{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:24:13Z","timestamp":1784035453312,"version":"3.55.0"},"reference-count":70,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["CAPES-PRINT 88887.370558\/2019-00"],"award-info":[{"award-number":["CAPES-PRINT 88887.370558\/2019-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["APQ-00901-21"],"award-info":[{"award-number":["APQ-00901-21"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["303757\/2019-1"],"award-info":[{"award-number":["303757\/2019-1"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais (FAPEMIG)","doi-asserted-by":"publisher","award":["CAPES-PRINT 88887.370558\/2019-00"],"award-info":[{"award-number":["CAPES-PRINT 88887.370558\/2019-00"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais (FAPEMIG)","doi-asserted-by":"publisher","award":["APQ-00901-21"],"award-info":[{"award-number":["APQ-00901-21"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais (FAPEMIG)","doi-asserted-by":"publisher","award":["303757\/2019-1"],"award-info":[{"award-number":["303757\/2019-1"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","doi-asserted-by":"publisher","award":["CAPES-PRINT 88887.370558\/2019-00"],"award-info":[{"award-number":["CAPES-PRINT 88887.370558\/2019-00"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","doi-asserted-by":"publisher","award":["APQ-00901-21"],"award-info":[{"award-number":["APQ-00901-21"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","doi-asserted-by":"publisher","award":["303757\/2019-1"],"award-info":[{"award-number":["303757\/2019-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pr\u00f3-Reitoria de Pesquisa (PRPq), Universidade Federal de Minas Gerais (UFMG)","award":["CAPES-PRINT 88887.370558\/2019-00"],"award-info":[{"award-number":["CAPES-PRINT 88887.370558\/2019-00"]}]},{"name":"Pr\u00f3-Reitoria de Pesquisa (PRPq), Universidade Federal de Minas Gerais (UFMG)","award":["APQ-00901-21"],"award-info":[{"award-number":["APQ-00901-21"]}]},{"name":"Pr\u00f3-Reitoria de Pesquisa (PRPq), Universidade Federal de Minas Gerais (UFMG)","award":["303757\/2019-1"],"award-info":[{"award-number":["303757\/2019-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Helicobacter pylori is the most common cause of gastritis and peptic ulcers, and the number of resistant strains to multiple conventional antimicrobial agents has been increasing in different parts of the world. Several studies have shown that some essential oils (EO) have bioactive compounds, which can be attributed to antimicrobial activity. Therefore, EOs have been proposed as a natural alternative to antibiotics, or for use in combination with conventional treatment for H. pylori infection. Campomanesia lineatifolia is an edible species found in the Brazilian forests, and their leaves are traditionally used for the treatment of gastrointestinal disorders. Anti-inflammatory, gastroprotective, and antioxidant properties are attributed to C. lineatifolia leaf extracts; however, studies related to the chemical constituents of the essential oil and anti-H. pylori activity is not described. This work aims to identify the chemical composition of the EO from C. lineatifolia leaves and evaluate the anti-H. pylori activity. The EO was obtained by hydrodistillation from C. lineatifolia leaves and characterized by gas chromatography\u2013mass spectrometry analyses. To assess the in vitro anti-H. pylori activity of the C. lineatifolia leaf\u2019s EO (6 \u03bcL\/mL\u201325 \u03bcL\/mL), we performed broth microdilution assays by using type cultures (ATCC 49503, NCTC 11638, both clarithromycin-sensitive) and clinical isolate strains (SSR359, clarithromycin-sensitive, and SSR366, clarithromycin-resistant). A total of eight new compounds were identified from the EO (3-hexen-1-ol (46.15%), \u03b1-cadinol (20.35%), 1,1-diethoxyethane (13.08%), 2,3-dicyano-7,7-dimethyl-5,6-benzonorbornadiene (10.78%), aromadendrene 2 (3.0%), [3-S-(3\u03b1, 3a\u03b1, 6\u03b1, 8a\u03b1)]-4,5,6,7,8,8a-hexahydro-3,7,7-trimethyl-8-methylene-3H-3a,6-methanoazulene (2.99%), \u03b1-bisabolol (0.94%), and \u03b2-curcumene (0.8%)), corresponding to 98.09% of the total oil composition. The EO inhibited the growth of all H. pylori strains tested (MIC 6 \u03bcL\/mL). To our knowledge, the current study investigates the relation between the chemical composition and the anti-H. pylori activity of the C. lineatifolia EO for the first time. Our findings show the potential use of the C. lineatifolia leaf EO against sensitive and resistant clarithromycin H. pylori strains and suggest that this antimicrobial activity could be related to its ethnopharmacological use.