{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:25:46Z","timestamp":1788531946614,"version":"build-2803163510"},"reference-count":57,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK118793"],"award-info":[{"award-number":["R01DK118793"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"award":["R01DK118793"],"award-info":[{"award-number":["R01DK118793"]}],"id":[{"id":"https:\/\/ror.org\/00adh9b73","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Background: Diabetic wounds are characterized by chronic inflammation, oxidative stress, impaired angiogenesis, and delayed tissue repair. Ferroptosis has emerged as a potential contributor to diabetic wound pathology; however, its relationship with impaired tissue regeneration remains incompletely understood. Objectives: We investigated cellular and transcriptional responses associated with cerium oxide nanoparticle-conjugated microRNA-146a (CNP-miR146a) treatment and whether wound repair is associated with ferroptosis-protective programs and immune\u2013vascular communication. Methods: Diabetic excisional wounds were treated with CNP-miR146a or phosphate-buffered saline controls. Single-cell RNA sequencing was performed on wound tissues, with primary analyses focused on postoperative Day 7. Cellular composition, ferroptosis-associated programs, pseudotime trajectories, and inferred ligand\u2013receptor communication networks were analyzed. Results: CNP-miR146a treatment was associated with transcriptional remodeling of the diabetic wound microenvironment, with myeloid cells exhibiting a prominent response. Treatment was associated with higher NRF2-related antioxidant, ferroptosis-protective, and iron-homeostasis transcriptional programs and with a repair-associated myeloid state. Pseudotime analysis identified a trajectory from monocytes toward pro-regenerative macrophages accompanied by dynamic expression of antioxidant, iron-homeostasis, and repair-associated genes. CellChat predicted increased immune\u2013vascular communication through angiogenic and extracellular matrix-associated pathways. Endothelial cells exhibited increased NRF2-associated transcriptional programs, angiogenesis-associated gene expression, and endothelial repair markers. Conclusions: CNP-miR146a-mediated wound repair is associated with coordinated ferroptosis-protective and NRF2-related transcriptional programs, pro-regenerative myeloid states, endothelial angiogenesis-associated programs, and predicted immune\u2013vascular communication. These findings identify ferroptosis-associated and immune\u2013vascular transcriptional networks as candidate mechanisms of CNP-miR146a-mediated diabetic wound repair requiring further functional validation.<\/jats:p>","DOI":"10.3390\/pharmaceutics18091116","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:50:44Z","timestamp":1788529844000},"page":"1116","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CNP-miR146a Promotes NRF2-Related Ferroptosis-Protective Myeloid Programs and Immune\u2013Vascular Regeneration in Diabetic Wounds"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5306-7135","authenticated-orcid":false,"given":"Melisa","family":"Kafali","sequence":"first","affiliation":[{"name":"Laboratory for Fetal and Regenerative Biology, Department of Surgery, University of Arizona College of Medicine, Banner Children\u2019s at Diamond Children\u2019s Medical Center, Tucson, AZ 85721, USA"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"given":"Emilia","family":"Mora Pinos","sequence":"additional","affiliation":[{"name":"Laboratory for Fetal and Regenerative Biology, Department of Surgery, University of Arizona College of Medicine, Banner Children\u2019s at Diamond Children\u2019s Medical Center, Tucson, AZ 85721, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9759-6901","authenticated-orcid":false,"given":"Katharina S.","family":"Berryman","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Arizona College of Medicine, Tucson, AZ 85724, USA"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Kellen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Arizona College of Medicine, Tucson, AZ 85724, USA"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"}]},{"given":"Geoffrey C.","family":"Gurtner","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Arizona College of Medicine, Tucson, AZ 85724, USA"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8530-4924","authenticated-orcid":false,"given":"Kenneth W.","family":"Liechty","sequence":"additional","affiliation":[{"name":"Laboratory for Fetal and Regenerative Biology, Department of Surgery, University of Arizona College of Medicine, Banner Children\u2019s at Diamond Children\u2019s Medical Center, Tucson, AZ 85721, USA"},{"name":"Ceria Therapeutics, Inc., Tucson, AZ 85721, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Zgheib","sequence":"additional","affiliation":[{"name":"Laboratory for Fetal and Regenerative Biology, Department of Surgery, University of Arizona College of Medicine, Banner Children\u2019s at Diamond Children\u2019s Medical Center, Tucson, AZ 85721, USA"},{"name":"Ceria Therapeutics, Inc., Tucson, AZ 85721, 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regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: A systematic analysis for the Global Burden of Disease Study 2021","volume":"402","author":"Collaborators","year":"2023","journal-title":"Lancet"},{"key":"ref_3","unstructured":"Centers for Disease Control and Prevention (2026). National Diabetes Statistics Report."