{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:27:53Z","timestamp":1785130073842,"version":"3.55.0"},"reference-count":96,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Species belonging to the genus Lippia are used worldwide as foods, beverages, and seasonings. Studies have demonstrated that these species have antioxidant, sedative, analgesic, anti-inflammatory, and antipyretic activities. This work aimed to evaluate the antibacterial activity and anxiolytic effect by different pathways of essential oils and ethanolic extracts of three species of Lippia (Lippia alba, Lippia sidoides, and Lippia gracilis). The ethanolic extracts were characterized by HPLC-DAD-ESI-MSn and their phenolics were quantified. The antibacterial activity was evaluated by determining the minimal inhibitory concentration and modulation of antibiotic activity, and toxic and anxiolytic effects were evaluated in the zebrafish model. The extracts showed compositions with a low ratio and shared compounds. L. alba and L. gracilis showed higher amounts of phenols and flavonoids, respectively. All extracts and essential oils presented antibacterial activity, especially those obtained from L. sidoides. On the other hand, L. alba extract presented the most significant antibiotic-enhancing effect. The samples were not toxic after 96 h of exposure, but showed an anxiolytic effect through modulation of the GABAA receptor, while L. alba extract acted via modulation of the 5-HT receptor. This new pharmacological evidence opens horizons for therapeutic approaches targeting anxiolytic and antibacterial therapies and food conservation using these species and their constituents.<\/jats:p>","DOI":"10.3390\/plants12081675","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T06:27:47Z","timestamp":1681712867000},"page":"1675","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Antibacterial Activity and Anxiolytic Effect in Adult Zebrafish of Genus Lippia L. Species"],"prefix":"10.3390","volume":"12","author":[{"given":"Carla de Fatima Alves","family":"Nonato","sequence":"first","affiliation":[{"name":"Postgraduate Program in Biological Chemistry, Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, CE, Brazil"},{"name":"Research Laboratory of Natural Products, Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emerson Vinicius Silva","family":"de Melo","sequence":"additional","affiliation":[{"name":"Research Laboratory of Natural Products, Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cicera Janaine","family":"Camilo","sequence":"additional","affiliation":[{"name":"Research Laboratory of Natural Products, Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Kueirislene Am\u00e2ncio","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biotechnology, Northeast Biotechnology Network, State University of Cear\u00e1, Fortaleza 60714-903, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane Eire Alencar","family":"de Meneses","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biotechnology, Northeast Biotechnology Network, State University of Cear\u00e1, Fortaleza 60714-903, CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1686-1644","authenticated-orcid":false,"given":"Antonio Wlisses","family":"da Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Natural Sciences, State University of Cear\u00e1, Fortaleza 60714-903, CE, 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