{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T16:29:44Z","timestamp":1768667384957,"version":"3.49.0"},"reference-count":35,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Cyperus articulatus L. (Priprioca) is a plant of the Cyperaceae family traditionally used in traditional medicine in the Amazon region. Studies of the essential oil of this species have identified many terpene compounds. However, little is known about the possible uses of solid waste generated by the extraction of essential oils. This study aimed to investigate the chemical composition of volatile compounds and to evaluate the antiproliferative activity of the ethanolic extract of solid residues generated by the extraction of the essential oil of C. articulatus L. rizhomes in experimental models in vitro using peritoneal macrophages of mice and human tumor cell lines. The analysis of the chemical composition of volatile compounds indicated the presence of sesquiterpenes and particularly sequiterpenic ketones as main constituents. The results showed that the treatment with ethanolic extract of C. articulatus L. reduced the activity of the enzyme arginase and proliferation of cancer cells (p &lt; 0.0001). The extract also showed no cytotoxicity in macrophages in concentrations between 12.5; 25 and 50 mg\/mL (p &lt; 0.0001). The results indicated that the extract of C. articulatus L. exerts antiproliferative activity (p &lt; 0.0001) with low toxicity on healthy cells in experimental models in vitro.<\/jats:p>","DOI":"10.3390\/plants10102084","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T21:26:20Z","timestamp":1633728380000},"page":"2084","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Chemical Composition and Antiproliferative Activity of the Ethanolic Extract of Cyperus articulatus L. (Cyperaceae)"],"prefix":"10.3390","volume":"10","author":[{"given":"\u00c9den Bruno Sousa da","family":"Silva","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacology, Institute of Public Health\u2014(ISCO), Federal University of Western Par\u00e1 (UFOPA), Santar\u00e9m 68040-255, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0909-769X","authenticated-orcid":false,"given":"Lauro Euclides Soares","family":"Barata","sequence":"additional","affiliation":[{"name":"P&DBIO-Laboratory of Bioactive Natural Products, Institute of Biodiversity and Forests (IBEF), Federal University of Western Par\u00e1 (UFOPA), Santar\u00e9m 68040-255, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelly Rios","family":"Ar\u00e9valo","sequence":"additional","affiliation":[{"name":"P&DBIO-Laboratory of Bioactive Natural Products, Institute of Biodiversity and Forests (IBEF), Federal University of Western Par\u00e1 (UFOPA), Santar\u00e9m 68040-255, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leda Quercia","family":"Vieira","sequence":"additional","affiliation":[{"name":"Laboratory of Gnotobiology and Immunology (LAGI), Department of Biochemistry and Immunology, Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waldion\u00ea","family":"Castro","sequence":"additional","affiliation":[{"name":"Laboratory of Gnotobiology and Immunology (LAGI), Department of Biochemistry and Immunology, Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana L\u00facia Tasca Gois","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Laboratory of Gnotobiology and Immunology (LAGI), Department of Biochemistry and Immunology, Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana Della","family":"Torre","sequence":"additional","affiliation":[{"name":"Laboratory of Gnotobiology and Immunology (LAGI), Department of Biochemistry and Immunology, Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly Christina Ferreira","family":"Castro","sequence":"additional","affiliation":[{"name":"P&DBIO-Laboratory of Bioactive Natural Products, Institute of Biodiversity and Forests (IBEF), Federal University of Western Par\u00e1 (UFOPA), Santar\u00e9m 68040-255, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adilson","family":"Sartoratto","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacognosy, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-599, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leopoldo C.","family":"Baratto","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacognosy, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-599, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxwell Barbosa","family":"de Santana","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Institute of Public Health\u2014(ISCO), Federal University of Western Par\u00e1 (UFOPA), Santar\u00e9m 68040-255, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6742-3652","authenticated-orcid":false,"given":"Antonio Humberto Hamad","family":"Minervino","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Health, LARSANA, Federal University of Western Par\u00e1, UFOPA, Santar\u00e9m 68040-255, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waldiney Pires","family":"Moraes","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Institute of Public Health\u2014(ISCO), Federal University of Western Par\u00e1 (UFOPA), Santar\u00e9m 68040-255, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.jep.2014.06.042","article-title":"Hot and cold: Medicinal plant uses in Quechua speaking communities in the high Andes (Callej\u00f3n de Huaylas, Ancash, Per\u00fa)","volume":"155","author":"Malpartida","year":"2014","journal-title":"J. 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