{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:38:16Z","timestamp":1783114696408,"version":"3.54.6"},"reference-count":66,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Technology (MOST)","award":["MOST 107-2314-B-006-063-MY3"],"award-info":[{"award-number":["MOST 107-2314-B-006-063-MY3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Dengue caused by dengue virus (DENV) is a mosquito-borne disease. Dengue exhibits a wide range of symptoms, ranging from asymptomatic to flu-like illness, and a few symptomatic cases may develop into severe dengue, leading to death. However, there are no effective and safe therapeutics for DENV infections. We have previously reported that cytokine expression, especially inflammatory cytokines, was altered in patients with different severities of dengue. Antrodia cinnamomea (A. cinnamomea) is a precious and endemic medical mushroom in Taiwan. It contains unique chemical components and exhibits biological activities, including suppressing effects on inflammation and viral infection-related diseases. According to previous studies, megakaryocytes can support DENV infection, and the number of megakaryocytes is positively correlated with the viral load in the serum of acute dengue patients. In the study, we investigated the anti-DENV effects of two ethanolic extracts (ACEs 1\u20132) and three isolated compounds (ACEs 3\u20135) from A. cinnamomea on DENV infection in Meg-01 cells. Our results not only demonstrated that ACE-3 and ACE-4 significantly suppressed DENV infection, but also reduced interleukin (IL)-6 and IL-8 levels. Moreover, the level of the antiviral cytokine interferon (IFN)-\u03b1 was also increased by ACE-3 and ACE-4 in Meg-01 cells after DENV infection. Here, we provide new insights into the potential use of A. cinnamomea extracts as therapeutic agents against DENV infection. However, the detailed mechanisms underlying these processes require further investigation.<\/jats:p>","DOI":"10.3390\/plants11192631","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T01:21:07Z","timestamp":1665364867000},"page":"2631","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Antrodia cinnamomea Suppress Dengue Virus Infection through Enhancing the Secretion of Interferon-Alpha"],"prefix":"10.3390","volume":"11","author":[{"given":"Yi-Ju","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Microbiology & Immunology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6692-7608","authenticated-orcid":false,"given":"Yu-Cian","family":"Tsao","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Chuan","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0182-3768","authenticated-orcid":false,"given":"Irwin","family":"Puc","sequence":"additional","affiliation":[{"name":"Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Chang","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Management, Feng Chia University, Taichung 40724, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guey-Chuen","family":"Perng","sequence":"additional","affiliation":[{"name":"Department of Microbiology & Immunology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan"},{"name":"Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5466-7674","authenticated-orcid":false,"given":"Hsiu-Man","family":"Lien","sequence":"additional","affiliation":[{"name":"Research Institute of Biotechnology, Hungkuang University, Taichung 43302, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1056\/NEJMra1110265","article-title":"Dengue","volume":"366","author":"Simmons","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_2","first-page":"299","article-title":"Epidemiology of dengue: Past, present and future prospects","volume":"5","author":"Murray","year":"2013","journal-title":"Clin. Epidemiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"999","DOI":"10.4269\/ajtmh.14-0628","article-title":"Dengue serotype-specific differences in clinical manifestation, laboratory parameters and risk of severe disease in adults, Singapore","volume":"92","author":"Yung","year":"2015","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1038\/s41564-019-0476-8","article-title":"The current and future global distribution and population at risk of dengue","volume":"4","author":"Messina","year":"2019","journal-title":"Nat. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.envres.2016.07.026","article-title":"Dengue in a changing climate","volume":"151","author":"Ebi","year":"2016","journal-title":"Environ. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/S0140-6736(02)09964-6","article-title":"Potential effect of population and climate changes on global distribution of dengue fever: An empirical model","volume":"360","author":"Hales","year":"2002","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"key":"ref_8","first-page":"333","article-title":"Clinical factors associated with mortality in dengue infection at a tertiary care center","volume":"41","author":"Almas","year":"2010","journal-title":"Southeast Asian J. Trop Med. Public Health"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2149\/tmh.2011-S10","article-title":"Clinical Manifestations and Management of Dengue\/DHF\/DSS","volume":"39","author":"Kalayanarooj","year":"2011","journal-title":"Trop Med. Health"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Puc, I., Ho, T.C., Yen, K.L., Vats, A., Tsai, J.J., Chen, P.L., Chien, Y.W., Lo, Y.C., and