{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:52:16Z","timestamp":1793742736669,"version":"4.6.1"},"reference-count":38,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>This study describes the antimicrobial and anti-inflammatory effects from extracts obtained from the leaves of Salvia lavanduloides. The plant material was macerated with three solvents of ascending polarity (n-hexane (Sl-Hex), ethyl acetate (Sl-AcOEt), and dichloromethane (Sl-D)). The extracts, fractions (SlD-2 and SlD-3), and isolated compounds (15,16-epoxy-10-\u03b2-hydroxy-neo-cleroda-3,7,13(16),14-tetraene-17,12R:18,19-diolide (1), salviandulin A (2), and eupatorin (3)) were evaluated as antimicrobials against Gram-negative, Gram-positive bacteria and the fungus Candida albicans (Ca) using the minimum inhibitory concentration (MIC) and the anti-inflammatory activity induced by 13-acetate of 12-O-tetradecanoylforbol (TPA). Sl-D and Sl-AcOEt extracts, SlD-2 and SlD-3 fractions showed the highest antimicrobial activity. The isolated compounds showed good activity against Pseudomonas aeruginosa with a MIC &lt; 2 \u03bcg\/mL, while the anti-inflammatory activity, the Sl-Hex, Sl-D extracts, and SlD-3 fraction presented an inhibition of 62, 45 and 61%, respectively, while (2) 70% and (3) 72%.<\/jats:p>","DOI":"10.3390\/plants11131739","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T01:40:36Z","timestamp":1656639636000},"page":"1739","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Eupatorin and Salviandulin-A, with Antimicrobial and Anti-Inflammatory Effects from Salvia lavanduloides Kunth Leaves"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3693-1670","authenticated-orcid":false,"given":"Manas\u00e9s","family":"Gonz\u00e1lez-Cortazar","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0183-4560","authenticated-orcid":false,"given":"David Osvaldo","family":"Salinas-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Biodiversidad y Conservaci\u00f3n (CIByC), Universidad Aut\u00f3noma del Estado de Morelos (UAEM), Av. Universidad 1001, Col. Chamilpa, Cuernavaca 62209, Morelos, Mexico"},{"name":"Escuela de Estudios Superiores del Jicarero (EESJ), Universidad Aut\u00f3noma del Estado de Morelos, Carretera Galeana-Tequesquitengo s\/n Col. el Jicarero, Jojutla 62909, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maribel","family":"Herrera-Ruiz","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dionisio Celerino","family":"Rom\u00e1n-Ramos","sequence":"additional","affiliation":[{"name":"Escuela de Estudios Superiores del Jicarero (EESJ), Universidad Aut\u00f3noma del Estado de Morelos, Carretera Galeana-Tequesquitengo s\/n Col. el Jicarero, Jojutla 62909, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2233-5958","authenticated-orcid":false,"given":"Alejandro","family":"Zamilpa","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0783-8274","authenticated-orcid":false,"given":"Enrique","family":"Jim\u00e9nez-Ferrer","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ever A.","family":"Ble-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Acad\u00e9mica de Ciencias B\u00e1sicas, Universidad Ju\u00e1rez Aut\u00f3noma de Tabasco, Carretera Cunduac\u00e1n-Jalpa Km. 0.5, Cunduac\u00e1n 86690, Tabasco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9552-3933","authenticated-orcid":false,"given":"Patricia","family":"\u00c1lvarez-Fitz","sequence":"additional","affiliation":[{"name":"Laboratorio de Toxicologia, C\u00e1tedra CONACyT-Universidad Aut\u00f3noma de Guerrero, Av. L\u00e1zaro C\u00e1rdenas s\/n. Col. La Haciendita, Chilpancingo 39070, Guerrero, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Castrej\u00f3n-Salgado","sequence":"additional","affiliation":[{"name":"Instituto Mexicano del Seguro Social, Unidad de Medicina Familiar N\u00famero 3, Avenida Insurgentes Esquina con Emiliano Zapata s\/n., Centro, Jiutepec 62550, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5456-0677","authenticated-orcid":false,"given":"Ma. Dolores","family":"P\u00e9rez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"ref_1","first-page":"196","article-title":"Importance of Staphylococcus aureus methicillin resistant in-hospital and acquired in the community","volume":"61","author":"Ceravantes","year":"2014","journal-title":"Mex. J. Clin. Pathol. Lab. Med."},{"key":"ref_2","unstructured":"(2018). CONAMED-PAHO Bulletin."