{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T02:43:44Z","timestamp":1779936224524,"version":"3.53.1"},"reference-count":45,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:00:00Z","timestamp":1673827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Fungi of the Candida genus are responsible for invasive candidiasis, which affects people all over the world and has high mortality rates. This is due to their virulence factors, which give them great resistance and pathogenicity. In addition, the emergence of multidrug-resistant strains makes it difficult to treat these infections. In this way, natural products have emerged as an alternative to standard drugs, where plants known for their medicinal properties such as Turnera subulata become attractive to research. The present work aimed to analyze the ethanol extract of Turnera subulata leaves against standard strains of Candida albicans, Candida krusei and Candida tropicalis using broth microdilution techniques. The identification of the compounds in T. subulata leaves by LC-MS revealed the presence of a wide variety of substances such as carboxylic acids and terpenes, with flavonoids and fatty acids being more evident. The antifungal assays showed that the extract was not able to inhibit the growth of the tested strains at concentrations with a clinical relevance. However, at higher concentrations, it was able to inhibit the fungal dimorphism of C. albicans and C. tropicalis. It is possible that the T. subulata extract has potential as an inhibitor of fungal virulence factors without affecting the cell viability. Further research should be carried out in order to assess its inhibitory potential for other fungal virulence factors.<\/jats:p>","DOI":"10.3390\/plants12020415","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T06:52:10Z","timestamp":1673851930000},"page":"415","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["LC-MS Analysis and Antifungal Activity of Turnera subulata Sm."],"prefix":"10.3390","volume":"12","author":[{"given":"Jacqueline Cosmo","family":"Andrade-Pinheiro","sequence":"first","affiliation":[{"name":"Pimenta Campus, Regional University of Cariri (URCA), Av. Cel Ant\u00f4nio Luis, 1161, Pimenta, Crato 63105-010, Brazil"},{"name":"Laborat\u00f3rio de Bioensaios, Federal University of Cariri (UFCA), R. Oleg\u00e1rio Emidio de Araujo, s\/n, Centro, Brejo Santo 63260-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celestina Elba","family":"Sobral de Souza","sequence":"additional","affiliation":[{"name":"Pimenta Campus, Regional University of Cariri (URCA), Av. Cel Ant\u00f4nio Luis, 1161, Pimenta, Crato 63105-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiany Alves","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Pimenta Campus, Regional University of Cariri (URCA), Av. Cel Ant\u00f4nio Luis, 1161, Pimenta, Crato 63105-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andressa de Alencar","family":"Silva","sequence":"additional","affiliation":[{"name":"Pimenta Campus, Regional University of Cariri (URCA), Av. Cel Ant\u00f4nio Luis, 1161, Pimenta, Crato 63105-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0581-2609","authenticated-orcid":false,"given":"Viviane Bezerra","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Botany, Federal University of Pernambuco (UFPE), Av. Prof. Moraes Rego, 1235, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia Thassya Lucas","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Pimenta Campus, Regional University of Cariri (URCA), Av. Cel Ant\u00f4nio Luis, 1161, Pimenta, Crato 63105-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Juno Alencar Fonseca","sequence":"additional","affiliation":[{"name":"Pimenta Campus, Regional University of Cariri (URCA), Av. 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Cel Ant\u00f4nio Luis, 1161, Pimenta, Crato 63105-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio J\u00fadson Targino","family":"Machado","sequence":"additional","affiliation":[{"name":"Pimenta Campus, Regional University of Cariri (URCA), Av. Cel Ant\u00f4nio Luis, 1161, Pimenta, Crato 63105-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Sampaio","family":"de Freitas","sequence":"additional","affiliation":[{"name":"Pimenta Campus, Regional University of Cariri (URCA), Av. Cel Ant\u00f4nio Luis, 1161, Pimenta, Crato 63105-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4084-8076","authenticated-orcid":false,"given":"Edy Sousa","family":"de Brito","sequence":"additional","affiliation":[{"name":"Embrapa Agroind\u00fastria Tropical, Tropical R. Pernambuco, 2270-Pici, Fortaleza 60511-110, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5258-4015","authenticated-orcid":false,"given":"Paulo Riceli Vasconcelos","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Embrapa Agroind\u00fastria Tropical, Tropical R. Pernambuco, 2270-Pici, Fortaleza 60511-110, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Galberto Martins","family":"da Costa","sequence":"additional","affiliation":[{"name":"Pimenta Campus, Regional University of Cariri (URCA), Av. Cel Ant\u00f4nio Luis, 1161, Pimenta, Crato 63105-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6634-4207","authenticated-orcid":false,"given":"Henrique Douglas Melo","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Pimenta Campus, Regional University of Cariri (URCA), Av. Cel Ant\u00f4nio Luis, 1161, Pimenta, Crato 63105-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1872-2381","authenticated-orcid":false,"given":"Gra\u017cyna","family":"Kowalska","sequence":"additional","affiliation":[{"name":"Department of Tourism and Recreation, University of Life Sciences in Lublin, 15 Akademicka Str., 20-950 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafa\u0142","family":"Rowi\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Tourism and Recreation, University of Life Sciences in Lublin, 15 Akademicka Str., 20-950 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3063-8710","authenticated-orcid":false,"given":"Rados\u0142aw","family":"Kowalski","sequence":"additional","affiliation":[{"name":"Department of Analysis and Food Quality Assessment, University of Life Sciences in Lublin, 8 Skromna Str., 20-704 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5898-1257","authenticated-orcid":false,"given":"Maria Flaviana Bezerra","family":"Morais-Braga","sequence":"additional","affiliation":[{"name":"Pimenta Campus, Regional University of Cariri (URCA), Av. 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