Perng, G.C. (2021). Cytokine Signature of Dengue Patients at Different Severity of the Disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22062879"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"943","DOI":"10.4269\/ajtmh.19-0487","article-title":"Cytokine Expression in Dengue Fever and Dengue Hemorrhagic Fever Patients with Bleeding and Severe Hepatitis","volume":"102","author":"Imad","year":"2020","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00281-017-0625-1","article-title":"Immune-mediated cytokine storm and its role in severe dengue","volume":"39","author":"Srikiatkhachorn","year":"2017","journal-title":"Semin. Immunopathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"590004","DOI":"10.3389\/fcimb.2020.590004","article-title":"Dysfunctional Innate Immune Responses and Severe Dengue","volume":"10","author":"Malavige","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_14","first-page":"202","article-title":"Role of TNF \u03b1, IL-6 and CXCL10 in Dengue disease severity","volume":"10","author":"Masood","year":"2018","journal-title":"Iran. J. Microbiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/1042819031000149368","article-title":"Type I interferon as a link between innate and adaptive immunity through dendritic cell stimulation","volume":"45","author":"Tough","year":"2004","journal-title":"Leuk Lymphoma"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1089\/jir.2014.0129","article-title":"Dengue Virus Control of Type I IFN Responses: A History of Manipulation and Control","volume":"35","year":"2015","journal-title":"J. Interferon Cytokine Res. Off. J. Int. Soc. Interferon Cytokine Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"605087","DOI":"10.3389\/fimmu.2020.605087","article-title":"Decreased Type I Interferon Production by Plasmacytoid Dendritic Cells Contributes to Severe Dengue","volume":"11","author":"Upasani","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_18","unstructured":"World Health Organization (2009). Dengue Guidelines for Diagnosis, Treatment, Prevention and Control: New Edition, World Health Organization."},{"key":"ref_19","first-page":"1","article-title":"Dengue Vaccine: Recommendations of the Advisory Committee on Immunization Practices, United States, 2021","volume":"70","author":"Adams","year":"2021","journal-title":"MMWR. Recomm. Rep. Morb. Mortal. Wkly. Report. Recomm. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1056\/NEJMoa1800820","article-title":"Effect of Dengue Serostatus on Dengue Vaccine Safety and Efficacy","volume":"379","author":"Sridhar","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"6355","DOI":"10.1016\/j.vaccine.2017.09.089","article-title":"Dengvaxia sensitizes seronegatives to vaccine enhanced disease regardless of age","volume":"35","author":"Halstead","year":"2017","journal-title":"Vaccine"},{"key":"ref_22","unstructured":"World Health Organization (2018). Dengue vaccines: WHO position paper\u2014September 2018. Wkly. Epidemiol. Rec., 93, 457\u2013476."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.coviro.2020.07.009","article-title":"Recent advances in antiviral drug development towards dengue virus","volume":"43","author":"Troost","year":"2020","journal-title":"Curr. Opin. Virol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"212641","DOI":"10.1093\/ecam\/nep108","article-title":"Review of Pharmacological Effects of Antrodia camphorata and Its Bioactive Compounds","volume":"2011","author":"Geethangili","year":"2011","journal-title":"Evid. -Based Complementary Altern. Med. ECAM"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.pharmthera.2013.04.001","article-title":"Recent research and development of Antrodia cinnamomea","volume":"139","author":"Lu","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Chang, J.-S., Kuo, H.-P., Chang, K.L.B., and Kong, Z.-L. (2015). Apoptosis of hepatocellular carcinoma cells induced by nanoencapsulated polysaccharides extracted from Antrodia camphorata. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0136782"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1039\/D0FO03345F","article-title":"Antrodin A from Antrodia camphorata modulates the gut microbiome and liver metabolome in mice exposed to acute alcohol intake","volume":"12","author":"Yi","year":"2021","journal-title":"Food Funct."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"450529","DOI":"10.1093\/ecam\/nep230","article-title":"Study of the Anti-Proliferative Activity of 5-Substituted 4,7-Dimethoxy-1,3-Benzodioxole Derivatives of SY-1 from Antrodia camphorata on Human COLO 205 Colon Cancer Cells","volume":"2011","author":"Lien","year":"2011","journal-title":"Evid. -Based Complementary Altern. Med. Ecam"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1111\/jocd.13847","article-title":"Extracts of Antrodia cinnamomea mycelium as a highly potent tyrosinase inhibitor","volume":"20","author":"Chen","year":"2021","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Senthil Kumar, K.J., Gokila Vani, M., Hsieh, H.-W., Lin, C.-C., and Wang, S.