{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:08:33Z","timestamp":1788246513776,"version":"build-2803163510"},"reference-count":112,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:00:00Z","timestamp":1647561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Kidney diseases are expected to become the fifth leading cause of death by 2040. Several physiological failures classified as pre-, intra-, and post-renal factors induce kidney damage. Diabetes, liver pathologies, rhabdomyolysis, and intestinal microbiota have been identified as pre-renal factors, and lithiasis or blood clots in the ureters, prostate cancer, urethral obstructions, prostate elongation, and urinary tract infections are post-renal factors. Additionally, the nephrotoxicity of drugs has been highlighted as a crucial factor inducing kidney injuries. Due to the adverse effects of drugs, it is necessary to point to other alternatives to complement the treatment of these diseases, such as nephroprotective agents. Plants are a wide source of nephroprotective substances and can have beneficial effects in different levels of the physiological pathways which lead to kidney damage. In traditional medicines, plants are used as antioxidants, anti-inflammatories, diuretics, and anticancer agents, among other benefits. However, the mechanism of action of some plants empirically used remains unknown and scientific data are required to support their nephroprotective effects. The present work reviewed the plants with a beneficial effect on kidney diseases. The classification of nephroprotective plants according to the clinical definition of pre-renal, intrinsic, and post-renal factors is proposed to orient their use as complementary treatments.<\/jats:p>","DOI":"10.3390\/plants11060818","type":"journal-article","created":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T21:34:27Z","timestamp":1647812067000},"page":"818","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Nephroprotective Plants: A Review on the Use in Pre-Renal and Post-Renal Diseases"],"prefix":"10.3390","volume":"11","author":[{"given":"Mario Adri\u00e1n","family":"Tienda-V\u00e1zquez","sequence":"first","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey 64849, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2789-3788","authenticated-orcid":false,"given":"Zo\u00e9 P.","family":"Morreeuw","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey 64849, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5441-4768","authenticated-orcid":false,"given":"Juan Eduardo","family":"Sosa-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey 64849, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2942-1186","authenticated-orcid":false,"given":"Anaberta","family":"Cardador-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey 64849, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Sabath","sequence":"additional","affiliation":[{"name":"Departamento de Nefrolog\u00eda, Hospital General de Quer\u00e9taro, Queretaro 76175, Mexico"},{"name":"Facultad de Ciencias Naturales, Universidad Aut\u00f3noma de Quer\u00e9taro, Juriquilla 76230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5434-2765","authenticated-orcid":false,"given":"Elda M.","family":"Melchor-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey 64849, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4855-2720","authenticated-orcid":false,"given":"Hafiz M. 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Appl. Pharm. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1093\/ndt\/gfz174","article-title":"A single number for advocacy and communication-worldwide more than 850 million individuals have kidney diseases","volume":"34","author":"Jager","year":"2019","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s11255-020-02451-9","article-title":"Chronic kidney disease is associated with severe coronavirus disease 2019 (COVID-19) infection","volume":"52","author":"Henry","year":"2020","journal-title":"Int. Urol. Nephrol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nrneph.2017.2","article-title":"Acute kidney disease and renal recovery: Consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup","volume":"13","author":"Chawla","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_6","unstructured":"KDIGO (2012). Kidney disease: Improving global outcomes (KDIGO) acute kidney injury workgroup. KDIGO clinical practice guideline for acute kidney injury. Kidney. Int. Suppl., 2, 1\u2013138."