{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:31:29Z","timestamp":1790994689729,"version":"4.1.0"},"reference-count":354,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T00:00:00Z","timestamp":1692316800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Economy and Competitiveness","award":["TED2021-129932B-C21"],"award-info":[{"award-number":["TED2021-129932B-C21"]}]},{"name":"Spanish Ministry of Economy and Competitiveness","award":["PID2021-125188OB-C32"],"award-info":[{"award-number":["PID2021-125188OB-C32"]}]},{"name":"Spanish Ministry of Economy and Competitiveness","award":["INNEST\/2022\/103"],"award-info":[{"award-number":["INNEST\/2022\/103"]}]},{"name":"Spanish Ministry of Economy and Competitiveness","award":["2021\/2023"],"award-info":[{"award-number":["2021\/2023"]}]},{"name":"Agencia Valenciana de la Innovaci\u00f3n","award":["TED2021-129932B-C21"],"award-info":[{"award-number":["TED2021-129932B-C21"]}]},{"name":"Agencia Valenciana de la Innovaci\u00f3n","award":["PID2021-125188OB-C32"],"award-info":[{"award-number":["PID2021-125188OB-C32"]}]},{"name":"Agencia Valenciana de la Innovaci\u00f3n","award":["INNEST\/2022\/103"],"award-info":[{"award-number":["INNEST\/2022\/103"]}]},{"name":"Agencia Valenciana de la Innovaci\u00f3n","award":["2021\/2023"],"award-info":[{"award-number":["2021\/2023"]}]},{"name":"Requalification of the Spanish University System","award":["TED2021-129932B-C21"],"award-info":[{"award-number":["TED2021-129932B-C21"]}]},{"name":"Requalification of the Spanish University System","award":["PID2021-125188OB-C32"],"award-info":[{"award-number":["PID2021-125188OB-C32"]}]},{"name":"Requalification of the Spanish University System","award":["INNEST\/2022\/103"],"award-info":[{"award-number":["INNEST\/2022\/103"]}]},{"name":"Requalification of the Spanish University System","award":["2021\/2023"],"award-info":[{"award-number":["2021\/2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Cistus albidus L. (Cistaceae) is a medicinal plant that has been used therapeutically since ancient times in the Mediterranean basin for its important pharmacological properties. The ability of C. albidus to produce large quantities of a wide range of natural metabolites makes it an attractive source of raw material. The main constituents with bioactive functions that exert pharmacological effects are terpenes and polyphenols, with more than 200 identified compounds. The purpose of this review is to offer a detailed account of the botanical, ethnological, phytochemical, and pharmacological characteristics of C. albidus with the aim of encouraging additional pharmaceutical investigations into the potential therapeutic benefits of this medicinal plant. This review was carried out using organized searches of the available literature up to July 2023. A detailed analysis of C. albidus confirms its traditional use as a medicinal plant. The outcome of several studies suggests a deeper involvement of certain polyphenols and terpenes in multiple mechanisms such as inflammation and pain, with a potential application focus on neurodegenerative diseases and disorders. Other diseases such as prostate cancer and leukemia have already been researched with promising results for this plant, for which no intoxication has been reported in humans.<\/jats:p>","DOI":"10.3390\/plants12162988","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T01:38:31Z","timestamp":1692581911000},"page":"2988","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Cistus albidus L.\u2014Review of a Traditional Mediterranean Medicinal Plant with Pharmacological Potential"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2999-7348","authenticated-orcid":false,"given":"Daniel","family":"Raus de Baviera","sequence":"first","affiliation":[{"name":"Department of Engineering, Area of Agroforestry, Miguel Hern\u00e1ndez University, 03312 Orihuela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Ruiz-Canales","sequence":"additional","affiliation":[{"name":"Department of Engineering, Area of Agroforestry, Miguel Hern\u00e1ndez University, 03312 Orihuela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8113-0795","authenticated-orcid":false,"given":"Enrique","family":"Barraj\u00f3n-Catal\u00e1n","sequence":"additional","affiliation":[{"name":"Institute for Research, Development and Innovation in Health Biotechnology, Miguel Hern\u00e1ndez University, 03202 Elche, Spain"},{"name":"Department of Pharmacy, Elche University Hospital-FISABIO, 03203 Elche, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.ympev.2005.04.026","article-title":"Systematics, Character Evolution, and Biogeography of Cistus L. (Cistaceae) Based on ITS, TrnL-TrnF, and MatK Sequences","volume":"37","author":"Vargas","year":"2005","journal-title":"Mol. Phylogenet. Evol."},{"key":"ref_2","unstructured":"Schubert, R., and Wagner, G. (1984). Pflanzennamen Und Botanische Fachw\u00f6rter: Botanisches Lexikon, Neumann-Neudamm. 8., neubearbeitete und erw. Aufl."},{"key":"ref_3","unstructured":"Schmidt, W. (1999). Geh\u00f6lze f\u00fcr Mediterrane G\u00e4rten, Ulmer. Hortus Mediterraneus."},{"key":"ref_4","unstructured":"Coombes, A.J. (1994). Dictionary of Plant Names, Hamlyn. [New ed.]."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/pca.1281","article-title":"A Systematic Study of the Polyphenolic Composition of Aqueous Extracts Deriving from Several Cistus Genus Species: Evolutionary Relationship: Polyphenolic Characterization of Cistus Aqueous Extracts","volume":"22","author":"Saura","year":"2011","journal-title":"Phytochem. Anal."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1007\/s10886-008-9515-2","article-title":"Production and Diversity of Volatile Terpenes from Plants on Calcareous and Siliceous Soils: Effect of Soil Nutrients","volume":"34","author":"Baldy","year":"2008","journal-title":"J. Chem. Ecol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0367-2530(17)30692-8","article-title":"Leaf Trichomes in the Genus Cistus","volume":"191","author":"Herrmann","year":"1996","journal-title":"Flora"},{"key":"ref_8","unstructured":"Pardo de Santayana, M. (2014). Inventario Espa\u00f1ol de los Conocimientos Tradicionales Relativos de la Biodiversidad: Primera fase: Introducci\u00f3n, Metodolog\u00eda y Fichas, Ministerio para la Transici\u00f3n Ecol\u00f3gica."},{"key":"ref_9","unstructured":"Verde, A., Fajardo, J., Ob\u00f3n, C., Cebr\u00edan, F., and Rivera, D. (2008). Gu\u00eda de las Plantas Medicinales de Castilla-La Mancha, Altab\u00e1n Ediciones."},{"key":"ref_10","unstructured":"Mulet Pascual, L. (1991). Estudio Etnobot\u00e1nico de La Provincia de Castell\u00f3n, Diputaci\u00f3n de Castell\u00f3n."