{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:17:06Z","timestamp":1787699826684,"version":"build-2784847793"},"reference-count":83,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T00:00:00Z","timestamp":1670630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Acute kidney injury and impaired kidney function is associated with reduced survival and increased morbidity. Porophyllum ruderale is an edible plant endemic to Mexico used in Mexican traditional medicine. The aim of this study was to evaluate the nephroprotective effect of a hydroalcoholic extract (MeOH:water 70:30, v\/v) from the aerial parts of P. ruderale (HEPr). Firstly, in vitro the antioxidant and anti-inflammatory activity of HEPr was determined; after the in vivo nephroprotective activity of HEPr was evaluated using a thioacetamide-induced injury model in rats. HEPr showed a slight effect on LPS-NO production in macrophages (15% INO at 40 \u00b5g\/mL) and high antioxidant activity in the ferric reducing antioxidant power (FRAP) test, followed by the activity on DPPH and ABTS radicals test (69.04, 63.06 and 32.96% of inhibition, respectively). In addition, values of kidney injury biomarkers in urine (urobilinogen, hemoglobin, bilirubin, ketones, glucose, protein, pH, nitrites, leukocytes, specific gravity, and the microalbumin\/creatinine) and serum (creatinine, urea, and urea nitrogen) of rats treated with HEPr were maintained in normal ranges. Finally, 5-O-caffeoylquinic, 4-O-caffeoylquinic and ferulic acids; as well as 3-O-quercetin glucoside and 3-O-kaempferol glucoside were identified by HPLC as major components of HEPr. In conclusion, Porophyllum ruderale constitutes a source of compounds for the treatment of acute kidney injury.<\/jats:p>","DOI":"10.3390\/plants11243460","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T03:36:09Z","timestamp":1670816169000},"page":"3460","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Nephroprotective Activity of Papaloquelite (Porophyllum ruderale) in Thioacetamide-Induced Injury Model"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6229-8848","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"V\u00e1zquez-Atanacio","sequence":"first","affiliation":[{"name":"\u00c1rea Acad\u00e9mica de Medicina Veterinaria y Zootecnia, Instituto de Ciencias Agropecuarias, Universidad Aut\u00f3noma del Estado de Hidalgo, Av. Universidad Km 1, Ex-Hda. de Aquetzalpa, Tulancingo 43600, Hidalgo, Mexico"},{"name":"\u00c1rea Acad\u00e9mica de Farmacia, Instituto de Ciencias de la Salud, Universidad Aut\u00f3noma del Estado de Hidalgo, Ex Hacienda la Concepci\u00f3n s\/n, San Agust\u00edn Tlaxiaca 42160, Hidalgo, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6725-270X","authenticated-orcid":false,"given":"Mirandeli","family":"Bautista","sequence":"additional","affiliation":[{"name":"\u00c1rea Acad\u00e9mica de Farmacia, Instituto de Ciencias de la Salud, Universidad Aut\u00f3noma del Estado de Hidalgo, Ex Hacienda la Concepci\u00f3n s\/n, San Agust\u00edn Tlaxiaca 42160, Hidalgo, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3693-1670","authenticated-orcid":false,"given":"Manas\u00e9s","family":"Gonz\u00e1lez-Cortazar","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1., Centro, Xochitepec 62790, Morelos, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Romero-Estrada","sequence":"additional","affiliation":[{"name":"Departamento de Madera, Celulosa y Papel, Centro Universitario de Ciencias Exactas e Ingenier\u00edas, Universidad de Guadalajara, Km 15.5 Carretera Guadalajara-Nogales, Col. Las Agujas, Zapopan 45100, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5765-1950","authenticated-orcid":false,"given":"Minarda","family":"De la O-Arciniega","sequence":"additional","affiliation":[{"name":"\u00c1rea Acad\u00e9mica de Farmacia, Instituto de Ciencias de la Salud, Universidad Aut\u00f3noma del Estado de Hidalgo, Ex Hacienda la Concepci\u00f3n