{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T17:30:40Z","timestamp":1775237440171,"version":"3.50.1"},"reference-count":42,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondo de Investigaci\u00f3n en Salud","award":["R-2019-1702-005"],"award-info":[{"award-number":["R-2019-1702-005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Tagetes lucida Cav., is a medicinal plant used in Mexico to alleviate different disorders related to alterations of the central nervous system, such as behaviors associated with psychosis. The present work evaluated the effect of different extracts separated from this plant, TlHex, TlEA, TlMet, and TlAq, and of two isolated coumarins, herniarin (HN) and dimethylfraxetin (DF), on haloperidol-induced catalepsy (HAL), and psychotic behaviors provoked with a glutamatergic antagonist, ketamine (KET) on ICR mice. The extracts TlEA, TlAq, and the isolated compounds HN and DF, induced an increment of the cataleptic effect of HAL. Schizophrenia-like symptoms caused by KET were analyzed through the behavior of the animals in the open field (OFT), forced swimming (FST), passive avoidance test (PAT), and social interaction test (SIT). Treatments derived from T. lucida could interact with this substance in all tests except for FST, in which only TlMet blocks its activity. Mainly, TlEA, TlAq, HN, and DF, blocked the effects of KET on stereotyped behavior, hyperlocomotion, cognitive impairment, and detriment in the social interaction of rodents. T. lucida interacted with dopaminergic and glutamatergic systems.<\/jats:p>","DOI":"10.3390\/plants11202789","type":"journal-article","created":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T08:19:06Z","timestamp":1666599546000},"page":"2789","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Herniarin, Dimethylfraxetin and Extracts from Tagetes lucida, in Psychosis Secondary to Ketamine and Its Interaction with Haloperidol"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7709-4258","authenticated-orcid":false,"given":"Sandra Liliana","family":"Porras-D\u00e1vila","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano Del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, Mexico"},{"name":"Doctorado en Ciencias Biol\u00f3gicas y de la Salud, Divisi\u00f3n de Ciencias Biol\u00f3gicas y de la Salud, Universidad Aut\u00f3noma Metropolitana (UAM), Ciudad de M\u00e9xico 04960, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0783-8274","authenticated-orcid":false,"given":"Enrique","family":"Jim\u00e9nez-Ferrer","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano Del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rub\u00e9n","family":"Rom\u00e1n Ramos","sequence":"additional","affiliation":[{"name":"Doctorado en Ciencias Biol\u00f3gicas y de la Salud, Divisi\u00f3n de Ciencias Biol\u00f3gicas y de la Salud, Universidad Aut\u00f3noma Metropolitana (UAM), Ciudad de M\u00e9xico 04960, Mexico"},{"name":"Departamento de Ciencias de la Salud, Divisi\u00f3n de Ciencias Biol\u00f3gicas y de la Salud, Universidad Aut\u00f3noma Metropolitana-Iztapalapa, Av. Ferrocarril San Rafael Atlixco 186, Leyes de Reforma 1era Secc., Ciudad de M\u00e9xico 09310, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3693-1670","authenticated-orcid":false,"given":"Manas\u00e9s","family":"Gonz\u00e1lez-Cortazar","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano Del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9417-5500","authenticated-orcid":false,"given":"Julio C\u00e9sar","family":"Almanza-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Doctorado en Ciencias Biol\u00f3gicas y de la Salud, Divisi\u00f3n de Ciencias Biol\u00f3gicas y de la Salud, Universidad Aut\u00f3noma Metropolitana (UAM), Ciudad de M\u00e9xico 04960, Mexico"},{"name":"Departamento de Ciencias de la Salud, Divisi\u00f3n de Ciencias Biol\u00f3gicas y de la Salud, Universidad Aut\u00f3noma Metropolitana-Iztapalapa, Av. Ferrocarril San Rafael Atlixco 186, Leyes de Reforma 1era Secc., Ciudad de M\u00e9xico 09310, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9056-3568","authenticated-orcid":false,"given":"Maribel","family":"Herrera-Ruiz","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano Del Seguro Social, Argentina No. 1, Col. Centro, Xochitepec 62790, Morelos, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"key":"ref_1","unstructured":"(2022, August 10). WHO|World Health Organization. Available online: https:\/\/www.who.int\/es\/news\/item\/17-06-2022-who-highlights-urgent-need-to-transform-mental-health-and-mental-health-care."},{"key":"ref_2","unstructured":"Garc\u00eda-Sancho, J.C.M. (2009). Gu\u00eda Pr\u00e1ctica Cl\u00ednica Para El Tratamiento de La Esquizofrenia En Centros de Salud Mental, Subdirecci\u00f3n de Salud Mental."},{"key":"ref_3","first-page":"227","article-title":"La Etiolog\u00eda de La Esquizofrenia","volume":"72","author":"Gejman","year":"2012","journal-title":"Medicina"},{"key":"ref_4","first-page":"314","article-title":"Modelos Fisiopatol\u00f3gicos de La Esquizofrenia; de Dopamina a Glutamato, de Glutamato a GABA Pathophysiologycal Models of Schizophrenia; from Dopamine to Glutamate, and Glutamate to GABA","volume":"43","author":"Paz","year":"2005","journal-title":"Rev. Chil. Neuro-Psiquiat."