{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:41:59Z","timestamp":1789346519085,"version":"build-2803163510"},"reference-count":76,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>The genus Helichrysum Mill comprises hundreds of species that are mostly flowering perennial shrubs. Some of these plants that belong to the Helichrysum species are used in traditional medicine to treat cough, back pain, diabetes, asthma, digestive problems, menstrual pain, chest pain, kidney disorders, skin disorders, wounds, open sores, among other conditions, but, only a few scientific studies are reported in the literature with sufficient information that validates the acclaimed folkloric benefits of these plants. This review, therefore, provides a comprehensive update of the available information on the cytotoxicity, genotoxicity, anti-proliferative, anti-bacterial, anti-fungal, anti-viral, anti-HIV, anti-malarial, anti-ulcerogenic, anti-tyrosinase, anti-inflammatory, and anti-oxidant activities of selected Helichrysum species of interest: H. petiolare, H. cymocum, H. foetidum, and H. pandurifolium Schrank, using scientific databases as well as electronic and print sources. The ethnobotanical and morphological characteristics as well as the phytochemical composition and biological activities of these plants are elucidated. The scientific rationale for their current use is discussed based on the evidence in the literature. This review highlights the putative use of the Helichrysum species as a reliable source of bioactive compounds for the production of standard commercial drugs to treat many ailments, including those reported in folkloric uses. Further research on the many plants in the genus Helichrysum is recommended to explore their economic importance both as edible crops and medicinal botanicals.<\/jats:p>","DOI":"10.3390\/plants10081566","type":"journal-article","created":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T21:44:32Z","timestamp":1627854272000},"page":"1566","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Medicinal Properties and In Vitro Biological Activities of Selected Helichrysum Species from South Africa: A Review"],"prefix":"10.3390","volume":"10","author":[{"given":"Kolajo Adedamola","family":"Akinyede","sequence":"first","affiliation":[{"name":"Department of Medical Bioscience, University of the Western Cape, Private Bag X17, Bellville 7530, South Africa"},{"name":"Department of Science Technology, Biochemistry Unit, The Federal Polytechnic P.M.B.5351, Ado Ekiti 360231, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Nelson","family":"Cupido","sequence":"additional","affiliation":[{"name":"Department of Botany, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail Denise","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Medical Bioscience, University of the Western Cape, Private Bag X17, Bellville 7530, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7299-1128","authenticated-orcid":false,"given":"Oluwafemi Omoniyi","family":"Oguntibeju","sequence":"additional","affiliation":[{"name":"Phytomedicine and Phytochemistry Group, Oxidative Stress Research Centre, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, P.O. Box 1906, Bellville 7535, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3193-7499","authenticated-orcid":false,"given":"Okobi Eko","family":"Ekpo","sequence":"additional","affiliation":[{"name":"Department of Medical Bioscience, University of the Western Cape, Private Bag X17, Bellville 7530, South Africa"},{"name":"Department of Anatomy and Cellular Biology, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"ref_1","first-page":"61","article-title":"Flora of southern Africa","volume":"Volume 33","author":"Leistner","year":"1983","journal-title":"Asteraceae"},{"key":"ref_2","unstructured":"Pooley, E. (2003). 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