-Y. (2021). Antcins from Antrodia cinnamomea and Antrodia salmonea Inhibit Angiotensin-Converting Enzyme 2 (ACE2) in Epithelial Cells: Can Be Potential Candidates for the Development of SARS-CoV-2 Prophylactic Agents. Plants, 10.","DOI":"10.3390\/plants10081736"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1574-6968.2002.tb11110.x","article-title":"Antrodia camphorata polysaccharides exhibit anti-hepatitis B virus effects","volume":"209","author":"Lee","year":"2002","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jep.2014.11.015","article-title":"Anti-inflammatory effects of Antrodia camphorata, a herbal medicine, in a mouse skin ischemia model","volume":"159","author":"Tsai","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e12936","DOI":"10.1111\/jfbc.12936","article-title":"Antrodia cinnamomea\u2014An updated minireview of its bioactive components and biological activity","volume":"43","author":"Ganesan","year":"2019","journal-title":"J. Food Biochem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1142\/S0192415X15500950","article-title":"Antrodia cinnamomea Inhibits Migration in Human Hepatocellular Carcinoma Cells: The Role of ERp57 and PGK-1","volume":"43","author":"Chen","year":"2015","journal-title":"Am. J. Chin. Med."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Wang, J.J., Wu, C.C., Lee, C.L., Hsieh, S.L., Chen, J.B., and Lee, C.I. (2017). Antimelanogenic, Antioxidant and Antiproliferative Effects of Antrodia camphorata Fruiting Bodies on B16-F0 Melanoma Cells. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0170924"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Kuo, Y.H., Lin, C.H., and Shih, C.C. (2016). Dehydroeburicoic Acid from Antrodia camphorata Prevents the Diabetic and Dyslipidemic State via Modulation of Glucose Transporter 4, Peroxisome Proliferator-Activated Receptor \u03b1 Expression and AMP-Activated Protein Kinase Phosphorylation in High-Fat-Fed Mice. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17060872"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1055\/s-2004-818941","article-title":"Evaluation of the anti-inflammatory activity of zhankuic acids isolated from the fruiting bodies of Antrodia camphorata","volume":"70","author":"Shen","year":"2004","journal-title":"Planta Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1016\/j.bmcl.2015.08.038","article-title":"Immunosuppressive effect of zhankuic acid C from Taiwanofungus camphoratus on dendritic cell activation and the contact hypersensitivity response","volume":"25","author":"Lin","year":"2015","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.intimp.2015.12.030","article-title":"4,7-Dimethoxy-5-methyl-1,3-benzodioxole from Antrodia camphorata inhibits LPS-induced inflammation via suppression of NF-\u03baB and induction HO-1 in RAW264.7 cells","volume":"31","author":"Shie","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s12906-019-2590-9","article-title":"Study of the antitumor mechanisms of apiole derivatives (AP-02) from Petroselinum crispum through induction of G0\/G1 phase cell cycle arrest in human COLO 205 cancer cells","volume":"19","author":"Wu","year":"2019","journal-title":"BMC Complementary Altern. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"867","DOI":"10.7326\/0003-4819-62-5-867","article-title":"Hematodepressive Virus Diseases of Thailand","volume":"62","author":"Bierman","year":"1965","journal-title":"Ann. Intern. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1590\/S0037-86822009000600014","article-title":"Hematological abnormalities in patients with dengue","volume":"42","author":"Oliveira","year":"2009","journal-title":"Rev. Soc. Bras. Med. Trop"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1177\/2040620711417660","article-title":"The importance of hematopoietic progenitor cells in dengue","volume":"3","author":"Tsai","year":"2012","journal-title":"Ther. Adv. Hematol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1574-695X.2008.00399.x","article-title":"Dengue 2 virus inhibits in vitro megakaryocytic colony formation and induces apoptosis in thrombopoietin-inducible megakaryocytic differentiation from cord blood CD34+ cells","volume":"53","author":"Basu","year":"2008","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"17990","DOI":"10.1038\/srep17990","article-title":"Infectious dengue vesicles derived from CD61+ cells in acute patient plasma exhibited a diaphanous appearance","volume":"5","author":"Hsu","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1182\/blood.V74.4.1235.bloodjournal7441235","article-title":"Dengue virus, a flavivirus, propagates in human bone marrow progenitors and hematopoietic cell lines","volume":"74","author":"Nakao","year":"1989","journal-title":"Blood"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Clark, K.B., Noisakran, S., Onlamoon, N., Hsiao, H.-M., Roback, J., Villinger, F., Ansari, A.A., and Perng, G.C. (2012). Multiploid CD61+ cells are the pre-dominant cell lineage infected during acute dengue virus infection in bone marrow. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0052902"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1182\/blood.V66.6.1384.1384","article-title":"Establishment of a novel human megakaryoblastic leukemia cell line, MEG-01, with positive Philadelphia chromosome","volume":"66","author":"Ogura","year":"1985","journal-title":"Blood"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1007\/s00280-003-0653-5","article-title":"New approaches to drug discovery and development: A mechanism-based approach to pharmaceutical research and its application to BNP7787, a novel chemoprotective agent","volume":"52","author":"Hausheer","year":"2003","journal-title":"Cancer Chemother Pharm."