s\/n, San Agust\u00edn Tlaxiaca 42160, Hidalgo, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0759-3198","authenticated-orcid":false,"given":"Araceli","family":"Casta\u00f1eda-Ovando","sequence":"additional","affiliation":[{"name":"\u00c1rea Acad\u00e9mica de Qu\u00edmica, Instituto de Ciencias B\u00e1sicas e Ingenier\u00eda, Universidad Aut\u00f3noma del Estado de Hidalgo, Pachuca-Tulancingo km 4.5 Carboneras, Mineral de la Reforma 42184, Hidalgo, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5109-4671","authenticated-orcid":false,"given":"Carolina G.","family":"Sosa-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"\u00c1rea Acad\u00e9mica de Medicina Veterinaria y Zootecnia, Instituto de Ciencias Agropecuarias, Universidad Aut\u00f3noma del Estado de Hidalgo, Av. Universidad Km 1, Ex-Hda. de Aquetzalpa, Tulancingo 43600, Hidalgo, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyanira","family":"Ojeda-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"\u00c1rea Acad\u00e9mica de Medicina Veterinaria y Zootecnia, Instituto de Ciencias Agropecuarias, Universidad Aut\u00f3noma del Estado de Hidalgo, Av. Universidad Km 1, Ex-Hda. de Aquetzalpa, Tulancingo 43600, Hidalgo, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/S0140-6736(11)61454-2","article-title":"Acute kidney injury","volume":"380","author":"Bellomo","year":"2012","journal-title":"Lancet"},{"key":"ref_2","first-page":"1","article-title":"Acute kidney injury","volume":"7","author":"Kellum","year":"2021","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Burki, S., Burki, Z.G., Asghar, M.A., Ali, I., and Zafar, S. (2021). Phytochemical, acute toxicity and renal protective appraisal of Ajuga parviflora hydromethanolic leaf extract against CCl4 induced renal injury in rats. BMC Complement. Med. Ther., 21.","DOI":"10.1186\/s12906-021-03360-9"},{"key":"ref_4","first-page":"6","article-title":"Epidemiolog\u00eda y desenlaces de la lesi\u00f3n renal aguda en Latinoam\u00e9rica","volume":"1","author":"Lombardi","year":"2018","journal-title":"Gac. Med. Mex."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000488303","article-title":"Novel Proinflammatory Function of Renal Intercalated Cells","volume":"72","author":"Breton","year":"2018","journal-title":"Ann. Nutr. Metab."},{"key":"ref_6","first-page":"1","article-title":"In vivo anti-inflammatory and in vitro antioxidant activities of Genista quadriflora Munby extracts","volume":"6","author":"Boukaabache","year":"2014","journal-title":"Sch. Res. Libr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2147\/ITT.S73223","article-title":"The role of adipokines in chronic inflammation","volume":"5","author":"Mancuso","year":"2016","journal-title":"ImmunoTargets Ther."},{"key":"ref_8","first-page":"3","article-title":"Inflamaci\u00f3n en la enfermedad renal cr\u00f3nica avanzada: Caracter\u00edsticas cl\u00ednicas asociadas y valor pron\u00f3stico","volume":"25","author":"Caravaca","year":"2004","journal-title":"DYT Premio Gen. Lab"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e08","DOI":"10.15171\/ipp.2019.08","article-title":"The role of nitric oxide in inflammation and oxidative stress","volume":"5","author":"Papi","year":"2019","journal-title":"Immunopathol. Persa"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.semnephrol.2004.04.007","article-title":"Nitric Oxide, oxidative stress, and progression of chronic renal failure","volume":"24","author":"Modlinger","year":"2004","journal-title":"Semin. Nephrol."},{"key":"ref_11","first-page":"8545695","article-title":"Renoprotective and Cardioprotective Potential of Moricandia sinaica (Boiss.) against Carbon Tetrachloride-Induced Toxicity in Rats","volume":"2022","author":"Abdelaaty","year":"2022","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_12","first-page":"2137","article-title":"Renoprotective effects of Silybum marianum (L.) Gaertn (Silymarin) on thioacetamide-induced renal injury: Biochemical and histopathological approach","volume":"31","author":"Cengiz","year":"2018","journal-title":"Pak. J. Pharm. