Mesenchymal Stem Cell Transplantation","volume":"70","author":"Jiang","year":"2022","journal-title":"Gen. Thorac. Cardiovasc. Surg."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"114300","DOI":"10.1016\/j.addr.2022.114300","article-title":"Mesenchymal Stem Cells: A Living Carrier for Active Tumor-Targeted Delivery","volume":"185","author":"Zhang","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Merino, J.J., and Caba\u00f1a-Mu\u00f1oz, M.E. (2023). Nanoparticles and Mesenchymal Stem Cell (MSC) Therapy for Cancer Treatment: Focus on Nanocarriers and a Si-RNA CXCR4 Chemokine Blocker as Strategies for Tumor Eradication In Vitro and In Vivo. Micromachines, 14.","DOI":"10.3390\/mi14112068"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"793","DOI":"10.18632\/oncotarget.28672","article-title":"Mesenchymal Stem Cells\u2014The Secret Agents of Cancer Immunotherapy: Promises, Challenges, and Surprising Twists","volume":"15","author":"Minev","year":"2024","journal-title":"Oncotarget"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1038\/s41551-021-00815-9","article-title":"Genetically Engineered and Enucleated Human Mesenchymal Stromal Cells for the Targeted Delivery of Therapeutics to Diseased Tissue","volume":"6","author":"Wang","year":"2022","journal-title":"Nat. Biomed. Eng."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"114295","DOI":"10.1016\/j.addr.2022.114295","article-title":"Advances in Salmonella Typhimurium-based drug delivery system for cancer therapy","volume":"185","author":"Chen","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/s44222-022-00006-4","article-title":"Bioinspired Oral Delivery Devices","volume":"1","author":"Zhang","year":"2023","journal-title":"Nat. Rev. Bioeng."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"110425","DOI":"10.1016\/j.biopha.2020.110425","article-title":"Inhibition of Acute Leukemia with Attenuated Salmonella typhimurium Strain VNP20009","volume":"129","author":"Li","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_94","unstructured":"(2026, May 13). Nanoparticle-Based Targeted Delivery Unleashes the Full Power of Anti-Cancer Drugs. Available online: https:\/\/phys.org\/news\/2025-07-nanoparticle-based-delivery-unleashes-full.html."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41565-023-01553-6","article-title":"Bacteria-Derived Nanovesicles Enhance Tumour Vaccination by Trained Immunity","volume":"19","author":"Liu","year":"2024","journal-title":"Nat. Nanotechnol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/s41586-021-04003-2","article-title":"Metabolic Modulation of Tumours with Engineered Bacteria for Immunotherapy","volume":"598","author":"Canale","year":"2021","journal-title":"Nature"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nrc2934","article-title":"Engineering the Perfect (Bacterial) Cancer Therapy","volume":"10","author":"Forbes","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Taniguchi, S. (2021). In Situ Delivery and Production System (iDPS) of Anti-Cancer Molecules with Gene-Engineered Bifidobacterium. J. Pers. Med., 11.","DOI":"10.3390\/jpm11060566"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"5152","DOI":"10.7150\/thno.99257","article-title":"Theoretical basis, state and challenges of living cell-based drug delivery systems","volume":"14","author":"Liu","year":"2024","journal-title":"Theranostics"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41565-021-00858-8","article-title":"Key Principles and Methods for Studying the Endocytosis of Biological and Nanoparticle Therapeutics","volume":"16","author":"Rennick","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ejpb.2023.07.005","article-title":"Modelling of Reversible Tissue Electroporation and Its Thermal Effects in Drug Delivery","volume":"190","author":"Mondal","year":"2023","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"13532","DOI":"10.1039\/D3NR02562D","article-title":"Ultrasound Meets the Cell Membrane: For Enhanced Endocytosis and Drug Delivery","volume":"15","author":"Wen","year":"2023","journal-title":"Nanoscale"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"665","DOI":"10.2147\/DDDT.S96470","article-title":"Drug-Loaded Erythrocytes: On the Road toward Marketing