{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:39:45Z","timestamp":1777473585968,"version":"3.51.4"},"reference-count":73,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PAICYT-UANL","award":["2021"],"award-info":[{"award-number":["2021"]}]},{"name":"PAICYT-UANL","award":["2022"],"award-info":[{"award-number":["2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Seven medicinal plants from Chiapas, Mexico, used by Native Americans were analyzed, aiming to improve the understanding of their medicinal properties through the evaluation of various biological activities, i.e., bactericidal, antioxidant, \u03b1-glucosidase inhibition, and toxicity, to provide a scientific basis for the management of infectious and hyperglycemic diseases in the Mexican southeast. Plant extracts were obtained from Cordia dodecandra, Gaultheria odorata, Heliotropium angiospermum, Justicia spicigera, Leucaena collinsii spp. collinsii, Tagetes nelsonii, and Talisia oliviformis through maceration techniques using methanol and chloroform (1:1). Minimum Inhibitory Concentration (MIC) was employed to determine the antibacterial activity against Staphylococcus aureus, Enterobacter faecalis, Escherichia coli, Enterobacter aerogenes, Enterobacter cloacae, Klebsiella pneumoniae, and Pseudomonas aeuroginosa. The antiradical\/antioxidant activity was determined by the 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2\u2019-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays and antihemolytic activity using the 2,2\u2019-Azobis(2-amidinopropane) dihydrochloride radical (APPH). The anti-\u03b1-glucosidase activity was evaluated in vitro through the chromogenic PNPG assay. The toxicity was assessed using the brine shrimp lethality assay. The highest antimicrobial activity was displayed by T. nelsonii, mainly against E. faecalis and P. aeuroginosa. The extracts of L. collinsii, J. spicigera, and T. nelsonii possess antioxidant properties with EC50 &lt; 50 \u03bcg\/mL. J. spicigera and T. nelsonii extracts showed the highest antihemolytic activity with IC50 &lt; 14 \u03bcg\/mL. T. nelsonii exhibited a remarkable inhibitor effect on the \u03b1-glucosidase enzyme and the greatest toxic effect on Artemia salina with IC50 = 193 \u00b1 20 \u03bcg\/mL and LD50 = 14 \u00b1 1 \u03bcg\/mL, respectively. According to our results, G. odorata, J. spicigera, T. nelsonii, and T. oliviformis extracts contained active antimicrobial compounds. At the same time, T. nelsonii stands to be a possible source of effective antineoplastic and antihyperglycemic compounds.<\/jats:p>","DOI":"10.3390\/plants11141790","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T09:41:10Z","timestamp":1657100470000},"page":"1790","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Biological Activities of Seven Medicinal Plants Used in Chiapas, Mexico"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9165-8961","authenticated-orcid":false,"given":"Liliana","family":"De La Cruz-Jim\u00e9nez","sequence":"first","affiliation":[{"name":"Department of Chemistry, College of Biological Sciences, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Av. Pedro de Alba S\/N, San Nicol\u00e1s de los Garza 66450, Nuevo Le\u00f3n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario Alberto","family":"Hern\u00e1ndez-Torres","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Biological Sciences, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Av. Pedro de Alba S\/N, San Nicol\u00e1s de los Garza 66450, Nuevo Le\u00f3n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imelda N.","family":"Monroy-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Biological Sciences, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Av. Pedro de Alba S\/N, San Nicol\u00e1s de los Garza 66450, Nuevo Le\u00f3n, Mexico"},{"name":"Tecnol\u00f3gico Nacional de M\u00e9xico, Instiuto Tecnol\u00f3gico de Los Mochis, Departamento de Ingenier\u00eda Qu\u00edmica y Bioqu\u00edmica, Juan de Dios B\u00e1tiz y 20 de Noviembre, Los Mochis 81259, Sinaloa, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catalina","family":"Rivas-Morales","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Biological Sciences, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Av. Pedro de Alba S\/N, San Nicol\u00e1s de los Garza 66450, Nuevo Le\u00f3n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Julia","family":"Verde-Star","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Biological Sciences, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Av. Pedro de Alba S\/N, San Nicol\u00e1s de los Garza 66450, Nuevo Le\u00f3n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vianey","family":"Gonzalez-Villasana","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology and Genetics, College of Biological Sciences, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Av. Pedro de Alba S\/N, San Nicol\u00e1s de los Garza 66450, Nuevo Le\u00f3n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5944-7972","authenticated-orcid":false,"given":"Ezequiel","family":"Viveros-Valdez","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Biological Sciences, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Av. Pedro de Alba S\/N, San Nicol\u00e1s de los Garza 66450, Nuevo Le\u00f3n, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.4103\/1995-7645.234763","article-title":"Traditional medicines and their in-vitro proof against Staphylococcus aureus in Pakistan","volume":"11","author":"Muhammad","year":"2018","journal-title":"Asian Pac. J. Trop. Med."},{"key":"ref_2","first-page":"69","article-title":"The value of plants used in traditional medicine for drug Discovery","volume":"11","author":"Fabricant","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"ref_3","first-page":"1","article-title":"Extraction, isolation and characterization of bioactive compounds from plant\u2019s extracts","volume":"8","author":"Sasidharan","year":"2011","journal-title":"Afr. J. Tradit. Complement Altern. 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