{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T11:49:38Z","timestamp":1771501778445,"version":"3.50.1"},"reference-count":61,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Vector-Borne Diseases Research Group","award":["RG-2-1"],"award-info":[{"award-number":["RG-2-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>This study aimed to increase the therapeutic potential of medicinal plants through inoculation with endophytic fungi. As endophytes influence medicinal plants\u2019 biological properties, twenty fungal strains were isolated from the medicinal plant Ocimum tenuiflorum. Among all fungal isolates, the R2 strain showed the highest antagonistic activity towards plant pathogenic fungi Rosellinia necatrix and Fusarium oxysporum. The partial ITS region of the R2 strain was deposited in the GenBank nucleotide sequence databases under accession number ON652311 as Fusarium fujikuroi isolate R2 OS. To ascertain the impact of an endophytic fungus on the biological functions of medicinal plants, Stevia rebaudiana seeds were inoculated with Fusarium fujikuroi (ON652311). In the DPPH assay, the IC50 value of the inoculated Stevia plant extracts (methanol, chloroform, and positive control) was 72.082 \u00b5g\/mL, 85.78 \u00b5g\/mL, and 18.86 \u00b5g\/mL, respectively. In the FRAP assay, the IC50 value of the inoculated Stevia extracts (methanol, chloroform extract, and positive control) was 97.064 \u00b5M Fe2+ equivalents, 117.662 \u00b5M Fe2+ equivalents, and 53.384 \u00b5M Fe2+ equivalents, respectively. In the extracts of the plant inoculated with endophytic fungus, rutin and syringic acid (polyphenols) concentrations were 20.8793 mg\/L and 5.4389 mg\/L, respectively, which were higher than in the control plant extracts. This approach can be further utilized for other medicinal plants to increase their phytochemical content and hence medicinal potential in a sustainable way.<\/jats:p>","DOI":"10.3390\/plants12051151","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T01:43:00Z","timestamp":1677807780000},"page":"1151","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Improvement in the Phytochemical Content and Biological Properties of Stevia rebaudiana (Bertoni) Bertoni Plant Using Endophytic Fungi Fusarium fujikuroi"],"prefix":"10.3390","volume":"12","author":[{"given":"Reema","family":"Devi","sequence":"first","affiliation":[{"name":"School of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan 173229, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Abdulhaq","sequence":"additional","affiliation":[{"name":"Unit of Medical Microbiology, Department of Medical Lab Technology, Faculty of Applied Medical Sciences, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5321-9450","authenticated-orcid":false,"given":"Rachna","family":"Verma","sequence":"additional","affiliation":[{"name":"School of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan 173229, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2755-8640","authenticated-orcid":false,"given":"Kiran","family":"Sharma","sequence":"additional","affiliation":[{"name":"School of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan 173229, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3485-6408","authenticated-orcid":false,"given":"Dinesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"School of Bioengineering and Food Technology, Shoolini University of Biotechnology and Business Management, Solan 173229, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6805-8696","authenticated-orcid":false,"given":"Ajay","family":"Kumar","sequence":"additional","affiliation":[{"name":"Himalayan Forest Research Institute, Conifer Campus, Shimla 171013, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7267-0500","authenticated-orcid":false,"given":"Ashwani","family":"Tapwal","sequence":"additional","affiliation":[{"name":"Himalayan Forest Research Institute, Conifer Campus, Shimla 171013, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Yadav","sequence":"additional","affiliation":[{"name":"Shoolini Life Sciences, Private Limited, Solan 173229, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2077-1278","authenticated-orcid":false,"given":"Syam","family":"Mohan","sequence":"additional","affiliation":[{"name":"Substance Abuse and Toxicology Research Centre, Jazan University, Jazan 45142, Saudi Arabia"},{"name":"School of Health Sciences, University