{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:15:24Z","timestamp":1767626124615,"version":"build-2065373602"},"reference-count":39,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ULL Research Group in Food and Environmental Toxicology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacy"],"abstract":"<jats:p>Background: Tolerance and dependence stand out as the most relevant risks observed during benzodiazepine (BZD) treatments. Objectives: To evaluate the degree of dependence of patients on BZD treatments using the Tyrer test; to define a profile of patients at risk of developing BZD dependence; and to discuss the role of the pharmaceutical care offered by the community pharmacy during dispensing. Methods: Prospective cross-sectional descriptive observational study (August 2020\u2013February 2021) involving 127 patients using BZD. They voluntarily answered a questionnaire during the dispensing pharmaceutical care service. The study was evaluated and codified (code: DAA-CLO-2020-01) by the Spanish Agency for Drugs and Health Products (AEMPS), and statistical analysis was performed with SPSS 25.0. Results: 19.05% of patients using BZD were suspected of suffering from BZD tolerance, and 77.88% of all patients were identified as being at a high risk of BZD dependence. The Tyrer test for dependence indicated a mean score of 5.59 out of 13 points. An 18-fold increased risk of developing dependence was detected in the case of coexistence of high anxiety or depression. Conclusions: The community pharmacy, through protocolized care practices and supported by tools such as the Tyrer test, can play a decisive role in the detection, prevention, and resolution of the risks associated with BZD treatments.<\/jats:p>","DOI":"10.3390\/pharmacy12040120","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T08:14:46Z","timestamp":1722500086000},"page":"120","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Risk Characterization in Patients Using Benzodiazepines While Providing Pharmaceutical Care Dispensing Service"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2481-7405","authenticated-orcid":false,"given":"Daida","family":"Alberto Armas","sequence":"first","affiliation":[{"name":"Research Group on Environmental Toxicology and Food and Drug Safety, University of La Laguna, Ofra, 38071 Canary Island, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1272-4850","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Hern\u00e1ndez Garc\u00eda","sequence":"additional","affiliation":[{"name":"Research Group on Environmental Toxicology and Food and Drug Safety, University of La Laguna, Ofra, 38071 Canary Island, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanira","family":"Rom\u00e1n Castillo","sequence":"additional","affiliation":[{"name":"Nursing Area of the Hospital Nuestra Se\u00f1ora de la Candelaria in Santa Cruz de Tenerife, 38010 Canary Islands, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6877-9734","authenticated-orcid":false,"given":"Juan Ram\u00f3n","family":"Santana Ayala","sequence":"additional","affiliation":[{"name":"Research Group on Environmental Toxicology and Food and Drug Safety, University of La Laguna, Ofra, 38071 Canary Island, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franc","family":"Capdevila Finestres","sequence":"additional","affiliation":[{"name":"Research Group on Environmental Toxicology and Food and Drug Safety, University of La Laguna, Ofra, 38071 Canary Island, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Hardisson de la Torre","sequence":"additional","affiliation":[{"name":"Research Group on Environmental Toxicology and Food and Drug Safety, University of La Laguna, Ofra, 38071 Canary Island, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8774-5870","authenticated-orcid":false,"given":"Carmen","family":"Rubio Armend\u00e1riz","sequence":"additional","affiliation":[{"name":"Research Group on Environmental Toxicology and Food and Drug Safety, University of La Laguna, Ofra, 38071 Canary Island, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.phrs.2015.12.030","article-title":"Activation-induced regulation of GABAA receptors: Is there a link with the molecular basis of benzodiazepine tolerance?","volume":"109","author":"Gravielle","year":"2016","journal-title":"Pharmacol. 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