},{"key":"ref_3","unstructured":"World Health Organization (WHO) (2017, June 01). WHO Publishes List of Bacteria for Which New Antibiotics Are Urgently Needed. Available online: http:\/\/www.who.int\/news-room\/detail\/27-02-2017-who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed."},{"key":"ref_4","first-page":"100","article-title":"An introduction to Staphylococcus aureus, and techniques for identifying and quantifying S. aureus adhesins in relation to adhesion to biomaterials: Review","volume":"4","author":"Harris","year":"2002","journal-title":"Eur. Cells Mater."},{"key":"ref_5","first-page":"31","article-title":"Management of refractory Pseudomonas aeruginosa infection in cystic fibrosis","volume":"4","author":"Pahissa","year":"2011","journal-title":"Infect. Drug. Resis."},{"key":"ref_6","first-page":"111","article-title":"The enzyme glycogen synthase kinase 3 regulates the activity of transcription factors NF-kB and creb during the inflammatory response caused by Staphylococcus aureus","volume":"36","author":"Mendoza","year":"2018","journal-title":"J. Biochem. Educ."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nrc3611","article-title":"Inflammation-induced cancer: Crosstalk between tumours, immune cells and microorganisms","volume":"13","author":"Elinav","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.eimc.2008.12.001","article-title":"Antibioticos betalactamicos","volume":"27","author":"Suarez","year":"2009","journal-title":"Enferm. Infecc. Y Microbiol. Clin."},{"key":"ref_9","first-page":"88","article-title":"NSAIDs in clinical practice: What you need to know","volume":"35","author":"Loza","year":"2011","journal-title":"Inf. Ter. Nat. Sys. Health"},{"key":"ref_10","unstructured":"Guzm\u00e1n, S.H., Maldonado, R.S., D\u00edaz, H.M., and Gonz\u00e1lez, C.M. (2017). Medicinal Plants the Reality of an Ancestral Tradition."},{"key":"ref_11","first-page":"118","article-title":"Anti-inflammatory medicinal plants used in the treatment of rheumatism","volume":"22","year":"2003","journal-title":"Phytotherapy"},{"key":"ref_12","first-page":"4710","article-title":"Salvia genus and triterpenoids","volume":"7","author":"Jash","year":"2016","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"ref_13","first-page":"571","article-title":"A revision of Salvia section Heterosphace (Lamiaceae) in western North America","volume":"19","author":"Walker","year":"2001","journal-title":"AIDS Contrib. Bot."},{"key":"ref_14","unstructured":"Ramamoorthy, T.P., Bye, R., Lot, A., and Fa, J. (1993). Lamiaceae of Mexico: Diversity, distribution, endemism and evolution. Biological Diversity of Mexico: Origins and Distribution, Institute of Biology, National Autonomous University of Mexico."},{"key":"ref_15","first-page":"105","article-title":"The vascular plant genera of the flora of Mexico","volume":"75","year":"2004","journal-title":"Bol. Soc. Bot. M\u00e9x."},{"key":"ref_16","first-page":"1279","article-title":"Diversity and distribution of the genus Salvia (Lamiaceae) in Michoac\u00e1n, Mexico","volume":"82","author":"Cornejo","year":"2011","journal-title":"Rev. Mex. De Biodivers."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1086\/709133","article-title":"Richness and distribution of Salvia subg. Calosphace (Lamiaceae)","volume":"181","author":"Bedolla","year":"2020","journal-title":"Int. J. Plant Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0378-8741(00)00396-2","article-title":"Topical anti-inflammatory activity of Salvia officinalis L. leaves: The relevance of ursolic acid","volume":"75","author":"Baricevic","year":"2001","journal-title":"J. Ethnopharmacol."},{"key":"ref_19","first-page":"13","article-title":"Experimental pharmacological study of three species from genus Salvia","volume":"10","author":"Todorov","year":"1984","journal-title":"Acta Physiol. Pharmacol. Bul."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0031-9422(03)00225-5","article-title":"Cardioactive and antibacterial terpenoids from some Salvia species","volume":"64","author":"Ulubelen","year":"2003","journal-title":"Phytochemistry"},{"key":"ref_21","unstructured":"Gait\u00e1n, F.I.C. (2022, April 18). Activity of Twelve Native Guatemalan Plants against Sporothrix Schenckii. Biology Chemestry Thesis. Available online: http:\/\/biblioteca.usac.edu.gt\/tesis\/06\/06_2289.pdf."},{"key":"ref_22","unstructured":"Monroy, O.C., and Castillo, E.P. (2007). Medicinal Plants Used in the State of Morelos, Autonomous University of the State of Morelos. [2nd ed.]