{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:22:13Z","timestamp":1789683733241,"version":"4.0.1"},"reference-count":49,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T00:00:00Z","timestamp":1680912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordination for the Improvement of Higher","award":["88887.568504\/2020-00"],"award-info":[{"award-number":["88887.568504\/2020-00"]}]},{"name":"CAPES\/BRASIL Scholar ship-Project","award":["88887.568504\/2020-00"],"award-info":[{"award-number":["88887.568504\/2020-00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus are the primary bacteria that cause clinical infections, such as urinary and intestinal infections, pneumonia, endocarditis, and sepsis. Bacterial resistance is an innate natural occurrence in microorganisms, resulting from mutations or the lateral exchange of genetic material. This serves as evidence for the association between drug consumption and pathogen resistance. Evidence has demonstrated that the association between conventional antibiotics and natural products is a promising pharmacological strategy to overcome resistance mechanisms. Considering the large body of research demonstrating the significant antimicrobial activities of Schinus terebinthifolius Raddi, the present study aimed to evaluate the chemical composition and antibiotic-enhancing effects of Schinus terebinthifolius Raddi essential oil (STEO) against the standard and multidrug-resistant strains of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The STEO was extracted by hydrodistillation using a Clevenger-type vacuum rotary evaporator. The Minimum Inhibitory Concentration (MIC) of the STEO was assessed by the microdilution method to evaluate the antibacterial activity. The antibiotic-enhancing activity of the essential oil was assessed by determining the MIC of antibiotics in the presence of a sub-inhibitory concentration (MIC\/8) of the natural product. The GC-MS analysis revealed alpha-pinene (24.3%), gamma-muurolene (16.6%), and myrcene (13.7%) as major constituents of the STEO. The STEO potentiated the enhanced antibacterial activity of norfloxacin and gentamicin against all the strains and increased the action of penicillin against the Gram-negative strains. Therefore, it is concluded that although the STEO does not exhibit clinically effective antibacterial activity, its association with conventional antibiotics results in enhanced antibiotic activity.<\/jats:p>","DOI":"10.3390\/plants12081587","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T03:15:57Z","timestamp":1681096557000},"page":"1587","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Antibiotic-Potentiating Activity of the Schinus terebinthifolius Raddi Essential Oil against MDR Bacterial Strains"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0676-4813","authenticated-orcid":false,"given":"Maria Milene","family":"Costa da Silva","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Regional University of Cariri\u2014URCA, Rua Cel. Antonio Luis 1161, Pimenta, Crato 63105-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1240-3654","authenticated-orcid":false,"given":"Jos\u00e9","family":"Bezerra de Ara\u00fajo Neto","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Regional University of Cariri\u2014URCA, Rua Cel. Antonio Luis 1161, Pimenta, Crato 63105-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia Thassya","family":"Lucas dos Santos","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Regional University of Cariri\u2014URCA, Rua Cel. Antonio Luis 1161, Pimenta, Crato 63105-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00edcera Datiane","family":"de Morais Oliveira-Tintino","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, Regional University of Cariri\u2014URCA, Rua Cel. Antonio Luis 1161, Pimenta, Crato 63105-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina Justino","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, Regional University of Cariri\u2014URCA, Rua Cel. Antonio Luis 1161, Pimenta, Crato 63105-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla Ramos","family":"Freitas","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, Regional University of Cariri\u2014URCA, Rua Cel. Antonio Luis 1161, Pimenta, Crato 63105-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2332-3553","authenticated-orcid":false,"given":"Luiz Everson","family":"da Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Sustainable Territorial Development, Coastal Sector, Federal University of Paran\u00e1, Curitiba 80060-000, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanderlei","family":"do Amaral","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Sustainable Territorial Development, Coastal Sector, Federal University of Paran\u00e1, Curitiba 80060-000, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00edcero","family":"Deschamps","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Sustainable Territorial Development, Coastal Sector, Federal University of Paran\u00e1, Curitiba 80060-000, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Roberto","family":"de Azevedo","sequence":"additional","affiliation":[{"name":"Centro de Ciencias Agrarias e da Biodiversidade, Federal University of Cariri\u2014UFCA, Crato 63048-080, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3150-9139","authenticated-orcid":false,"given":"Clara Mariana","family":"Gon\u00e7alves Lima","sequence":"additional","affiliation":[{"name":"Department of Food Science, Federal University of Lavras, Lavras 37203-202, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadezhda","family":"Golubkina","sequence":"additional","affiliation":[{"name":"Federal Scientific Center of Vegetable Production, Selectsionnaya 14, VNIISSOK, Odintsovo District, 143072 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Tavares","family":"Calixto-J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Regional University of Cariri\u2014URCA, Rua Cel. Antonio Luis 1161, Pimenta, Crato 63105-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3126-6509","authenticated-orcid":false,"given":"Jaime","family":"Ribeiro-Filho","sequence":"additional","affiliation":[{"name":"Oswaldo Cruz Foundation (Fiocruz), Fiocruz Cear\u00e1, Eus\u00e9bio 61773-270, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6634-4207","authenticated-orcid":false,"given":"Henrique Douglas Melo","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, Regional University of Cariri\u2014URCA, Rua Cel. Antonio Luis 1161, Pimenta, Crato 63105-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Caruso","sequence":"additional","affiliation":[{"name":"Department of Agricultural Sciences, University of Naples Federico II, 80055 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7733-9331","authenticated-orcid":false,"given":"Saulo Relison","family":"Tintino","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Regional University of Cariri\u2014URCA, Rua Cel. 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