{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T02:48:59Z","timestamp":1782442139592,"version":"3.54.5"},"reference-count":47,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondo Nacional de Desarrollo Cientifico, Tecnol\u00f3gico y de Innovacion Tecnologica (FONDECYT) del Consejo Nacional de Ciencia Tecnologia e Innovacion Tecnologica (CONCYTEC- Peru)","award":["110-2018\u2014FONDECYT"],"award-info":[{"award-number":["110-2018\u2014FONDECYT"]}]},{"name":"Fondo Nacional de Desarrollo Cientifico, Tecnol\u00f3gico y de Innovacion Tecnologica (FONDECYT) del Consejo Nacional de Ciencia Tecnologia e Innovacion Tecnologica (CONCYTEC- Peru)","award":["416RT0511"],"award-info":[{"award-number":["416RT0511"]}]},{"name":"Fondo Nacional de Desarrollo Cientifico, Tecnol\u00f3gico y de Innovacion Tecnologica (FONDECYT) del Consejo Nacional de Ciencia Tecnologia e Innovacion Tecnologica (CONCYTEC- Peru)","award":["13553135"],"award-info":[{"award-number":["13553135"]}]},{"name":"Fondo Nacional de Desarrollo Cientifico, Tecnol\u00f3gico y de Innovacion Tecnologica (FONDECYT) del Consejo Nacional de Ciencia Tecnologia e Innovacion Tecnologica (CONCYTEC- Peru)","award":["380791\/2022-6"],"award-info":[{"award-number":["380791\/2022-6"]}]},{"name":"Programa Iberoamericano de Ciencia y Tecnologia para el Desarrollo","award":["110-2018\u2014FONDECYT"],"award-info":[{"award-number":["110-2018\u2014FONDECYT"]}]},{"name":"Programa Iberoamericano de Ciencia y Tecnologia para el Desarrollo","award":["416RT0511"],"award-info":[{"award-number":["416RT0511"]}]},{"name":"Programa Iberoamericano de Ciencia y Tecnologia para el Desarrollo","award":["13553135"],"award-info":[{"award-number":["13553135"]}]},{"name":"Programa Iberoamericano de Ciencia y Tecnologia para el Desarrollo","award":["380791\/2022-6"],"award-info":[{"award-number":["380791\/2022-6"]}]},{"name":"CAPES (Coordena\u00e7\u00e3o de Pessoal de N\u00edvel Superior)","award":["110-2018\u2014FONDECYT"],"award-info":[{"award-number":["110-2018\u2014FONDECYT"]}]},{"name":"CAPES (Coordena\u00e7\u00e3o de Pessoal de N\u00edvel Superior)","award":["416RT0511"],"award-info":[{"award-number":["416RT0511"]}]},{"name":"CAPES (Coordena\u00e7\u00e3o de Pessoal de N\u00edvel Superior)","award":["13553135"],"award-info":[{"award-number":["13553135"]}]},{"name":"CAPES (Coordena\u00e7\u00e3o de Pessoal de N\u00edvel Superior)","award":["380791\/2022-6"],"award-info":[{"award-number":["380791\/2022-6"]}]},{"name":"CNPq (Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico)","award":["110-2018\u2014FONDECYT"],"award-info":[{"award-number":["110-2018\u2014FONDECYT"]}]},{"name":"CNPq (Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico)","award":["416RT0511"],"award-info":[{"award-number":["416RT0511"]}]},{"name":"CNPq (Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico)","award":["13553135"],"award-info":[{"award-number":["13553135"]}]},{"name":"CNPq (Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico)","award":["380791\/2022-6"],"award-info":[{"award-number":["380791\/2022-6"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Natural products have always played a significant role in the search for new drugs. One of the most relevant alkaloid-containing plant groups is the Amaryllidaceae family, a source of exclusive structures with a wide variety of pharmacological activities. The aim of this work was to determine the alkaloid composition and biological potential of an extract from the bulbs of an endemic Peruvian Amaryllidaceae species Ismene amancaes (Ker Gawl.) Herb. The alkaloid profiling was carried out by GC-MS, which revealed the presence of 13 compounds, 2 of them unidentified. The plant extract was found to contain high amounts of lycoramine, a galanthamine-type alkaloid. The extract also presented low inhibitory potential against the enzymes AChE and BuChE, with IC50 values of 14.6 \u00b1 0.6 and 37.6 \u00b1 1.4 \u03bcg\u00b7mL\u22121, respectively, and good to moderate inhibitory activity against the protozoan Plasmodium falciparum strain FCR-3 (chloroquine-resistant), with IC50 values of 3.78 \u00b1 0.3 \u03bcg\u00b7mL\u22121. This is the first report of the alkaloid profile of a plant of the Ismene genus, which could be an interesting source of bioactive compounds.<\/jats:p>","DOI":"10.3390\/plants11151906","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T01:42:13Z","timestamp":1658713333000},"page":"1906","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Alkaloid Composition and Biological Activities of the Amaryllidaceae Species Ismene amancaes (Ker Gawl.) Herb."],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1178-4678","authenticated-orcid":false,"given":"Maril\u00fa Roxana","family":"Soto-V\u00e1squez","sequence":"first","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica, Universidad Nacional de Trujillo, Av. Juan Pablo II, Trujillo 13011, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia Anataly","family":"Rodr\u00edguez-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica, Universidad Nacional de Trujillo, Av. Juan Pablo II, Trujillo 13011, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana R.","family":"Tallini","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Faculdade de Farm\u00e1cia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, Porto Alegre 90610-000, RS, Brazil"},{"name":"Departament de Biologia, Sanitat i Medi Ambient, Facultat de Farm\u00e0cia i Ci\u00e8ncies de l\u2019Alimentaci\u00f3, Universitat de Barcelona, Av. Joan XXIII #27\u201331, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Bastida","sequence":"additional","affiliation":[{"name":"Departament de Biologia, Sanitat i Medi Ambient, Facultat de Farm\u00e0cia i Ci\u00e8ncies de l\u2019Alimentaci\u00f3, Universitat de Barcelona, Av. Joan XXIII #27\u201331, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"ref_1","unstructured":"WHO (2019). World Malarie Report 2019, World Health Organization."},{"key":"ref_2","unstructured":"WHO (2022, May 25). World Health Organization\u2014Malaria. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/malaria."},{"key":"ref_3","unstructured":"WHO (2020). 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