},{"key":"ref_5","first-page":"835","article-title":"Bases Neurobiol\u00f3gicas de La Depression","volume":"16","author":"Callado","year":"2009","journal-title":"Salud Cienc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.rpsm.2012.05.003","article-title":"Asignaci\u00f3n de Relevancia (Salience) y Desregulaci\u00f3n Del Sistema Dopamin\u00e9rgico","volume":"6","author":"Lahera","year":"2013","journal-title":"Rev. Psiquiatr. Salud Ment."},{"key":"ref_7","first-page":"1","article-title":"The Treatment of Psychopathic and Antisocial Personality Disorders: A Review","volume":"22","author":"Bermejo","year":"2007","journal-title":"Int. Rev. Psychiatry"},{"key":"ref_8","first-page":"194","article-title":"Atypical Antipsychotic Use in the Treatment of Psychosis in Primary Care","volume":"2","author":"Leo","year":"2000","journal-title":"Prim. Care Companion J. Clin. Psychiatry"},{"key":"ref_9","unstructured":"(2022, September 15). UNAM Biblioteca Digital de La Medicina Tradicional Mexicana. Available online: http:\/\/www.medicinatradicionalmexicana.unam.mx."},{"key":"ref_10","unstructured":"Indigenista, I.N. (1994). Atlas de Las Plantas de La Medicina Tradicional Mexicana, Ilustrada."},{"key":"ref_11","first-page":"103","article-title":"Phytochemicals and Their Biological Activities of Plants in Tagetes L.","volume":"4","author":"Xu","year":"2012","journal-title":"Chinese Herb. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1021\/np020018i","article-title":"An Extract of Tagetes Lucida and Its Phenolic Constituents as Antioxidants","volume":"65","author":"Aquino","year":"2002","journal-title":"J. Nat. Prod."},{"key":"ref_13","first-page":"3244","article-title":"Anti-Inflammatory Activity of Coumarins Isolated from Tagetes Lucida Cav","volume":"34","year":"2019","journal-title":"Nat. Prod. Res."},{"key":"ref_14","first-page":"986","article-title":"Hepatoprotective Effects of Tagetes Lucida Root Extract in Carbon Tetrachloride-Induced Hepatotoxicity in Wistar Albino Rats through Amelioration of Oxidative Stress","volume":"59","author":"Ismail","year":"2021","journal-title":"Pharm. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s11418-015-0909-5","article-title":"Antidepressant-like Activity of Tagetes Lucida Cav. Is Mediated by 5-HT1A and 5-HT2A Receptors","volume":"69","year":"2015","journal-title":"J. Nat. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jep.2016.01.040","article-title":"Tagetes Lucida Cav.: Ethnobotany, Phytochemistry and Pharmacology of Its Tranquilizing Properties","volume":"181","author":"Brindis","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_17","unstructured":"Brenda, M., and Diaz, S. (1998). Evaluaci\u00f3n de La Toxicidad Subaguda de Las Partes A\u00e9reas de Tagetas Lucida [Peric\u00f3n] y Hojas de Sanseviera Guineensis [Curarina], Universidad de San Carlos Guatemala."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1142\/S0192415X12500565","article-title":"Antidepressant-like Effect of Tagetes Lucida Cav. Extract in Rats: Involvement of the Serotonergic System","volume":"40","author":"Aguilar","year":"2012","journal-title":"Am. J. Chin. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1600-0536.2010.01730.x","article-title":"The Coumarin Herniarin as a Sensitizer in German Chamomile [Chamomilla Recutita (L.) Rauschert, Compositae]","volume":"62","author":"Paulsen","year":"2010","journal-title":"Contact Dermatitis"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3109\/01480545.2013.834352","article-title":"Antigenotoxic Activities of the Natural Dietary Coumarins Umbelliferone, Herniarin and 7-Isopentenyloxy Coumarin on Human Lymphocytes Exposed to Oxidative Stress","volume":"0545","author":"Rezaee","year":"2014","journal-title":"Drug Chem. Toxicol."},{"key":"ref_21","first-page":"10","article-title":"Herniarin, a Natural Coumarin, Inhibits Mammary Carcinogenesis by Modulating Liver X Receptor -\u03b1\/\u03b2-PI3K-Akt-Maf1 Pathway in Sprague\u2014Dawley Rats","volume":"15","author":"Bose","year":"2019","journal-title":"Pharmacogn. Mag."},{"key":"ref_22","first-page":"93","article-title":"The Effect of Herniarin on Anxiety behaviors and Depression Following chronic Cerebral Ischemia hypoperfusion in Male Rats","volume":"9","author":"Rafieirad","year":"2021","journal-title":"Exp. Anim. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"42","DOI":"10.32598\/CJNS.7.24.5","article-title":"The Effect of Herniarin on Spatial Working Memory, Pain Threshold, and Oxidative Stress in Ischemic Hypoperfusion Model in Rats","volume":"7","author":"Rafieirad","year":"2021","journal-title":"Casp. J. Neurol. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Salehi, B., Azzini, E., Zucca, P., Varoni, E.M., Kumar, N.V.A., Dini, L., Panzarini, E., Rajkovic, J., Fokou, P.V.T., and Peluso, I. (2020). Plant-Derived Bioactives and Oxidative Stress-Related Disorders: A Key Trend towards Healthy Aging and Longevity Promotion. Appl. Sci., 10.","DOI":"10.3390\/app10030947"},{"key":"ref_25","first-page":"30","article-title":"Plantas Medicinales Para El Tratamiento Del Susto Y Mal De Ojo. An\u00e1lisis De Sus Posibles Efectos Sobre El Sistema Nervioso Central Por V\u00eda Transd\u00e9rmica E Inhalatoria","volume":"16","author":"Hobompich","year":"2018","journal-title":"Rev. Etnobiolog\u00eda"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jep.2008.08.013","article-title":"Antidepressant-like Effects of Tagetes Lucida Cav. in the Forced Swimming Test","volume":"120","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0920-9964(91)90027-O","article-title":"Drug Treatment of Schizophrenia. Overview of Recent Research","volume":"4","author":"Marder","year":"1991","journal-title":"Schizophr. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1017\/S1461145711001696","article-title":"Haloperidol Conditioned Catalepsy in Rats: A Possible Role for D 1-like Receptors","volume":"15","author":"Banasikowski","year":"2012","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_29","first-page":"8404258","article-title":"Galphimia Glauca and Natural Galphimines Block Schizophrenia-Like Symptoms Induced with Apomorphine and MK-801 in Mice","volume":"2019","author":"Zamilpa","year":"2019","journal-title":"Evidence-Based Complement. Altern. Med."},{"key":"ref_30","first-page":"221","article-title":"La Cafe\u00edna Como Un F\u00e1rmaco Preventivo de La Enfermedad de Parkinson: Evidencias Epidemiol\u00f3gicas y Sustrato Experimental","volume":"50","year":"2010","journal-title":"Rev. Neurol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.phrs.2015.11.023","article-title":"Implication of Coumarins towards Central Nervous System Disorders","volume":"103","author":"Orhan","year":"2016","journal-title":"Pharmacol. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1002\/jnr.22009","article-title":"Effects of Scoparone on Dopamine Biosynthesis and L-DOPA-Induced Cytotoxicity in PC12 Cells","volume":"87","author":"Yang","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/s41401-019-0296-7","article-title":"wu Isosibiricin Inhibits Microglial Activation by Targeting the Dopamine D1\/D2 Receptor-Dependent NLRP3\/Caspase-1 Inflammasome Pathway","volume":"41","author":"Wang","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.schres.2019.03.010","article-title":"NMDA Receptor Hypofunction for Schizophrenia Revisited: Perspectives from Epigenetic Mechanisms","volume":"217","author":"Snyder","year":"2020","journal-title":"Schizophr. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1177\/0269881107077716","article-title":"From Prediction Error to Psychosis: Ketamine as a Pharmacological Model of Delusions","volume":"21","author":"Corlett","year":"2007","journal-title":"J. Psychopharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Choi, K.H., Berman, R.Y., Zhang, M., Spencer, H.F., and Radford, K.D. (2020). Effects of Ketamine on Rodent Fear Memory. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197173"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.biopha.2018.04.082","article-title":"Pharmacological Interaction of Galphimia Glauca Extract and Natural Galphimines with Ketamine and Haloperidol on Different Behavioral Tests","volume":"103","author":"Zamilpa","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/00008877-200006000-00006","article-title":"Animal Models for the Negative Symptoms of Schizophrenia","volume":"11","author":"Ellenbroek","year":"2000","journal-title":"Behav. Pharmacol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0091-3057(91)90571-I","article-title":"Ketamine-Induced Hyperlocomotion Associated with Alteration of Presynaptic Components of Dopamine Neurons in the Nucleus Accumbens of Mice","volume":"40","author":"Irifune","year":"1991","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_40","first-page":"4751","article-title":"Isolation, Chemical Characterization, and Anti-Inflammatory Activity of Coumarins, Flavonoids, and Terpenes from Tagetes Lucida","volume":"36","author":"Zamilpa","year":"2022","journal-title":"Nat. Prod. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0014-2999(02)02037-X","article-title":"Rosmarinic Acid and Caffeic Acid Produce Antidepressive-like Effect in the Forced Swimming Test in Mice","volume":"449","author":"Takeda","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1037\/0033-2909.83.3.482","article-title":"The Open-Field Test: A Critical Review","volume":"83","author":"Walsh","year":"1976","journal-title":"Psychol. Bull."}],"container-title":["Plants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2223-7747\/11\/20\/2789\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:58:36Z","timestamp":1760144316000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2223-7747\/11\/20\/2789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,21]]},"references-count":42,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["plants11202789"],"URL":"https:\/\/doi.org\/10.3390\/plants11202789","relation":{},"ISSN":["2223-7747"],"issn-type":[{"value":"2223-7747","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,21]]}}}