of Petroleum and Energy Studies, Dehradun 248007, India"},{"name":"Center for Transdisciplinary Research, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai 600077, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1590\/S1516-8913201402043","article-title":"Endophytes: Exploitation as a tool in plant protection","volume":"57","author":"Dutta","year":"2014","journal-title":"Braz. Arch. Biol. Technol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s41742-022-00439-0","article-title":"Role of endophytes in abiotic stress tolerance: With special emphasis on Serendipita indica","volume":"16","author":"Tyagi","year":"2022","journal-title":"Int. J. Environ. Rese."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.4014\/jmb.1305.05070","article-title":"Taxol production by an endophytic fungus, Fusarium redolens, isolated from Himalayan yew","volume":"23","author":"Garyali","year":"2013","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1929731","DOI":"10.1080\/15592324.2021.1929731","article-title":"Endophytic fungi stimulate the concentration of medicinal secondary metabolites in Houttuynia cordata thunb","volume":"16","author":"Ye","year":"2021","journal-title":"Plant Signal. Behavi."},{"key":"ref_5","first-page":"906","article-title":"A friendly relationship between endophytic fungi and medicinal plants: A systematic review","volume":"9","author":"Jia","year":"2016","journal-title":"Front Microbiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"8193","DOI":"10.1038\/s41598-020-65148-0","article-title":"New chlamydosporol derivatives from the endophytic fungus Pleosporales sp. Sigrf05 and their cytotoxic and antimicrobial activities","volume":"10","author":"Lai","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"6985","DOI":"10.1039\/D0RA00538J","article-title":"Lophiostomin A\u2013D: New 3, 4-dihydroisocoumarin derivatives from the endophytic fungus Lophiostoma sp. Sigrf10","volume":"10","author":"Mao","year":"2020","journal-title":"RSC Adv."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1099\/mic.0.019869-0","article-title":"Antioxidant enzyme activities in maize plants colonized with Piriformospora indica","volume":"155","author":"Kumar","year":"2009","journal-title":"Microbiology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00253-017-8679-5","article-title":"Secondary metabolism in Fusarium fujikuroi: Strategies to unravel the function of biosynthetic pathways","volume":"102","author":"Janevska","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_10","first-page":"125","article-title":"Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its pharmacological actions: A short review","volume":"49","author":"Prakash","year":"2005","journal-title":"Indian J. Physiol. Pharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4103\/0973-7847.65323","article-title":"Ocimum sanctum Linn. A reservoir plant for therapeutic applications: An overview","volume":"4","author":"Pattanayak","year":"2010","journal-title":"Pharmacogn. Rev."},{"key":"ref_12","first-page":"1","article-title":"Ocimum phytochemicals and their potential impact on human health","volume":"23","author":"Bhattacharjya","year":"2019","journal-title":"Phytochemicals in Human Health."},{"key":"ref_13","first-page":"1346","article-title":"Phytochemical efficiency of Ocimum sanctum (Tulsi) in health enhancement and disease prevention: A review","volume":"9","author":"Satyendra","year":"2020","journal-title":"IJARESM"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"112844","DOI":"10.1016\/j.indcrop.2020.112844","article-title":"Phytol, (E)-nerolidol and spathulenol from Stevia rebaudiana leaf essential oil as effective and eco-friendly botanical insecticides against Metopolophium dirhodum","volume":"155","author":"Benelli","year":"2020","journal-title":"Ind. Crop. Prod."},{"key":"ref_15","unstructured":"(2016, April 10). Available online: http:\/\/eagri.tnau.ac.in\/eagri50\/HORT282\/pdf\/lec34.pdF."},{"key":"ref_16","first-page":"915","article-title":"Sweet glycosides from the Stevia plant","volume":"22","author":"Crammer","year":"1986","journal-title":"Chem. Ber."},{"key":"ref_17","first-page":"1455","article-title":"Antimicrobial compounds from the endophytic fungus Fusarium sp. Ppf4 isolated from the medicinal plant Paris polyphylla var. yunnanensis","volume":"4","author":"Huang","year":"2009","journal-title":"Nat. Prod. Commun."