{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:11:25Z","timestamp":1787062285936,"version":"build-2736575974"},"reference-count":80,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005880","name":"National Institute of Biological Resources (NIBR)","doi-asserted-by":"publisher","award":["NIBR202106204"],"award-info":[{"award-number":["NIBR202106204"]}],"id":[{"id":"10.13039\/501100005880","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005880","name":"National Institute of Biological Resources (NIBR)","doi-asserted-by":"publisher","award":["NIBR202207203"],"award-info":[{"award-number":["NIBR202207203"]}],"id":[{"id":"10.13039\/501100005880","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Grewia tomentosa Juss. is a deciduous shrub that mainly grows in Asia. Despite studies of other Grewia species for treatment of various diseases, Grewia tomentosa Juss. has not been studied as a medicinal herb. This study evaluates the anti-allergic and anti-topic dermatitis activity of Grewia tomentosa Juss. ethanol extract (Gt-EE). The results show that Gt-EE suppressed IgE\u2013antigen-induced \u03b2-hexosaminidase release. The mRNA expression of IL-1\u03b2, IL-4, IL-5, IL-6, IL-13, TNF-\u03b1, MCP-1, and TSLP, which are involved in allergic responses, was inhibited by Gt-EE in IgE-stimulated RBL-2H3 cells. In addition, the phosphorylation of Syk, PLC\u03b31, PKC\u03b4, PI3K, AKT, NF-\u03baB p65, NF-\u03baB p50, p38, JNK, and ERK1\/2 was decreased by Gt-EE in these cells. Gt-EE also showed anti-inflammatory effects in in vivo mouse models. In passive cutaneous anaphylaxis (PCA), a commonly used mouse model, Gt-EE decreased the allergic response, infiltration of mast cells, and mRNA level of IL-4. Furthermore, Gt-EE ameliorated symptoms of DNCB-induced atopic dermatitis (AD). In DNCB-induced AD, Gt-EE suppressed the increase in mast cells, serum IgE level, expression of allergic mediators (IL-1\u03b2, IL-4, IL-5, IL-6, TNF-\u03b1), and phosphorylation of proteins (I\u03baB\u03b1, NF-\u03baB p65, NF-\u03baB p50, p38, JNK, and ERK1\/2) implicated in allergic reactions<\/jats:p>","DOI":"10.3390\/plants11192540","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T03:30:37Z","timestamp":1664335837000},"page":"2540","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Inhibitory Effects of Grewia tomentosa Juss. on IgE-Mediated Allergic Reaction and DNCB-Induced Atopic Dermatitis"],"prefix":"10.3390","volume":"11","author":[{"given":"Hwa Pyoung","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wooram","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Woong","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6978-0066","authenticated-orcid":false,"given":"Long","family":"You","sequence":"additional","affiliation":[{"name":"Department of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7977-1814","authenticated-orcid":false,"given":"Laily","family":"Rahmawati","sequence":"additional","affiliation":[{"name":"Department of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van Dung","family":"Luong","sequence":"additional","affiliation":[{"name":"Department of Biology, Dalat University, 01 Phu Dong Thien Vuong, Dalat 670000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wonhee","family":"Kim","sequence":"additional","affiliation":[{"name":"National Institute of Biological Resources, Environmental Research Complex, Incheon 222689, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5920-8277","authenticated-orcid":false,"given":"Byoung-Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"National Institute of Biological Resources, Environmental Research Complex, Incheon 222689, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Lee","sequence":"additional","affiliation":[{"name":"National Institute of Biological Resources, Environmental Research Complex, Incheon 222689, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hye","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8141-9927","authenticated-orcid":false,"given":"Jae Youl","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.3389\/fimmu.2020.02116","article-title":"The potential of clinical decision support systems for prevention, diagnosis, and monitoring of allergic diseases","volume":"11","author":"Dramburg","year":"2020","journal-title":"Front. 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