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Lukas, B., Jovanovic, D., Schmiderer, C., Kostas, S., Kanellis, A., G\u00f3mez Navarro, J., Ayta\u00e7, Z., Ko\u00e7, A., S\u00f6zen, E., and Novak, J. (2021). Intraspecific Genetic Diversity of Cistus creticus L. and Evolutionary Relationships to Cistus albidus L. (Cistaceae): Meeting of the Generations?. Plants, 10.","DOI":"10.3390\/plants10081619"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e2100053","DOI":"10.1002\/cbdv.202100053","article-title":"Analytical Profiling of Phenolic Compounds in Extracts of Three Cistus Species from Sardinia and Their Potential Antimicrobial and Antioxidant Activity","volume":"18","author":"Mastino","year":"2021","journal-title":"Chem. Biodivers."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jep.2017.07.012","article-title":"The Flavonol-Enriched Cistus albidus Chloroform Extract Possesses in Vivo Anti-Inflammatory and Anti-Nociceptive Activity","volume":"209","author":"Tahiri","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.3987\/COM-16-13557","article-title":"Synthesis of Prodelphinidin Trimer Isolated from Cistus albidus and Its Growth Inhibitory Activity Against Human Prostate Cancer Cell Lines","volume":"92","author":"Makabe","year":"2016","journal-title":"Heterocycles"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"159860","DOI":"10.1016\/j.scitotenv.2022.159860","article-title":"Silvicultural Management and Altitude Prevail on Soil Properties and Fungal Community in Shaping Understorey Plant Communities in a Mediterranean Pine Forest","volume":"858","author":"Centenaro","year":"2023","journal-title":"Sci. Total Environ."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"115603","DOI":"10.1016\/j.geoderma.2021.115603","article-title":"Changes in Soil Functionality Eight Years after Fire and Post-Fire Hillslope Stabilisation in Mediterranean Forest Ecosystems","volume":"409","author":"Jing","year":"2022","journal-title":"Geoderma"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/rem.21638","article-title":"Zinc, Lead, and Cadmium Tolerance and Accumulation in Cistus libanotis, Cistus albidus and Cistus salviifolius: Perspectives on Phytoremediation","volume":"30","author":"Mouna","year":"2020","journal-title":"Remediat. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00606-011-0458-7","article-title":"Molecular Systematics, Character Evolution, and Pollen Morphology of Cistus and Halimium (Cistaceae)","volume":"295","author":"Civeyrel","year":"2011","journal-title":"Plant Syst. Evol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00425-014-2221-0","article-title":"Redox Proteomics and Physiological Responses in Cistus albidus Shrubs Subjected to Long-Term Summer Drought Followed by Recovery","volume":"241","author":"Brossa","year":"2015","journal-title":"Planta"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s00425-021-03570-y","article-title":"Linking Jasmonates with Vitamin E Accumulation in Plants: A Case Study in the Mediterranean Shrub Cistus albidus L.","volume":"253","author":"Bouchikh","year":"2021","journal-title":"Planta"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Guzm\u00e1n, B., Lled\u00f3, M.D., and Vargas, P. (2009). Adaptive Radiation in Mediterranean Cistus (Cistaceae). PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0006362"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/plb.12207","article-title":"Zeatin Modulates Flower Bud Development and Tocopherol Levels in Cistus albidus (L.) Plants as They Age","volume":"17","author":"Miret","year":"2015","journal-title":"Plant Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.flora.2019.02.003","article-title":"Phenological and Genetic Characterization of Mediterranean Plants at the Peripheral Range: The Case of Cistus albidus near Lake Garda","volume":"252","author":"Bertolasi","year":"2019","journal-title":"Flora"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1071\/FP05245","article-title":"Genetic Diversity of Cistus albidus in South-East Spain Does Not Relate to Mesoclimate","volume":"33","author":"Grant","year":"2006","journal-title":"Funct. Plant Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1111\/j.1365-2699.2008.02040.x","article-title":"Long-Distance Colonization of the Western Mediterranean by Cistus ladanifer (Cistaceae) despite the Absence of Special Dispersal Mechanisms","volume":"36","author":"Vargas","year":"2009","journal-title":"J. Biogeogr."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Kubitzki, K., and Bayer, C. (2003). Flowering Plants Dicotyledons, Springer.","DOI":"10.1007\/978-3-662-07255-4"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/jxb\/ert372","article-title":"Perennially Young: Seed Production and Quality in Controlled and Natural Populations of Cistus albidus Reveal Compensatory Mechanisms That Prevent Senescence in Terms of Seed Yield and Viability","volume":"65","author":"Siles","year":"2014","journal-title":"J. Exp. Bot."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"767","DOI":"10.3389\/fpls.2019.00767","article-title":"Leaf Orientation as Part of the Leaf Developmental Program in the Semi-Deciduous Shrub, Cistus albidus L.: Diurnal, Positional, and Photoprotective Effects During Winter","volume":"10","year":"2019","journal-title":"Front. Plant Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1007\/s00425-019-03234-y","article-title":"Contrasting Patterns of Hormonal and Photoprotective Isoprenoids in Response to Stress in Cistus albidus during a Mediterranean Winter","volume":"250","year":"2019","journal-title":"Planta"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/treephys\/23.1.1","article-title":"Enhanced Photo- and Antioxidative Protection, and Hydrogen Peroxide Accumulation in Drought-Stressed Cistus clusii and Cistus albidus Plants","volume":"23","author":"Alegre","year":"2003","journal-title":"Tree Physiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"647","DOI":"10.2307\/2404472","article-title":"Germination and Population Dynamics of Cistus Species in Relation to Fire","volume":"29","author":"Roy","year":"1992","journal-title":"J. Appl. Ecol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"104842","DOI":"10.1016\/j.jaridenv.2022.104842","article-title":"Contrasting Seasonal Abiotic Stress and Herbivory Incidence in Cistus albidus L. Plants Growing in Their Natural Habitat on a Mediterranean Mountain","volume":"206","author":"Bouchikh","year":"2022","journal-title":"J. Arid Environ."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"179","DOI":"10.24310\/abm.v18i.8992","article-title":"Estudios Fenomorfol\u00f3gicos En La Vegetaci\u00f3n Del Sur de Espa\u00f1a. II. Alcornocales Mesomediterr\u00e1neos. (Montes de M\u00e1laga, M\u00e1laga)","volume":"18","author":"Cabezudo","year":"1993","journal-title":"Acta Bot. Malacit."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/12538078.1995.10515713","article-title":"Flowering and Fruiting Phenology and Breeding System of Cistus albidus L. Acta Bot","volume":"142","author":"Blasco","year":"1995","journal-title":"Gallica"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/17550874.2017.1350765","article-title":"Marked Differences in Seed Dormancy in Two Populations of the Mediterranean Shrub, Cistus albidus L.","volume":"10","author":"Siles","year":"2017","journal-title":"Plant Ecol. Divers."