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1094\/PDIS-09-18-1612-PDN","article-title":"First report of Rhizopus oryzae causing potato soft rot in the hebei province of China","volume":"103","author":"Cui","year":"2019","journal-title":"Plant Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s11274-018-2431-x","article-title":"Fungal endophytes of turmeric (Curcuma longa L.) and their biocontrol potential against pathogens Pythium aphanidermatum and Rhizoctonia solani","volume":"34","author":"Vinayarani","year":"2018","journal-title":"World J. Microbiol. Biotechnol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1046\/j.1469-8137.2000.00716.x","article-title":"Identification of endophytic fungi from Livistona chinensis based on morphology and rDNA sequences","volume":"147","author":"Guo","year":"2000","journal-title":"New Phytol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"74","DOI":"10.5943\/ppq\/5\/2\/6","article-title":"A rapid and efficient method of fungal genomic DNA extraction, suitable for PCR based molecular methods","volume":"5","author":"Aamir","year":"2015","journal-title":"Plant Pathol. Quar."},{"key":"ref_22","first-page":"1","article-title":"Antimicrobial and phytochemical screening of endophytic fungi isolated from spikes of Pinus roxburghii","volume":"6","author":"Bhardwaj","year":"2015","journal-title":"Arch. Clin. Microbiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/jam.13176","article-title":"Evaluation of antagonistic and plant growth promoting activities of chitinolytic endophytic actinomycetes associated with medicinal plants against Sclerotium rolfsii in chickpea","volume":"121","author":"Singh","year":"2016","journal-title":"J. Appl. Microbiol."},{"key":"ref_24","first-page":"4","article-title":"In Vitro propagation by axillary shoot proliferation, assessment of antioxidant activity, and genetic fidelity of micropropagated Paederia foetida L.","volume":"6","author":"Behera","year":"2018","journal-title":"J. Appl. Biol. Biotechnol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.foodchem.2004.12.004","article-title":"Screening of 70 medicinal plant extracts for antioxidant capacity and total phenols","volume":"94","author":"Katalinic","year":"2006","journal-title":"Food Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/abio.1996.0292","article-title":"The ferric reducing ability of plasma (FRAP) as a measure of \u201cantioxidant power\u201d: The FRAP assay","volume":"239","author":"Benzie","year":"1996","journal-title":"Anal. Biochem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1007\/s11033-020-05394-7","article-title":"Antibiofilm, antiproliferative, antioxidant and antimutagenic activities of an endophytic fungus Aspergillus fumigatus from Moringa oleifera","volume":"47","author":"Kaur","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13568-022-01408-8","article-title":"Harnessing endophytic fungi for biosynthesis of selenium nanoparticles and exploring their bioactivities","volume":"12","author":"Hussein","year":"2022","journal-title":"AMB Express"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13568-022-01386-x","article-title":"Bioprospecting endophytic fungi for bioactive metabolites and use of irradiation to improve their bioactivities","volume":"12","author":"Hazaa","year":"2022","journal-title":"AMB Express"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3468","DOI":"10.1007\/s12010-022-03876-x","article-title":"Antifungal activity of endophytic Aspergillus terreus extract against some fungi causing mucormycosis: Ultrastructural study","volume":"194","author":"Hashem","year":"2022","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1002\/mbo3.903","article-title":"Antioxidant activity of exo-metabolites produced by Fusarium oxysporum: An endophytic fungus isolated from leaves of Otobagracilipes","volume":"8","author":"Caicedo","year":"2019","journal-title":"Microbiol. Open"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3389\/fbioe.2020.00467","article-title":"Elucidating mechanisms of endophytes used in plant protection and other bioactivities with multifunctional prospects","volume":"8","author":"Fadiji","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_33","unstructured":"Eid, A.M., Salim, S.S., Hassan, S.E., Ismail, M.A., and Fouda, A. (2019). Microbiome in Plant Health and Disease, Springer."