{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T21:10:29Z","timestamp":1785186629024,"version":"3.55.0"},"reference-count":21,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacy"],"abstract":"<jats:p>Polysubstance use (PSU) involving marijuana among women of reproductive age (WRA) is linked to psychosocial harm, yet research on the combined effects of marijuana with stimulants, opioids, tobacco, and binge drinking remains limited. The purpose of this study was to assess the prevalence of PSU in WRA with past month MJ use and examine the association between PSU status and social sequelae, including getting in trouble with the law, relationship difficulty with others, and lower achievement in job or educational settings, in this group of women. We used data from the United States 2015\u20132019 National Survey on Drug Use and Health, which included 11,895 non-institutionalized WRA (18\u201344 years old) with reported use of MJ in the past month. Descriptive statistics, chi-squared tests, and multivariable logistic regression analyses were conducted to describe the sample and assess associations between PSU and social sequelae. Nearly 4.5% of the women who used MJ in the past month had experienced social sequelae regardless of PSU status. Women who used three or more substances along with MJ had the highest adjusted odds (AOR = 3.18, 95% CI 1.90, 5.31) of social sequelae relative to monosubstance MJ users. Concurrent use of multiple substances significantly increased the likelihood of social sequelae among women MJ users.<\/jats:p>","DOI":"10.3390\/pharmacy13040092","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T07:55:43Z","timestamp":1751442943000},"page":"92","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Polysubstance Use and Social Sequelae in Women of Reproductive Age with Recent Marijuana Use"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4520-8994","authenticated-orcid":false,"given":"Sean Hyungwoo","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Biopharmaceutics and Pharmacogenomics, Bernard J. Dunn School of Pharmacy, Shenandoah University, 1775 N. Sector Court, Winchester, VA 22601, USA"},{"name":"Department of Health Administration and Policy, College of Public Health, George Mason University, 4400 University Drive, Fairfax, VA 22030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2422-0043","authenticated-orcid":false,"given":"Hua","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Health Administration and Policy, College of Public Health, George Mason University, 4400 University Drive, Fairfax, VA 22030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Health Administration and Policy, College of Public Health, George Mason University, 4400 University Drive, Fairfax, VA 22030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiota","family":"Kitsantas","sequence":"additional","affiliation":[{"name":"Department of Health Administration and Policy, College of Public Health, George Mason University, 4400 University Drive, Fairfax, VA 22030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.drugalcdep.2018.07.025","article-title":"The importance of considering polysubstance use: Lessons from cocaine research","volume":"192","author":"Liu","year":"2018","journal-title":"Drug Alcohol Depend."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"American College of Obstetricians and Gynecologists Committee on Obstetric Practice (2017). Committee Opinion No. 722: Marijuana Use During Pregnancy and Lactation. Obstet. Gynecol., 130, e205\u2013e209.","DOI":"10.1097\/AOG.0000000000002354"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"201.e1","DOI":"10.1016\/j.ajog.2015.03.021","article-title":"Prevalence and patterns of marijuana use among pregnant and nonpregnant women of reproductive age","volume":"213","author":"Ko","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"108161","DOI":"10.1016\/j.drugalcdep.2020.108161","article-title":"Current marijuana use among women of reproductive age","volume":"214","author":"Ewing","year":"2020","journal-title":"Drug Alcohol Depend."