{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:30:52Z","timestamp":1779323452758,"version":"3.51.4"},"reference-count":50,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T00:00:00Z","timestamp":1668124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["407449\/2016-7"],"award-info":[{"award-number":["407449\/2016-7"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["PR20101000360100\/15"],"award-info":[{"award-number":["PR20101000360100\/15"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["PRONEX\/FUNCAP\/CNPq"],"award-info":[{"award-number":["PRONEX\/FUNCAP\/CNPq"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)","award":["407449\/2016-7"],"award-info":[{"award-number":["407449\/2016-7"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)","award":["PR20101000360100\/15"],"award-info":[{"award-number":["PR20101000360100\/15"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)","award":["PRONEX\/FUNCAP\/CNPq"],"award-info":[{"award-number":["PRONEX\/FUNCAP\/CNPq"]}]},{"DOI":"10.13039\/501100005283","name":"Funda\u00e7\u00e3o Cearense de Apoio ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (FUNCAP)","doi-asserted-by":"publisher","award":["407449\/2016-7"],"award-info":[{"award-number":["407449\/2016-7"]}],"id":[{"id":"10.13039\/501100005283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005283","name":"Funda\u00e7\u00e3o Cearense de Apoio ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (FUNCAP)","doi-asserted-by":"publisher","award":["PR20101000360100\/15"],"award-info":[{"award-number":["PR20101000360100\/15"]}],"id":[{"id":"10.13039\/501100005283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005283","name":"Funda\u00e7\u00e3o Cearense de Apoio ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (FUNCAP)","doi-asserted-by":"publisher","award":["PRONEX\/FUNCAP\/CNPq"],"award-info":[{"award-number":["PRONEX\/FUNCAP\/CNPq"]}],"id":[{"id":"10.13039\/501100005283","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Background: Hyptis crenata is a plant of great ethnopharmacological importance widely distributed in South American countries. In Northeast Brazil, teas or infusions of its aerial parts are used in folk medicine to treat several acute and chronic inflammatory diseases. In a previous work we have demonstrated that the essential oil of H. crenata (EOHc) has an antiedematogenic effect. The aim of this work was to evaluate the effect of EOHc on cytokines secretion and cellular infiltration. Methods: Peritonitis and paw edema models induced by carrageenan were used to determine leucocyte count, myeloperoxidase (MPO) activity, nitrite, and cytokines secretion. Results: EOHc (10\u2013300 mg\/kg) significantly inhibited leucocyte migration and reduced the neutrophil count (control: 1.46 \u00d7 103 \u00b1 0.031 \u00d7 103\/mL) of the total leucocytes population in extracellular exudate (control: 2.14 \u00d7 103 \u00b1 0.149 \u00d7 103\/mL) by 15.00%, 43.29%, 65.52%, and 72.83% for the doses of 10, 30, 100, and 300 mg\/kg EOHc, respectively (EC50: 24.15 mg\/kg). EOHc (100 mg\/kg) inhibited the increase in myeloperoxidase activity and completely blocked the increase in nitrite concentration induced by carrageenan. EOHc markedly reduced the pro-inflammatory cytokines (IL-6, MCP-1, IFN-\u03b3, TNF-\u03b1, and IL-12p70) and increased IL-10, an anti-inflammatory cytokine (compared to control group, p &lt; 0.05). Conclusions: This study demonstrates that EOHc has a long-lasting anti-inflammatory effect mediated through interference on MPO activity, and nitrite, and cytokines secretion. This effect, coupled with low EOHc toxicity, as far as results obtained in mice could be translated to humans, suggests that EOHc has great potentiality as a therapeutic agent.<\/jats:p>","DOI":"10.3390\/plants11223048","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T01:39:54Z","timestamp":1668130794000},"page":"3048","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Essential Oil of Hyptis crenata Inhibits the Increase in Secretion of Inflammatory Mediators"],"prefix":"10.3390","volume":"11","author":[{"given":"Rutyleia","family":"Alves-Soares","sequence":"first","affiliation":[{"name":"Postgraduate Program in Physiological Sciences, Superior Institute of Biomedical Sciences (ISCB), Campus do Itaperi, State University of Ceara (UECE), Av. Silas Munguba 1700, Fortaleza CEP 60.714.903, Ceara, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4633-5597","authenticated-orcid":false,"given":"Herm\u00f3genes David","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biochemistry, Department of Biochemistry and Molecular Biology, Campus do Pici, Federal University of Ceara (UFC), Av. Humberto Monte, s\/n Bloco 907, Fortaleza CEP 60440-990, Ceara, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dy\u00e9ly de Carvalho Oliveira","family":"Campos","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Physiological Sciences, Superior Institute of Biomedical Sciences (ISCB), Campus do Itaperi, State University of Ceara (UECE), Av. Silas Munguba 1700, Fortaleza CEP 60.714.903, Ceara, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri de Abreu","family":"Gomes-Vasconcelos","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Physiological Sciences, Superior Institute of Biomedical Sciences (ISCB), Campus do Itaperi, State University of Ceara (UECE), Av. Silas Munguba 1700, Fortaleza CEP 60.714.903, Ceara, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2012-2040","authenticated-orcid":false,"given":"Francisco Walber","family":"Ferreira-da-Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Physiological Sciences, Superior Institute of Biomedical Sciences (ISCB), Campus do Itaperi, State University of Ceara (UECE), Av. Silas Munguba 1700, Fortaleza CEP 60.714.903, Ceara, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerly Shamyra","family":"Silva-Alves","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Physiological Sciences, Superior Institute of Biomedical Sciences (ISCB), Campus do Itaperi, State University of Ceara (UECE), Av. Silas Munguba 1700, Fortaleza CEP 60.714.903, Ceara, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianna Noronha","family":"Coelho-de-Souza","sequence":"additional","affiliation":[{"name":"Graduate Program of Medicine, Center for Health Sciences (CCS), Fortaleza University (UNIFOR), Av. Washington Soares 1321, Edson Queiroz, Fortaleza CEP 60811-905, Ceara, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00facio Ricardo Leite","family":"Diniz","sequence":"additional","affiliation":[{"name":"Researcher at the National Institute of the Semiarid Region (INSA), Av. Francisco Lopes de Almeida, s\/n Serrot\u00e3o, Campina Grande CEP 58434-70, Paraiba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3972-1361","authenticated-orcid":false,"given":"Jos\u00e9 Henrique","family":"Leal-Cardoso","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Physiological Sciences, Superior Institute of Biomedical Sciences (ISCB), Campus do Itaperi, State University of Ceara (UECE), Av. Silas Munguba 1700, Fortaleza CEP 60.714.903, Ceara, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7357-0958","authenticated-orcid":false,"given":"Andrelina Noronha","family":"Coelho-de-Souza","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Physiological Sciences, Superior Institute of Biomedical Sciences (ISCB), Campus do Itaperi, State University of Ceara (UECE), Av. Silas Munguba 1700, Fortaleza CEP 60.714.903, Ceara, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/ffj.1031","article-title":"Chemical variation in the essential oils of Hyptis crenata Pohl ex Benth","volume":"17","author":"Zoghbi","year":"2002","journal-title":"Flavour Fragr. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.jep.2013.07.026","article-title":"Gastroprotective effects of the essential oil of Hyptis crenata Pohl ex Benth. on gastric ulcer models","volume":"149","author":"Diniz","year":"2013","journal-title":"J. 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