{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:53:50Z","timestamp":1779324830803,"version":"3.51.4"},"reference-count":64,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>The application of metallic nanoparticles improves the yield and content of bioactive compounds in plants. The aim of the present study was to determine the effects of the foliar application of copper nanoparticles (CuO-NPs) in the yield and content of bioactive compounds in lettuce. Different concentrations of CuO-NPs (0, 0.5, 1, 2, 4, and 6 mg mL\u22121) were applied in lettuce. The yield, nutraceutical quality, and enzymatic activity were determined. Foliar spraying of CuO-NPs induced an increase in the biosynthesis of bioactive compounds. In addition to an increase in the activity of the enzymes superoxide dismutase (SOD) and catalase (CAT) in lettuce plants, there were no negative effects on yield. Therefore, with the application of CuO-NPs, better quality lettuces are produced for the human diet due to the higher production of bioactive compounds.<\/jats:p>","DOI":"10.3390\/plants11070912","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T21:41:30Z","timestamp":1648590090000},"page":"912","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["CuO-NPs Improve Biosynthesis of Bioactive Compounds in Lettuce"],"prefix":"10.3390","volume":"11","author":[{"given":"Jazm\u00edn M.","family":"Gaucin-Delgado","sequence":"first","affiliation":[{"name":"Tecnol\u00f3gico Nacional de Mexico, Instituto Tecnol\u00f3gico de Torre\u00f3n, Carretera Torre\u00f3n-San Pedro km 7.5, Torre\u00f3n 27170, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriel","family":"Ortiz-Campos","sequence":"additional","affiliation":[{"name":"Tecnol\u00f3gico Nacional de Mexico, Instituto Tecnol\u00f3gico de Torre\u00f3n, Carretera Torre\u00f3n-San Pedro km 7.5, Torre\u00f3n 27170, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8236-1074","authenticated-orcid":false,"given":"Luis G.","family":"Hernandez-Montiel","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biol\u00f3gicas del Noroeste, Av. Polit\u00e9cnico Nacional 195, Col. Playa Palo Santa Rita, La Paz 23090, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7374-8779","authenticated-orcid":false,"given":"Manuel","family":"Fortis-Hernandez","sequence":"additional","affiliation":[{"name":"Tecnol\u00f3gico Nacional de Mexico, Instituto Tecnol\u00f3gico de Torre\u00f3n, Carretera Torre\u00f3n-San Pedro km 7.5, Torre\u00f3n 27170, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5372-2523","authenticated-orcid":false,"given":"Juan J.","family":"Reyes-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Pecuarias, Universidad T\u00e9cnica Estatal de Quevedo, Av. Quito km 1.5 v\u00eda a Santo Domingo, Quevedo 120501, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A.","family":"Gonz\u00e1les-Fuentes","sequence":"additional","affiliation":[{"name":"Horticulture Department, Universidad Aut\u00f3noma Agraria Antonio Narro, Calzada Antonio Narro 1923, Buenavista, Saltillo 25315, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3450-4739","authenticated-orcid":false,"given":"Pablo","family":"Preciado-Rangel","sequence":"additional","affiliation":[{"name":"Tecnol\u00f3gico Nacional de Mexico, Instituto Tecnol\u00f3gico de Torre\u00f3n, Carretera Torre\u00f3n-San Pedro km 7.5, Torre\u00f3n 27170, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Hern\u00e1ndez-Hern\u00e1ndez, H., Quiterio-Guti\u00e9rrez, T., Cadenas-Pliego, G., Ortega-Ortiz, H., Hern\u00e1ndez-Fuentes, A.D., Cabrera de la Fuente, M., Vald\u00e9s-Reyna, J., and Ju\u00e1rez-Maldonado, A. 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