},{"key":"ref_7","unstructured":"Manzoor, H., and Bhatt, H. (2020). Prerenal Kidney Failure, StatPearls Publishing."},{"key":"ref_8","first-page":"1074","article-title":"Acute kidney injury, its definition, and treatment in adults: Guidelines and reality","volume":"130","year":"2020","journal-title":"Pol. Arch. Intern Med."},{"key":"ref_9","first-page":"85","article-title":"Acute Kidney Injury: Definition, Pathophysiology and Clinical Phenotypes","volume":"37","author":"Makris","year":"2016","journal-title":"Clin. Biochem. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s10157-017-1448-z","article-title":"Guidelines for treatment of renal injury during cancer chemotherapy 2016","volume":"22","author":"Horie","year":"2018","journal-title":"Clin. Exp. Nephrol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1590\/2175-8239-jbn-2018-0107","article-title":"Pathophysiological aspects of nephropathy caused by non-steroidal anti-inflammatory drugs","volume":"41","author":"Lucas","year":"2019","journal-title":"J. Bras. Nefrol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Petejova, N., Martinek, A., Zadrazil, J., Kanova, M., Klementa, V., Sigutova, R., Kacirova, I., Hrabovsky, V., Svagera, Z., and Stejskal, D. (2020). Acute kidney injury in septic patients treated by selected nephrotoxic antibiotic agents\u2014Pathophysiology and biomarkers\u2014A review. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197115"},{"key":"ref_13","first-page":"1","article-title":"Proton pump inhibitors associated acute kidney injury and chronic kidney disease: Data mining of US FDA adverse event reporting system","volume":"11","author":"Wu","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Lawson, S.K., Satyal, P., and Setzer, W.N. (2021). The volatile phytochemistry of seven native american aromatic medicinal plants. Plants, 10.","DOI":"10.3390\/plants10061061"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s40659-019-0246-3","article-title":"Stress and defense responses in plant secondary metabolites production","volume":"52","author":"Isah","year":"2019","journal-title":"Biol. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.31254\/phyto.2019.8106","article-title":"Kidney disorders and management through herbs: A Review","volume":"8","author":"Das","year":"2019","journal-title":"J. Phytopharm."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"50284","DOI":"10.18632\/oncotarget.17466","article-title":"Integration of phytochemicals and phytotherapy into cancer precision medicine","volume":"8","author":"Efferth","year":"2017","journal-title":"Oncotarget"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Governa, P., Baini, G., Borgonetti, V., Cettolin, G., Giachetti, D., Magnano, A.R., Miraldi, E., and Biagi, M. (2018). Phytotherapy in the Management of Diabetes: A Review. Molecules, 23.","DOI":"10.3390\/molecules23010105"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"38","DOI":"10.21010\/ajtcam.v13i5.6","article-title":"The purview of phytotherapy in the management of kidney disorders: A systematic review on Nigeria and South Africa","volume":"13","author":"Sabiu","year":"2016","journal-title":"Afr. J. Tradit. Complement. Altern. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"114743","DOI":"10.1016\/j.jep.2021.114743","article-title":"Potential nephroprotective phytochemicals: Mechanism and future prospects","volume":"283","author":"Basist","year":"2022","journal-title":"J. Ethnopharm."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"170","DOI":"10.4172\/2161-0959.1000170","article-title":"An Appraisal of Nephroprotection and the Scope of Natural Products in Combating Renal Disorders","volume":"04","author":"Ahmad","year":"2014","journal-title":"J. Nephrol. Ther."