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/00837792.1979.10670127","article-title":"Ricerche tassonomiche e corologiche sulle Cistaceae. 1: Il genere Cistus L. in Italia","volume":"33","author":"Rizzotto","year":"1979","journal-title":"Webbia"},{"key":"ref_37","first-page":"437","article-title":"Inhibition Mechanisms and Successional Processes: A Case Study of Cistus albidus L. in Provence","volume":"1","author":"Robles","year":"1998","journal-title":"Ecosyst. Sustain. Dev."},{"key":"ref_38","first-page":"251","article-title":"Cistaceae: A plant family with hard seeds","volume":"41","author":"Thanos","year":"1993","journal-title":"Isr. J. Bot."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0367-2530(17)31557-8","article-title":"Heat Requirements for Seed Germination of Three Cistus Species in the Garrigue of Southern France","volume":"183","author":"Trabaud","year":"1989","journal-title":"Flora"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/07929978.1999.10676745","article-title":"Do light and litter influence the recruitment of cistus spp. Stands?","volume":"47","author":"Trabaud","year":"1999","journal-title":"Isr. J. Plant Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1079\/SSR2003150","article-title":"A Classification System for Seed Dormancy","volume":"14","author":"Baskin","year":"2004","journal-title":"Seed Sci. Res."},{"key":"ref_42","unstructured":"Polunin, O., Schauer, T., and Everard, B. (1971). Pflanzen Europas, BLV(-Verl. Ges.). BLV-Bestimmungsbuch."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/S0031-9422(97)01124-2","article-title":"Essential Oil Composition of Cistus albidus Leaves","volume":"48","author":"Robles","year":"1998","journal-title":"Phytochemistry"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00442-003-1258-8","article-title":"Is There a Feedback between N Availability in Siliceous and Calcareous Soils and Cistus albidus Leaf Chemical Composition?","volume":"136","author":"Castells","year":"2003","journal-title":"Oecologia"},{"key":"ref_45","unstructured":"(2013). International Organization for Standardization Aromatic Natural Raw Materials (Standard No. ISO Standard No. 9235:2013)."},{"key":"ref_46","first-page":"283","article-title":"Chemical Analysis of the Essential Oils of Three Cistus Species Growing in North- West of Algeria","volume":"84","author":"Bechlaghem","year":"2019","journal-title":"Agric. Conspec. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s11738-009-0416-y","article-title":"Annual and Seasonal Changes in Foliar Terpene Content and Emission Rates in Cistus albidus L. Submitted to Soil Drought in Prades Forest (Catalonia, NE Spain)","volume":"32","author":"Ogaya","year":"2010","journal-title":"Acta Physiol. Plant."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/10412905.2005.9698818","article-title":"Seasonal Variation in Chemical Composition of Cistus albidus L.","volume":"17","author":"Sanz","year":"2005","journal-title":"from Spain. J. Essent. Oil Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/ffj.1759","article-title":"In Vivo Volatiles Emission and Essential Oils from Different Organs and Pollen Of Cistus albidus from Caprione (Eastern Liguria, Italy)","volume":"22","author":"Maccioni","year":"2007","journal-title":"Flavour Fragr. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.indcrop.2015.04.034","article-title":"Volatile Profile of Spanish Cistus Plants as Sources of Antimicrobials for Industrial Applications","volume":"74","author":"Elmore","year":"2015","journal-title":"Ind. Crops Prod."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.chemosphere.2006.10.029","article-title":"Water Deficit Stress Induces Different Monoterpene and Sesquiterpene Emission Changes in Mediterranean Species. Relationship between Terpene Emissions and Plant Water Potential","volume":"67","author":"Vila","year":"2007","journal-title":"Chemosphere"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s10886-006-9219-4","article-title":"Effect of Intraspecific Competition and Substrate Type on Terpene Emissions from Some Mediterranean Plant Species","volume":"33","author":"Greff","year":"2007","journal-title":"J. Chem. Ecol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1080\/14786410701766083","article-title":"Detailed Analysis of the Essential Oil from Cistus albidus L. by Combination of GC\/RI, GC\/MS and 13C-NMR Spectroscopy","volume":"22","author":"Paolini","year":"2008","journal-title":"Nat. Prod. Res."},{"key":"ref_54","unstructured":"Gao, H., and Gao, X. (2019). Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and and Nanoparticulates, Academic Press."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"8924","DOI":"10.1523\/JNEUROSCI.2574-05.2005","article-title":"Camphor Activates and Strongly Desensitizes the Transient Receptor Potential Vanilloid Subtype 1 Channel in a Vanilloid-Independent Mechanism","volume":"25","author":"Xu","year":"2005","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"5434","DOI":"10.3390\/molecules18055434","article-title":"Camphor\u2014A Fumigant during the Black Death and a Coveted Fragrant Wood in Ancient Egypt and Babylon\u2014A Review","volume":"18","author":"Chen","year":"2013","journal-title":"Molecules"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0304-3835(94)03633-T","article-title":"Modulatory Influence of Camphor on the Activities of Hepatic Carcinogen Metabolizing Enzymes and the Levels of Hepatic and Extrahepatic Reduced Glutathione in Mice","volume":"88","author":"Banerjee","year":"1995","journal-title":"Cancer Lett."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/pulp.1994.1021","article-title":"The Antitussive Effects of Menthol, Camphor and Cineole in Conscious Guinea-Pigs","volume":"7","author":"Laude","year":"1994","journal-title":"Pulm. Pharmacol."},{"key":"ref_59","first-page":"97","article-title":"Effect of Menthol and Camphor on Permeation of Compound Diphenhydramine Cream in Vitro","volume":"9","author":"Liu","year":"2011","journal-title":"Cent South Pharm."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1002\/ptr.6614","article-title":"Star Anise (Illicium verum): Chemical Compounds, Antiviral Properties, and Clinical Relevance","volume":"34","author":"Patra","year":"2020","journal-title":"Phytother. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/ptr.2247","article-title":"Low Concentration of 3-Carene Stimulates the Differentiation of Mouse Osteoblastic MC3T3-E1 Subclone 4 Cells","volume":"22","author":"Jeong","year":"2008","journal-title":"Phytother. Res."