{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:15:26Z","timestamp":1788362126545,"version":"build-2803163510"},"reference-count":25,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2025MS1264"],"award-info":[{"award-number":["ZR2025MS1264"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3502100"],"award-info":[{"award-number":["2022YFC3502100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Advanced Medical Research Institute","award":["GYY2023QY01"],"award-info":[{"award-number":["GYY2023QY01"]}]},{"award":["GYY2023QY01"],"award-info":[{"award-number":["GYY2023QY01"]}],"id":[{"id":"https:\/\/ror.org\/04ppky291","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Background\/Objectives: Psoriasis is a chronic inflammatory skin disease driven by Th17\/Treg imbalance. Colquhounia Root Tablet (CRT), derived from Tripterygium hypoglaucum, has shown clinical potential for psoriasis, but its mechanisms remain unclear. This study aimed to evaluate the anti-psoriatic effects of CRT and elucidate its underlying mechanisms. Methods: Anti-psoriatic activity was evaluated in an IMQ-induced psoriasis-like mouse model. Mice received oral CRT at 0.085, 0.17, or 0.35 g\/kg daily from days 2 to 8. Immune-cell populations were analyzed by flow cytometry. Bone marrow-derived dendritic cells (BMDCs) were used for in vitro studies. Network pharmacology, transcriptomics, molecular docking, and experimental validation were integrated to explore the mechanisms. Results: CRT dose-dependently ameliorated psoriasiform dermatitis and reduced Th17\/Treg ratio while inhibiting CD11c+MHC II+ DC activation in vivo. In vitro, CRT suppressed R848-induced BMDC maturation and inhibited p65\/I\u03baB\u03b1 phosphorylation. Transcriptomic analysis revealed modulation of TNF, NF-\u03baB, IL-17, and JAK-STAT pathways. Molecular docking predicted the strong binding of multiple CRT compounds to RELA. Conclusions: CRT exerts anti-psoriatic effects in a murine model with concurrent modulation of NF-\u03baB-related DC maturation and Th17\/Treg correction, suggesting a potential immunomodulatory mechanism requiring further causal validation.<\/jats:p>","DOI":"10.3390\/pharmaceutics18091105","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T14:35:29Z","timestamp":1788359729000},"page":"1105","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Colquhounia Root Tablet Modulates Psoriatic Immune Responses Involving NF-\u03baB-Driven Dendritic-Cell Maturation and Th17\/Treg Imbalance: An Integrative Network Pharmacology and Transcriptomic Study"],"prefix":"10.3390","volume":"18","author":[{"given":"Qingqing","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Dermato-Venereology, The Second Qilu Hospital of Shandong University, Jinan 250033, China"},{"name":"Basic Medical Research Institute, Integrated Traditional Chinese and Western Medicine Center, The Second Qilu Hospital of Shandong University, Jinan 250033, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6667-5807","authenticated-orcid":false,"given":"Lisong","family":"Sheng","sequence":"additional","affiliation":[{"name":"Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Du","sequence":"additional","affiliation":[{"name":"Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Dermato-Venereology, The Second Qilu Hospital of Shandong University, Jinan 250033, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Basic Medical Research Institute, Integrated Traditional Chinese and Western Medicine Center, The Second Qilu Hospital of Shandong University, Jinan 250033, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Basic Medical Research Institute, Integrated Traditional Chinese and Western Medicine Center, The Second Qilu Hospital of Shandong University, Jinan 250033, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermato-Venereology, The Second Qilu Hospital of Shandong University, Jinan 250033, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermato-Venereology, The Second Qilu Hospital of Shandong University, Jinan 250033, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Sun","sequence":"additional","affiliation":[{"name":"Basic Medical Research Institute, Integrated Traditional Chinese and Western Medicine Center, The Second Qilu Hospital of Shandong University, Jinan 250033, China"},{"name":"Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan 250012, China"},{"name":"National Administration of Traditional Chinese Medicine, High-Level Key Disciplines of Traditional Chinese Medicine, Toxicology of Traditional Chinese Medicine, Cheeloo College of Medicine, Shandong University, Jinan 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"ref_1","first-page":"467","article-title":"Psoriasis as a Systemic Disease","volume":"121","author":"Mrowietz","year":"2024","journal-title":"Dtsch. 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