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"31059","DOI":"10.1038\/s41598-025-16291-z","article-title":"Single-cell RNA transcriptome analysis reveals regulatory programs of RNA binding proteins in diabetic foot ulcers","volume":"15","author":"Hu","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.4239\/wjd.v13.i12.1106","article-title":"Diabetic foot ulcers: A devastating complication of diabetes mellitus continues non-stop in spite of new medical treatment modalities","volume":"13","author":"Akkus","year":"2022","journal-title":"World J. Diabetes"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jcot.2021.01.017","article-title":"The current burden of diabetic foot disease","volume":"17","author":"Edmonds","year":"2021","journal-title":"J. Clin. Orthop. Trauma."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Dawi, J., Tumanyan, K., Tomas, K., Misakyan, Y., Gargaloyan, A., Gonzalez, E., Hammi, M., Tomas, S., and Venketaraman, V. (2025). Diabetic Foot Ulcers: Pathophysiology, Immune Dysregulation, and Emerging Therapeutic Strategies. Biomedicines, 13.","DOI":"10.3390\/biomedicines13051076"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Soliman, A.M., and Barreda, D.R. (2022). Acute Inflammation in Tissue Healing. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010641"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1524-475X.2009.00466.x","article-title":"Interactions between extracellular matrix and growth factors in wound healing","volume":"17","author":"Schultz","year":"2009","journal-title":"Wound Repair Regen."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41420-025-02808-y","article-title":"Research progress on the role and mechanisms of ferroptosis in diabetic wound repair","volume":"11","author":"Zhang","year":"2025","journal-title":"Cell Death Discov."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"6145","DOI":"10.1021\/acs.jafc.1c01404","article-title":"Efficacy and Mechanisms of Oleuropein in Mitigating Diabetes and Diabetes Complications","volume":"69","author":"Zheng","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41392-020-00428-9","article-title":"Ferroptosis: Mechanisms and links with diseases","volume":"6","author":"Yan","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"103211","DOI":"10.1016\/j.redox.2024.103211","article-title":"Ferroptosis in health and disease","volume":"75","author":"Berndt","year":"2024","journal-title":"Redox Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1080\/15384101.2022.2079054","article-title":"The role of ferroptosis in endothelial cell dysfunction","volume":"21","author":"Yuan","year":"2022","journal-title":"Cell Cycle"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"165","DOI":"10.14348\/molcells.2023.0005","article-title":"Anti-Ferroptotic Effects of Nrf2: Beyond the Antioxidant Response","volume":"46","author":"Shakya","year":"2023","journal-title":"Mol. Cells"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41420-024-02181-2","article-title":"Repair and regeneration: Ferroptosis in the process of remodeling and fibrosis in impaired organs","volume":"10","author":"Yin","year":"2024","journal-title":"Cell Death Discov."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41419-025-07583-3","article-title":"Mechanisms and therapeutic opportunities in metabolic aberrations of diabetic wounds: A narrative review","volume":"16","author":"Xiong","year":"2025","journal-title":"Cell Death Dis."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Cioce, A., Cavani, A., Cattani, C., and Scopelliti, F. (2024). Role of the Skin Immune System in Wound Healing. Cells, 13.","DOI":"10.3390\/cells13070624"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/micc.12259","article-title":"Macrophages: An Inflammatory Link Between Angiogenesis and Lymphangiogenesis","volume":"23","author":"Corliss","year":"2016","journal-title":"Microcirculation"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"tkae052","DOI":"10.1093\/burnst\/tkae052","article-title":"Angiogenesis during diabetic wound repair: From mechanism to therapy opportunity","volume":"13","author":"Huang","year":"2025","journal-title":"Burns Trauma"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jss.2008.04.023","article-title":"The role of vascular endothelial growth factor in wound healing","volume":"153","author":"Bao","year":"2009","journal-title":"J. Surg. