{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T19:39:13Z","timestamp":1783971553910,"version":"3.55.0"},"reference-count":100,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Anacyclus pyrethrum (L.) (Asteraceae) is an important annual medicinal herb and is widespread in Morocco and Algeria. Most of its parts are used in traditional medicine and the roots are the most important parts used. The present review gives an account of the updated information on its phytochemical and pharmacological properties. We have collected the essential characteristics and the different scientific data of the A. pyrethrum species, and reviewed its potential. It is seen from the literature that A. pyrethrum is a rich source of the phytochemical constituents such as alkaloids (pellitorin) and n-alkylamides. This species also contains pyrethrins, sesamin, traces of essential oils and a wide range of other chemical compounds. These active substances possess antimicrobial and anti-inflammatory activities. The plant has an antidiabetic, insecticidal and immunostimulatory effect, as well as an aphrodisiac and antioxidant potentials, and various other important medicinal properties. Many traditional uses are also reported in previous research such as for rheumatism, sciatica, colds, neuralgia and paralysis. This species is considered to be a sialagogue, and used in the treatment of stomach ailments, diseases of inflammation of the mouth, against cysts in the genital tract and to relieve toothaches. Thus, further research must be carried out in order to establish any relationship between the traditional uses, phytochemistry and toxicity. Moreover, A. pyrethrum is quite promising as a medicinal agent, so further clinical trials should be performed to prove its efficacy.<\/jats:p>","DOI":"10.3390\/plants11192578","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T01:21:07Z","timestamp":1665364867000},"page":"2578","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Phytochemistry, Biological and Pharmacological Activities of the Anacyclus pyrethrum (L.) Lag: A Systematic Review"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2498-2518","authenticated-orcid":false,"given":"Hanane","family":"Elazzouzi","sequence":"first","affiliation":[{"name":"Research Team of Chemistry, Bioactive Molecules and Environment, Laboratoire des Mat\u00e9riaux Innovants and Biotechnologie of Naturelles Ressources, University Moulay Ismail Faculty of Sciences, Zitoune, Mekn\u00e8s B.P. 11201, Morocco"},{"name":"Laboratory of Spectroscopy, Molecular Modeling, Materials, Nanomaterials, Water and Environment, University Mohammed V Faculty of Sciences, 4-Avenue IbnBattouta, Rabat B.P. 1014 RP, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Fadili","sequence":"additional","affiliation":[{"name":"Research Team of Chemistry, Bioactive Molecules and Environment, Laboratoire des Mat\u00e9riaux Innovants and Biotechnologie of Naturelles Ressources, University Moulay Ismail Faculty of Sciences, Zitoune, Mekn\u00e8s B.P. 11201, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Cherrat","sequence":"additional","affiliation":[{"name":"Research Team of Chemistry, Bioactive Molecules and Environment, Laboratoire des Mat\u00e9riaux Innovants and Biotechnologie of Naturelles Ressources, University Moulay Ismail Faculty of Sciences, Zitoune, Mekn\u00e8s B.P. 11201, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smail","family":"Amalich","sequence":"additional","affiliation":[{"name":"Research Team of Chemistry, Bioactive Molecules and Environment, Laboratoire des Mat\u00e9riaux Innovants and Biotechnologie of Naturelles Ressources, University Moulay Ismail Faculty of Sciences, Zitoune, Mekn\u00e8s B.P. 11201, Morocco"},{"name":"Laboratory of Phytochemistry, National Agency of Medicinal and Aromatic Plants, Taounate 34000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-405X","authenticated-orcid":false,"given":"Nadia","family":"Zekri","sequence":"additional","affiliation":[{"name":"Research Team of Chemistry, Bioactive Molecules and Environment, Laboratoire des Mat\u00e9riaux Innovants and Biotechnologie of Naturelles Ressources, University Moulay Ismail Faculty of Sciences, Zitoune, Mekn\u00e8s B.P. 11201, Morocco"},{"name":"Laboratory of Spectroscopy, Molecular Modeling, Materials, Nanomaterials, Water and Environment, University Mohammed V Faculty of Sciences, 4-Avenue IbnBattouta, Rabat B.P. 1014 RP, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannou","family":"Zerkani","sequence":"additional","affiliation":[{"name":"Research Team of Chemistry, Bioactive Molecules and Environment, Laboratoire des Mat\u00e9riaux Innovants and Biotechnologie of Naturelles Ressources, University Moulay Ismail Faculty of Sciences, Zitoune, Mekn\u00e8s B.P. 11201, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imane","family":"Tagnaout","sequence":"additional","affiliation":[{"name":"Research Team of Chemistry, Bioactive Molecules and Environment, Laboratoire des Mat\u00e9riaux Innovants and Biotechnologie of Naturelles Ressources, University Moulay Ismail Faculty of Sciences, Zitoune, Mekn\u00e8s B.P. 11201, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9938-0151","authenticated-orcid":false,"given":"Christophe","family":"Hano","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie des Ligneux et des Grandes Cultures, INRA USC1328, Orleans University, CEDEX 2, 45067 Orl\u00e9ans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7725-9294","authenticated-orcid":false,"given":"Jose M.","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Centro Tecnol\u00f3gico de la Carne de Galicia, R\u00faa Galicia No 4, Parque Tecnol\u00f3gico de Galicia, San Cibraodas Vi\u00f1as, 32900 Ourense, Spain"},{"name":"\u00c1rea de Tecnolog\u00eda de los Alimentos, Facultad de Ciencias de Ourense, Universidad de Vigo, 32004 Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Touria","family":"Zair","sequence":"additional","affiliation":[{"name":"Research Team of Chemistry, Bioactive Molecules and Environment, Laboratoire des Mat\u00e9riaux Innovants and Biotechnologie of Naturelles Ressources, University Moulay Ismail Faculty of Sciences, Zitoune, Mekn\u00e8s B.P. 11201, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Etude ethnobotanique, ethno-taxonomique et ethno\u00e9cologique de Anacyclus pyrethrum var. pyrethrum (L.) 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