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/S0140-6736(04)16200-4","article-title":"Psychological and social sequelae of cannabis and other illicit drug use by young people: A systematic review of longitudinal, general population studies","volume":"363","author":"Macleod","year":"2004","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Steinhoff, A., Bechtiger, L., Ribeaud, D., Eisner, M.P., Quednow, B.B., and Shanahan, L. (2022). Polysubstance Use in Early Adulthood: Patterns and Developmental Precursors in an Urban Cohort. Front. Behav. Neurosci., 15.","DOI":"10.3389\/fnbeh.2021.797473"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/YCO.0000000000000069","article-title":"Polysubstance use: Diagnostic challenges, patterns of use and health","volume":"27","author":"Connor","year":"2014","journal-title":"Curr. Opin. Psychiatry"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S2215-0366(14)70307-4","article-title":"Young adult sequelae of adolescent cannabis use: An integrative analysis","volume":"1","author":"Silins","year":"2014","journal-title":"Lancet Psychiatry"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1111\/j.1360-0443.2008.02221.x","article-title":"Cannabis use and later life outcomes","volume":"103","author":"Fergusson","year":"2008","journal-title":"Addiction"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1080\/08897077.2013.775092","article-title":"Adult work commitment, financial stability, and social environment as related to trajectories of marijuana use beginning in adolescence","volume":"34","author":"Brook","year":"2013","journal-title":"Subst. Abus."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1007\/s00127-015-1070-x","article-title":"Psychosocial sequelae of cannabis use and implications for policy: Findings from the Christchurch Health and Development Study","volume":"50","author":"Fergusson","year":"2015","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"ref_12","unstructured":"National Academies of Sciences, Engineering, and Medicine (2025, March 10). The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research. Available online: https:\/\/nap.nationalacademies.org\/catalog\/24625\/the-health-effects-of-cannabis-and-cannabinoids-the-current-state."},{"key":"ref_13","unstructured":"Center for Behavioral Health Statistics and Quality (2025, March 10). 2019 National Survey on Drug Use and Health Final Analytic File Codebook, Substance Abuse and Mental Health Services Administration, Rockville, MD, Available online: https:\/\/www.samhsa.gov\/data\/sites\/default\/files\/2021-09\/NSDUHAnalyticCodebookRDC2019.pdf."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1080\/10826080601006805","article-title":"Patterns of drug use among drug misusers in Sweden. Gender differences","volume":"41","author":"Byqvist","year":"2006","journal-title":"Subst. Use Misuse"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e1009","DOI":"10.1542\/peds.2012-3931","article-title":"Prenatal substance abuse: Short- and long-term effects on the exposed fetus","volume":"131","author":"Behnke","year":"2013","journal-title":"Pediatrics"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"American College of Obstetricians and Gynecologists (2008). ACOG Committee Opinion No. 422. At-risk drinking and illicit drug use: Ethical issues in obstetric and gynecologic practice. Obstet. Gynecol., 112, 1449\u20131460.","DOI":"10.1097\/AOG.0b013e318192499b"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S2215-0366(14)70343-8","article-title":"Adolescent cannabis use and adverse sequelae in adulthood","volume":"1","author":"Nordentoft","year":"2014","journal-title":"Lancet Psychiatry"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00737-020-01089-x","article-title":"Prevalence and correlates of suicidal behaviors during pregnancy: Evidence from the National Survey on Drug Use and Health","volume":"24","author":"Kitsantas","year":"2021","journal-title":"Arch. Women\u2019s Ment. Health"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"106759","DOI":"10.1016\/j.cct.2022.106759","article-title":"Addressing opioid medication misuse at point of service in community pharmacy: A study protocol for an interdisciplinary behavioral health trial","volume":"116","author":"Cochran","year":"2022","journal-title":"Contemp. Clin. Trials"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e540","DOI":"10.1542\/peds.2011-3212","article-title":"Neonatal drug withdrawal","volume":"129","author":"Hudak","year":"2012","journal-title":"Pediatrics"},{"key":"ref_21","unstructured":"World Health Organization (2025, March 10). Guidelines for the Identification and Management of Substance Use and Substance Use Disorders in Pregnancy, Available online: http:\/\/www.who.int\/substance_abuse\/publications\/pregnancy_guidelines\/en\/."}],"container-title":["Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2226-4787\/13\/4\/92\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:02:51Z","timestamp":1760032971000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2226-4787\/13\/4\/92"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,2]]},"references-count":21,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["pharmacy13040092"],"URL":"https:\/\/doi.org\/10.3390\/pharmacy13040092","relation":{},"ISSN":["2226-4787"],"issn-type":[{"value":"2226-4787","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,2]]}}}