{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T21:27:37Z","timestamp":1785533257322,"version":"3.56.0"},"reference-count":74,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Researchers Supporting Project No. (RSP-2021\/294), King Saud University, Riyadh,Saudi Arabia","award":["(RSP-2021\/294),"],"award-info":[{"award-number":["(RSP-2021\/294),"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>A facile, eco-friendly fluorescence approach based on the biogenic formation of zinc oxide nanoparticles using the biomass of Plicosepalus curviflorus shoots was developed. The suggested approach was employed to analyze three phenolic compounds (catechin, curviflorside, and curviflorin) isolated from the shoots of P. curviflorus. The surface morphology of the prepared ZnONPs was characterized by carrying out different microscopic and spectroscopic investigations. A significant UV-Vis absorption peak of ZnONPs was recognized at 345 nm and the FT-IR spectra of the isolated catechin, curviflorside, and curviflorin in the presence of sodium dodecyl sulfate (SDS) and ZnONPs were recorded at \u03bbem 470, 490, and 484 nm after excitation at \u03bbex 380, 420, and 410 nm. The suggested fluorescence method displayed linear concentration ranges of 10\u2013120, 5\u2013100, and 10\u2013150 \u03bcg mL\u22121 for the three isolated compounds, respectively. The shoot extract, isolated compounds, and ZnONPs were screened for antibacterial and anticancer effects against four different types of bacterial strains and HeLa cells, respectively. The ZnONPs exhibited the highest zone of inhibition against Escherichia coli and Staphylococcus aureus strains when compared with pure, isolated compounds and shoot extract. The anticancer potential of ZnONPs (64%) was stronger as compared to the 160 \u00b5g mL\u22121 of shoot extract (49%), catechin (52%), curviflorside (54%), and curviflorin (58%) at 160 \u00b5g mL\u22121. Moreover, all the samples were investigated for hemolysis activity and showed a potent anti-hemolytic effect. The developed analytical method showed excellent sensitivity and reliability for the concurrent analysis of the isolated bioactive markers.<\/jats:p>","DOI":"10.3390\/plants11030361","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T01:43:27Z","timestamp":1643420607000},"page":"361","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Fluorescence Detection of Phenolic Compounds in Plicosepalus curviflorus Extract Using Biosynthesized ZnO Nanoparticles and Their Biomedical Potential"],"prefix":"10.3390","volume":"11","author":[{"given":"Musarat","family":"Amina","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Pharmacy College, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawal M.","family":"Al Musayeib","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Pharmacy College, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawal A.","family":"Alarfaj","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha F.","family":"El-Tohamy","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5313-7153","authenticated-orcid":false,"given":"Gadah A.","family":"Al-Hamoud","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Pharmacy College, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muneerah K. M.","family":"Alqenaei","sequence":"additional","affiliation":[{"name":"Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jpba.2019.02.027","article-title":"Screening techniques for the identification of bioactive compounds in natural products","volume":"168","author":"Fu","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1039\/C6NP00016A","article-title":"Comparison of analytical techniques for the identification of bioactive compounds from natural products","volume":"33","author":"Ciesla","year":"2016","journal-title":"Nat. Prod. 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