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L. as a source of high added value bioproducts. For that purpose, leaves and root ethanol extracts and fractions (chloroform, ethyl acetate, n-butanol, and water) were prepared and evaluated for radical scavenging activity (RSA) on 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2\u2032-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals, ferric reducing antioxidant power (FRAP), and metal chelating potential against copper and iron ions. Extracts were also appraised for in vitro inhibition of enzymes implicated on the onset of neurological diseases (acetylcholinesterase: AChE and butyrylcholinesterase: BuChE), type-2 diabetes mellitus (T2DM, \u03b1-glucosidase), obesity\/acne (lipase), and skin hyperpigmentation\/food oxidation (tyrosinase). The total content of phenolics (TPC), flavonoids (TFC), and hydrolysable tannins (THTC) was evaluated by colorimetric methods, while the phenolic profile was determined by high-performance liquid chromatography, coupled to a diode-array ultraviolet detector (HPLC-UV-DAD). Extracts had significant RSA and FRAP, and moderate copper chelation, but no iron chelating capacity. Samples had a higher activity towards \u03b1-glucosidase and tyrosinase, especially those from roots, a low capacity to inhibit AChE, and no activity towards BuChE and lipase. The ethyl acetate fraction of roots had the highest TPC and THTC, whereas the ethyl acetate fraction of leaves had the highest flavonoid levels. Gallic, gentisic, ferulic, and trans-cinnamic acids were identified in both organs. The results suggest that L. intricatum is a promising source of bioactive compounds with food, pharmaceutical, and biomedical applications.<\/jats:p>","DOI":"10.3390\/plants12050996","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T05:01:32Z","timestamp":1677042092000},"page":"996","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["New Insights into the Phytochemical Profile and Biological Properties of Lycium intricatum Bois. (Solanaceae)"],"prefix":"10.3390","volume":"12","author":[{"given":"Houaria","family":"Bendjedou","sequence":"first","affiliation":[{"name":"Faculty of Natural Sciences and Life, Department of Biology, University of Oran1, El M\u2019Naouer, P.O. Box 1524, Oran 31000, Algeria"},{"name":"Laboratory of Research in Arid Areas, University of Science and Technology Houari Boumediene, P.O. Box 32, Algiers 16111, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8987-2635","authenticated-orcid":false,"given":"Houari","family":"Benamar","sequence":"additional","affiliation":[{"name":"Faculty of Natural Sciences and Life, Department of Biology, University of Oran1, El M\u2019Naouer, P.O. Box 1524, Oran 31000, Algeria"},{"name":"Laboratory of Research in Arid Areas, University of Science and Technology Houari Boumediene, P.O. Box 32, Algiers 16111, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malika","family":"Bennaceur","sequence":"additional","affiliation":[{"name":"Faculty of Natural Sciences and Life, Department of Biology, University of Oran1, El M\u2019Naouer, P.O. Box 1524, Oran 31000, Algeria"},{"name":"Laboratory of Research in Arid Areas, University of Science and Technology Houari Boumediene, P.O. Box 32, Algiers 16111, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8732-710X","authenticated-orcid":false,"given":"Maria Jo\u00e3o","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Centre of Marine Sciences (CCMAR), Faculdade de Ci\u00eancias e Tecnologia, Universidade do Algarve, Ed. 7, Campus de Gambelas, 8005-139 Faro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1131-8773","authenticated-orcid":false,"given":"Catarina Guerreiro","family":"Pereira","sequence":"additional","affiliation":[{"name":"Centre of Marine Sciences (CCMAR), Faculdade de Ci\u00eancias e Tecnologia, Universidade do Algarve, Ed. 7, Campus de Gambelas, 8005-139 Faro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Trentin","sequence":"additional","affiliation":[{"name":"Centre of Marine Sciences (CCMAR), Faculdade de Ci\u00eancias e Tecnologia, Universidade do Algarve, Ed. 7, Campus de Gambelas, 8005-139 Faro, Portugal"},{"name":"Department of Biology, University of Padova, Via U. Bassi, 58\/B 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4338-7703","authenticated-orcid":false,"given":"Lu\u00edsa","family":"Cust\u00f3dio","sequence":"additional","affiliation":[{"name":"Centre of Marine Sciences (CCMAR), Faculdade de Ci\u00eancias e Tecnologia, Universidade do Algarve, Ed. 7, Campus de Gambelas, 8005-139 Faro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,22]]},"reference":[{"key":"ref_1","first-page":"1000129","article-title":"Antidiabetic and Safety of Lantana rhodesiensis in Alloxan Induced Diabetic Rats","volume":"4","author":"Piero","year":"2015","journal-title":"J. Dev. 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