Approval","volume":"10","author":"Bourgeaux","year":"2016","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"13894","DOI":"10.1021\/acsnano.0c06290","article-title":"Smart Nanoparticle-Laden and Remote-Controlled Self-Destructive Macrophage for Enhanced Chemo\/Chemodynamic Synergistic Therapy","volume":"14","author":"Sun","year":"2020","journal-title":"ACS Nano"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/nnano.2017.54","article-title":"Neutrophil-Mediated Anticancer Drug Delivery for Suppression of Postoperative Malignant Glioma Recurrence","volume":"12","author":"Xue","year":"2017","journal-title":"Nat. Nanotechnol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1038\/s41467-026-70453-9","article-title":"Surface Hydrophobicity and Rigidity Determines Protein Corona on Orally Delivered Nanoparticles Treating Colitis","volume":"17","author":"Wu","year":"2026","journal-title":"Nat. Commun."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev.immunol.17.1.593","article-title":"Mechanisms of Phagocytosis in Macrophages","volume":"17","author":"Aderem","year":"1999","journal-title":"Annu. Rev. Immunol."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Liebl, D., Qi, X., Zhe, Y., Barnett, T.C., and Teasdale, R.D. (2017). SopB-Mediated Recruitment of SNX18 Facilitates Salmonella Typhimurium Internalization by the Host Cell. Front. Cell. Infect. Microbiol., 7.","DOI":"10.3389\/fcimb.2017.00257"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1603121","DOI":"10.1002\/smll.201603121","article-title":"Immune Cell-Mediated Biodegradable Theranostic Nanoparticles for Melanoma Targeting and Drug Delivery","volume":"13","author":"Xie","year":"2017","journal-title":"Small"},{"key":"ref_110","first-page":"101063","article-title":"Macrophage-Centered Therapy Strategies: A Promising Weapon in Cancer Immunotherapy","volume":"20","author":"Wang","year":"2025","journal-title":"Asian J. Pharm. Sci."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00249-017-1255-1","article-title":"Simulation of the Osmosis-Based Drug Encapsulation in Erythrocytes","volume":"47","author":"Ge","year":"2018","journal-title":"Eur. Biophys. J."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Bax, B.E. (2020). Erythrocytes as Carriers of Therapeutic Enzymes. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12050435"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"e01437","DOI":"10.1002\/smtd.202501437","article-title":"Osmolarity-Directed Encapsulation of Size-Tuned Nanoparticles into Red Blood Cells","volume":"10","author":"Bai","year":"2026","journal-title":"Small Methods"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Gutierrez-Millan, C., Barez Diaz, C., Alvarez Vizan, L., and Colino, C.I. (2023). Evaluation of Two Osmosis-Based Methods for the Preparation of Drug Delivery Systems Based on Red Blood Cells. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15092281"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1002\/jps.22395","article-title":"Encapsulation of Valproate-Loaded Hydrogel Nanoparticles in Intact Human Erythrocytes: A Novel Nano-Cell Composite for Drug Delivery","volume":"100","author":"Hamidi","year":"2011","journal-title":"J. Pharm. Sci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"17727","DOI":"10.1073\/pnas.2002880117","article-title":"Erythrocyte-Driven Immunization via Biomimicry of Their Natural Antigen-Presenting Function","volume":"117","author":"Ukidve","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1021\/nn901319y","article-title":"Nanoparticulate Cellular Patches for Cell-Mediated Tumoritropic Delivery","volume":"4","author":"Cheng","year":"2010","journal-title":"ACS Nano"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1038\/s41556-022-00997-7","article-title":"Spatiotemporal Dynamics of Membrane Surface Charge Regulates Cell Polarity and Migration","volume":"24","author":"Banerjee","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"e2404152","DOI":"10.1002\/smll.202404152","article-title":"Membrane-Nanoparticle Interactions: The Impact of Membrane Lipids","volume":"20","author":"Issler","year":"2024","journal-title":"Small"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"eaax9250","DOI":"10.1126\/sciadv.aax9250","article-title":"Erythrocyte Leveraged Chemotherapy (ELeCt): Nanoparticle Assembly on Erythrocyte Surface to Combat Lung Metastasis","volume":"5","author":"Zhao","year":"2019","journal-title":"Sci. Adv."