{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:45:32Z","timestamp":1791639932619,"version":"4.3.4"},"reference-count":33,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["RSP-2021\/146"],"award-info":[{"award-number":["RSP-2021\/146"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Skimmia anquetilia is a plant species native to the Western Himalaya region that has tremendous potential for phytochemical activities. This study aimed to identify bioactive compounds and assess the antibacterial activity of S. anquetilia. To determine the major bioactive chemicals in the methanol leaf extract of S. anquetilia, we used a gas chromatography\u2013mass spectrometer (GC-MS). The presence of 35 distinct phytoconstituents was discovered using GC-MS, which could contribute to the therapeutic capabilities of this plant species. The most predominant compound was 2R-acetoxymethyl-1,3,3-trimethyl-4t-(3-methyl-2-buten-1-yl)-1t-cyclohexanol (23.9%). Further, the leaf extract was evaluated for antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Salmonella typhi, and Staphylococcus aureus. The extract showed the highest zone of inhibition against E. coli (19 mm) followed by P. aeruginosa (18 mm) and K. Pneumoniae (17 mm) at 160 mg mL\u22121. The minimum inhibitory concentration (MIC) of methanol extract against the strain of P. aeruginosa (2 mg mL\u22121) demonstrated significant antibacterial activity. The findings of the present study highlight the potential of S. anquetilia for the development of herbal medicines for the treatment of various pathogenic infections.<\/jats:p>","DOI":"10.3390\/plants11131667","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T22:43:00Z","timestamp":1656024180000},"page":"1667","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Phytochemical Profiling and Antibacterial Activity of Methanol Leaf Extract of Skimmia anquetilia"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1677-6498","authenticated-orcid":false,"given":"Masarat","family":"Nabi","sequence":"first","affiliation":[{"name":"Department of Environmental Science, University of Kashmir, Srinagar 190006, Jammu & Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Iqbal","family":"Zargar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Kashmir, Srinagar 190006, Jammu & Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahida","family":"Tabassum","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Kashmir, Srinagar 190006, Jammu & Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bashir Ahmad","family":"Ganai","sequence":"additional","affiliation":[{"name":"Center of Research for Development, University of Kashmir, Srinagar 190006, Jammu & Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9860-0124","authenticated-orcid":false,"given":"Shahid Ud Din","family":"Wani","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Kashmir, Srinagar 190006, Jammu & Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0922-9819","authenticated-orcid":false,"given":"Sultan","family":"Alshehri","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prawez","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiyaz","family":"Shakeel","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.sjbs.2021.10.008","article-title":"Therapeutic potential of selected medicinal plant extracts against multi-drug resistant Salmonella enterica serovar typhi","volume":"29","author":"Naz","year":"2022","journal-title":"Saudi J. 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