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Stub, T., Quandt, S.A., Arcury, T.A., Sandberg, J.C., Kristoffersen, A.E., Musial, F., and Salamonsen, A. (2016). Perception of risk and communication among conventional and complementary health care providers involving cancer patients\u2019 use of complementary therapies: A literature review. BMC Complement. Altern. Med., 16.","DOI":"10.1186\/s12906-016-1326-3"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Khalil, H., and Huang, C. (2020). Adverse drug reactions in primary care: A scoping review. BMC Health Serv. Res., 20.","DOI":"10.1186\/s12913-019-4651-7"},{"key":"ref_24","unstructured":"World Health Organization (WHO) (2013). WHO Traditional Medicines Strategy 2014\u20132023, World Health Organization."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s12955-020-01432-x","article-title":"A critical review to grading systems and recommendations of traditional Chinese medicine guidelines","volume":"18","author":"Li","year":"2020","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e23702","DOI":"10.1097\/MD.0000000000023702","article-title":"Efficacy and safety of traditional Chinese medicine injection with mecobalamin in treating diabetic peripheral neuropathy: A protocol for systematic review and meta-analysis","volume":"100","author":"Mai","year":"2021","journal-title":"Medicine"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1089\/acm.2018.0273","article-title":"Reliability of Ayurvedic Diagnosis for Knee Osteoarthritis Patients: A Nested Diagnostic Study Within a Randomized Controlled Trial","volume":"25","author":"Kessler","year":"2019","journal-title":"J. Altern. Complement. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1089\/acm.2017.0083","article-title":"Therapeutic uses of Triphala in ayurvedic medicine","volume":"23","author":"Peterson","year":"2017","journal-title":"J. Altern Complement. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.biotechadv.2015.08.001","article-title":"Discovery and resupply of pharmacologically active plant-derived natural products: A review","volume":"33","author":"Atanasov","year":"2015","journal-title":"Biotechnol. Adv."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural products in drug discovery: Advances and opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12934-020-01473-3","article-title":"Formulation of traditional Chinese medicine and its application on intestinal flora of constipated rats","volume":"19","author":"Li","year":"2020","journal-title":"Microb. Cell Fact."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13020-021-00428-z","article-title":"Research progress on quality assurance of genuine Chinese medicinal in Sichuan","volume":"16","author":"Luo","year":"2021","journal-title":"Chin. Med."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Nyakudya, T., Tshabalala, T., Dangarembizi, R., Erlwanger, K., and Ndhlala, A.R. (2020). The Potential Therapeutic Value of Medicinal Plants in the Management of Metabolic Disorders. Molecules, 25.","DOI":"10.3390\/molecules25112669"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jaim.2019.09.009","article-title":"Emanating the specialty clinical practices in Ayurveda: Preliminary observations from an arthritis clinic and its implications","volume":"12","author":"Rastogi","year":"2020","journal-title":"J. Ayurveda Integr. Med."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Yoo, S., Kim, K., Nam, H., and Lee, D. (2018). Discovering Health Benefits of Phytochemicals with Integrated Analysis of the Molecular Network, Chemical Properties and Ethnopharmacological Evidence. Nutrients, 10.","DOI":"10.3390\/nu10081042"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"525340","DOI":"10.1155\/2014\/525340","article-title":"Historical Perspective of Traditional Indigenous Medical Practices: The Current Renaissance and Conservation of Herbal Resources","volume":"2014","author":"Pan","year":"2014","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/bcp.13811","article-title":"The impact of tacrolimus exposure on extrarenal adverse effects in adult renal transplant recipients","volume":"85","author":"Campagne","year":"2019","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1177\/2156587216671392","article-title":"The Significance of Ayurvedic Medicinal Plants","volume":"22","author":"Kumar","year":"2017","journal-title":"J. Evid.-Based Complement. Altern. Med."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Pfister, B., Jonsson, J., and Gustafsson, M. (2017). Drug-related problems and medication reviews among old people with dementia. BMC Pharmacol. Toxicol., 18.","DOI":"10.1186\/s40360-017-0157-2"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Stocco, G., Lucaf\u00f2, M., and Decorti, G. (2020). Pharmacogenomics of Antibiotics. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21175975"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1093\/jac\/dkw329","article-title":"Predicting the risk of nephrotoxicity in patients receiving colistimethate sodium: A multicentre, retrospective, cohort study","volume":"71","author":"Phe","year":"2016","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Dwyer, J.T., Coates, P.M., and Smith, M.J. (2018). Dietary Supplements: Regulatory Challenges and Research Resources. Nutrients, 10.","DOI":"10.3390\/nu10010041"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"233","DOI":"10.5527\/wjn.v5.i3.233","article-title":"Soy-based renoprotection","volume":"5","author":"McGraw","year":"2016","journal-title":"World J. Nephrol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11892-017-0843-x","article-title":"Diet and Diabetic Kidney Disease: Plant Versus Animal Protein","volume":"17","author":"Moorthi","year":"2017","journal-title":"Curr. Diabetes Rep."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Alabi, T., Brooks, N., and Oguntibeju, O. (2021). Leaf Extracts of Anchomanes difformis Ameliorated Kidney and Pancreatic Damage in Type 2 Diabetes. Plants, 10.","DOI":"10.3390\/plants10020300"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Al-Anbaki, M., Cavin, A.-L., Nogueira, R., Taslimi, J., Ali, H., Najem, M., Mahmood, M.S., Khaleel, I.A., Mohammed, A.S., and Hasan, H.R. (2021). Hibiscus sabdariffa, a Treatment for Uncontrolled Hypertension. Pilot Comparative Intervention. Plants, 10.","DOI":"10.3390\/plants10051018"},{"key":"ref_47","first-page":"21","article-title":"Toxicity and safety of medicinal plants","volume":"2","author":"Nasri","year":"2013","journal-title":"J. HerbMed. Pharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Kharchoufa, L., Bouhrim, M., Bencheikh, N., Addi, M., Hano, C., Mechchate, H., and Elachouri, M. (2021). Potential Toxicity of Medicinal Plants Inventoried in Northeastern Morocco: An Ethnobotanical Approach. Plants, 10.","DOI":"10.3390\/plants10061108"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.toxrep.2020.02.008","article-title":"United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts","volume":"7","author":"Roe","year":"2020","journal-title":"Toxicol. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/fsn3.1339","article-title":"Antipyretic and hepatoprotective potential of Tinospora crispa and investigation of possible lead compounds through in silico approaches","volume":"8","author":"Rakib","year":"2020","journal-title":"Food Sci. Nutr."},{"key":"ref_51","first-page":"S860","article-title":"Hepatoprotective Effects of Nonpolar Extracts from Inflorescences of Thistles Cirsium vulgare and Cirsium ehrenbergii on Acute Liver Damage in Rat","volume":"13","author":"Shibayama","year":"2018","journal-title":"Pharmacogn. Mag."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Mohammed, S.A.A., Khan, R.A., El-readi, M.Z., Emwas, A.H., Sioud, S., Poulson, B.G., Jaremko, M., Eldeeb, H.M., Al-Omar, M.S., and Mohammed, H.A. (2020). Suaeda vermiculata aqueous-ethanolic extract-based mitigation of ccl4-induced hepatotoxicity in rats, and hepg-2 and hepg-2\/adr cell-lines-based cytotoxicity evaluations. Plants, 9.","DOI":"10.3390\/plants9101291"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"139","DOI":"10.30699\/jambs.29.134.139","article-title":"The Effect of Descurainia Sophia Seed Extract on Nephrotoxicity Markers Induced by Acetaminophen in Mice","volume":"29","author":"Bahari","year":"2021","journal-title":"J. Adv. Med Biomed. Res."},{"key":"ref_54","first-page":"4916519","article-title":"Nephroprotective Effect of Herbal Extract Eurycoma longifolia on Paracetamol-Induced Nephrotoxicity in Rats","volume":"2019","author":"Chinnappan","year":"2019","journal-title":"Evid.-based Complement. Altern. Med."