<\/jats:p>","DOI":"10.3390\/plants11151945","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T04:59:16Z","timestamp":1658897956000},"page":"1945","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Chemical Composition and In Vitro Anti-Helicobacter pylori Activity of Campomanesia lineatifolia Ruiz &amp; Pav\u00f3n (Myrtaceae) Essential Oil"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6565-7925","authenticated-orcid":false,"given":"N\u00edvea Cristina Vieira","family":"Neves","sequence":"first","affiliation":[{"name":"GnosiaH, Laborat\u00f3rio de Farmacognosia, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil"},{"name":"School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Institute, Trinity College Dublin, Dublin 2, Ireland"},{"name":"Departamento de Farm\u00e1cia, Centro Universit\u00e1rio Santa Rita, Conselheiro Lafaiete 36408-899, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgana Pinheiro","family":"de Mello","sequence":"additional","affiliation":[{"name":"GnosiaH, Laborat\u00f3rio de Farmacognosia, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3460-3590","authenticated-orcid":false,"given":"Sin\u00e9ad Marian","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Trinity Centre, Tallaght University Hospital, Dublin 24, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5531-1787","authenticated-orcid":false,"given":"Fabio","family":"Boylan","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Institute, Trinity College Dublin, Dublin 2, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8354-8407","authenticated-orcid":false,"given":"Marcelo Vidigal","family":"Caliari","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Geral, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel Oliveira","family":"Castilho","sequence":"additional","affiliation":[{"name":"GnosiaH, Laborat\u00f3rio de Farmacognosia, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil"},{"name":"Cons\u00f3rcio Acad\u00eamico Brasileiro de Sa\u00fade Integrativa, CABSIN, S\u00e3o Paulo 05449-070, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0140-6736(84)91816-6","article-title":"Unidentified curved bacilli in the stomach of patients with gastritis and peptic and peptic ulceration","volume":"323","author":"Marshall","year":"1984","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.33590\/emjgastroenterol\/10310813","article-title":"An update on the treatment of Helicobacter pylori infection","volume":"4","author":"Smith","year":"2015","journal-title":"EMJ Gastroenterol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1053\/j.gastro.2016.04.006","article-title":"The Toronto consensus for the treatment of Helicobacter pylori infection in adults","volume":"151","author":"Fallone","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/ajg.2016.563","article-title":"ACG clinical guideline: Treatment of Helicobacter pylori infection","volume":"112","author":"Chey","year":"2017","journal-title":"Am. J. Gastroenterol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1136\/gutjnl-2016-312288","article-title":"Management of Helicobacter pylori infection\u2014the Maastricht V\/Florence consensus report","volume":"66","author":"Malfertheiner","year":"2017","journal-title":"Gut"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e12475","DOI":"10.1111\/hel.12475","article-title":"Fifth Chinese National Consensus Report on the management of Helicobacter pylori infection","volume":"23","author":"Liu","year":"2018","journal-title":"Helicobacter"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1590\/s0004-2803.201800000-20","article-title":"IVth Brazilian Consensus Conference on Helicobacter pylori infection","volume":"16","author":"Coelho","year":"2018","journal-title":"Arq. Gastroenterol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.jep.2006.06.001","article-title":"Flavonoids