."},{"key":"ref_23","unstructured":"Del Cid, A.N.E. (2005). Activity of Seventeen Extracts of Twelve Native Guatemalan Plants against Fonsecaea Pedrosoi, USAC."},{"key":"ref_24","first-page":"19","article-title":"Medicinal uses of the Labiatae family in Chiapas, Mexico","volume":"2","author":"Castro","year":"2002","journal-title":"Ethnobiology"},{"key":"ref_25","unstructured":"Arellano, R.B. (2017). Medicinal Ethnobotany of the Me\u2019phaa Culture in La Ci\u00e9nega, Municipality of Malinaltepec, Guerrero, Mexico, UAGro."},{"key":"ref_26","unstructured":"Palacios, V.M.C. (2004). Inhibition of the Growth of Gardnerella Vaginalis by Six Medicinal Plants of the Southwestern Guatemalan Flora, University of San Carlos de Guatemala. Available online: https:\/\/biblioteca-farmacia.usac.edu.gt\/Tesis\/QB782.pdf."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1016\/0031-9422(91)83209-4","article-title":"Salviandulines A and B. Two secoclerodane diterpenoids from Salvia lavanduloides","volume":"30","author":"Ortega","year":"1991","journal-title":"Phytochemistry"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0031-9422(91)83039-N","article-title":"Salvianduline C, a 5, 6-secoclerodane diterpenoid from Salvia lavanduloides","volume":"31","author":"Maldonado","year":"1992","journal-title":"Phytochemistry"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1080\/13880209.2017.1305423","article-title":"Anti-inflammatory activity of standardized dichloromethane extract of Salvia connivens on macrophages stimulated by LPS","volume":"55","author":"Ramos","year":"2017","journal-title":"Pharm. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.phytochem.2010.11.011","article-title":"Phytotoxic clerodane diterpenes from Salvia miniata Fernald (Lamiaceae)","volume":"72","author":"Bisio","year":"2011","journal-title":"Phytochemistry"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1248\/bpb.25.875","article-title":"Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis B RIQ. and consideration of structure\u2013activity relationship","volume":"25","author":"Nagao","year":"2002","journal-title":"Biol. Pharm. Bull."},{"key":"ref_32","unstructured":"Argueta, A., Cano, A.L.M., and Rodarte, G.M.E. (1994). Atlas of the Plants of Traditional Mexican Medicine."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5967","DOI":"10.1021\/cr200058f","article-title":"Constituents from Salvia species and their biological activities","volume":"112","author":"Wu","year":"2012","journal-title":"Chem. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/head.12769","article-title":"The pharmacology of indomethacin","volume":"56","author":"Lucas","year":"2016","journal-title":"Headache J. Head Face Pain"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1055\/s-0031-1298458","article-title":"Flavonoids eupatorin and sinensetin present in Orthosiphon stamineus leaves inhibit inflammatory gene expression and STAT1 activation","volume":"78","author":"Laavola","year":"2012","journal-title":"Planta Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.micpath.2019.01.030","article-title":"Antibacterial activity of Morinda citrifolia Linneo sedes against Methicillin Resistant Staphylococcus spp.","volume":"128","author":"Alvarez","year":"2019","journal-title":"Microb. Pathog."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"8136","DOI":"10.3390\/molecules18078136","article-title":"Anti-inflammatory activity of different Agave plants and the compound Cantalasaponin-1","volume":"18","author":"Monterrosas","year":"2013","journal-title":"Molecules"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.3390\/molecules17044292","article-title":"Anti-inflammatory activity of hautriwaic acid isolated from Dodonaea viscosa leaves","volume":"17","author":"Salinas","year":"2012","journal-title":"Molecules"}],"container-title":["Plants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2223-7747\/11\/13\/1739\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:41:04Z","timestamp":1760139664000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2223-7747\/11\/13\/1739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,30]]},"references-count":38,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["plants11131739"],"URL":"https:\/\/doi.org\/10.3390\/plants11131739","relation":{},"ISSN":["2223-7747"],"issn-type":[{"value":"2223-7747","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,30]]}}}