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1039\/b602241n","article-title":"The value of natural products to future pharmaceutical discovery","volume":"24","author":"Baker","year":"2007","journal-title":"Nat. Prod. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1126\/science.1168243","article-title":"Drug discovery and natural products: End of an era or an endless frontier?","volume":"325","author":"Li","year":"2009","journal-title":"Science"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"775034","DOI":"10.3389\/fphar.2021.775034","article-title":"The Use of Ginkgo Biloba, L. as a Neuroprotective Agent in the Alzheimer\u2019s Disease","volume":"12","author":"Nowak","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"93","DOI":"10.14218\/JCTH.2015.00006","article-title":"Liver Injury from Herbal, Dietary, and Weight Loss Supplements: A Review","volume":"3","author":"Zheng","year":"2015","journal-title":"J. Clin. Transl. Hepatol."},{"key":"ref_54","first-page":"39","article-title":"International Comparison of Five Herbal Medicine Registration Systems to Inform Regulation Development: United Kingdom, Germany, United States of America, United Arab Emirates and Kingdom of Bahrain","volume":"32","author":"Alostad","year":"2018","journal-title":"Pharmaceut. Med."},{"key":"ref_55","unstructured":"World Health Organization (2002). Programme on Traditional, M. WHO Traditional Medicine Strategy 2002\u20132005, World Health Organization."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"8556","DOI":"10.1021\/jf402849b","article-title":"Establishment of the Metabolite Profile for an Antrodia cinnamomea Health Food Product and Investigation of Its Chemoprevention Activity","volume":"61","author":"Wang","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.toxrep.2015.10.007","article-title":"Genotoxic, teratotoxic and oral toxic assessments of Antrodia cinnamomea health food product (Leader Deluxe Antrodia cinnamomea\u00ae)","volume":"2","author":"Lin","year":"2015","journal-title":"Toxicol. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1006\/viro.2002.1685","article-title":"Mycophenolic Acid Inhibits Dengue Virus Infection by Preventing Replication of Viral RNA","volume":"304","author":"Diamond","year":"2002","journal-title":"Virology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"285","DOI":"10.4049\/jimmunol.99.2.285","article-title":"A plaque reduction test for dengue virus neutralizing antibodies","volume":"99","author":"Russell","year":"1967","journal-title":"J. Immunol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1021\/np50125a002","article-title":"New Steroid Acids from Antrodia cinnamomea, a Fungal Parasite of Cinnamomum micranthum","volume":"58","author":"Chen","year":"1995","journal-title":"J. Nat. Prod."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0031-9422(95)00025-3","article-title":"A sesquiterpene lactone, phenyl and biphenyl compounds from Antrodia cinnamomea","volume":"39","author":"Cherng","year":"1995","journal-title":"Phytochemistry"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/0031-9422(95)00767-9","article-title":"Steroids and triterpenoids of Antodia cinnamomea\u2014A fungus parasitic on Cinnamomum micranthum","volume":"41","author":"Yang","year":"1996","journal-title":"Phytochemistry"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1142\/S0192415X03000886","article-title":"New Ergostane and Lanostane from Antrodia Camphorata","volume":"14","author":"Shen","year":"2003","journal-title":"J. Chin. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"6345","DOI":"10.21873\/anticanres.14655","article-title":"Potentiation of Differentiation and Apoptosis in a Human Promyelocytic Leukemia Cell Line by Garlic Essential Oil and Its Organosulfur Compounds","volume":"40","author":"Agassi","year":"2020","journal-title":"Anticancer. Res."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Leneva, I., Kartashova, N., Poromov, A., Gracheva, A., Korchevaya, E., Glubokova, E., Borisova, O., Shtro, A., Loginova, S., and Shchukina, V. (2021). Antiviral Activity of Umifenovir In Vitro against a Broad Spectrum of Coronaviruses, Including the Novel SARS-CoV-2 Virus. Viruses, 13.","DOI":"10.3390\/v13081665"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Theerawatanasirikul, S., Lueangaramkul, V., Thangthamniyom, N., Chankeeree, P., Semkum, P., and Lekcharoensuk, P. (2022). Andrographolide and Deoxyandrographolide Inhibit Protease and IFN-Antagonist Activities of Foot-and-Mouth Disease Virus 3C(pro). Animals, 12.","DOI":"10.3390\/ani12151995"}],"container-title":["Plants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2223-7747\/11\/19\/2631\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:47:26Z","timestamp":1760143646000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2223-7747\/11\/19\/2631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,6]]},"references-count":66,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["plants11192631"],"URL":"https:\/\/doi.org\/10.3390\/plants11192631","relation":{},"ISSN":["2223-7747"],"issn-type":[{"value":"2223-7747","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,6]]}}}