{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:31:18Z","timestamp":1760059878907,"version":"build-2065373602"},"reference-count":23,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacy"],"abstract":"<jats:p>A total of 38% of Americans do not meet the Recommended Dietary Allowance (RDA) for calcium including those at risk for osteoporosis. To increase the percentage of patients at risk for osteoporosis who achieve goal calcium RDA intake, a collaborative specialty pharmacy-registered dietitian-nutritionist (RDN) quality improvement program was developed. Patients aged 18 to 90 years old receiving osteoporosis therapy (denosumab, teriparatide, zoledronic acid) or medications that increase bone loss (elagolix, oral prednisone) were provided with a structured assessment and educational intervention. Daily calcium intake included patient self-reported dietary intake plus supplement use. Written and verbal education on increasing dietary intake based on patient preferences was provided with 5 calcium-rich food-source store coupons. Recommendations for supplement selection (citrate vs. carbonate) and\/or medication-related problem resolution were provided. Follow-up occurred at 3\u20136 months. Fifty patients enrolled [94% female, mean age 66.6 years (SD 15.3)] were taking denosumab (36), teriparatide (1), zoledronic acid (1), elagolix (7) and prednisone (5). The mean baseline daily dietary calcium intake was 500 mg (SD 247) with none achieving goal intake with diet alone. Average calcium supplement use in 22 (44%) patients was 686 mg daily (SD 284). At baseline, 17 (34%) met goal daily calcium intake compared to 30 (60%) at post intervention follow-up (p = 0.009). Over half of the store coupons were redeemed. A specialty pharmacy-RDN customized intervention program provides a model for aiding patients to modify calcium intake.<\/jats:p>","DOI":"10.3390\/pharmacy13040100","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T10:49:17Z","timestamp":1753267757000},"page":"100","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CalOPT: A Specialty Pharmacy\u2013Dietitian Quality Improvement Initiative for Calcium Optimization in Patients with Osteoporosis Risk"],"prefix":"10.3390","volume":"13","author":[{"given":"Jennifer","family":"Cerulli","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, NY 12208, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alisha","family":"Roberts","sequence":"additional","affiliation":[{"name":"Northeast Shared Services, Schenectady, NY 12308, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellie","family":"Wilson","sequence":"additional","affiliation":[{"name":"Northeast Shared Services, Schenectady, NY 12308, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Guisinger","sequence":"additional","affiliation":[{"name":"Northeast Shared Services, Schenectady, NY 12308, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"ref_1","unstructured":"International Osteoporosis Foundation (2019). Compendium of Osteoporosis, International Osteoporosis Foundation. [2nd ed.]. Available online: https:\/\/www.osteoporosis.foundation\/system\/files\/eh\/2020-01\/IOF-Compendium-of-Osteoporosis-web-V02.pdf."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4158\/GL-2020-0524SUPPL","article-title":"American Association of Clinical Endocrinologists\/ American College of Endocrinology Clinical Practice Guidelines for the Diagnosis and Treatment of Postmenopausal Osteoporosis\u20142020 Update","volume":"26","author":"Camacho","year":"2020","journal-title":"Endocr. Pract."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1007\/s00198-021-05900-y","article-title":"The clinician\u2019s guide to prevention and treatment of osteoporosis","volume":"33","author":"LeBoff","year":"2022","journal-title":"Osteoporos. Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1002\/jbmr.4701","article-title":"Effective Communication and the Osteoporosis Care Gap","volume":"37","author":"Ralston","year":"2022","journal-title":"J. Bone Miner. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1136\/annrheumdis-2020-216931","article-title":"2019 EULAR points to consider for non-physician health professionals to prevent and manage fragility fractures in adults 50 years or older","volume":"80","author":"Adams","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e001143","DOI":"10.1136\/rmdopen-2019-001143","article-title":"Prevention and management of osteoporotic fractures by non-physician health professionals: A systematic literature review to inform EULAR points to consider","volume":"6","author":"Wilson","year":"2020","journal-title":"RMD Open"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00198-022-06561-1","article-title":"Pharmacist interventions in osteoporosis management: A systematic review","volume":"34","author":"Laird","year":"2023","journal-title":"Osteoporos. Int."