{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T10:20:05Z","timestamp":1785493205513,"version":"3.56.0"},"reference-count":19,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T00:00:00Z","timestamp":1667088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacy"],"abstract":"<jats:p>We describe the risk factors for the development, timing, and severity of doxycycline induced acute pancreatitis (DIAP) in two case reports and a review of prior published cases, to better understand DIAP. Clinicians must maintain a high level of suspicion for DIAP in patients presenting with acute pancreatitis, while on doxycycline therapy. The latency and severity of DIAP are variable, making diagnosis challenging. Treatment includes bowel rest, hydration, and discontinuation of doxycycline.<\/jats:p>","DOI":"10.3390\/pharmacy10060144","type":"journal-article","created":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T09:01:42Z","timestamp":1667120502000},"page":"144","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Doxycycline Induced Pancreatitis: An Uncommon Complication of a Common Drug"],"prefix":"10.3390","volume":"10","author":[{"given":"William","family":"Reiche","sequence":"first","affiliation":[{"name":"Department of Medicine, CHI Health Creighton University Medical Center, Omaha, NE 68124, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faith","family":"Abodunrin","sequence":"additional","affiliation":[{"name":"Department of Medicine, CHI Health Creighton University Medical Center, Omaha, NE 68124, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7923-3939","authenticated-orcid":false,"given":"Chris","family":"Destache","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Creighton University School of Pharmacy and Health Professions, Omaha, NE 68178, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajani","family":"Rangray","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, CHI Creighton University Medical Center, Omaha, NE 68124, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4045-3261","authenticated-orcid":false,"given":"Manasa","family":"Velagapudi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, CHI Creighton University Medical Center, Omaha, NE 68124, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,30]]},"reference":[{"key":"ref_1","first-page":"45","article-title":"Drug-induced acute pancreatitis: A review","volume":"15","author":"Jones","year":"2015","journal-title":"Ochsner J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.bpg.2010.02.002","article-title":"Drug induced pancreatitis","volume":"24","author":"Nitsche","year":"2010","journal-title":"Best Pract. Amp. Res. Clin. Gastroenterol."},{"key":"ref_3","first-page":"e7496","article-title":"A Common Medication with an Uncommon Adverse Event: A Case of Doxycycline-induced Pancreatitis","volume":"12","author":"Paulraj","year":"2020","journal-title":"Cureus"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/ecco-jcc\/jjx167","article-title":"Vedolizumab-Associated Pancreatitis in Paediatric Ulcerative Colitis: Functional Selectivity of the \u03b14\u03b27integrin and MAdCAM-1 Pathway?","volume":"12","author":"Lopez","year":"2018","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Picardo, S., So, K., Venugopal, K., and Chin, M. (2018). Vedolizumab-induced acute pancreatitis: The first reported clinical case. BMJ Case Rep., 2018.","DOI":"10.1136\/bcr-2017-222554"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1179\/joc.2010.22.1.63","article-title":"Ceftriaxone-induced pancreatitis in a pediatric patient: Case report","volume":"22","author":"Ruggiero","year":"2010","journal-title":"J. Chemother."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1177\/106002809302700108","article-title":"Ceftriaxone-induced acute pancreatitis","volume":"27","author":"Zimmermann","year":"1993","journal-title":"Ann. Pharmacother."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.cgh.2006.11.023","article-title":"Drug-Induced Acute Pancreatitis: An Evidence-Based Review","volume":"5","author":"Badalov","year":"2007","journal-title":"Clin. Gastroenterol. 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