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Buzgaia, N., Awin, T., Elabbar, F., Abdusalam, K., Lee, S.Y., Rukayadi, Y., Abas, F., and Shaari, K. (2020). Antibacterial Activity of Arbutus pavarii Pamp against Methicillin-Resistant Staphylococcus aureus (MRSA) and UHPLC-MS\/MS Profile of the Bioactive Fraction. Plants, 9.","DOI":"10.3390\/plants9111539"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jaim.2017.09.006","article-title":"Punica granatum improves renal function in gentamicin-induced nephropathy in rats via attenuation of oxidative stress","volume":"11","author":"Mestry","year":"2020","journal-title":"J. Ayurveda Integr. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"7134","DOI":"10.1007\/s11356-020-10999-3","article-title":"The efficiency of pomegranate (Punica granatum) peel ethanolic extract in attenuating the vancomycin-triggered liver and kidney tissues injury in rats","volume":"28","author":"Khalil","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.fct.2019.03.002","article-title":"Cocoa intake attenuates renal injury in Zucker Diabetic fatty rats by improving glucose homeostasis","volume":"127","author":"Goya","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Boonphang, O., Ontawong, A., Pasachan, T., Phatsara, M., Duangjai, A., Amornlerdpison, D., Jinakote, M., and Srimaroeng, C. (2021). Antidiabetic and Renoprotective Effects of Coffea arabica Pulp Aqueous Extract through Preserving Organic Cation Transport System Mediated Oxidative Stress Pathway in Experimental Type 2 Diabetic Rats. Molecules, 26.","DOI":"10.3390\/molecules26071907"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"9156510","DOI":"10.1155\/2016\/9156510","article-title":"Properties of Flavonoids Isolated from the Bark of Eysenhardtia polystachya and Their Effect on Oxidative Stress in Streptozotocin-Induced Diabetes Mellitus in Mice","volume":"2016","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Fierros, F.L., Guarner-Lans, V., Soto, M.E., Manzano-Pech, L., D\u00edaz-D\u00edaz, E., Soria-Castro, E., Rubio-Ruiz, M.E., Jim\u00e9nez-Trejo, F., and P\u00e9rez-Torres, I. (2021). Modulation of Renal Function in a Metabolic Syndrome Rat Model by Antioxidants in Hibiscus sabdariffa L. Molecules, 26.","DOI":"10.3390\/molecules26072074"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Epure, A., P\u00e2rvu, A.E., Vlase, L., Benedec, D., Hanganu, D., Gheldiu, A.-M., Toma, V.A., and Oniga, I. (2020). Phytochemical Profile, Antioxidant, Cardioprotective and Nephroprotective Activity of Romanian Chicory Extract. Plants, 10.","DOI":"10.3390\/plants10010064"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"949","DOI":"10.2147\/DDDT.S292107","article-title":"Geniposide from Gardenia jasminoides var. radicans Makino Attenuates Myocardial Injury in Spontaneously Hypertensive Rats via Regulating Apoptotic and Energy Metabolism Signalling Pathway","volume":"15","author":"Hou","year":"2021","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"8961","DOI":"10.1096\/fj.201900077R","article-title":"Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death","volume":"33","author":"Garc","year":"2019","journal-title":"FASEB J."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1080\/13813455.2017.1422766","article-title":"Chemoprotective effects of curcumin on doxorubicin-induced nephrotoxicity in wistar rats: By modulating inflammatory cytokines, apoptosis, oxidative stress and oxidative DNA damage","volume":"124","author":"Benzer","year":"2018","journal-title":"Arch. Physiol. Biochem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"536","DOI":"10.3889\/oamjms.2019.153","article-title":"Hepatoprotective Activity and Nephroprotective Activity of Peel Extract from Three Varieties of the Passion Fruit (Passiflora Sp.) in the Albino Rat","volume":"7","author":"Nerdy","year":"2019","journal-title":"Open Access Maced. J. Med. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.sjbs.2020.11.011","article-title":"Nephroprotective, cytotoxic and antioxidant activities of Euphorbia paralias","volume":"28","author":"Alqahtani","year":"2021","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1080\/19390211.2016.1267062","article-title":"Nephroprotective and Anti-Inflammatory Effects of Pistacia atlantica Leaf Hydroethanolic Extract Against Gentamicin-Induced Nephrotoxicity in Rats","volume":"14","author":"Heidarian","year":"2017","journal-title":"J. Diet. Suppl."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s40816-016-0025-4","article-title":"Nephroprotective and antioxidant effect of aqueous leaf extract of Costus afer Ker gawl on cyclosporin-a (Csa) induced nephrotoxicity","volume":"2","author":"Ezejiofor","year":"2016","journal-title":"Clin. Phytosci."