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"5273","DOI":"10.1039\/D5NA00233H","article-title":"Insights into the Physicochemical Interactions of Ionic Liquid-Coated Polymeric Nanoparticles with Red Blood Cells","volume":"7","author":"Hamadani","year":"2025","journal-title":"Nanoscale Adv."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1021\/acs.biomac.5c02390","article-title":"Selective mRNA Delivery to Activated Macrophages via Hyaluronic Acid-Functionalized Lipid Nanoparticles with Optimized PEGylation","volume":"27","author":"Cao","year":"2026","journal-title":"Biomacromolecules"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Hlaing, S.P., Cao, J., Lee, J., Kim, J., Saparbayeva, A., Kwak, D., Kim, H., Hwang, S., Yun, H., and Moon, H.R. (2022). Hyaluronic Acid-Conjugated PLGA Nanoparticles Alleviate Ulcerative Colitis via CD44-Mediated Dual Targeting to Inflamed Colitis Tissue and Macrophages. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14102118"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Lupoae, M., Elisei, A.M., Iacob, A., Lupoae, A., Tatu, A.L., Nicule\u021b, E., C\u0103u\u0219, M.N., Bat\u00eer, D., Nechita, A., and Matei, M.N. (2026). Cutaneous-Tropism Viruses: Unraveling Pathogenetic Mechanisms and Immunoprophylactic Strategies. Life, 16.","DOI":"10.3390\/life16010174"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nbt.4181","article-title":"Enhancing T Cell Therapy through TCR-Signaling-Responsive Nanoparticle Drug Delivery","volume":"36","author":"Tang","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jconrel.2019.12.049","article-title":"Multivalent HER2-Binding Polymer Conjugates Facilitate Rapid Endocytosis and Enhance Intracellular Drug Delivery","volume":"319","author":"Radford","year":"2020","journal-title":"J. Control. Release"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jconrel.2016.11.016","article-title":"The Principles and Applications of Avidin-Based Nanoparticles in Drug Delivery and Diagnosis","volume":"245","author":"Jain","year":"2017","journal-title":"J. Control. Release"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"10403","DOI":"10.1039\/C5CC03075G","article-title":"Recent Development of Biotin Conjugation in Biological Imaging, Sensing, and Target Delivery","volume":"51","author":"Ren","year":"2015","journal-title":"Chem. Commun."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jconrel.2014.06.015","article-title":"Conjugation of pH-responsive nanoparticles to neural stem cells improves intratumoral therapy","volume":"191","author":"Mooney","year":"2014","journal-title":"J. Control. Release"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1517\/17425241003677749","article-title":"Avidin-Biotin Technology in Targeted Therapy","volume":"7","author":"Lesch","year":"2010","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Wei, Z., Zhou, Y., Wang, R., Wang, J., and Chen, Z. (2022). Aptamers as Smart Ligands for Targeted Drug Delivery in Cancer Therapy. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14122561"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Van den Avont, A., and Sharma-Walia, N. (2023). Anti-Nucleolin Aptamer AS1411: An Advancing Therapeutic. Front. Mol. Biosci., 10.","DOI":"10.3389\/fmolb.2023.1217769"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"12822","DOI":"10.1021\/acsami.2c22820","article-title":"Engineering Circular Aptamer Assemblies with Tunable Selectivity to Cell Membrane Antigens In Vitro and In Vivo","volume":"15","author":"Qi","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"24329","DOI":"10.1021\/acsnano.3c10238","article-title":"Investigation of the Relationship between Aptamers\u2019 Targeting Functions and Human Plasma Proteins","volume":"17","author":"Liu","year":"2023","journal-title":"ACS Nano"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1021\/acs.molpharmaceut.7b00160","article-title":"Polymeric Nanocarriers Based on Cyclodextrins for Drug Delivery: Host-Guest Interaction as Stimuli Responsive Linker","volume":"14","author":"Peng","year":"2017","journal-title":"Mol. Pharm."