{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T18:46:26Z","timestamp":1787942786045,"version":"build-2784847793"},"reference-count":9,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacy"],"abstract":"<jats:p>(1) Background: The incidence of vancomycin-induced neutropenia in hospitalized patients is estimated to be around 2 to 8 percent Data surrounding vancomycin-induced neutropenia is limited as it is based on a small number of observational case reports. Additionally, it is difficult to provide generalized conclusions since patient characteristics and indications for treatment vary between reports. (2) Case Reports: We present two cases of vancomycin-induced neutropenia that occurred at our facility; a 50-year-old male who developed neutropenia after treatment with vancomycin for a gluteal abscess and a 51-year-old female who developed neutropenia after treatment with vancomycin for lumbar osteomyelitis. In both cases, neutropenia resolved within 2 days of discontinuation of vancomycin. (3) Conclusions: Vancomycin-induced neutropenia is thought to be a relatively uncommon adverse drug reaction. These two cases of neutropenia likely caused by prolonged exposure to vancomycin occurred at our facility within 3 months of each other. Additional studies are needed to better understand the true incidence of this adverse drug reaction and to identify risk factors that may predispose patients to vancomycin-induced neutropenia.<\/jats:p>","DOI":"10.3390\/pharmacy12010038","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T11:23:57Z","timestamp":1708341837000},"page":"38","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Two Cases of Vancomycin-Induced Neutropenia"],"prefix":"10.3390","volume":"12","author":[{"given":"Kirsten","family":"Ganaja","sequence":"first","affiliation":[{"name":"Dignity Health Marian Regional Medical Center, Santa Maria, CA 93454, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4348-176X","authenticated-orcid":false,"given":"Sarah","family":"Scoular","sequence":"additional","affiliation":[{"name":"Skaggs School of Pharmacy, University of Montana, Missoula, MT 59812, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staci","family":"Hemmer","sequence":"additional","affiliation":[{"name":"Skaggs School of Pharmacy, University of Montana, Missoula, MT 59812, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.12659\/AJCR.909956","article-title":"Agranulocytosis induced by vancomycin. Case report and literature review","volume":"19","author":"Castroagudin","year":"2018","journal-title":"Am. J. Case Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1345\/aph.1G436","article-title":"Epidemiology of vancomycin-induced neutropenia in patients receiving home intravenous infusion therapy","volume":"40","author":"Pai","year":"2006","journal-title":"Ann. Pharmacother."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.21307\/immunohematology-2019-103","article-title":"Drug-induced immune neutropenia\/agranulocytosis","volume":"30","author":"Curtis","year":"2014","journal-title":"Immunohematology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e93164","DOI":"10.12659\/AJCR.931647","article-title":"Neutropenia, thrombocytopenia, and eosinophilia: An unusual triad in a patient on long-term vancomycin therapy","volume":"22","author":"Lintel","year":"2021","journal-title":"Am. J. Case Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.4172\/2332-0877.1000336","article-title":"Vancomycin induced neutropenia associated with fever: A case report","volume":"5","author":"Shaukat","year":"2017","journal-title":"J. Infect. Dis. Ther."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1345\/aph.1Q467","article-title":"Severe neutropenia following a prolonged course of vancomycin that progressed to agranulocytosis with drug reexposure","volume":"46","author":"Duff","year":"2012","journal-title":"Ann. Pharmacother."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/clpt.1981.154","article-title":"A Method for estimating the probability of adverse drug reactions","volume":"30","author":"Naranjo","year":"1981","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1345\/aph.1P583","article-title":"Vancomycin-induced neutropenia: Is it dose- or duration-related?","volume":"45","author":"Black","year":"2011","journal-title":"Ann. Pharmacother."}],"container-title":["Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2226-4787\/12\/1\/38\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:01:59Z","timestamp":1760104919000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2226-4787\/12\/1\/38"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,19]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["pharmacy12010038"],"URL":"https:\/\/doi.org\/10.3390\/pharmacy12010038","relation":{},"ISSN":["2226-4787"],"issn-type":[{"value":"2226-4787","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,19]]}}}