},{"key":"ref_62","first-page":"284","article-title":"Comparative Study of Different Essential Oils of Bupleurum gibraltaricum Lamarck","volume":"44","author":"Gil","year":"1989","journal-title":"Pharmazie"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1468-3083.2004.00886.x","article-title":"Antifungal Activity of Thymus Oils and Their Major Compounds","volume":"18","author":"Pinto","year":"2004","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0278-6915(84)90033-4","article-title":"Antioxidant Actions of Thymol, Carvacrol, 6-Gingerol, Zingerone and Hydroxytyrosol","volume":"32","author":"Aeschbach","year":"1994","journal-title":"Food Chem. Toxicol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11010-011-1043-7","article-title":"Potential Preventive Effect of Carvacrol against Diethylnitrosamine-Induced Hepatocellular Carcinoma in Rats","volume":"360","author":"Jayakumar","year":"2012","journal-title":"Mol. Cell. Biochem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1194\/jlr.M900255-JLR200","article-title":"Carvacrol, a Component of Thyme Oil, Activates PPAR alpha and Gamma and Suppresses COX-2 Expression","volume":"51","author":"Hotta","year":"2010","journal-title":"J. Lipid Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jnutbio.2010.11.016","article-title":"Carvacrol Prevents Diet-Induced Obesity by Modulating Gene Expressions Involved in Adipogenesis and Inflammation in Mice Fed with High-Fat Diet","volume":"23","author":"Cho","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"ref_68","first-page":"183","article-title":"Galactosamine Induced Liver Injury. Prog","volume":"4","author":"Decker","year":"1972","journal-title":"Liver Dis."},{"key":"ref_69","first-page":"661","article-title":"Relaxant Effects of Carvacrol on Guinea Pig Tracheal Chains and Its Possible Mechanisms","volume":"58","author":"Boskabady","year":"2003","journal-title":"Pharmazie"},{"key":"ref_70","first-page":"341","article-title":"Vasorelaxant Effects of the Monoterpenic Phenol Isomers, Carvacrol and Thymol, on Rat Isolated Aorta. Fundam","volume":"24","author":"Gomes","year":"2010","journal-title":"Clin. Pharmacol."},{"key":"ref_71","first-page":"459530","article-title":"Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p -Cymene, and Geranyl Acetate in Experimental Models","volume":"2013","author":"Moreira","year":"2013","journal-title":"ISRN Toxicol."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Arabloei Sani, M., Yaghmaei, P., Hajebrahimi, Z., and Hayati Roodbari, N. (2022). Therapeutic Effect of P-Cymene on Lipid Profile, Liver Enzyme, and Akt\/Mtor Pathway in Streptozotocin-Induced Diabetes Mellitus in Wistar Rats. J. Obes., 1\u201312.","DOI":"10.1155\/2022\/1015669"},{"key":"ref_73","first-page":"259","article-title":"D-Limonene: Safety and Clinical Applications","volume":"12","author":"Sun","year":"2007","journal-title":"Altern. Med. Rev. J. Clin. Ther."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"8817309","DOI":"10.1155\/2021\/8817309","article-title":"Limonene through Attenuation of Neuroinflammation and Nitrite Level Exerts Antidepressant-Like Effect on Mouse Model of Maternal Separation Stress","volume":"2021","author":"Lorigooini","year":"2021","journal-title":"Behav. Neurol."},{"key":"ref_75","first-page":"39","article-title":"Antibacterial and Antifungal Activity of Aromatic Constituents of Essential Oils","volume":"89","author":"Pattnaik","year":"1997","journal-title":"Microbios"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.phymed.2009.10.002","article-title":"Effects of Inhaled Linalool in Anxiety, Social Interaction and Aggressive Behavior in Mice","volume":"17","author":"Linck","year":"2010","journal-title":"Phytomedicine"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1080\/01635581.2014.904906","article-title":"Antitumorigenic Potential of Linalool Is Accompanied by Modulation of Oxidative Stress: An in Vivo Study in Sarcoma-180 Solid Tumor Model","volume":"66","author":"Jana","year":"2014","journal-title":"Nutr. Cancer"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/chemse\/25.1.77","article-title":"Odor Distinctiveness between Enantiomers of Linalool: Difference in Perception and Responses Elicited by Sensory Test and Forehead Surface Potential Wave Measurement","volume":"25","author":"Sugawara","year":"2000","journal-title":"Chem. Senses"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1078\/094471102321621322","article-title":"Anti-Inflammatory Activity of Linalool and Linalyl Acetate Constituents of Essential Oils","volume":"9","author":"Peana","year":"2002","journal-title":"Phytomedicine"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1080\/19336950.2019.1654347","article-title":"Myrcene and Terpene Regulation of TRPV1","volume":"13","author":"Jansen","year":"2019","journal-title":"Channels"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/bcpt.12488","article-title":"Antitumour Activity of the Microencapsulation of Annona vepretorum Essential Oil","volume":"118","author":"Bomfim","year":"2016","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jep.2004.05.021","article-title":"Anticonvulsant Activity and Chemical Composition of Artemisia dracunculus L. Essential Oil","volume":"94","author":"Sayyah","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Pulaj, B., Mustafa, B., Nelson, K., Quave, C.L., and Hajdari, A. (2016). Chemical Composition and in Vitro Antibacterial Activity of Pistacia terebinthus Essential Oils Derived from Wild Populations in Kosovo. BMC Complement. Altern. Med., 16.","DOI":"10.1186\/s12906-016-1135-8"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40529-017-0168-8","article-title":"Anti-Fungal Activity, Mechanism Studies on \u03b1-Phellandrene and Nonanal against Penicillium cyclopium","volume":"58","author":"Zhang","year":"2017","journal-title":"Bot. Stud."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1179\/1476830514Y.0000000119","article-title":"Antihyperalgesic and Antidepressive Actions of (R)-(+)-Limonene, \u03b1-Phellandrene, and Essential Oil from Schinus terebinthifolius Fruits in a Neuropathic Pain Model","volume":"18","author":"Piccinelli","year":"2015","journal-title":"Nutr. Neurosci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.2042-7158.2011.01401.x","article-title":"Antinociceptive Activity of the Monoterpene \u03b1-Phellandrene in Rodents: Possible Mechanisms of Action","volume":"64","author":"Lima","year":"2012","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_87","first-page":"583","article-title":"Alpha-Phellandrene, a Natural Active Monoterpene, Influences a Murine WEHI-3 Leukemia Model in Vivo by Enhancing Macrophague Phagocytosis and Natural Killer Cell Activity","volume":"28","author":"Lin","year":"2014","journal-title":"In Vivo"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.lfs.2018.10.004","article-title":"Alpha Pinene Modulates UVA-Induced Oxidative Stress, DNA Damage and Apoptosis in Human Skin Epidermal Keratinocytes","volume":"212","author":"Karthikeyan","year":"2018","journal-title":"Life Sci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"6631","DOI":"10.12659\/MSM.916419","article-title":"\u03b1-Pinene Induces Apoptotic Cell Death via Caspase Activation in Human Ovarian Cancer Cells","volume":"25","author":"Hou","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jep.2014.11.024","article-title":"Syzygium Cumini (L.) Skeels Essential Oil and Its Major Constituent \u03b1-Pinene Exhibit Anti-Leishmania Activity through Immunomodulation in Vitro","volume":"160","author":"Rodrigues","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"123","DOI":"10.4103\/0973-1296.149725","article-title":"Gastroprotective Effect of Alpha-Pinene and Its Correlation with Antiulcerogenic Activity of Essential Oils Obtained from Hyptis Species","volume":"11","author":"Pinheiro","year":"2015","journal-title":"Pharmacogn. Mag."