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/j.sjbs.2020.05.034","article-title":"Physiological and histopathological study on the influence of Ocimum basilicum leaves extract on thioacetamide-induced nephrotoxicity in male rats","volume":"27","author":"Alomar","year":"2020","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Wang, K., Deng, Y., Zhang, J., Cheng, B., Huang, Y., Meng, Y., Zhong, K., Xiong, G., Guo, J., and Liu, Y. (2021). Toxicity of thioacetamide and protective effects of quercetin in zebrafish (Danio rerio) larvae. Environ. Toxicol., 1\u201311.","DOI":"10.1002\/tox.23323"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Zargar, S., Alonazi, M., Rizwana, H., and Wani, T.A. (2019). Resveratrol reverses thioacetamide-induced renal assault with respect to oxidative stress, renal function, DNA damage, and cytokine release in Wistar rats. Oxid. Med. Cell Longev., 1\u20138.","DOI":"10.1155\/2019\/1702959"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1293\/tox.26.175","article-title":"Thioacetamide-induced hepatocellular necrosis is attenuated in diet-induced obese mice","volume":"26","author":"Shirai","year":"2013","journal-title":"J. Toxicol. Pathol."},{"key":"ref_17","unstructured":"Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM) (2022, October 02). Biblioteca Digital de la Medicina Tradicional Mexicana. P\u00e1palo o Papaloquelite. Available online: http:\/\/www.medicinatradicionalmexicana.unam.mx\/apmtm\/termino.php?l=3&t=papalo-papaloquelite."},{"key":"ref_18","unstructured":"Castro Lara, D., Basurto Pe\u00f1a, F., Mera Ovando, L.M., and Bye Boettler, R.A. (2022). Los Quelites, Tradici\u00f3n Milenaria en M\u00e9xico, Le\u00f3n M\u00e1rquez Ort\u00edz.. [1st ed.]."},{"key":"ref_19","unstructured":"Castro Lara, D., Bye Boettler, R.A., and Mera Ovando, L.M. (2011). Diagn\u00f3stico del P\u00e1paloquelite en M\u00e9xico, Le\u00f3n M\u00e1rquez Ort\u00edz.. [1st ed.]."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Fukalova Fukalova, T., Garc\u00eda-Mart\u00ednez, M.D., and Raig\u00f3n, M.D. (2022). Nutritional composition, bioactive compounds, and volatiles profile characterization of two edible undervalued plants: Portulaca oleracea L. and Porophyllum ruderale (Jacq.) Cass. Plants, 11.","DOI":"10.3390\/plants11030377"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1590\/S1516-89132006000100016","article-title":"Comparative leaf morphology and anatomy of three Asteraceae species","volume":"49","author":"Milan","year":"2006","journal-title":"Braz. Arch. Biol. Technol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.pdpdt.2017.10.023","article-title":"Antifungal photosensitive activity of Porophyllum obscurum (Spreng.) DC.: Correlation of the chemical composition of the hexane extract with the bioactivity","volume":"20","author":"Postigo","year":"2017","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"ref_23","unstructured":"Villavicencio-Araujo, N.Y. (2017). Evaluaci\u00f3n de la Actividad Antiespasm\u00f3dica del Extracto Hidroalcoh\u00f3lico de Hojas de Porophyllum Ruderale (Jac.) Cassini \u201cRupay Wachi\u201d, Sobre el \u00cdleon Aislado de Cavia Porcellus \u201cCobayo\u201d, Ayacucho 2016, Universidad Nacional de San Crist\u00f3bal de Huamanga."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.3390\/molecules16053469","article-title":"Thiophene Derivatives with Antileishmanial Activity Isolated from Aerial Parts of Porophyllum ruderale (Jacq.) Cass","volume":"16","author":"Takahashi","year":"2011","journal-title":"Molecules"},{"key":"ref_25","first-page":"73","article-title":"Antioxidant activity of hydroalcoholic extract of medicinal plants and stimulation of fibroblast proliferation","volume":"76","year":"2010","journal-title":"Rev. Soc. Qu\u00edm. Per\u00fa"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1590\/S0102-695X2011005000051","article-title":"Assessment of antinociceptive and anti- inflammatory activities of Porophyllum ruderale aqueous extract","volume":"21","author":"Lima","year":"2011","journal-title":"Rev. Braz. J. Pharmacogn."