with anti-Helicobacter pylori activity from Cistus laurifolius leaves","volume":"108","author":"Abbasoglu","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"17020","DOI":"10.3748\/wjg.v20.i45.17020","article-title":"Efficacy and safety of herbal medicines in treating gastric ulcer: A review","volume":"20","author":"Bi","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Krzy\u017cek, P., Junka, A., S\u0142upski, W., Do\u0142owacka-J\u00f3\u017awiak, A., P\u0142achno, B.J., Sobiecka, A., Matkowski, A., Chodaczek, G., P\u0142usa, T., and Go\u015bciniak, G. (2021). Antibiofilm and antimicrobial-enhancing activity of Chelidonium majus and Corydalis cheilanthifolia extracts against multidrug-resistant Helicobacter pylori. Pathogens, 10.","DOI":"10.3390\/pathogens10081033"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.3109\/13880209.2015.1126618","article-title":"In vitro synergistic effect of Hibiscus sabdariffa aqueous extract in combination with standard antibiotics against Helicobacter pylori clinical isolates","volume":"54","author":"Hassan","year":"2016","journal-title":"Pharm. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"6379","DOI":"10.3748\/wjg.v23.i35.6379","article-title":"Resistance to clarithromycin and gastroenterologist\u2019s persistence roles in nomination for Helicobacter pylori as high priority pathogen by World Health Organization","volume":"23","author":"Abadi","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.2307\/3558428","article-title":"Myrtaceae revisited: A reassessment of infrafamilial groups","volume":"88","author":"Wilson","year":"2001","journal-title":"Am. J. Bot."},{"key":"ref_14","unstructured":"Sobral, M., Proen\u00e7a, C., Souza, M., Mazine, F., and Lucas, E. (2022, June 08). Myrtaceae, Lista de Esp\u00e9cies da Flora do Brasil, Available online: http:\/\/floradobrasil2015.jbrj.gov.br\/FB171."},{"key":"ref_15","unstructured":"Villachica, H., Carvalho, J.F.U., Muller, C.H., Diaz, C.S., and Almanza, M. (1996). Frutales y Hortializas Promisorios de la Amazonia. Tratado de Cooperacion Amazonica, Secretaria Pro-Tempore Publicaciones."},{"key":"ref_16","unstructured":"Lorenzi, H., Bacher, L., Lacerda, M., and Sartori, S. (2006). Frutas Brasileiras e Ex\u00f3ticas Cultivadas: (de Consumo in Natura), Instituto Plantarum. [1st ed.]."},{"key":"ref_17","unstructured":"Pio Corr\u00eaa, M. (1952). Dicion\u00e1rio das Plantas \u00dateis do Brasil e das Ex\u00f3ticas Cultivadas."},{"key":"ref_18","unstructured":"D\u2019\u00c1villa, M.C. (1910). Da Flora Medicinal do Rio Grande do Sul, Faculdade Livre de Medicina e Pharmacia de Porto Alegre."},{"key":"ref_19","unstructured":"Moraes, M. (1881). Bot\u00e2nica Brasileira: Applicada \u00e0 Medicina \u00e0s Artes e \u00e0 Ind\u00fastria (Seguida de um Suplemento de Mat\u00e9ria M\u00e9dica, Inclusive as Plantas Conhecidas e Applicadas Pelos \u00cdndios em Suas Enfermidades), Garnier."},{"key":"ref_20","unstructured":"Watson, R.R. (2019). Polyphenols present in Campomanesia Genus: Pharmacological and nutraceutical approach. Polyphenols in Plants, Academic Press. [2nd ed.]. Chapter 25."},{"key":"ref_21","first-page":"593","article-title":"GC\u00d7GC\/qMS analyses of Campomanesia guazumifolia (Cambess.) O. Berg essential oils and their antioxidant and antimicrobial activity","volume":"16","author":"Polidoro","year":"2019","journal-title":"Nat. Prod. Res."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"De Jesus, G.S., Micheletti, A.C., Padilha, R.G., de Souza de Paula, J., Alves, F.M., Leal, C.R.B., Garcez, F.R., Garcez, W.S., and Yoshida, N.C. (2020). Antimicrobial potential of essential oils from cerrado plants against multidrug\u2013resistant foodborne microorganisms. Molecules, 25.","DOI":"10.3390\/molecules25143296"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1590\/1519-6984.219889","article-title":"Chemical characterization and antimicrobial activity of Campomanesia aurea against three strains of Listeria monocytogenes","volume":"81","author":"Pacheco","year":"2021","journal-title":"Braz. J. Biol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Korona-Glowniak, I., Glowniak-Lipa, A., Ludwiczuk, A., Baj, T., and