{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:33:36Z","timestamp":1792445616371,"version":"4.5.0"},"reference-count":35,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T00:00:00Z","timestamp":1670630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacy"],"abstract":"<jats:p>Background: The objective of this systematic review was to characterize the efficacy and safety of evening primrose (EP) for facilitation of parturition in peripartum persons. Methods: This search sought records related to the efficacy and safety of EP preparations to facilitate parturition. Eligibility criteria were primary literature with efficacy or safety outcomes reported; studied in peripartum persons; and available in English. Records were excluded if they were available as abstracts only. Data was synthesized by study characteristics, patient demographics, and outcomes. The RoB2 and ROBINS-I were used to assess risk of bias. Results: A total of 11 studies met inclusion criteria: seven randomized placebo-controlled trials, one randomized non placebo-controlled trial, one case study, one observational retrospective study, and one quasi-experimental cross-sectional study. Efficacy outcomes included Bishop scores and duration of labor during the different phases. Reported adverse events were generally mild and included increased blood pressure, decreased heart rate, pain, bleeding, nausea, and vomiting. Important risks of bias exist across the literature reviewed. Conclusions: The use of EP for parturition in peripartum individuals is not recommended. Further research is warranted before use during parturition or the peripartum period. Other: The authors deny conflicts of interest. The study was neither registered nor funded.<\/jats:p>","DOI":"10.3390\/pharmacy10060172","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T02:15:33Z","timestamp":1670811333000},"page":"172","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Systematic Review of Evening Primrose (Oenothera biennis) Preparations for the Facilitation of Parturition"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1630-874X","authenticated-orcid":false,"given":"Timothy C.","family":"Hutcherson","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, School of Pharmacy, D\u2019Youville University, Buffalo, NY 14201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2861-3074","authenticated-orcid":false,"given":"Nicole E.","family":"Cieri-Hutcherson","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14214, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maggie M.","family":"Lycouras","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Mount Saint Mary\u2019s Hospital, Lewiston, NY 14092, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharmista","family":"Koehler","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, School of Pharmacy, D\u2019Youville University, Buffalo, NY 14201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison","family":"Mortimer","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, School of Pharmacy, D\u2019Youville University, Buffalo, NY 14201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina J.","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, School of Pharmacy, D\u2019Youville University, Buffalo, NY 14201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia S.","family":"Costa","sequence":"additional","affiliation":[{"name":"The Janssen Pharmaceuticals Companies of Johnson & Johnson, Albany, NY 19044, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley L.","family":"Bohlmann","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Rochester General Hospital, Rochester, NY 14621, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mudit K.","family":"Singhal","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical, Social and Administrative Sciences, School of Pharmacy, D\u2019Youville University, Buffalo, NY 14201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,10]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Births: Final data for 2019","volume":"70","author":"Martin","year":"2021","journal-title":"Natl. 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