{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:58:35Z","timestamp":1791889115059,"version":"4.3.4"},"reference-count":43,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2023,7,23]],"date-time":"2023-07-23T00:00:00Z","timestamp":1690070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ERASMUS PLUS program"},{"name":"Tunisian Minister of Higher Education and Scientific Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Prunus dulcis is one of the most widely cultivated species in the world. Its fruit (almond) is rich in various nutritious and bioactive compounds that exert several beneficial effects. The aim of this study was to determine the chemical profile and evaluate the biological potential in vitro of almond shell extracts. The chemical analysis of shell extracts led to the identification of 15 compounds by HPLC-DAD, of which 11 were first detected in the almond plant. Twenty-six volatile compounds were identified by the GC-MS technique; among them, seven were firstly detected in the studied plant. For the biological activities, the extracts demonstrated moderate inhibition potential against the antioxidant, antidiabetic, and cytotoxic activities. The methanol extract at 50 \u00b5g\/mL showed the highest antioxidant (45%) and antidiabetic activities (45% against alpha-glucosidase and 31% against alpha-amylase extracts), while the cyclohexane and dichloromethane at 50 \u00b5g\/mL showed the highest cytotoxic activity towards Hela (32.2% with cyclohexane) and RAW 264-7 (45% with dichloromethane). Overall, these findings demonstrate the potential of almond shell extracts as a source of bioactive compounds that could be applied in the pharmaceutical and medical fields.<\/jats:p>","DOI":"10.3390\/plants12142733","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T01:12:28Z","timestamp":1690161148000},"page":"2733","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Phytochemical Profiling and Biological Potential of Prunus dulcis Shell Extracts"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0927-5604","authenticated-orcid":false,"given":"Talel","family":"Ben Khadher","sequence":"first","affiliation":[{"name":"Laboratoire de G\u00e9nie Chimique, Universit\u00e9 de Toulouse, CNRS, INP, UPS, F-31062 Toulouse, France"},{"name":"Laboratory of Biodiversity and Valorization of Bioressources in Arid Zones, Faculty of Sciences, The University of Gabes, Zrig, Gabes 6072, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7718-8847","authenticated-orcid":false,"given":"Sameh","family":"Sassi-Aydi","sequence":"additional","affiliation":[{"name":"Laboratory of Biodiversity and Valorization of Bioressources in Arid Zones, Faculty of Sciences, The University of Gabes, Zrig, Gabes 6072, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6343-6501","authenticated-orcid":false,"given":"Samir","family":"Aydi","sequence":"additional","affiliation":[{"name":"Laboratory of Biodiversity and Valorization of Bioressources in Arid Zones, Faculty of Sciences, The University of Gabes, Zrig, Gabes 6072, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Mars","sequence":"additional","affiliation":[{"name":"Laboratory of Biodiversity and Valorization of Bioressources in Arid Zones, Faculty of Sciences, The University of Gabes, Zrig, Gabes 6072, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2439-5145","authenticated-orcid":false,"given":"Jalloul","family":"Bouajila","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9nie Chimique, Universit\u00e9 de Toulouse, CNRS, INP, UPS, F-31062 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.lwt.2015.08.076","article-title":"Phytochemical Investigations and Evaluation of Antidiabetic Potential of Prunus dulcis Nuts","volume":"66","author":"Qureshi","year":"2016","journal-title":"LWT Food Sci. 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