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1038\/s42003-025-08980-2","article-title":"OSMRbeta-mediated signals on resident fibroblasts restore healing in diabetic skin wounds through promoting angiogenesis and granulation tissue formation","volume":"8","author":"Ishida","year":"2025","journal-title":"Commun. Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"102987","DOI":"10.1016\/j.tice.2025.102987","article-title":"Optimizing thrombospondin function through repositioning: Implications for injury and diabetic foot ulcer management","volume":"96","year":"2025","journal-title":"Tissue Cell"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"102483","DOI":"10.1016\/j.nano.2021.102483","article-title":"Cerium oxide nanoparticle conjugation to microRNA-146a mechanism of correction for impaired diabetic wound healing","volume":"40","author":"Dewberry","year":"2022","journal-title":"Nanomedicine"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Fu, Y., Kolanthai, E., Neal, C.J., Kumar, U., Zgheib, C., Liechty, K.W., and Seal, S. (2022). Engineered Faceted Cerium Oxide Nanoparticles for Therapeutic miRNA Delivery. Nanomaterials, 12.","DOI":"10.3390\/nano12244389"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Corsi, F., Deidda Tarquini, G., Urbani, M., Bejarano, I., Traversa, E., and Ghibelli, L. (2023). The Impressive Anti-Inflammatory Activity of Cerium Oxide Nanoparticles: More than Redox?. Nanomaterials, 13.","DOI":"10.3390\/nano13202803"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1016\/j.biomaterials.2012.11.061","article-title":"Effects of cerium oxide nanoparticles on the growth of keratinocytes, fibroblasts and vascular endothelial cells in cutaneous wound healing","volume":"34","author":"Chigurupati","year":"2013","journal-title":"Biomaterials"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s00109-025-02554-9","article-title":"Cerium oxide nanoparticles as potent inhibitors of ferroptosis: Role of antioxidant activity and protein regulation","volume":"103","author":"Feng","year":"2025","journal-title":"J. Mol. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41392-022-01263-w","article-title":"MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Lyttle, B.D., Vaughn, A.E., Bardill, J.R., Apte, A., Gallagher, L.T., Zgheib, C., and Liechty, K.W. (2023). Effects of microRNAs on angiogenesis in diabetic wounds. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1140979"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.2337\/db12-0145","article-title":"The role of microRNA-146a in the pathogenesis of the diabetic wound-healing impairment: Correction with mesenchymal stem cell treatment","volume":"61","author":"Xu","year":"2012","journal-title":"Diabetes"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1021\/acsabm.1c01155","article-title":"Photopolymerized Zwitterionic Hydrogels with a Sustained Delivery of Cerium Oxide Nanoparticle-miR146a Conjugate Accelerate Diabetic Wound Healing","volume":"5","author":"Stager","year":"2022","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Niemiec, S.M., Louiselle, A.E., Hilton, S.A., Dewberry, L.C., Zhang, L., Azeltine, M., Xu, J., Singh, S., Sakthivel, T.S., and Seal, S. (2020). Nanosilk Increases the Strength of Diabetic Skin and Delivers CNP-miR146a to Improve Wound Healing. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.590285"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jamcollsurg.2018.09.017","article-title":"Use of Cerium Oxide Nanoparticles Conjugated with MicroRNA-146a to Correct the Diabetic Wound Healing Impairment","volume":"228","author":"Zgheib","year":"2019","journal-title":"J. Am. Coll. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.tibs.2020.08.008","article-title":"Hippo Signaling in Embryogenesis and Development","volume":"46","author":"Wu","year":"2021","journal-title":"Trends Biochem. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"102348","DOI":"10.1016\/j.jvsv.2025.102348","article-title":"A synergistic multimodality treatment approach to address the key drivers of wound chronicity","volume":"14","author":"Lohr","year":"2025","journal-title":"J. Vasc. Surg. Venous Lymphat. Disord."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/j.yexcr.2007.02.020","article-title":"VEGF and VEGFR-2 (KDR) internalization is required for endothelial recovery during wound healing","volume":"313","author":"Santos","year":"2007","journal-title":"Exp. Cell Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e70406","DOI":"10.1002\/mco2.70406","article-title":"Diabetic Wound Repair: From Mechanism to Therapeutic Opportunities","volume":"6","author":"Wang","year":"2025","journal-title":"MedComm"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/s41420-025-02780-7","article-title":"Ferroptosis in diabetes mellitus and its complications: Overview of clinical and preclinical research","volume":"11","author":"Li","year":"2025","journal-title":"Cell Death Discov."