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.jconrel.2022.08.029","article-title":"Supramolecular Erythrocytes-Hitchhiking Drug Delivery System for Specific Therapy of Acute Pneumonia","volume":"350","author":"Li","year":"2022","journal-title":"J. Control. Release"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/nm.2198","article-title":"Therapeutic Cell Engineering Using Surface-Conjugated Synthetic Nanoparticles","volume":"16","author":"Stephan","year":"2010","journal-title":"Nat. Med."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Liu, L., He, H., and Liu, J. (2019). Advances on Non-Genetic Cell Membrane Engineering for Biomedical Applications. Polymers, 11.","DOI":"10.3390\/polym11122017"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"e2409945","DOI":"10.1002\/adma.202409945","article-title":"Conjugation Chemistry Markedly Impacts Toxicity and Biodistribution of Targeted Nanoparticles, Mediated by Complement Activation","volume":"37","author":"Zaleski","year":"2025","journal-title":"Adv. Mater."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"eaaz6667","DOI":"10.1126\/scitranslmed.aaz6667","article-title":"Combination of Metabolic Intervention and T Cell Therapy Enhances Solid Tumor Immunotherapy","volume":"12","author":"Hao","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"eady6730","DOI":"10.1126\/scitranslmed.ady6730","article-title":"In Vivo Generation of CAR Myeloid Cells through Erythrocyte-Mediated mRNA Delivery for Cancer Immunotherapy","volume":"18","author":"Nie","year":"2026","journal-title":"Sci. Transl. Med."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1021\/acs.bioconjchem.6b00117","article-title":"Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody-Maytansinoid Conjugates","volume":"27","author":"Ponte","year":"2016","journal-title":"Bioconjug. Chem."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.biomaterials.2015.11.016","article-title":"Hitchhiking Nanoparticles: Reversible Coupling of Lipid-Based Nanoparticles to Cytotoxic T Lymphocytes","volume":"77","author":"Wayteck","year":"2016","journal-title":"Biomaterials"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1021\/bm4003943","article-title":"Therapeutic Cells via Functional Modification: Influence of Molecular Properties of Polymer Grafts on In Vivo Circulation, Clearance, Immunogenicity, and Antigen Protection","volume":"14","author":"Chapanian","year":"2013","journal-title":"Biomacromolecules"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.actbio.2019.10.027","article-title":"Erythrocytes as Carriers of Immunoglobulin-Based Therapeutics","volume":"101","author":"Ji","year":"2020","journal-title":"Acta Biomater."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Takayama, Y., Kusamori, K., and Nishikawa, M. (2019). Click Chemistry as a Tool for Cell Engineering and Drug Delivery. Molecules, 24.","DOI":"10.3390\/molecules24010172"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1038\/s41467-023-40886-7","article-title":"Metabolic Glycan Labeling Immobilizes Dendritic Cell Membrane and Enhances Antitumor Efficacy of Dendritic Cell Vaccine","volume":"14","author":"Han","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"e2300339","DOI":"10.1002\/biot.202300339","article-title":"A Versatile Method for Conjugating Lipid Nanoparticles on T Cells through Combination of Click Chemistry and Metabolic Glycoengineering","volume":"19","author":"Li","year":"2024","journal-title":"Biotechnol. J."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"27264","DOI":"10.1039\/C9RA03668G","article-title":"Model Affitin and PEG Modifications onto siRNA Lipid Nanocapsules: Cell Uptake and In Vivo Biodistribution Improvements","volume":"9","author":"Resnier","year":"2019","journal-title":"RSC Adv."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Feng, C., Wang, Y., Xu, J., Zheng, Y., Zhou, W., Wang, Y., and Luo, C. (2024). Precisely Tailoring Molecular Structure of Doxorubicin Prodrugs to Enable Stable Nanoassembly, Rapid Activation, and Potent Antitumor Effect. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16121582"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"108192","DOI":"10.1016\/j.cclet.2023.108192","article-title":"Copper Carbonate Nanoparticles as an Effective Biomineralized Carrier to Load Macromolecular Drugs for Multimodal Therapy","volume":"34","author":"Dong","year":"2023","journal-title":"Chin. Chem. Lett."