Malm, A. (2020). The in vitro activity of essential oils against Helicobacter pylori growth and urease activity. Molecules, 25.","DOI":"10.3390\/molecules25030586"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ajg.2021.05.016","article-title":"Potentiation of anti-Helicobacter pylori activity of clarithromycin by Pelargonium graveolens oil","volume":"22","author":"Ibrahim","year":"2021","journal-title":"Arab J. Gastroenterol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2018.12.032","article-title":"In vitro and in vivo anti-Helicobacter pylori activity of Casearia sylvestris leaf derivatives","volume":"233","author":"Oda","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.jep.2011.12.014","article-title":"Campomanesia lineatifolia Ruiz & Pav. as a gastroprotective agent","volume":"139","author":"Madalosso","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"9872598","DOI":"10.1155\/2016\/9872598","article-title":"In vitro TNF-\u03b1 inhibitory activity of brazilian plants and anti-inflammatory effect of Stryphnodendron adstringens in an acute arthritis model","volume":"2016","author":"Henriques","year":"2016","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"9583","DOI":"10.1021\/jf403024t","article-title":"Characterization of the key aroma compounds in bartlett pear brandies by means of the sensomics concept","volume":"61","author":"Willner","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/ffj.1021","article-title":"Extraction and isolation of Salvia desoleana and Mentha spicata subsp. insularis essential oils by supercritical CO2","volume":"16","author":"Marongiu","year":"2001","journal-title":"Flavour Fragr. J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3830","DOI":"10.1021\/jo00194a031","article-title":"Revised structure of zizanol","volume":"49","author":"Kang","year":"1984","journal-title":"J. Org. Chem."},{"key":"ref_32","first-page":"540","article-title":"Essential oil composition of Eucalyptus microtheca and Eucalyptus viminalis","volume":"5","author":"Maghsoodlou","year":"2015","journal-title":"Avicenna J. Phytomed."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1080\/10412905.2003.9712083","article-title":"The essential oil composition of Psorothamnus scoparius (A. Gray) RybB","volume":"15","author":"Lucero","year":"2003","journal-title":"J. Essent. Oil Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/ffj.1447","article-title":"Characterization of potent aroma compounds in Chrysanthemum coronarium L. (Garland) using aroma extract dilution analysis","volume":"19","author":"Zheng","year":"2004","journal-title":"Flavour Fragr. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/ffj.1337","article-title":"Aroma-active compounds of Pinus densiflora (red pine) needles","volume":"19","author":"Yu","year":"2004","journal-title":"Flavour Fragr. J."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Dhifi, W., Bellili, S., Jazi, S., Bahloul, N., and Mnif, W. (2016). Essential oils\u2019 chemical characterization and investigation of some biological activities: A critical review. Medicines, 3.","DOI":"10.3390\/medicines3040025"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1021\/jf052098c","article-title":"Characterization of odor-active volatiles in champa (Campomanesia lineatifolia R. & P.)","volume":"54","author":"Osorio","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_38","unstructured":"Craveiro, A.A., Fernandes, G.F., and Andrade, C.H.S. (1981). \u00d3leos Essenciais de Plantas do Nordeste, Edi\u00e7\u00f5es UFC."},{"key":"ref_39","first-page":"18","article-title":"Chemical composition, insecticidal and fungicidal activities of essential oils isolated from Mentha microphylla and Lantana camara growing in Egypt","volume":"27","author":"Abdelgaleil","year":"2006","journal-title":"Alex. Sci. Exch. J."},{"key":"ref_40","unstructured":"Coffie, E. (2019). Essential Oils and Compounds Isolated from the Leaves and Rhizomes of Aframomum atewae. [Ph.D. Thesis, University of Ghana]."