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Ranfaing, J., Dunyach-Remy, C., Lavigne, J.-P., and Sotto, A. (2018). Propolis potentiates the effect of cranberry (Vaccinium macrocarpon) in reducing the motility and the biofilm formation of uropathogenic Escherichia coli. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0202609"},{"key":"ref_71","first-page":"126","article-title":"Influence of Cranberry Extract on Tamm-Horsfall Protein in Human Urine and its Antiadhesive Activity Against Uropathogenic Escherichia coli","volume":"85","author":"Scharf","year":"2018","journal-title":"Planta Med."},{"key":"ref_72","first-page":"228","article-title":"Preventive and curative effects of aqueous extracts of Descurainia sophia L on nephrolithiasis induced in rats","volume":"2018","author":"Saremi","year":"2018","journal-title":"Asian J. Pharm."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"760683","DOI":"10.1155\/2014\/760683","article-title":"Randomized, Double-Blind Clinical Trial to Assess the Acute Diuretic Effect ofEquisetum arvense(Field Horsetail) in Healthy Volunteers","volume":"2014","author":"Carneiro","year":"2014","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3060525","DOI":"10.1155\/2018\/3060525","article-title":"Equisetum arvense L. Extract Induces Antibacterial Activity and Modulates Oxidative Stress, Inflammation, and Apoptosis in Endothelial Vascular Cells Exposed to Hyperosmotic Stress","volume":"2018","author":"Pallag","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Lee, G., Shin, J., Choi, H., Jo, A., Pan, S., Bae, D., Lee, Y., and Choi, C. (2017). Cynanchum wilfordii Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia by Regulating 5\u03b1-Reductase and Androgen Receptor Activities in a Rat Model. Nutrients, 9.","DOI":"10.3390\/nu9101070"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1089\/jmf.2018.0106","article-title":"Effects of an Oil-Free Hydroethanolic Pumpkin Seed Extract on Symptom Frequency and Severity in Men with Benign Prostatic Hyperplasia: A Pilot Study in Humans","volume":"22","author":"Leibbrand","year":"2019","journal-title":"J. Med. Food"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Csik\u00f3s, E., Horv\u00e1th, A., \u00c1cs, K., Papp, N., Bal\u00e1zs, V.L., Dolenc, M.S., Kenda, M., Glava\u010d, N.K., Nagy, M., and Protti, M. (2021). Treatment of Benign Prostatic Hyperplasia by Natural Drugs. Molecules, 26.","DOI":"10.3390\/molecules26237141"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"nzy002","DOI":"10.1093\/cdn\/nzy002","article-title":"Broccoli Sprouts Delay Prostate Cancer Formation and Decrease Prostate Cancer Severity with a Concurrent Decrease in HDAC3 Protein Expression in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) Mice","volume":"2","author":"Beaver","year":"2018","journal-title":"Curr. Dev. Nutr."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/dom.13942","article-title":"Chronic kidney disease in type 2 diabetes: Implications for managing glycaemic control, cardiovascular and renal risk","volume":"22","author":"Stephens","year":"2020","journal-title":"Diabetes Obes. Metab."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Kartha, C., Ramachandran, S., and Pillai, R.M. (2017). Genetic basis for increased risk for vascular diseases in diabetes. Mechanisms of Vascular Defects in Diabetes Mellitus, India Springer.","DOI":"10.1007\/978-3-319-60324-7"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"622593","DOI":"10.3389\/fmed.2020.622593","article-title":"Nephroprotection by SGLT2i in CKD Patients: May It Be Modulated by Low-Protein Plant-Based Diets?","volume":"7","author":"Cupisti","year":"2020","journal-title":"Front. Med."},{"key":"ref_82","unstructured":"Hall, J., and Hall, M. (2020). Adrenocorcical hormones. Guyton and Hall Textbook of Medical Physiology, Elsevier. [14th ed.]."