{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:17:39Z","timestamp":1767907059071,"version":"3.49.0"},"reference-count":43,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordination for the Improvement of Higher Education Personnel","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Coordination for the Improvement of Higher Education Personnel","award":["88887.363006\/2019-00"],"award-info":[{"award-number":["88887.363006\/2019-00"]}]},{"name":"Coordination for the Improvement of Higher Education Personnel","award":["CNPq 315225\/2021-1"],"award-info":[{"award-number":["CNPq 315225\/2021-1"]}]},{"name":"Coordination for the Improvement of Higher Education Personnel","award":["CNPq 313348\/2021-9"],"award-info":[{"award-number":["CNPq 313348\/2021-9"]}]},{"name":"Oswaldo Cruz Institute\/FIOCRUZ","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Oswaldo Cruz Institute\/FIOCRUZ","award":["88887.363006\/2019-00"],"award-info":[{"award-number":["88887.363006\/2019-00"]}]},{"name":"Oswaldo Cruz Institute\/FIOCRUZ","award":["CNPq 315225\/2021-1"],"award-info":[{"award-number":["CNPq 315225\/2021-1"]}]},{"name":"Oswaldo Cruz Institute\/FIOCRUZ","award":["CNPq 313348\/2021-9"],"award-info":[{"award-number":["CNPq 313348\/2021-9"]}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","award":["88887.363006\/2019-00"],"award-info":[{"award-number":["88887.363006\/2019-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","award":["CNPq 315225\/2021-1"],"award-info":[{"award-number":["CNPq 315225\/2021-1"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","award":["CNPq 313348\/2021-9"],"award-info":[{"award-number":["CNPq 313348\/2021-9"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"productivity scholarship PQ-2","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"productivity scholarship PQ-2","award":["88887.363006\/2019-00"],"award-info":[{"award-number":["88887.363006\/2019-00"]}]},{"name":"productivity scholarship PQ-2","award":["CNPq 315225\/2021-1"],"award-info":[{"award-number":["CNPq 315225\/2021-1"]}]},{"name":"productivity scholarship PQ-2","award":["CNPq 313348\/2021-9"],"award-info":[{"award-number":["CNPq 313348\/2021-9"]}]},{"name":"productivity scholarship PQ-2","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"productivity scholarship PQ-2","award":["88887.363006\/2019-00"],"award-info":[{"award-number":["88887.363006\/2019-00"]}]},{"name":"productivity scholarship PQ-2","award":["CNPq 315225\/2021-1"],"award-info":[{"award-number":["CNPq 315225\/2021-1"]}]},{"name":"productivity scholarship PQ-2","award":["CNPq 313348\/2021-9"],"award-info":[{"award-number":["CNPq 313348\/2021-9"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>New agents that can suppress inflammatory responses are being sought, since chronic inflammation is associated with several pathologies. This work aims to elucidate phytochemicals from the hydroethanolic extract of mistletoe Passovia ovata (POH) and its anti-inflammatory potential. POH is submitted to HPLC-UV, qualitative analysis of chemical constituents, and flavonoid quantification. Cytotoxicity is evaluated in RAW 264.7 macrophages by MTT. LPS-stimulated RAW 264.7 cells are treated with POH and, after 48 h, the nitrite and cytokine levels are quantified. BALB\/c mice are treated by gavage with POH and stimulated with \u03bb-carrageenan to induce paw oedema or peritonitis. POH yield is 25% with anthraquinones, tannins, anthocyanins, anthocyanidins, flavonols, catechins and flavanones present and flavonoid content of 4.44 \u00b1 0.157 mg QE\/g dry weight. POH exhibits low cytotoxicity and significantly reduced (p &lt; 0.01) nitrite, IL-1\u03b2, IL-6, and TNF-\u03b1 quantification at 500 \u03bcg\/mL. POH at 500 mg\/kg prevents paw edema increase and also reduces inflammatory infiltrate and mast cells in the footpad. In the peritonitis model, POH does not influence cytokines levels or cell counts. Overall, POH demonstrates a high concentration of flavonoids and prominent effects in the reduction in pro-inflammatory markers in vitro and in the inhibition of paw oedema.<\/jats:p>","DOI":"10.3390\/plants12091814","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T06:12:55Z","timestamp":1682662375000},"page":"1814","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Passovia ovata Mistletoe on Pro-Inflammatory Markers In Vitro and In Vivo"],"prefix":"10.3390","volume":"12","author":[{"given":"Isadora de F\u00e1tima Braga","family":"Magalh\u00e3es","sequence":"first","affiliation":[{"name":"Postgraduate Program in Animal Science, State University of Maranh\u00e3o, Sao Luis 65055-310, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Let\u00edcia Marinho","family":"Figueir\u00eado","sequence":"additional","affiliation":[{"name":"Veterinary Medicine Graduation School, State University of Maranh\u00e3o, Sao Luis 65055-310, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizeu Mendes","family":"da Silva","sequence":"additional","affiliation":[{"name":"Veterinary Medicine Graduation School, State University of Maranh\u00e3o, Sao Luis 65055-310, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adryan Adam Batalha","family":"de Miranda","sequence":"additional","affiliation":[{"name":"Veterinary Medicine Graduation School, State University of Maranh\u00e3o, Sao Luis 65055-310, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3578-1869","authenticated-orcid":false,"given":"Cl\u00e1udia Quintino","family":"da Rocha","sequence":"additional","affiliation":[{"name":"Postgraduate Programs in Chemistry, Federal University of Maranh\u00e3o, S\u00e3o Lu\u00eds 65080-805, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katia","family":"da Silva Calabrese","sequence":"additional","affiliation":[{"name":"Laboratory of Immunomodulation and Protozoology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21041-250, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0047-6159","authenticated-orcid":false,"given":"Fernando","family":"Almeida-Souza","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Animal Science, State University of Maranh\u00e3o, Sao Luis 65055-310, Brazil"},{"name":"Laboratory of Immunomodulation and Protozoology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21041-250, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2167-3725","authenticated-orcid":false,"given":"Ana L\u00facia","family":"Abreu-Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Animal Science, State University of Maranh\u00e3o, Sao Luis 65055-310, Brazil"},{"name":"Veterinary Medicine Graduation School, State University of Maranh\u00e3o, Sao Luis 65055-310, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e12812","DOI":"10.1111\/sji.12812","article-title":"Decoding inflammation, its causes, genomic responses, and emerging countermeasures","volume":"90","author":"Hawiger","year":"2019","journal-title":"Scand. 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