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1055\/s-0030-1250116","article-title":"The Essential Oil of Eucalyptus tereticornis and Its Constituents, \u03b1- and \u03b2-Pinene, Show Accelerative Properties on Rat Gastrointestinal Transit","volume":"77","author":"Okoba","year":"2011","journal-title":"Planta Med."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Utegenova, G., Pallister, K., Kushnarenko, S., \u00d6zek, G., \u00d6zek, T., Abidkulova, K., Kirpotina, L., Schepetkin, I., Quinn, M., and Voyich, J. (2018). Chemical Composition and Antibacterial Activity of Essential Oils from Ferula L. Species against Methicillin-Resistant Staphylococcus aureus. Molecules, 23.","DOI":"10.3390\/molecules23071679"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.3390\/molecules16021044","article-title":"Comparative Anti-Infectious Bronchitis Virus (IBV) Activity of (-)-Pinene: Effect on Nucleocapsid (N) Protein","volume":"16","author":"Yang","year":"2011","journal-title":"Molecules"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1590\/0004-282x20180147","article-title":"The Anticonvulsant Effects of Ducrosia anethifolia (Boiss) Essential Oil Are Produced by Its Main Component Alpha-Pinene in Rats","volume":"77","author":"Zamyad","year":"2019","journal-title":"Arq. Neuropsiquiatr."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.bioorg.2018.12.010","article-title":"Design, Synthesis and Biological Evaluation of Novel \u03b2-Pinene-Based Thiazole Derivatives as Potential Anticancer Agents via Mitochondrial-Mediated Apoptosis Pathway","volume":"84","author":"Wang","year":"2019","journal-title":"Bioorg. Chem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.bmcl.2016.02.024","article-title":"One-Pot Synthesis and Antimicrobial Evaluation of Novel 3-Cyanopyridine Derivatives of (\u2212)-\u03b2-Pinene","volume":"26","author":"Liao","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/fcp.12416","article-title":"Comparative Study of Alpha- and Beta-Pinene Effect on PTZ-Induced Convulsions in Mice","volume":"33","author":"Felipe","year":"2019","journal-title":"Fundam. Clin. Pharmacol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1002\/ptr.1749","article-title":"Radical Scavenging Activity of Crocus sativus L. Extract and Its Bioactive Constituents","volume":"19","author":"Assimopoulou","year":"2005","journal-title":"Phytother. Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.foodcont.2010.09.031","article-title":"Bactericidal Effect of Saffron (Crocus sativus L.) on Salmonella enterica during Storage","volume":"22","author":"Pintado","year":"2011","journal-title":"Food Control"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.fitote.2005.07.008","article-title":"Anticonvulsant Evaluation of Safranal and Crocin from Crocus sativus in Mice","volume":"76","author":"Hosseinzadeh","year":"2005","journal-title":"Fitoterapia"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/ptr.2597","article-title":"Anxiolytic and Hypnotic Effect of Crocus sativus Aqueous Extract and Its Constituents, Crocin and Safranal, in Mice","volume":"23","author":"Hosseinzadeh","year":"2009","journal-title":"Phytother. Res."},{"key":"ref_103","first-page":"30","article-title":"Effects of Saffron and Its Active Constituents, Crocin and Safranal, on Prevention of Indomethacin Induced Gastric Ulcers in Diabetic and Nondiabetic Rats","volume":"8","author":"Kianbakht","year":"2009","journal-title":"JMPIR"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1021\/tx200486f","article-title":"\u03b1-Terpinene, an Antioxidant in Tea Tree Oil, Autoxidizes Rapidly to Skin Allergens on Air Exposure","volume":"25","author":"Nilsson","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.exppara.2016.01.004","article-title":"In Vitro and in Vivo Action of Terpinen-4-Ol, \u03b3-Terpinene, and \u03b1-Terpinene against Trypanosoma evansi","volume":"162","author":"Baldissera","year":"2016","journal-title":"Exp. Parasitol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"38","DOI":"10.12816\/0058534","article-title":"Identification of Volatile Components and Antioxidant Assessment of the Aerial Part Extracts from an Algerian Cistus albidus L.","volume":"10","author":"Fadel","year":"2020","journal-title":"of the Aures Region. J. New Technol. Mater."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1515\/chem-2018-0040","article-title":"\u03b1-Terpineol, a Natural Monoterpene: A Review of Its Biological Properties","volume":"16","author":"Khaleel","year":"2018","journal-title":"Open Chem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/ptr.1093","article-title":"Composition and Antimicrobial Activity of the Essential Oil Of Hypericum rumeliacum Subsp.Apollinis (Boiss. & Heldr.)","volume":"17","author":"Couladis","year":"2003","journal-title":"Phytother. Res."},{"key":"ref_109","first-page":"277","article-title":"Gastroprotective Activity of \u03b1-Terpineol in Two Experimental Models of Gastric Ulcer in Rats","volume":"19","author":"Souza","year":"2011","journal-title":"Daru J. Fac. Pharm. Tehran Univ. Med. Sci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"380","DOI":"10.3389\/fphar.2017.00380","article-title":"Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development","volume":"8","author":"Javed","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cbi.2015.12.006","article-title":"Thymol, a Dietary Monoterpene Phenol Abrogates Mitochondrial Dysfunction in \u03b2-Adrenergic Agonist Induced Myocardial Infarcted Rats by Inhibiting Oxidative Stress","volume":"244","author":"Jagadeesh","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ejphar.2015.05.034","article-title":"Role of Thymol on Hyperglycemia and Hyperlipidemia in High Fat Diet-Induced Type 2 Diabetic C57BL\/6J Mice","volume":"761","author":"Saravanan","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jep.2010.04.005","article-title":"Evaluation of the Analgesic and Anti-Inflammatory Effects of the Essential Oil of Lippia gracilis Leaves","volume":"129","author":"Mendes","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Bukovsk\u00e1, A., Ciko\u0161, \u0160., Juh\u00e1s, \u0160., Il\u2019kov\u00e1, G., Reh\u00e1k, P., and Koppel, J. (2007). Effects of a Combination of Thyme and Oregano Essential Oils on TNBS-Induced Colitis in Mice. Mediators Inflamm., 1\u20139.","DOI":"10.1155\/2007\/23296"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S2221-6189(14)60030-5","article-title":"To Evaluate Anti-Anxiety Activity of Thymol","volume":"3","author":"Bhandari","year":"2014","journal-title":"J. Acute Dis."