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Hoque, M.N., Tahjib-Ul-Arif, M., Hannan, A., Sultana, N., Akhter, S., Hasanuzzaman, M., Akter, F., Hossain, M.S., Sayed, M.A., and Hasan, M.T. (2021). Melatonin modulates plant tolerance to heavy metal stress: Morphological responses to molecular mechanisms. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111445"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13568-022-01414-w","article-title":"Effects of endophytic fungi on the secondary metabolites of Hordeum bogdanii under alkaline stress","volume":"12","author":"Han","year":"2022","journal-title":"AMB Express"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Hasanuzzaman, M., Bhuyan, M.B., Zulfiqar, F., Raza, A., Mohsin, S.M., Mahmud, J.A., Fujita, M., and Fotopoulos, V. (2020). Reactive oxygen species and antioxidant defense in plants under abiotic stress: Revisiting the crucial role of a universal defense regulator. Antioxidants, 9.","DOI":"10.3390\/antiox9080681"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/j.1469-8137.2009.03149.x","article-title":"Ethylene signalling and ethylene-targeted transcription factors are required to balance beneficial and nonbeneficial traits in the symbiosis between the endophytic fungus Piriformospora indica and Arabidopsis thaliana","volume":"185","author":"Camehl","year":"2010","journal-title":"New Phytol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.3389\/fpls.2021.791033","article-title":"Endophytic fungi: From symbiosis to secondary metabolite communications or vice versa?","volume":"12","author":"Alam","year":"2021","journal-title":"Front. Plant Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"10227","DOI":"10.1038\/s41598-018-26809-3","article-title":"Transcriptional responses of soybean roots to colonization with the root endophytic fungus Piriformospora indica reveals altered phenylpropanoid and secondary metabolism","volume":"8","author":"Bajaj","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1007\/s10529-015-1814-4","article-title":"Plants and endophytes: Equal partners in secondary metabolite production?","volume":"37","year":"2015","journal-title":"Biotechnol. Lett."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"12540","DOI":"10.1038\/s41598-017-12895-2","article-title":"Fungal endophyte-induced salidroside and tyrosol biosynthesis combined with signal cross-talk and the mechanism of enzyme gene expression in Rhodiola crenulata","volume":"7","author":"Cui","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.pbi.2018.01.010","article-title":"The fine balance between mutualism and antagonism in the Epichlo\u00eb festucae-grass symbiotic interaction","volume":"44","author":"Scott","year":"2018","journal-title":"Curr. Opin. Plant Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"16924","DOI":"10.1038\/s41598-017-17110-w","article-title":"Plant-endophytes interaction influences the secondary metabolism in Echinacea purpurea (L.) Moench: An in vitro model","volume":"7","author":"Maggin","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.30848\/PJB2020-5(10)","article-title":"Thermal stress alleviating potential of endophytic fungus Rhizopus oryzae inoculated to sunflower (Helianthus annuus L.) and soybean (Glycine max L.)","volume":"52","author":"Ismail","year":"2020","journal-title":"Pak. J. Bot."},{"key":"ref_45","first-page":"1337","article-title":"Effect of endophytic fungus, Piriformospora indica, on growth and activity of antioxidant enzymes of rice (Oryza sativa L.) under salinity stress","volume":"1","author":"Bagheri","year":"2013","journal-title":"Int. J. Adv. Biol. Biomed. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s11738-016-2153-3","article-title":"Trichoderma atroviride ID20G inoculation ameliorates drought stress-induced damages by improving antioxidant defence in maize seedlings","volume":"38","author":"Guler","year":"2016","journal-title":"Acta. Physiologiae. Plantarum."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.15244\/pjoes\/125770","article-title":"An endophytic fungus Gliocladium cibotii regulates metabolic and antioxidant system of Glycine max and Helianthus annuus under heat stress","volume":"30","author":"Hamayun","year":"2021","journal-title":"Pol. J. Environ. Stud."},{"key":"ref_48","first-page":"61","article-title":"Yearly variation in biochemical composition, morphological aspects, and antimicrobial activities of Justicia adhatoda L. growing wildly in Western Himalayas","volume":"11","author":"Jamwal","year":"2022","journal-title":"J. Appl. Biol. Biotechnol."