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Esquivel-Guti\u00e9rrez, E.R., Manzo-Avalos, S., Pe\u00f1a-Montes, D.J., Saavedra-Molina, A., Morreeuw, Z.P., and Reyes, A.G. (2021). Hypolipidemic and Antioxidant Effects of Guishe Extract from Agave lechuguilla, a Mexican Plant with Biotechnological Potential, on Streptozotocin-Induced Diabetic Male Rats. Plants, 10.","DOI":"10.3390\/plants10112492"},{"key":"ref_84","unstructured":"Cardador Mart\u00ednez, A., Rodriguez, V., Manzano-Santana, P., and Alonzo, M. (2020). Medicinal plants with the potential to treat hypertension: Studies that were done in the last decade. Medicinal Plants for the Treatment of Metabolic Disorders, Nova Medicine & Health. [1st ed.]."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.cca.2016.12.014","article-title":"Hypertension: The role of biochemistry in the diagnosis and management","volume":"465","author":"Griffin","year":"2017","journal-title":"Clin. Chim. Acta"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1007\/s40265-014-0306-5","article-title":"Updated National and International Hypertension Guidelines: A Review of Current Recommendations","volume":"74","author":"Kjeldsen","year":"2014","journal-title":"Drugs"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1001\/jama.2013.284427","article-title":"2014 evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the Eighth Joint National Committee (JNC 8)","volume":"311","author":"James","year":"2014","journal-title":"JAMA"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s40265-019-1064-1","article-title":"Management of Hypertension in Chronic Kidney Disease","volume":"79","author":"Pugh","year":"2019","journal-title":"Drugs"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1080\/14779072.2018.1540301","article-title":"Pathophysiology of essential hypertension: An update","volume":"16","author":"Saxena","year":"2018","journal-title":"Expert Rev. Cardiovasc. Ther."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e009992","DOI":"10.1161\/JAHA.118.009992","article-title":"Use of Antihypertensive Agents and Association with Risk of Adverse Outcomes in Chronic Kidney Disease: Focus on Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers","volume":"7","author":"Ku","year":"2018","journal-title":"J. Am. Hear. Assoc."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Levi, M., Takahashi, S., Wang, X., and Levi, M. (2020). The Kidney in Liver Disease. The Liver Biology and Pathobiol, John Wiley & Sons, Ltd.. [6th ed.].","DOI":"10.1002\/9781119436812.ch49"},{"key":"ref_92","first-page":"75","article-title":"Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: Current understanding and future perspectives","volume":"4","author":"Ramachandran","year":"2018","journal-title":"J. Clin. Transl. Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"207","DOI":"10.5005\/jp-journals-10071-23721","article-title":"Renal Dysfunction in Cirrhosis: Critical Care Management","volume":"25","author":"Rajakumar","year":"2021","journal-title":"Indian J. Crit. Care Med."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Ramachandran, A., and Jaeschke, H. (2016). Experimental Models of Hepatotoxicity for the Testing of Natural Products [Internet], Elsevier Inc.. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering.","DOI":"10.1016\/B978-0-12-409547-2.11715-9"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e123673","DOI":"10.1172\/jci.insight.123673","article-title":"Human kidney on a chip assessment of polymyxin antibiotic nephrotoxicity","volume":"3","author":"Weber","year":"2018","journal-title":"JCI Insight"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Winther, S.A., \u00d8llgaard, J.C., Hansen, T.W., von Scholten, B.J., Reinhard, H., Ahluwalia, T.S., Wang, Z., G\u00e6de, P., Parving, H.-H., and Hazen, S. (2021). Plasma trimethylamine N-oxide and its metabolic precursors and risk of mortality, cardiovascular and renal disease in individuals with type 2-diabetes and albuminuria. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0244402"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1053\/j.jrn.2020.04.007","article-title":"Plant-Based Diets, the Gut Microbiota, and Trimethylamine N-Oxide Production in Chronic Kidney Disease: Therapeutic Potential and Methodological Considerations","volume":"31","author":"Wiese","year":"2021","journal-title":"J. Ren. Nutr."