{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T22:50:30Z","timestamp":1781218230033,"version":"3.54.1"},"reference-count":55,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deanship of Scientific Research","award":["(10201-cos-2020-1-3-I) during the academic year 1442 AH \/ 2020 AD\""],"award-info":[{"award-number":["(10201-cos-2020-1-3-I) during the academic year 1442 AH \/ 2020 AD\""]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>The current study aimed to evaluate the naturally occurring antimicrobial and antidiabetic potential of various Echium humile (E. humile) solvent extracts (hexane, dichloromethane, ethyl acetate, methanol and aqueous). The bioactive compounds were identified using HPLC\u2013MS, revealing the presence of sixteen phytochemical compounds, with the most abundant being p-coumaric acid, followed by 4,5-di-O-caffeoylquinic acid, trans-ferulic acid and acacetin. Furthermore, E. humile extracts showed marked antimicrobial properties against human pathogen strains, with MIC values for the most relevant extracts (methanol and ethyl acetate) ranging from 0.19 to 6.25 mg\/mL and 0.39 to 12.50 mg\/mL, respectively. Likewise, methanol was found to be bactericidal towards S. aureus, B. cereus and M. luteus, fungicidal against P. catenulatum and F. oxysporum and have a bacteriostatic\/fungicidal effect for the other strains. In addition, the E. humile methanolic extract had the greatest \u03b1-glucosidase inhibitory effect (IC50 = 0.06 \u00b1 0.29 mg\/mL), which is higher than the standard drug, acarbose (IC50 = 0.80 \u00b1 1.81 mg\/mL) and the aqueous extract (IC50 = 0.70 \u00b1 0.67 mg\/mL). A correlation study between the major phytochemicals and the evaluated activities was investigated. Docking studies evidenced that most of the identified phenolic compounds showed strong interactions into the binding sites of S. aureus tyrosyl-tRNA synthetase and human lysosomal acid-\u03b1-glucosidase, confirming their suitable inhibitory effect. In summary, these results may provide rational support to explore the clinical efficacy of E. humile and its secondary metabolites in the treatment of dual diabetes and infections.<\/jats:p>","DOI":"10.3390\/plants11091131","type":"journal-article","created":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T00:45:21Z","timestamp":1650761121000},"page":"1131","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Phytochemical Profiling, Antimicrobial and \u03b1-Glucosidase Inhibitory Potential of Phenolic-Enriched Extracts of the Aerial Parts from Echium humile Desf.: In Vitro Combined with In Silico Approach"],"prefix":"10.3390","volume":"11","author":[{"given":"Ka\u00efss","family":"Aouadi","sequence":"first","affiliation":[{"name":"Department of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia"},{"name":"Department of Chemistry, Faculty of Sciences of Monastir, University of Monastir, Avenue of the Environment, Monastir 5019, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafedh","family":"Hajlaoui","sequence":"additional","affiliation":[{"name":"Research Unit Valorization and Optimization of Resource Exploitation (UR16ES04), Faculty of Science and Technology of Sidi Bouzid, Campus University Agricultural City, University of Kairouan, Sidi Bouzid 9100, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumaya","family":"Arraouadi","sequence":"additional","affiliation":[{"name":"Regional Center of Agricultural Research (CRRA) Sidi Bouzid, Gafsa Road Km 6, PB 357, Sidi Bouzid 9100, Tunisia"},{"name":"Research Laboratory, Valorization of Non-Conventional Waters, University of Carthage, Road Hedi EL Karray, El Menzah IV, PB 10, Ariana 2080, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwar","family":"Ghannay","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mejdi","family":"Snoussi","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, Hail University, Ha\u2019il 2440, Saudi Arabia"},{"name":"Laboratory of Genetic, Biodiversity and Valorization of Bioressources, Higher Institute of Bio-Technology of Monastir, University of Monastir, Avenue Taher Hadded, B.P. 74, Monastir 5000, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Kadri","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science of Sfax, University of Sfax, B.P. 1171, Sfax 3000, Tunisia"},{"name":"Faculty of Science and Arts in Baljurashi, Albaha University, Albaha 65527, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zaky, A.S., Kandeil, M., Abdel-Gabbar, M., Fahmy, E.M., Almehmadi, M.M., Ali, T.M., and Ahmed, O.M. 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