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"154887","DOI":"10.1016\/j.phymed.2023.154887","article-title":"Quercetin: A promising therapy for diabetic encephalopathy through inhibition of hippocampal ferroptosis","volume":"126","author":"Cheng","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"107632","DOI":"10.1016\/j.phrs.2025.107632","article-title":"Histone lysine crotonylation accelerates ACSL4-mediated ferroptosis of keratinocytes via modulating autophagy in diabetic wound healing","volume":"213","author":"Li","year":"2025","journal-title":"Pharmacol. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.7150\/ijbs.86492","article-title":"The PTGS2\/COX2-PGE(2) signaling cascade in inflammation: Pro or anti? A case study with type 1 diabetes mellitus","volume":"19","author":"Lorenzo","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Feng, J., Wang, J., Wang, Y., Huang, X., Shao, T., Deng, X., Cao, Y., Zhou, M., and Zhao, C. (2022). Oxidative Stress and Lipid Peroxidation: Prospective Associations Between Ferroptosis and Delayed Wound Healing in Diabetic Ulcers. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.898657"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/s41420-023-01437-7","article-title":"Defective NCOA4-dependent ferroptosis in senescent fibroblasts retards diabetic wound healing","volume":"9","author":"Wei","year":"2023","journal-title":"Cell Death Discov."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41389-026-00630-4","article-title":"Tipping the balance: NRF2\u2019s dual role in ferroptotic fate","volume":"15","year":"2026","journal-title":"Oncogenesis"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e37477","DOI":"10.1016\/j.heliyon.2024.e37477","article-title":"Targeting ferroptosis promotes diabetic wound healing via Nrf2 activation","volume":"10","author":"Wang","year":"2024","journal-title":"Heliyon"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Lyttle, B.D., Bardill, J., Vaughn, A.E., Apte, A., San Agustin, A., Kolanthai, E., Seal, S., Jackson, D.M., Liechty, K.W., and Zgheib, C. (2026). Topical delivery of CNP-miR146a via a pluronic lecithin organogel enhances diabetic wound healing. Pharmaceutics, 18.","DOI":"10.3390\/pharmaceutics18020248"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Liao, W., Lin, J., Wang, W., Zhang, M., Chen, Y., Li, X., Liu, H., Wang, P.X., Zhao, G., and Fu, J. (2024). Assembly of ceria-Nrf2 nanoparticles as macrophage-targeting ROS scavengers protects against myocardial infarction. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1503757"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: Molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"ref_51","first-page":"918267","article-title":"Endothelial dysfunction and diabetes: Effects on angiogenesis, vascular remodeling, and wound healing","volume":"2012","author":"Kolluru","year":"2012","journal-title":"Int. J. Vasc. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s10020-026-01451-2","article-title":"Endothelial ferroptosis: A novel mechanism and therapeutic target in diabetic microvascular complications","volume":"32","author":"Xie","year":"2026","journal-title":"Mol. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.matbio.2012.01.006","article-title":"Thrombospondin-1 in tissue repair and fibrosis: TGF-beta-dependent and independent mechanisms","volume":"31","author":"Sweetwyne","year":"2012","journal-title":"Matrix Biol."},{"key":"ref_54","first-page":"17","article-title":"A nanoenzyme-modified hydrogel targets macrophage reprogramming-angiogenesis crosstalk to boost diabetic wound repair","volume":"35","author":"He","year":"2024","journal-title":"Bioact. Mater."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Fu, Z., Chen, L., Mo, L., Zhan, Y., and Ma, L. (2026). Cerium oxide nanoparticles for enhanced healing of diabetic foot ulcers. Front. Bioeng. Biotechnol., 13.","DOI":"10.3389\/fbioe.2025.1695821"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"122","DOI":"10.56782\/pps.250","article-title":"Metabolite profiling, antioxidant, and in vitro wound healing activities of Citrus medica L. and Citrus \u00d7 microcarpa Bunge peels and leaves essential oils","volume":"22","author":"Husni","year":"2024","journal-title":"Prospects Pharm. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/18\/9\/1116\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:57:22Z","timestamp":1788530242000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/18\/9\/1116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,4]]},"references-count":57,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["pharmaceutics18091116"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics18091116","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,4]]}}}