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.plaphy.2008.12.016","article-title":"Enhanced Determination of Abscisic Acid (ABA) and Abscisic Acid Glucose Ester (ABA-GE) in Cistus albidus Plants by Liquid Chromatography-Mass Spectrometry in Tandem Mode","volume":"47","author":"Gabasa","year":"2009","journal-title":"Plant Physiol. Biochem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1093\/treephys\/tpab047","article-title":"The Threshold between Life and Death in Cistus albidus L. Seedlings: Mechanisms Underlying Drought Tolerance and Resilience","volume":"41","author":"Caselles","year":"2021","journal-title":"Tree Physiol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"467","DOI":"10.2174\/092986710790226110","article-title":"Mechanisms of Action and Medicinal Applications of Abscisic Acid","volume":"17","author":"Skoneczka","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ejphar.2018.05.013","article-title":"Phytohormone Abscisic Acid Elicits Antinociceptive Effects in Rats through the Activation of Opioid and Peroxisome Proliferator-Activated Receptors \u03b2\/\u03b4","volume":"832","author":"Mollashahi","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.phymed.2010.06.018","article-title":"Synergistic Properties of the Terpenoids Aromadendrene and 1,8-Cineole from the Essential Oil of Eucalyptus globulus against Antibiotic-Susceptible and Antibiotic-Resistant Pathogens","volume":"17","author":"Mulyaningsih","year":"2010","journal-title":"Phytomedicine"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/ptr.5543","article-title":"\u03b2-Bisabolene, a Sesquiterpene from the Essential Oil Extract of Opoponax (Commiphora guidottii), Exhibits Cytotoxicity in Breast Cancer Cell Lines: Anti-tumour properties of \u03b2-bisabolene","volume":"30","author":"Yeo","year":"2016","journal-title":"Phytother. Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2174\/1389201015666140528152946","article-title":"\u03b1-(-)-Bisabolol Reduces pro-Inflammatory Cytokine Production and Ameliorates Skin Inflammation","volume":"15","author":"Maurya","year":"2014","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/10412905.2006.12067134","article-title":"The Biological Activities of 20 Nature Identical Essential Oil Constituents","volume":"18","author":"Seatlholo","year":"2006","journal-title":"J. Essent. Oil Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1111\/j.1349-7006.2011.02082.x","article-title":"Antitumor Effects of \u03b1-Bisabolol against Pancreatic Cancer","volume":"102","author":"Seki","year":"2011","journal-title":"Cancer Sci."},{"key":"ref_125","first-page":"1357","article-title":"Composition and Antifungal Activities of the Leaf Essential Oil of Neolitsea parvigemma from Taiwan","volume":"6","author":"Ho","year":"2011","journal-title":"Nat. Prod. Commun."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/14786419.2016.1236095","article-title":"Comparison of Essential Oils from Cistus Species Growing in Sardinia","volume":"31","author":"Mastino","year":"2017","journal-title":"Nat. Prod. Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ejphar.2006.02.047","article-title":"T-Cadinol and Calamenene Induce Dendritic Cells from Human Monocytes and Drive Th1 Polarization","volume":"537","author":"Takei","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"11808","DOI":"10.3390\/molecules200711808","article-title":"The Anticancer, Antioxidant and Antimicrobial Properties of the Sesquiterpene \u03b2-Caryophyllene from the Essential Oil of Aquilaria crassna","volume":"20","author":"Dahham","year":"2015","journal-title":"Molecules"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11010-016-2733-y","article-title":"\u03b2-Caryophyllene, a Phytocannabinoid Attenuates Oxidative Stress, Neuroinflammation, Glial Activation, and Salvages Dopaminergic Neurons in a Rat Model of Parkinson Disease","volume":"418","author":"Ojha","year":"2016","journal-title":"Mol. Cell. Biochem."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.physbeh.2014.06.003","article-title":"\u03b2-Caryophyllene, a CB2 Receptor Agonist Produces Multiple Behavioral Changes Relevant to Anxiety and Depression in Mice","volume":"135","author":"Bahi","year":"2014","journal-title":"Physiol. Behav."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.yebeh.2015.12.040","article-title":"Anticonvulsant Activity of \u03b2-Caryophyllene against Pentylenetetrazol-Induced Seizures","volume":"56","author":"Grigoletto","year":"2016","journal-title":"Epilepsy Behav."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1002\/cam4.816","article-title":"\u03b2-Caryophyllene and \u03b2-Caryophyllene Oxide-Natural Compounds of Anticancer and Analgesic Properties","volume":"5","author":"Fidyt","year":"2016","journal-title":"Cancer Med."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s10616-013-9611-1","article-title":"Effects of Copaene, a Tricyclic Sesquiterpene, on Human Lymphocytes Cells in Vitro","volume":"66","year":"2014","journal-title":"Cytotechnology"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"21","DOI":"10.5455\/jice.20131229104710","article-title":"Tricyclic Sesquiterpene Copaene Prevents H2O2-Induced Neurotoxicity","volume":"3","author":"Turkez","year":"2014","journal-title":"J. Intercult. Ethnopharmacol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.neulet.2013.09.053","article-title":"\u03b1-Iso-Cubebene Exerts Neuroprotective Effects in Amyloid Beta Stimulated Microglia Activation","volume":"555","author":"Park","year":"2013","journal-title":"Neurosci. Lett."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.bbrc.2012.08.070","article-title":"\u03b1-Iso-Cubebene, a Natural Compound Isolated from Schisandra chinensis Fruit, Has Therapeutic Benefit against Polymicrobial Sepsis","volume":"426","author":"Lee","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"109121","DOI":"10.1016\/j.intimp.2022.109121","article-title":"\u03b1-Iso-Cubebene Attenuates Neointima Formation by Inhibiting HMGB1-Induced Monocyte to Macrophage Differentiation via Suppressing ROS Production","volume":"111","author":"Baek","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.fitote.2010.04.001","article-title":"Antiproliferative Effects of Curcuphenol, a Sesquiterpene Phenol","volume":"81","author":"Rodrigo","year":"2010","journal-title":"Fitoterapia"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Bai, Z., Yao, C., Zhu, J., Xie, Y., Ye, X.-Y., Bai, R., and Xie, T. (2021). Anti-Tumor Drug Discovery Based on Natural Product \u03b2-Elemene: Anti-Tumor Mechanisms and Structural Modification. Molecules, 26.","DOI":"10.3390\/molecules26061499"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0014-2999(00)00102-3","article-title":"\u03c9-Agatoxin IVA-Sensitive Ca2+ Channel Blocker, \u03b1-Eudesmol, Protects against Brain Injury after Focal Ischemia in Rats","volume":"394","author":"Asakura","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cbi.2018.08.026","article-title":"\u03b2-Eudesmol Inhibits Thymic Stromal Lymphopoietin through Blockade of Caspase-1\/NF-\u039aB Signal Cascade in Allergic Rhinitis Murine Model","volume":"294","author":"Moon","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"ref_142","first-page":"7","article-title":"\u03b2-Eudesmol Induces the Expression of Apoptosis Pathway Proteins in Cholangiocarcinoma Cell Lines","volume":"25","author":"Narahara","year":"2020","journal-title":"J. Res. Med. Sci. Off. J. Isfahan Univ. Med. Sci."