{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:33:37Z","timestamp":1791318817958,"version":"4.3.1"},"reference-count":66,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This work was supported by grants from the Ministry of Science and Technology of Taiwan","award":["(Grant number: MOST 106-2320-B-037-008-MY2, MOST 108-2320-B-037-022-MY3, 108-2811-B-037-511, and 109-2927-I-037-502, awarded to F.-R. Chang; and MOST 108-2320-B-037-004, awarded to B.-H. Chen)"],"award-info":[{"award-number":["(Grant number: MOST 106-2320-B-037-008-MY2, MOST 108-2320-B-037-022-MY3, 108-2811-B-037-511, and 109-2927-I-037-502, awarded to F.-R. Chang; and MOST 108-2320-B-037-004, awarded to B.-H. Chen)"]}]},{"name":"In addition, this research was funded by the Drug Development and Value Creation Research Center, Kaohsiung Medical University &amp; Department of Medical Research, Kaohsiung Medical University Hospital","award":["Grant number: KMU-TC108A03-11, KMU-TC109A03-2) and Chang Gung Memorial Hospital (CMRPF1G0241-3; BMRP450)."],"award-info":[{"award-number":["Grant number: KMU-TC108A03-11, KMU-TC109A03-2) and Chang Gung Memorial Hospital (CMRPF1G0241-3; BMRP450)."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>This study aims to comprehensively explore the phytoconstituents as well as investigate the different biological activities of Chasmanthe aethiopica (Iridaceae) for the first time. Metabolic profiling of the leaf methanol extract of C. aethiopica (CAL) was carried out using HPLC-PDA-ESI-MS\/MS. Twenty-nine compounds were annotated belonging to various phytochemical classes including organic acids, cinnamic acid derivatives, flavonoids, isoflavonoids, and fatty acids. Myricetin-3-O-rhamnoside was the major compound identified. GLC\/MS analysis of the n-hexane fraction (CAL-A) resulted in the identification of 45 compounds with palmitic acid (16.08%) and methyl hexadecanoic acid ester (11.91%) representing the major constituents. CAL-A exhibited a potent anti-allergic activity as evidenced by its potent inhibition of \u03b2-hexosaminidase release triggered by A23187 and IgE by 72.7% and 48.7%, respectively. Results were comparable to that of dexamethasone (10 nM) in the A23187 degranulation assay showing 80.7% inhibition for \u03b2-hexosaminidase release. Both the n-hexane (CAL-A) and dichloromethane (CAL-B) fractions exhibited potent anti-inflammatory activity manifested by the significant inhibition of superoxide anion generation and prohibition of elastase release. CAL showed anti-hyperglycemic activity in vivo using streptozotocin-induced diabetic rat model by reducing fasting blood glucose levels (FBG) by 53.44% as compared with STZ-treated rats along with a substantial increase in serum insulin by 22.22%. Molecular modeling studies indicated that dicaffeoylquinic acid showed the highest fitting with free binding energies (\u2206G) of \u221247.24 and \u221260.50 Kcal\/mol for human \u03b1-amylase and \u03b1-glucosidase, respectively confirming its anti-hyperglycemic activity. Thus, C. aethiopica leaf extract could serve as an effective antioxidant natural remedy combating inflammation, allergy, and hyperglycemia.<\/jats:p>","DOI":"10.3390\/plants10061118","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T23:33:33Z","timestamp":1622504013000},"page":"1118","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Anti-Allergic, Anti-Inflammatory, and Anti-Hyperglycemic Activity of Chasmanthe aethiopica Leaf Extract and Its Profiling Using LC\/MS and GLC\/MS"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2382-8241","authenticated-orcid":false,"given":"Iriny M.","family":"Ayoub","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo 11566, 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Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo 11566, Egypt"},{"name":"Department of Pharmaceutical Biology, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Wetterauer","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, INF 364, D-69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4357-0981","authenticated-orcid":false,"given":"Hesham A.","family":"El-Beshbishy","sequence":"additional","affiliation":[{"name":"Medical Laboratory Sciences Department, Fakeeh College for Medical Sciences, Jeddah 21461, Saudi Arabia"},{"name":"Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo 11231, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5780-3977","authenticated-orcid":false,"given":"Tsong-Long","family":"Hwang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan"},{"name":"Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33302, Taiwan"},{"name":"Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 33302, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-Hung","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2549-4193","authenticated-orcid":false,"given":"Fang-Rong","family":"Chang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"},{"name":"Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"},{"name":"Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"},{"name":"Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7875-4510","authenticated-orcid":false,"given":"Michael","family":"Wink","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy and Molecular Biotechnology, Heidelberg 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