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"611323","DOI":"10.3389\/fmicb.2021.611323","article-title":"Resveratrol Improves Liver Steatosis and Insulin Resistance in Non-alcoholic Fatty Liver Disease in Association with the Gut Microbiota","volume":"12","author":"Du","year":"2021","journal-title":"Front. Microbiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"4265898","DOI":"10.1155\/2017\/4265898","article-title":"Reclamation of Herb Residues Using Probiotics and Their Therapeutic Effect on Diarrhea","volume":"2017","author":"Meng","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.kint.2020.09.033","article-title":"Complement activation is a crucial driver of acute kidney injury in rhabdomyolysis","volume":"99","author":"Boudhabhay","year":"2021","journal-title":"Kidney Int."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.rmclc.2018.08.003","article-title":"\u00c1ngeles Rabdomi\u00f3lisis metab\u00f3lica: Actualizaci\u00f3n","volume":"29","author":"Kleinsteuber","year":"2018","journal-title":"Rev. M\u00e9dica Cl\u00ednica Las Condes"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.7150\/ijms.38605","article-title":"Rhabdomyolysis Associations with Antibiotics: A Pharmacovigilance Study of the FDA Adverse Event Reporting System (FAERS)","volume":"16","author":"Teng","year":"2019","journal-title":"Int. J. Med. Sci."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nm.4462","article-title":"Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury","volume":"24","author":"Okubo","year":"2018","journal-title":"Nat. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"479","DOI":"10.12998\/wjcc.v8.i2.479","article-title":"Multiple organ dysfunction and rhabdomyolysis associated with moonwort poisoning: Report of four cases","volume":"8","author":"Li","year":"2020","journal-title":"World J. Clin. Cases"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3947\/ic.2018.50.1.67","article-title":"Clinical Practice Guidelines for the Antibiotic Treatment of Community-Acquired Urinary Tract Infections","volume":"50","author":"Kang","year":"2018","journal-title":"Infect. Chemother."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1128\/microbiolspec.UTI-0012-2012","article-title":"Gram-Positive Uropathogens, Polymicrobial Urinary Tract Infection, and the Emerging Microbiota of the Urinary Tract","volume":"4","author":"Kline","year":"2016","journal-title":"Microbiol. Spectr."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1242\/dmm.036798","article-title":"Correction: Renal scar formation and kidney function following antibiotic-treated murine pyelonephritis","volume":"11","author":"Olson","year":"2018","journal-title":"Dis. Model. Mech."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Nirumand, M.C., Hajialyani, M., Rahimi, R., Farzaei, M.H., Zingue, S., Nabavi, S.M., and Bishayee, A. (2018). Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19030765"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1590\/s1679-45082017ao4029","article-title":"Metabolic investigation in patients with nephrolithiasis","volume":"15","author":"Santos","year":"2017","journal-title":"Einstein"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1101\/gad.315739.118","article-title":"Genetics and biology of prostate cancer","volume":"32","author":"Wang","year":"2018","journal-title":"Genes Dev."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/s41391-021-00348-x","article-title":"Hormone therapy use and the risk of acute kidney injury in patients with prostate cancer: A population-based cohort study","volume":"24","author":"Cardwell","year":"2021","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/s41391-021-00383-8","article-title":"Androgen deprivation therapy and acute kidney injury in prostate cancer: Room for debate?","volume":"24","author":"Daskivich","year":"2021","journal-title":"Prostate Cancer Prostatic Dis."}],"container-title":["Plants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2223-7747\/11\/6\/818\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:39:16Z","timestamp":1760135956000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2223-7747\/11\/6\/818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,18]]},"references-count":112,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["plants11060818"],"URL":"https:\/\/doi.org\/10.3390\/plants11060818","relation":{},"ISSN":["2223-7747"],"issn-type":[{"value":"2223-7747","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,18]]}}}