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1186\/s12935-022-02721-9","article-title":"Sesquiterpenoid Lactones as Potential Anti-Cancer Agents: An Update on Molecular Mechanisms and Recent Studies","volume":"22","author":"Dhyani","year":"2022","journal-title":"Cancer Cell Int."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"115941","DOI":"10.1016\/j.jep.2022.115941","article-title":"Eugenia gracillima Essential Oil Has Pharmaceutical Applications in Pain and Inflammation without Toxic Effects in Mice","volume":"303","author":"Guedes","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1080\/10412905.2017.1338625","article-title":"Kundmannia sicula (L.) DC: A Rich Source of Germacrene D","volume":"29","author":"Casiglia","year":"2017","journal-title":"J. Essent. Oil Res."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.tifs.2021.06.049","article-title":"Pharmacological and Toxicological Activities of \u03b1-Humulene and Its Isomers: A Systematic Review","volume":"115","author":"Bezerra","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"112956","DOI":"10.1016\/j.biopha.2022.112956","article-title":"Downregulation of Hepatic Fat Accumulation, Inflammation and Fibrosis by Nerolidol in Purpose Built Western-Diet-Induced Multiple-Hit Pathogenesis of NASH Animal Model","volume":"150","author":"Sabir","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"112901","DOI":"10.1016\/j.phytochem.2021.112901","article-title":"Nerolidol Inhibits Proliferation of Leiomyoma Cells via Reactive Oxygen Species-Induced DNA Damage and Downregulation of the ATM\/Akt Pathway","volume":"191","author":"Dong","year":"2021","journal-title":"Phytochemistry"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.phymed.2012.12.017","article-title":"Evaluation of in Vivo Anti-Hyperglycemic and Antioxidant Potentials of \u03b1-Santalol and Sandalwood Oil","volume":"20","author":"Misra","year":"2013","journal-title":"Phytomedicine"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"112178","DOI":"10.1016\/j.bbr.2019.112178","article-title":"GABAa Receptor Subunits Expression in Silver Catfish (Rhamdia Quelen) Brain and Its Modulation by Nectandra grandiflora Nees Essential Oil and Isolated Compounds","volume":"376","author":"Garlet","year":"2019","journal-title":"Behav. Brain Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s10637-015-0296-5","article-title":"Identification of a Novel Compound (\u03b2-Sesquiphellandrene) from Turmeric (Curcuma longa) with Anticancer Potential: Comparison with Curcumin","volume":"33","author":"Tyagi","year":"2015","journal-title":"Investig. New Drugs"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"7547","DOI":"10.3390\/molecules15117547","article-title":"Free Radical Scavenging Activity and Characterization of Sesquiterpenoids in Four Species of Curcuma Using a TLC Bioautography Assay and GC-MS Analysis","volume":"15","author":"Zhao","year":"2010","journal-title":"Molecules"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"119511","DOI":"10.1016\/j.saa.2021.119511","article-title":"Impact on Cholinesterase-Inhibition and in Silico Investigations of Sesquiterpenoids from Amazonian Siparuna guianensis Aubl","volume":"252","author":"Martins","year":"2021","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"101396","DOI":"10.1016\/j.genrep.2021.101396","article-title":"Spathulenol Attenuates 6-Hydroxydopamine Induced Neurotoxicity in SH-SY5Y Neuroblastoma Cells","volume":"25","author":"Manjima","year":"2021","journal-title":"Gene Rep."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jep.2017.08.030","article-title":"Antioxidant, Anti-Inflammatory, Antiproliferative and Antimycobacterial Activities of the Essential Oil of Psidium guineense Sw. and Spathulenol","volume":"210","author":"Moreira","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"115785","DOI":"10.1016\/j.jep.2022.115785","article-title":"Potential Anti-Arthritic and Analgesic Properties of Essential Oil and Viridiflorol Obtained from Allophylus edulis Leaves in Mice","volume":"301","author":"Arena","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.sjbs.2021.10.026","article-title":"Viridiflorol Induces Anti-Neoplastic Effects on Breast, Lung, and Brain Cancer Cells through Apoptosis","volume":"29","author":"Akiel","year":"2022","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.jep.2016.08.053","article-title":"Anti-Inflammatory, Antioxidant and Anti-Mycobacterium tuberculosis Activity of Viridiflorol: The Major Constituent of Allophylus edulis (A. St.-Hil., A. Juss. & Cambess.) Radlk","volume":"192","author":"Trevizan","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12935-015-0255-4","article-title":"Xanthorrhizol: A Review of Its Pharmacological Activities and Anticancer Properties","volume":"15","author":"Oon","year":"2015","journal-title":"Cancer Cell Int."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"127651","DOI":"10.1016\/j.bmcl.2020.127651","article-title":"The Food-Grade Antimicrobial Xanthorrhizol Targets the Enoyl-ACP Reductase (FabI) in Escherichia coli","volume":"30","author":"Mordukhova","year":"2020","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.bbrc.2016.08.136","article-title":"Hypolipidemic Activities of Xanthorrhizol Purified from Centrifugal TLC","volume":"478","author":"Oon","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.lfs.2011.03.007","article-title":"Xanthorrhizol Attenuates Dextran Sulfate Sodium-Induced Colitis via the Modulation of the Expression of Inflammatory Genes in Mice","volume":"88","author":"Cho","year":"2011","journal-title":"Life Sci."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"154670","DOI":"10.1016\/j.phymed.2023.154670","article-title":"Zingiberene, a Non-Zinc-Binding Class I HDAC Inhibitor: A Novel Strategy for the Management of Neuropathic Pain","volume":"111","author":"Borgonetti","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"9477","DOI":"10.3390\/molecules18089477","article-title":"Chemical Composition and Cytotoxicity Evaluation of Essential Oil from Leaves of Casearia sylvestris, Its Main Compound \u03b1-Zingiberene and Derivatives","volume":"18","author":"Bou","year":"2013","journal-title":"Molecules"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.1080\/14786419.2021.2019729","article-title":"de A. \u03b1-Zingiberene, a Sesquiterpene from Essential Oil from Leaves of Casearia sylvestris, Suppresses Inflammatory Angiogenesis and Stimulates Collagen Deposition in Subcutaneous Implants in Mice","volume":"36","author":"Ferreira","year":"2022","journal-title":"Nat. Prod. Res."