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1007\/s00198-022-06453-4","article-title":"Effectiveness Working Group of the Royal Osteoporosis Society Osteoporosis, Bone Research Academy. Supporting patients to get the best from their osteoporosis treatment: A rapid realist review of what works, for whom, and in what circumstance","volume":"33","author":"Paskins","year":"2022","journal-title":"Osteoporos. Int."},{"key":"ref_9","unstructured":"Institute of Medicine (2011). Dietary Reference Intakes for Calcium and Vitamin D, The National Academies Press."},{"key":"ref_10","unstructured":"Bone Health and Osteoporosis Foundation (2024, June 07). Calcium and Vitamin D Supplement Safety Fact Sheet. Available online: https:\/\/www.bonehealthandosteoporosis.org\/calcium-vitamin-d-supplement-facts\/."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.3945\/jn.111.142257","article-title":"Foods, fortificants, and supplements: Where do Americans get their nutrients?","volume":"141","author":"Fulgoni","year":"2011","journal-title":"J. Nutr."},{"key":"ref_12","first-page":"1","article-title":"Dietary intake of vitamins, minerals, and fiber of persons ages 2 months and over in the United States: Third National Health and Nutrition Examination Survey, Phase 1, 1988\u20131991","volume":"258","author":"Alaimo","year":"1994","journal-title":"Adv. Data"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1331\/JAPhA.2007.06072","article-title":"Evaluation of calcium and vitamin D supplementation in bisphosphonate therapy","volume":"47","author":"Rush","year":"2007","journal-title":"J. Am. Pharm. Assoc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1177\/1060028018770622","article-title":"Impact of pharmacist-physician collaboration on osteoporosis treatment rates","volume":"52","author":"Bowers","year":"2018","journal-title":"Ann. Pharmacother."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1524-4733.2005.04007.x","article-title":"An evaluation of managing and educating patients on the risk of glucocorticoid-induced osteoporosis","volume":"8","author":"McDonough","year":"2005","journal-title":"Value Health"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00198-009-0977-z","article-title":"Community pharmacist-initiated screening program for osteoporosis: Randomized controlled trial","volume":"21","author":"Yuksel","year":"2010","journal-title":"Osteoporos. Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s13063-015-0720-3","article-title":"Successful knowledge translation intervention in long-term care: Final results from the vitamin D and osteoporosis study (ViDOS) pilot cluster randomized controlled trial","volume":"16","author":"Kennedy","year":"2015","journal-title":"Trials"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1345\/aph.1M366","article-title":"Evaluation of compliance with osteoporosis treatment guidelines after initiation of a pharmacist-run osteoporosis service at a family medicine clinic","volume":"43","author":"Hall","year":"2009","journal-title":"Ann. Pharmacother."},{"key":"ref_19","unstructured":"National Association of Specialty Pharmacy (NASP) (2025, July 14). What Is Specialty Pharmacy. Available online: https:\/\/naspnet.org\/wp-content\/uploads\/2024\/05\/What-is-Specialty-Pharmacy_Student_Aug23.pdf."},{"key":"ref_20","unstructured":"(2024, June 13). FRAX Fracture Risk Assessment Tool. Available online: https:\/\/www.sheffield.ac.uk\/FRAX\/tool.aspx?country=9."},{"key":"ref_21","unstructured":"(2024, June 13). International Osteoporosis Foundation (IOF). Available online: https:\/\/www.osteoporosis.foundation\/educational-hub\/topic\/calcium-calculator."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e085323","DOI":"10.1136\/bmjopen-2024-085323","article-title":"A person-centred primary care pharmacist-led osteoporosis review for optimising medicines (PHORM): A protocol for the development and co-design of a model consultation intervention","volume":"14","author":"Sturrock","year":"2024","journal-title":"BMJ Open"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Luc, M., Corriveau, H., Boire, G., Filiatrault, J., Beaulieu, M.C., and Gaboury, I. (2018). Patient-Related Factors Associated with Adherence to Recommendations Made by a Fracture Liaison Service: A Mixed-Method Prospective Study. Int. J. Environ. Res. Public Health, 15.","DOI":"10.3390\/ijerph15050944"}],"container-title":["Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2226-4787\/13\/4\/100\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:14:24Z","timestamp":1760033664000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2226-4787\/13\/4\/100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,23]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["pharmacy13040100"],"URL":"https:\/\/doi.org\/10.3390\/pharmacy13040100","relation":{},"ISSN":["2226-4787"],"issn-type":[{"type":"electronic","value":"2226-4787"}],"subject":[],"published":{"date-parts":[[2025,7,23]]}}}