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"126501","DOI":"10.1016\/j.ijpharm.2025.126501","article-title":"Advances in Metal Ion\u2013Mediated Macromolecular Drug Delivery","volume":"689","author":"Li","year":"2026","journal-title":"Int. J. Pharm."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/s41587-025-02664-2","article-title":"Self-Assembling Protein Nanoparticles for Cytosolic Delivery of Nucleic Acids and Proteins","volume":"44","author":"Eweje","year":"2026","journal-title":"Nat. Biotechnol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41557-021-00854-4","article-title":"Phase-Separating Peptides for Direct Cytosolic Delivery and Redox-Activated Release of Macromolecular Therapeutics","volume":"14","author":"Sun","year":"2022","journal-title":"Nat. Chem."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Wu, H., Zhang, X., Shu, X., Zhang, H., Zhou, W., Zhang, S., and Luo, C. (2026). Molecularly Tailored Artesunate Nanomedicine with Well-Balanced Nanoassembly and Anticancer Performance. Pharmaceutics, 18.","DOI":"10.3390\/pharmaceutics18020240"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"114347","DOI":"10.1016\/j.jconrel.2025.114347","article-title":"A Biocompatible Tea Polyphenol Nanoplatform for Efficient Cytosolic Delivery of Protein Therapeutics","volume":"388","author":"Wang","year":"2025","journal-title":"J. Control. Release"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.tips.2020.08.005","article-title":"Accessing Intracellular Targets through Nanocarrier-Mediated Cytosolic Protein Delivery","volume":"41","author":"Goswami","year":"2020","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"H105-109","DOI":"10.1002\/adma.201004074","article-title":"Cell-Based Drug Delivery Devices Using Phagocytosis-Resistant Backpacks","volume":"23","author":"Doshi","year":"2011","journal-title":"Adv. Mater."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"2214842","DOI":"10.1002\/adfm.202214842","article-title":"Metal-Coordinated Adsorption of Nanoparticles to Macrophages for Targeted Cancer Therapy","volume":"33","author":"Zhu","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.2217\/nnm.11.41","article-title":"Macrophage Scavenger Receptor A Mediates the Uptake of Gold Colloids by Macrophages In Vitro","volume":"6","author":"Aggarwal","year":"2011","journal-title":"Nanomed."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"122187","DOI":"10.1016\/j.biomaterials.2023.122187","article-title":"Maleimide as the PEG End-Group Promotes Macrophage-Targeted Drug Delivery of PEGylated Nanoparticles In Vivo by Enhancing Interaction with Circulating Erythrocytes","volume":"300","author":"Wang","year":"2023","journal-title":"Biomaterials"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"6320","DOI":"10.1002\/anie.202015625","article-title":"Covalent Cell Surface Conjugation of Nanoparticles by a Combination of Metabolic Labeling and Click Chemistry","volume":"60","author":"Lamoot","year":"2021","journal-title":"Angew. Chem."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"2301348","DOI":"10.1002\/advs.202301348","article-title":"Ligustrazine Nanoparticle Hitchhiking on Neutrophils for Enhanced Therapy of Cerebral Ischemia-Reperfusion Injury","volume":"10","author":"Mu","year":"2023","journal-title":"Adv. Sci."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/d41573-020-00202-0","article-title":"Addressing Cancer\u2019s Grand Challenges","volume":"19","author":"Mullard","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1016\/j.apsb.2020.11.024","article-title":"Emerging Nanomedicine-Based Therapeutics for Hematogenous Metastatic Cascade Inhibition: Interfering with the Crosstalk between \u201cSeed and Soil\u201d","volume":"11","author":"Wu","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"120055","DOI":"10.1016\/j.biomaterials.2020.120055","article-title":"Targeting Self-Assembly Peptide for Inhibiting Breast Tumor Progression and Metastasis","volume":"249","author":"Luo","year":"2020","journal-title":"Biomaterials"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jconrel.2020.03.045","article-title":"Albumin-Biomineralized Nanoparticles to Synergize Phototherapy and Immunotherapy against Melanoma","volume":"322","author":"Zhu","year":"2020","journal-title":"J. Control. Release Off. J. Control. Release Soc."