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1089\/jmf.2010.0263","article-title":"Antimicrobial activity of Northwestern Mexican plants against Helicobacter pylori","volume":"14","year":"2011","journal-title":"J. Med. Food"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.foodchem.2013.07.078","article-title":"Total phenolics and antioxidant activity of Piper auritum and Porophyllum ruderale","volume":"142","year":"2014","journal-title":"Food Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.supflu.2017.03.026","article-title":"Supercritical extraction of essential oils of Piper auritum and Porophyllum ruderale","volume":"127","year":"2017","journal-title":"J. Supercrit. Fluids"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"131116","DOI":"10.1016\/j.foodchem.2021.131116","article-title":"The contribution of phenolics to the anti-inflammatory potential of the extract from Bolivian coriander (Porophyllum ruderale subsp. ruderale)","volume":"371","author":"Baracz","year":"2022","journal-title":"Food Chem."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Ramos, M., \u00c1lvarez, L., Romero-Estrada, A., Bernab\u00e9-Antonio, A., Marquina-Bahena, S., and Cruz-Sosa, F. (2020). Establishment of a Cell Suspension Culture of Ageratina pichinchensis (Kunth) for the Improved Production of Anti-Inflammatory Compounds. Plants, 9.","DOI":"10.20944\/preprints202008.0443.v1"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0023-6438(95)80008-5","article-title":"Use of a Free Radical Method to Evaluate Antioxidant Activity","volume":"28","author":"Cuvelier","year":"1995","journal-title":"LWT-Food Sci. Technol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"7832","DOI":"10.1021\/jf0512353","article-title":"Assessing the Antioxidant Activity of Melanoidins from Coffee Brews by Different Antioxidant Methods","volume":"53","author":"Morales","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_34","first-page":"493203","article-title":"Principal Component Analysis of Phenolic Acid Spectra","volume":"2012","author":"Holser","year":"2012","journal-title":"Int. Sch. Res. Netw."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Santib\u00e1\u00f1ez, A., Herrera-Ruiz, M., Gonz\u00e1lez-Cortazar, M., Nicasio-Torres, P., Sharma, A., and Jim\u00e9nez-Ferrer, E. (2022). Pharmacokinetics and Tissue Distribution of Coumarins from Tagetes lucida in an LPS-Induced Neuroinflammation Model. Plants, 11.","DOI":"10.3390\/plants11212805"},{"key":"ref_36","first-page":"88","article-title":"Actividad antioxidante y citot\u00f3xica de extractos de Pilea dauciodora Weed (Urticaceae)","volume":"20","author":"Garro","year":"2015","journal-title":"Rev. Cuba. Plantas Med."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Yang, F., Qi, Y., Liu, W., Li, J., Wang, D., Fang, L., and Zhang, Y. (2019). Separation of Five Flavonoids from Aerial Parts of Salvia Miltiorrhiza Bunge Using HSCCC and Their Antioxidant Activities. Molecules, 24.","DOI":"10.3390\/molecules24193448"},{"key":"ref_38","first-page":"582","article-title":"Evaluation of anti-inflammatory activity of essential oils from two Asteraceae species","volume":"58","author":"Souza","year":"2003","journal-title":"Pharmazie"},{"key":"ref_39","first-page":"50","article-title":"Anti-inflammatory and antinociceptive properties of the extracts from the leaves of Porophyllum tagetoides and Annona reticulata","volume":"7","year":"2019","journal-title":"J. Med. Plants Stud."