},{"key":"ref_49","first-page":"201","article-title":"Rutin content in plant products","volume":"44","author":"Atanassova","year":"2009","journal-title":"J. Chem. Technol. Metall."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/srt.12265","article-title":"Rutin increases critical wavelength of systems containing a single UV filter and with good skin compatibility","volume":"22","author":"Peres","year":"2016","journal-title":"Skin Res. Technol."},{"key":"ref_51","first-page":"164","article-title":"Influence of extraction process on antioxidant activity and rutin content in Physalis peruviana calyces extract","volume":"7","author":"Cardona","year":"2017","journal-title":"J. Appl. Pharm. Sci."},{"key":"ref_52","first-page":"1","article-title":"Potential impact of seed coating with beneficial microorganisms to meticulousness sustainable organic agriculture for quality nutritive food production for modern lifestyle, improve global soil and environmental health towards green technology","volume":"2","author":"Prasad","year":"2021","journal-title":"Aditum J. Clin. Biomed. Res."},{"key":"ref_53","first-page":"3217","article-title":"Volatile metabolites analysis and molecular identification of endophytic fungi bn12 from Cinnamomum camphora chvar. borneol","volume":"36","author":"Chen","year":"2011","journal-title":"China Chin. Med. J."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.procbio.2013.01.014","article-title":"Preparation, structural characterization and antioxidant activity of an extracellular polysaccharide produced by the fungus Oidiodendron truncatum GW","volume":"48","author":"Guo","year":"2013","journal-title":"Process Biochem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/jipb.13054","article-title":"Contribution of phenylpropanoid metabolism to plant development and plant\u2013environment interactions","volume":"63","author":"Dong","year":"2020","journal-title":"J. Int. Plant Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"7967","DOI":"10.1039\/C9FO02127B","article-title":"Angiotensin-converting enzyme inhibiting ability of ethanol extracts, steviol glycosides and protein hydrolysates from Stevia leaves","volume":"10","author":"Wang","year":"2019","journal-title":"Food Fun"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.sajb.2021.07.041","article-title":"Fungal endophytes from medicinal plant Bletilla striata (Thunb.) Reichb. F. promote the host plant growth and phenolic accumulation","volume":"143","author":"Chen","year":"2021","journal-title":"South African J. Bot."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.scienta.2017.04.002","article-title":"Inducing phenolic production and volatile organic compounds emission by inoculating Mentha piperita with plant growth-promoting Rhizobacteria","volume":"220","author":"Cappellari","year":"2017","journal-title":"Sci. Hortic."},{"key":"ref_59","first-page":"6770","article-title":"Antibacterial and antimutagenic activity of extracts aboveground parts of three Solidago species: Solidago Virgaurea L., Solidago Canadensis L. and Solidago Gigantea Ait","volume":"5","author":"Kowalski","year":"2011","journal-title":"J. Med. Plants Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1007\/s12161-017-1015-y","article-title":"UHPLC-DAD multi-method for determination of phenolics in aromatic plants","volume":"11","author":"Oliveira","year":"2018","journal-title":"Food Anal."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jpba.2018.09.046","article-title":"New insights into phenol and polyphenol composition of Stevia rebaudiana leaves","volume":"163","author":"Pacifico","year":"2019","journal-title":"J. Pharmed. Biomed. Anal."}],"container-title":["Plants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2223-7747\/12\/5\/1151\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:46:45Z","timestamp":1760122005000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2223-7747\/12\/5\/1151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,3]]},"references-count":61,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["plants12051151"],"URL":"https:\/\/doi.org\/10.3390\/plants12051151","relation":{},"ISSN":["2223-7747"],"issn-type":[{"value":"2223-7747","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,3]]}}}