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"114889","DOI":"10.1016\/j.jconrel.2026.114889","article-title":"Biomineralized Nanoemulsion Delivers mRNA for Potent Cancer Immunotherapy","volume":"394","author":"Xu","year":"2026","journal-title":"J. Control. Release Off. J. Control. Release Soc."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"10382","DOI":"10.1038\/s41467-024-54854-2","article-title":"MMP-2-Triggered, Mitochondria-Targeted PROTAC-PDT Therapy of Breast Cancer and Brain Metastases Inhibition","volume":"15","author":"Tong","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1700860","DOI":"10.1002\/advs.201700860","article-title":"Mutual Destruction of Deep Lung Tumor Tissues by Nanodrug-Conjugated Stealth Mesenchymal Stem Cells","volume":"5","author":"Kim","year":"2018","journal-title":"Adv. Sci."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.jconrel.2024.02.003","article-title":"Genetically Engineered Macrophages as Living Cell Drug Carriers for Targeted Cancer Therapy","volume":"367","author":"Ning","year":"2024","journal-title":"J. Control. Release"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"15432","DOI":"10.1021\/acsnano.3c09165","article-title":"A Two-Pronged Delivery Strategy Disrupting Positive Feedback Loop of Neutrophil Extracellular Traps for Metastasis Suppression","volume":"18","author":"Kong","year":"2024","journal-title":"ACS Nano"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1038\/s41467-021-22454-z","article-title":"Targeted Apoptosis of Macrophages and Osteoclasts in Arthritic Joints Is Effective against Advanced Inflammatory Arthritis","volume":"12","author":"Deng","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.apsb.2021.03.013","article-title":"Nanomedicines for the Treatment of Rheumatoid Arthritis: State of Art and Potential Therapeutic Strategies","volume":"11","author":"Wang","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jconrel.2021.05.008","article-title":"Shield and Sword Nano-Soldiers Ameliorate Rheumatoid Arthritis by Multi-Stage Manipulation of Neutrophils","volume":"335","author":"Li","year":"2021","journal-title":"J. Control. Release"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"102096","DOI":"10.1016\/j.nantod.2023.102096","article-title":"Targeting Neutrophils Potentiates Hitchhiking Delivery of Drugs and Agonists for Postsurgical Chemo-Immunotherapy","volume":"54","author":"Gao","year":"2024","journal-title":"Nano Today"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"120670","DOI":"10.1016\/j.biomaterials.2021.120670","article-title":"In Situ Poly I:C Released from Living Cell Drug Nanocarriers for Macrophage-Mediated Antitumor Immunotherapy","volume":"269","author":"Zhou","year":"2021","journal-title":"Biomaterials"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.jconrel.2025.02.011","article-title":"A Cerium Single-Atom Catalyst Enables Targeted Catalytic Therapy for Acute Kidney Injury via Neutrophil Hitchhiking","volume":"380","author":"Pu","year":"2025","journal-title":"J. Control. Release"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.apsb.2016.05.013","article-title":"Progress and Perspectives on Targeting Nanoparticles for Brain Drug Delivery","volume":"6","author":"Gao","year":"2016","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/s41586-025-08589-9","article-title":"Glycocalyx Dysregulation Impairs Blood-Brain Barrier in Ageing and Disease","volume":"639","author":"Shi","year":"2025","journal-title":"Nature"},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Gheibihayat, S.M., Cabezas, R., Nikiforov, N.G., Jamialahmadi, T., Johnston, T.P., and Sahebkar, A. (2021). CD47 in the Brain and Neurodegeneration: An Update on the Role in Neuroinflammatory Pathways. Molecules, 26.","DOI":"10.3390\/molecules26133943"},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Mac, C.-H., Chiang, Y.-W., Nguyen, H.-N., Wang, J.-T., Chu, L.-A., Lin, Y.-H., Nguyen, V.K., Peng, S.-Y., Lo, S.