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"6578","DOI":"10.1021\/jf049182x","article-title":"Valorization of brazilian vetiver (Vetiveria zizanioides (L.) nash ex small) oil","volume":"52","author":"Martinez","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"ref_42","first-page":"122","article-title":"Antioxidant potential of the root of Vetiveria zizanioides (L.) nash","volume":"46","author":"Luqman","year":"2009","journal-title":"Indian J. Biochem. Biophys."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1080\/13880200500387471","article-title":"Detection of antibacterial activity in spent roots of two genotypes of aromatic grass Vetiveria zizanioides","volume":"43","author":"Luqman","year":"2005","journal-title":"Pharm. Biol."},{"key":"ref_44","first-page":"191","article-title":"Traditional and medicinal uses of vetiver","volume":"1","author":"Balasankar","year":"2013","journal-title":"J. Med. Plants Stud."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e1700058","DOI":"10.1002\/cbdv.201700058","article-title":"Essential oils of myrtaceae species growing wild in tunisia: Chemical variability and antifungal activity against Biscogniauxia mediterranea, the causative agent of charcoal canker","volume":"14","author":"Yangui","year":"2017","journal-title":"Chem. Biodivers."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e2000564","DOI":"10.1002\/cbdv.202000564","article-title":"Profile of terpenoid compounds mediating a plant-herbivore interaction: Screening by static headspace solid-phase microextraction-gas chromatography\/Q-ToF mass spectrometry","volume":"17","author":"Trejo","year":"2020","journal-title":"Chem. Biodivers."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.phytochem.2008.01.016","article-title":"Bullatenone, 1,3-dione and sesquiterpene chemotypes of Lophomyrtus species","volume":"69","author":"Woollard","year":"2008","journal-title":"Phytochemistry"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/10412905.2001.9699608","article-title":"Constituents of the rhizome essential oil of Curcuma amada Roxb. from India","volume":"13","author":"Srivastava","year":"2001","journal-title":"J. Essent. Oil Res."},{"key":"ref_49","unstructured":"Minist\u00e9rio da Sa\u00fade (2015). Monografia da Esp\u00e9cie Curcuma longa L. (curcuma)."},{"key":"ref_50","first-page":"83","article-title":"Ethnobotanical diversity in zingibers of India","volume":"7","author":"Jain","year":"1995","journal-title":"Ethnobotany"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jep.2008.11.001","article-title":"Bactericidal activity of medicinal plants, employed for the treatment of gastrointestinal ailments, against Helicobacter pylori","volume":"121","author":"Zaidi","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.intimp.2010.04.021","article-title":"Investigation of the anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patients","volume":"10","author":"Koosirirat","year":"2010","journal-title":"Int. Immunopharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9734\/EJMP\/2016\/25494","article-title":"Composition and antimicrobial activity of leaf essential oils of Myrcia sylvatica (G. Mey.) DC","volume":"13","author":"Silva","year":"2016","journal-title":"Eur. J. Med. Plants"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1016\/j.biortech.2009.11.021","article-title":"Composition and biological activity of the essential oil from leaves of Plinia cerrocampanensis, a new source of \u03b1-bisabolol","volume":"101","author":"Vila","year":"2010","journal-title":"Bioresour. Technol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1080\/14786419.2018.1457664","article-title":"Chemical composition and in vitro antibacterial and antiproliferative activities of the essential oil from the leaves of Psidium myrtoides O. Berg (Myrtaceae)","volume":"33","author":"Dias","year":"2019","journal-title":"Nat. Prod. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1136\/gutjnl-2019-319954","article-title":"Seven-day vonoprazan and low-dose amoxicillin dual therapy as first-line Helicobacter pylori treatment: A multicentre randomised trial in Japan","volume":"69","author":"Suzuki","year":"2020","journal-title":"Gut"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/BF02064374","article-title":"Chili protects against aspirin-induced gastroduodenal mucosal injury in humans","volume":"40","author":"Yeoh","year":"1995","journal-title":"Dig. Dis. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1046\/j.1365-2036.2002.01280.x","article-title":"The treatment of functional dyspepsia with red pepper","volume":"16","author":"Bortolotti","year":"2002","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/jgh.15705","article-title":"Curcuma longa Linn versus omeprazole in treatment of functional dyspepsia: A randomized, double-blind, placebo-controlled trial","volume":"37","author":"Yongwatana","year":"2022","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1590\/S0102-695X2009000400025","article-title":"Revis\u00e3o da Maytenus ilicifolia Mart. ex Reissek, Celastraceae. Contribui\u00e7\u00e3o ao estudo das propriedades farmacol\u00f3gicas","volume":"19","year":"2009","journal-title":"Rev. Bras. Farmacogn."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Zhao, J., Jiang, L., Tang, X., Peng, L., Li, X., Zhao, G., and Zhong, L. (2018). Chemical composition, antimicrobial and antioxidant activities of the flower volatile oils of Fagopyrum esculentum, Fagopyrum tataricum and Fagopyrum Cymosum. Molecules, 23.","DOI":"10.3390\/molecules23010182"},{"key":"ref_62","first-page":"1831","article-title":"Essential oil of Galinsoga parviflora leaves from Colombia","volume":"5","author":"Pino","year":"2010","journal-title":"Nat. Prod. Commun."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"David, A., Wang, F., Sun, X., Li, H., Lin, J., Li, P., and Deng, G. (2019). Chemical composition, antioxidant, and antimicrobial activities of Vetiveria zizanioides (L.) nash essential oil extracted by carbon dioxide expanded ethanol. Molecules, 24.","DOI":"10.3390\/molecules24101897"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.phymed.2010.06.018","article-title":"Synergistic properties of the terpenoids aromadendrene and 1,8-cineole from the essential oil of Eucalyptus globulus against antibiotic-susceptible and antibiotic-resistant pathogens","volume":"17","author":"Mulyaningsih","year":"2010","journal-title":"Phytomedicine"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1089\/jmf.2009.0047","article-title":"Antimicrobial activity of the extracts and fractions of hexanic fruits of Campomanesia species (Myrtaceae)","volume":"13","author":"Cardoso","year":"2010","journal-title":"J. Med. Food."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1128\/AAC.47.10.3357-3360.2003","article-title":"Sensitization of Staphylococcus aureus and Escherichia coli to antibiotics by the sesquiterpenoids nerolidol, farnesol, bisabolol, and apritone","volume":"47","author":"Johnson","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1128\/AAC.47.10.3240-3246.2003","article-title":"Essential oils as components of a diet-based approach to management of Helicobacter infection","volume":"47","author":"Bergonzelli","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1046\/j.1523-5378.2003.00146.x","article-title":"Antimicrobial activity of essential oils against Helicobacter pylori","volume":"8","author":"Ohno","year":"2003","journal-title":"Helicobacter"},{"key":"ref_69","first-page":"29","article-title":"M100-S25 performance standards for antimicrobial susceptibility testing; twenty-fifth informational supplement","volume":"35","author":"Patel","year":"2015","journal-title":"Clin. Lab. Stand. Inst."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"112207","DOI":"10.1016\/j.indcrop.2020.112207","article-title":"Plectranthus barbatus Andrews as anti-Helicobacter pylori agent with activity against adenocarcinoma gastric cells","volume":"146","author":"Borges","year":"2020","journal-title":"Ind. Crops Prod."}],"container-title":["Plants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2223-7747\/11\/15\/1945\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:57:08Z","timestamp":1760140628000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2223-7747\/11\/15\/1945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,27]]},"references-count":70,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["plants11151945"],"URL":"https:\/\/doi.org\/10.3390\/plants11151945","relation":{},"ISSN":["2223-7747"],"issn-type":[{"value":"2223-7747","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,27]]}}}