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"V\u00e1zquez-Atanacio, M.J., Bautista-\u00c1vila, M., Vel\u00e1zquez-Gonz\u00e1lez, C., Casta\u00f1eda-Ovando, A., Gonz\u00e1lez-Cort\u00e1zar, M., Sosa-Guti\u00e9rrez, C., and Ojeda-Ram\u00edrez, D. (2021). Porophyllum Genus Compounds and Pharmacological Activities: A Review. Sci. Pharm., 89.","DOI":"10.3390\/scipharm89010007"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s12272-001-1162-0","article-title":"Inhibitory effect of Citral on NO production by suppression of iNOS expression and NF-\u03baB activation in RAW264.7 cells","volume":"31","author":"Lee","year":"2008","journal-title":"Arch. Pharm. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1021\/jf051960d","article-title":"Modified 2,2-Azino-bis-3-ethylbenzothiazoline-6-sulfonic Acid (ABTS) Method to Measure Antioxidant Capacity of Selected Small Fruits and Comparison to Ferric Reducing Antioxidant Power (FRAP) and 2,2\u2032-Diphenyl-1-picrylhydrazyl (DPPH) Methods","volume":"54","author":"Ozgen","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/10408690490464960","article-title":"Comprehensive study on vitamin C equivalent antioxidant capacity (VCEAC) of various polyphenolics in scavenging a free radical and its structural relationship","volume":"44","author":"Kim","year":"2004","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"309","DOI":"10.17921\/1415-6938.2021v25n3p309-314","article-title":"Effect of Porophyllum ruderale (Jacq.) Cass. in the Liver of the B16-F10 Murine Melanoma Model and Antioxidant Potential","volume":"25","author":"Malzac","year":"2021","journal-title":"Ensaios Ci\u00eancia"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11130-011-0270-0","article-title":"Volatile Compounds and Antioxidative Activity of Porophyllum tagetoides Extracts","volume":"67","author":"Jimenez","year":"2012","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Khan, Y., Khan, S.M., ul Haq, I., Farzana, F., Abdullah, A., Abbasi, A.M., Alamri, S., Hashem, M., Sakhi, S., and Asif, M. (2021). Antioxidant potential in the leaves of grape varieties (Vitis vinifera L.) grown in different soil compositions. Arab. J. Chem., 14.","DOI":"10.1016\/j.arabjc.2021.103412"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"11850","DOI":"10.1021\/jf303047k","article-title":"Proanthocyanidin composition and antioxidant potential of the stem winemaking byproducts from 10 different grape varieties (Vitis vinifera L.)","volume":"60","author":"Jourdes","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1177\/0192623320985045","article-title":"A Review of Specific Biomarkers of Chronic Renal Injury and Their Potential Application in Nonclinical Safety Assessment Studies","volume":"20","author":"Obert","year":"2021","journal-title":"Toxicol. Pathol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"National Kidney Foundation [NKF] (2021). KDIGO Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease. Kidney Int., 99, S1\u2013S87.","DOI":"10.1016\/j.kint.2020.11.003"},{"key":"ref_50","first-page":"1","article-title":"Factores de progresi\u00f3n de la enfermedad renal cr\u00f3nica en la diabetes mellitus. Diagn\u00f3stico y cribado de la enfermedad renal cr\u00f3nica en la diabetes mellitus","volume":"28","year":"2016","journal-title":"Soc. Espa\u00f1ola Nefrol."},{"key":"ref_51","first-page":"13","article-title":"Fisiopatolog\u00eda del s\u00edndrome ur\u00e9mico","volume":"6","year":"2003","journal-title":"Rev. Del Hosp. Gen. Dr. Man. Gea Gonz\u00e1lez"},{"key":"ref_52","first-page":"553","article-title":"Metabolic syndrome and kidney disease","volume":"21","author":"Molina","year":"2010","journal-title":"Rev. M\u00e9d. Cl\u00edn. Condes."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1021\/tx049869b","article-title":"Metabonomic Deconvolution Of Embedded Toxicity: Application To Thioacetamide Hepato- and Nephrotoxicity","volume":"18","author":"Waters","year":"2005","journal-title":"Chem. Res. Toxicol."