-K., and Chang, Y. (2026). Chemically Programmed Prodrug Nanoparticles for Precise Oral Dopamine Delivery to Deep Brain Regions in Parkinson\u2019s Disease. Adv. Mater., e74148.","DOI":"10.1002\/adma.74148"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41573-022-00476-6","article-title":"Engineering the next Generation of Cell-Based Therapeutics","volume":"21","author":"Bashor","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41587-020-0601-5","article-title":"Engineered Off-the-Shelf Therapeutic T Cells Resist Host Immune Rejection","volume":"39","author":"Mo","year":"2021","journal-title":"Nat. Biotechnol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nbt.3525","article-title":"Quality Cell Therapy Manufacturing by Design","volume":"34","author":"Lipsitz","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jcyt.2015.11.017","article-title":"Chromosomal Stability of Mesenchymal Stromal Cells during In Vitro Culture","volume":"18","author":"Stultz","year":"2016","journal-title":"Cytotherapy"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.imr.2016.12.001","article-title":"Cryopreservation and Its Clinical Applications","volume":"6","author":"Jang","year":"2017","journal-title":"Integr. Med. Res."},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Ekpo, M.D., Xie, J., Liu, X., Onuku, R., Boafo, G.F., and Tan, S. (2022). Incorporating Cryopreservation Evaluations Into the Design of Cell-Based Drug Delivery Systems: An Opinion Paper. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.967731"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"e1805557","DOI":"10.1002\/adma.201805557","article-title":"Nanoparticle-Laden Macrophages for Tumor-Tropic Drug Delivery","volume":"30","author":"Zhang","year":"2018","journal-title":"Adv. Mater."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"120084","DOI":"10.1016\/j.ijpharm.2020.120084","article-title":"Red Blood Cell-Hitchhiking Chitosan Nanoparticles for Prolonged Blood Circulation Time of Vitamin K1","volume":"592","author":"Wang","year":"2021","journal-title":"Int. J. Pharm."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"13325","DOI":"10.1039\/D3SC04597H","article-title":"Advancing Cell Surface Modification in Mammalian Cells with Synthetic Molecules","volume":"14","author":"Yang","year":"2023","journal-title":"Chem. Sci."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.molimm.2014.06.038","article-title":"Complement Activation-Related Pseudoallergy: A Stress Reaction in Blood Triggered by Nanomedicines and Biologicals","volume":"61","author":"Szebeni","year":"2014","journal-title":"Mol. Immunol."},{"key":"ref_194","first-page":"55","article-title":"Macrophage Based Drug Delivery: Key Challenges and Strategies","volume":"38","author":"Guo","year":"2024","journal-title":"Bioact. Mater."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1800017","DOI":"10.1002\/advs.201800017","article-title":"Biotinylated Bilirubin Nanoparticles as a Tumor Microenvironment-Responsive Drug Delivery System for Targeted Cancer Therapy","volume":"5","author":"Lee","year":"2018","journal-title":"Adv. Sci."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"e2103836","DOI":"10.1002\/advs.202103836","article-title":"Tumor-Microenvironment-Responsive Nanomedicine for Enhanced Cancer Immunotherapy","volume":"9","author":"Peng","year":"2022","journal-title":"Adv. Sci."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"6457","DOI":"10.1039\/D3BM00840A","article-title":"MMP-Responsive Nanomaterials","volume":"11","author":"Son","year":"2023","journal-title":"Biomater. Sci."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"15392","DOI":"10.1073\/pnas.1819415116","article-title":"Programmable Microencapsulation for Enhanced Mesenchymal Stem Cell Persistence and Immunomodulation","volume":"116","author":"Mao","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/18\/9\/1070\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:07:29Z","timestamp":1787818049000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/18\/9\/1070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":198,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["pharmaceutics18091070"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics18091070","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,27]]}}}