{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T08:11:10Z","timestamp":1781597470728,"version":"3.54.5"},"reference-count":50,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"RUSSIAN SCIENCE FOUNDATION","doi-asserted-by":"publisher","award":["21-76-10055"],"award-info":[{"award-number":["21-76-10055"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>The demographic situation of the last few decades is characterized by the increased numbers of elderly and senile people, i.e., by the aging of the population. In humans, ageing is closely associated with the enhanced production of reactive oxygen species (ROS), development of systemic inflammation and related vascular atherosclerotic alterations and metabolic disorders, like obesity, diabetes mellitus and neurodegenerative diseases. As these age-related alterations are directly associated with up-regulation of ROS production and development of chronic oxidative stress, their onset can be essentially delayed by continuous daily consumption of dietary antioxidants\u2014natural products of plant origin. Such antioxidants (in the form of plant extracts, biologically active complexes or individual compounds) can be supplemented to functional foods, i.e., dietary supplementations for daily diet aiming prolongation of active life and delay of the senescence onset. Thereby, use of widely spread medicinal plants might essentially improve cost efficiency of this strategy and availability of antioxidant-rich functional foods. Therefore, here we addressed, to the best of our knowledge for the first time, the antioxidant activity of the extracts prepared from the aerial parts of Filipendula ulmaria and Alnus glutinosa growing in the Kaliningrad region of Russia, and assessed the contents of the biologically active substances underlying these properties. It was found that the extract prepared with the leaves of Filipendula ulmaria and female catkins of Alnus glutinosa demonstrated high antioxidant activity, although the former plant was featured with a higher antioxidant potential. The highest antioxidant activity detected in the methanol extracts of Alnus glutinosa reached 1094.02 \u00b1 14.53 \u00b5mol TE\/g, radical scavenging of activity was 584.45 \u00b1 35.3 \u00b5mol TE\/g, reducing capacity at interaction with iron complex\u2014471.63 \u00b1 7.06 \u00b5mol TE\/g. For the methanol extracts of Filipendula ulmaria the antioxidant activity reached 759.78 \u00b1 19.08 \u00b5mol TE\/g, antioxidant activity for free radical removal was 451.08 \u00b1 24.45 \u00b5mol TE\/g and antioxidant activity for restorative ability with iron complex was 332.28 \u00b1 10.93 \u00b5mol TE\/g. These values are consistent with the total yields of the extracts and their content of ellagic acid. The ethyl acetate extracts of the both plants showed just minimal antioxidant activity. Thus, the considered extracts have an essential potential. This creates good prospects for the further use of herbal extracts of Filipendula ulmaria and Alnus glutinosa as a source of natural antioxidants.<\/jats:p>","DOI":"10.3390\/plants11182415","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T04:49:22Z","timestamp":1663562962000},"page":"2415","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Study of the Antioxidant Properties of Filipendula ulmaria and Alnus glutinosa"],"prefix":"10.3390","volume":"11","author":[{"given":"Stanislav","family":"Sukhikh","sequence":"first","affiliation":[{"name":"Institute of Living Systems, Immanuel Kant Baltic Federal University, A. Nevskogo Street 14, 236016 Kaliningrad, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1252-9572","authenticated-orcid":false,"given":"Svetlana","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Natural Nutraceutical Biotesting Laboratory, Kemerovo State University, Krasnaya Street 6, 650043 Kemerovo, Russia"},{"name":"Department of General Mathematics and Informatics, Kemerovo State University, Krasnaya Street, 6, 650043 Kemerovo, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6280-1194","authenticated-orcid":false,"given":"Liubov","family":"Skrypnik","sequence":"additional","affiliation":[{"name":"Institute of Living Systems, Immanuel Kant Baltic Federal University, A. Nevskogo Street 14, 236016 Kaliningrad, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4017-0111","authenticated-orcid":false,"given":"Alina","family":"Bakhtiyarova","sequence":"additional","affiliation":[{"name":"Institute of Living Systems, Immanuel Kant Baltic Federal University, A. Nevskogo Street 14, 236016 Kaliningrad, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"Larina","sequence":"additional","affiliation":[{"name":"Institute of Living Systems, Immanuel Kant Baltic Federal University, A. Nevskogo Street 14, 236016 Kaliningrad, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olesia","family":"Krol","sequence":"additional","affiliation":[{"name":"Institute of Living Systems, Immanuel Kant Baltic Federal University, A. Nevskogo Street 14, 236016 Kaliningrad, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5630-3196","authenticated-orcid":false,"given":"Alexander","family":"Prosekov","sequence":"additional","affiliation":[{"name":"Laboratory of Biocatalysis, Kemerovo State University, Krasnaya Street 6, 650043 Kemerovo, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Frolov","sequence":"additional","affiliation":[{"name":"K.A. Timiryazev Institute of Plant Physiology RAS, Botanicheskaya Uliza 35, 127276 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Povydysh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Saint Petersburg State Chemical Pharmaceutical University, Professora Popova 14A, 197376 Saint Petersburg, Russia"},{"name":"Department of Pharmacognosy, Saint Petersburg State Chemical Pharmaceutical University, Professora Popova 14A, 197376 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4921-8997","authenticated-orcid":false,"given":"Olga","family":"Babich","sequence":"additional","affiliation":[{"name":"Institute of Living Systems, Immanuel Kant Baltic Federal University, A. Nevskogo Street 14, 236016 Kaliningrad, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zhao, E., and Crimmins, E. (2022). Mortality and morbidity in ageing men: Biology, Lifestyle and Environment. Rev. Endocr. Metab. Disord., 1\u201321.","DOI":"10.1007\/s11154-022-09737-6"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Rodgers, J.L., Jones, J., Bolleddu, S.I., Vanthenapalli, S., Rodgers, L.E., Shah, K., Karia, K., and Panguluri, S.K. (2019). Cardiovascular Risks Associated with Gender and Aging. J. Cardiovasc. Dev. Dis., 6.","DOI":"10.3390\/jcdd6020019"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Zeka, K., Ruparelia, K., Arroo, R.R.J., Budriesi, R., and Micucci, M. (2017). Flavonoids and Their Metabolites: Prevention in Cardiovascular Diseases and Diabetes. 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