},{"key":"ref_54","first-page":"233","article-title":"Documento de consenso para la detecci\u00f3n y manejo de la enfermedad renal cr\u00f3nica","volume":"42","author":"Bover","year":"2022","journal-title":"Nefrol. Rev. Soc. Espa\u00f1ola Nefrol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.sjbs.2015.08.013","article-title":"Protective effect of olive and juniper leaves extracts on nephrotoxicity induced by thioacetamide in male mice","volume":"24","author":"Alrobai","year":"2017","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/j.sjbs.2016.09.021","article-title":"The potential protective influence of flaxseed oil against renal toxicity induced by thioacetamide in rats","volume":"25","year":"2018","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s12291-018-0803-5","article-title":"Allium porrum and Bauhinia Variegata Mitigate Acute Liver Failure and Nephrotoxicity Induced by Thioacetamide in Male Rats","volume":"35","author":"Bashandy","year":"2020","journal-title":"Indian J. Clin. Biochem."},{"key":"ref_58","first-page":"4","article-title":"Effect of oral administration of ethanolic extract of Vitex negundo on thioacetamide-induced nephrotoxicity in rats. BMC Complement","volume":"13","author":"Kadir","year":"2013","journal-title":"Altern. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"113149","DOI":"10.1016\/j.jep.2020.113149","article-title":"Metabolomic analysis among ten traditional \u201cArnica\u201d (Asteraceae) from Brazil","volume":"265","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"43","DOI":"10.4067\/S0718-07642018000400043","article-title":"Componentes Bioactivos de Diferentes Marcas de Caf\u00e9 Comerciales de Panam\u00e1. Relaci\u00f3n entre \u00c1cidos Clorog\u00e9nicos y Cafe\u00edna","volume":"29","author":"Vega","year":"2018","journal-title":"Informaci\u00f3n Tecnol\u00f3gica"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/jfs.12060","article-title":"Antibacterial activity and antifungal and anti-mycotoxigenic activities against Aspergillus flavus and A. ochraceus of green coffee chlorogenic acids and dodecyl chlorogenates","volume":"33","author":"Taillefer","year":"2013","journal-title":"J. Food Saf."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/ajcn\/79.5.727","article-title":"Polyphenols: Food sources and bioavailability","volume":"79","author":"Manach","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1002\/jsfa.1873","article-title":"Ferulic acid: Pharmaceutical functions, preparation and applications in foods","volume":"84","author":"Ou","year":"2004","journal-title":"J. Sci. Food Agric."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Teixeira, J., Gaspar, A., Garrido, E.M., Garrido, J., and Borges, F. (2013). Hydroxycinnamic Acid Antioxidants: An Electrochemical Overview. Biomed Res. Int., 1\u201311.","DOI":"10.1155\/2013\/251754"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1017\/S0007114507742666","article-title":"Bioavailability and antioxidant capacity of plant extracts rich in polyphenols, given as a single acute dose, in sheep made highly susceptible to lipoperoxidation","volume":"98","author":"Gladine","year":"2007","journal-title":"Br. J. Nutr."},{"key":"ref_66","first-page":"142","article-title":"Evaluaci\u00f3n de la capacidad antioxidante y contenido de compuestos fen\u00f3licos en recursos vegetales promisorios","volume":"73","year":"2007","journal-title":"Revista Sociedad Qu\u00edmica Per\u00fa"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3164\/jcbn.40.92","article-title":"Ferulic acid: Therapeutic potential through its antioxidant property","volume":"40","author":"Srinivasan","year":"2007","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/ajcn\/74.4.418","article-title":"Flavonoids: A review of probable mechanisms of action and potential applications","volume":"74","author":"Nijveldt","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.bcp.2006.08.001","article-title":"Therapeutic and preventive properties of quercetin in experimental arthritis correlate with decreased macrophage inflammatory mediators","volume":"72","author":"Kauss","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1093\/ndt\/gfr195","article-title":"Original Article Quercetin reduces cisplatin nephrotoxicity in rats without compromising its anti-tumour activity","volume":"26","author":"Morales","year":"2011","journal-title":"Nephrol. Dial. Transpl."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1016\/j.fct.2006.07.012","article-title":"Protective effect of quercetin on experimental chronic cadmium nephrotoxicity in rats is based on its antioxidant properties","volume":"44","author":"Morales","year":"2006","journal-title":"Food Chem. Toxicol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.taap.2005.09.006","article-title":"Effect of quercetin on metallothionein, nitric oxide synthases and cyclooxygenase-2 expression on experimental chronic cadmium nephrotoxicity in rats","volume":"210","author":"Morales","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_73","first-page":"24","article-title":"Antioxidant activity of coumarins","volume":"8","author":"Kadhum","year":"2017","journal-title":"Syst. Rev. Pharm."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.2174\/092986711803414395","article-title":"Coumarins as Antioxidants","volume":"18","author":"Kostova","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"887","DOI":"10.2174\/0929867053507315","article-title":"Simple Coumarins and Analogues in Medicinal Chemistry: Occurrence, Synthesis and Biological Activity","volume":"12","author":"Borges","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"ref_76","first-page":"44","article-title":"Estr\u00e9s oxidativo y da\u00f1o renal","volume":"8","author":"Castillo","year":"2003","journal-title":"CIMEL Ciencia Investigaci\u00f3n M\u00e9dica Estudiantil Latinoamericana"},{"key":"ref_77","first-page":"16","article-title":"Oxidative stress in hypertension-related renal failure","volume":"31","author":"Ruiz","year":"2012","journal-title":"Revista Cuba. Plantas Med."},{"key":"ref_78","first-page":"1","article-title":"Actividad antioxidante de extractos de diferente polaridad de Ageratum conyzoides L.","volume":"14","author":"Arana","year":"2015","journal-title":"Bolet\u00edn Latinoam. Caribe Plantas Med. Arom\u00e1ticas"},{"key":"ref_79","unstructured":"Apak, R., Capanoglu, E., and Shahidi, F. (2017). The Ferric Reducing\/Antioxidant Power (FRAP) Assay for Non-Enzymatic Antioxidant Capacity: Concepts, Procedures, Limitations and Applications. Measurement of Antioxidant Activity and Capacity: Recent Trends and Applications, John Wiley & Sons Ltd."},{"key":"ref_80","unstructured":"(2022, December 08). FRAP Antioxidant Assay: G-Biosciences. Available online: https:\/\/cdn.gbiosciences.com\/pdfs\/protocol\/FRAP_Assay.pdf."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0021-9258(18)84277-6","article-title":"On Tyrosine and Tryptophane determinations in Proteins","volume":"LXXIII","author":"Folin","year":"1927","journal-title":"J. Biol. Chem."},{"key":"ref_82","unstructured":"OECD (2002). Test No. 423: Acute Oral toxicity - Acute Toxic Class Method. OECD Guidelines for the Testing of Chemicals, OECD Publishing."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.1080\/14786419.2020.1758093","article-title":"Angiotensin-converting enzyme inhibitors from Salvia elegans Vahl","volume":"35","author":"Zamilpa","year":"2021","journal-title":"Nat. Prod. Res."}],"container-title":["Plants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2223-7747\/11\/24\/3460\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:37:42Z","timestamp":1760146662000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2223-7747\/11\/24\/3460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,10]]},"references-count":83,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["plants11243460"],"URL":"https:\/\/doi.org\/10.3390\/plants11243460","relation":{},"ISSN":["2223-7747"],"issn-type":[{"value":"2223-7747","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,10]]}}}