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/cbf.3618","article-title":"The diterpene manool extracted from Salvia tingitana lowers free radical production in retinal rod outer segments by inhibiting the extramitochondrial F1 F0 ATP synthase","volume":"39","author":"Ravera","year":"2021","journal-title":"Cell Biochem. Funct."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.fct.2014.06.025","article-title":"Differential Effect of Manool\u2014A Diterpene from Salvia officinalis, on Genotoxicity Induced by Methyl Methanesulfonate in V79 and HepG2 Cells","volume":"72","author":"Nicolella","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"669","DOI":"10.36660\/abc.20190198","article-title":"Efeito Do Diterpeno Manool Sobre a Press\u00e3o Arterial e Reatividade Vascular Em Ratos Normotensos e Hipertensos","volume":"115","author":"Monteiro","year":"2020","journal-title":"Arq. Bras. Cardiol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"678","DOI":"10.36660\/abc.20200552","article-title":"Efeitos Cardiovasculares Do Diterpeno Manool Em Ratos Normotensos e Hipertensos","volume":"115","author":"Castro","year":"2020","journal-title":"Arq. Bras. Cardiol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1055\/s-2001-11497","article-title":"Essential Oils and Hexane Extracts from Leaves and Fruits of Cistus monspeliensis. Cytotoxic Activity of Ent-13-Epi-Manoyl Oxide and Its Isomers","volume":"67","author":"Angelopoulou","year":"2001","journal-title":"Planta Med."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.freeradbiomed.2008.06.019","article-title":"The Non-Provitamin A Carotenoid, Lutein, Inhibits NF-KappaB-Dependent Gene Expression through Redox-Based Regulation of the Phosphatidylinositol 3-Kinase\/PTEN\/Akt and NF-KappaB-Inducing Kinase Pathways: Role of H(2)O(2) in NF-KappaB Activation","volume":"45","author":"Kim","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1615\/JEnvironPatholToxicolOncol.2018027418","article-title":"Lutein Inhibits Cell Growth and Activates Apoptosis via the PI3K\/AKT\/MTOR Signaling Pathway in A549 Human Non-Small-Cell Lung Cancer Cells","volume":"37","author":"Zhang","year":"2018","journal-title":"J. Environ. Pathol. Toxicol. Oncol. Off."},{"key":"ref_173","first-page":"315205","article-title":"Lutein Has a Protective Effect on Hepatotoxicity Induced by Arsenic via Nrf2 Signaling","volume":"2015","author":"Li","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1080\/13880209.2019.1649436","article-title":"The Protective Role of Lutein on Isoproterenol-Induced Cardiac Failure Rat Model through Improving Cardiac Morphology, Antioxidant Status via Positively Regulating Nrf2\/HO-1 Signalling Pathway","volume":"57","author":"Ouyang","year":"2019","journal-title":"Pharm. Biol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"345","DOI":"10.5650\/jos.57.345","article-title":"Suppressive Effect of Neoxanthin on the Differentiation of 3T3-L1 Adipose Cells","volume":"57","author":"Okada","year":"2008","journal-title":"J. Oleo Sci."},{"key":"ref_176","unstructured":"Teuscher, E. (2023, August 10). Biogene Arzneimittel: Lehrbuch der Pharmazeutischen Biologie; 2020; ISBN 978-3-8047-3607-8. Available online: https:\/\/www.amazon.de\/Biogene-Arzneimittel-Lehrbuch-Pharmazeutischen-Biologie\/dp\/3804736076."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.fct.2013.01.006","article-title":"Correlation between the Antibacterial Activity and the Composition of Extracts Derived from Various Spanish Cistus Species","volume":"55","author":"Micol","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_178","unstructured":"Sticher, O., Heilmann, J., Z\u00fcndorf, I., H\u00e4nsel, R., and Steinegger, E. (2015). Pharmakognosie\u2014Phytopharmazie, Wissenschaftliche Verlagsgesellschaft. 10., v\u00f6llig neu Bearbeitete Auflage."},{"key":"ref_179","unstructured":"Belitz, H.-D., Grosch, W., and Schieberle, P. (2008). Lehrbuch der Lebensmittelchemie, Springer. Springer-Lehrbuch; Sechste, Vollst\u00e4ndig \u00dcberarbeitete Auflage."},{"key":"ref_180","first-page":"416","article-title":"Prodelphinidin Trimers and Characterization of a Proanthocyanidin Oligomer from Cistus albidus","volume":"58","author":"Petereit","year":"2003","journal-title":"Pharmazie"},{"key":"ref_181","unstructured":"Wiesner, J.V. (1921). Die Rohstoffe des Pflanzenreiches, Verlag W. Engelmann."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.indcrop.2012.07.066","article-title":"The Phenolic Content and Antioxidant Activity of Infusions from Mediterranean Medicinal Plants","volume":"43","author":"Gomes","year":"2013","journal-title":"Ind. Crops Prod."},{"key":"ref_183","first-page":"7010467","article-title":"A Review on Flavonoid Apigenin: Dietary Intake, ADME, Antimicrobial Effects, and Interactions with Human Gut Microbiota","volume":"2019","author":"Wang","year":"2019","journal-title":"BioMed Res. Int."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0091-3057(97)00054-3","article-title":"Anxiolytic Natural and Synthetic Flavonoid Ligands of the Central Benzodiazepine Receptor Have No Effect on Memory Tasks in Rats","volume":"58","author":"Salgueiro","year":"1997","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Tyszka-Czochara, M., Konieczny, P., and Majka, M. (2017). Caffeic Acid Expands Anti-Tumor Effect of Metformin in Human Metastatic Cervical Carcinoma HTB-34 Cells: Implications of AMPK Activation and Impairment of Fatty Acids De Novo Biosynthesis. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18020462"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1039\/C3AY41807C","article-title":"Caffeic Acid: A Review of Its Potential Use in Medications and Cosmetics","volume":"6","author":"Magnani","year":"2014","journal-title":"Anal Methods"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"860508","DOI":"10.3389\/fonc.2022.860508","article-title":"Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases","volume":"12","author":"Alam","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"183727","DOI":"10.1016\/j.bbamem.2021.183727","article-title":"Caffeic Acid Phenolipids in the Protection of Cell Membranes from Oxidative Injuries. Interaction with the Membrane Phospholipid Bilayer","volume":"1863","author":"Lopes","year":"2021","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.biopha.2018.10.044","article-title":"Cardio-Protective and Antioxidant Properties of Caffeic Acid and Chlorogenic Acid: Mechanistic Role of Angiotensin Converting Enzyme, Cholinesterase and Arginase Activities in Cyclosporine Induced Hypertensive Rats","volume":"109","author":"Agunloye","year":"2019","journal-title":"Biomed. Pharmacother. Biomed. Pharmacother."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.fct.2012.12.042","article-title":"The Hepatoprotection of Caffeic Acid and Rosmarinic Acid, Major Compounds of Perilla frutescens, against t-BHP-Induced Oxidative Liver Damage","volume":"55","author":"Yang","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.2174\/1570159X19666210608165509","article-title":"Neuroprotective Potential of Caffeic Acid Phenethyl Ester (CAPE) in CNS Disorders: Mechanistic and Therapeutic Insights","volume":"19","author":"Kulkarni","year":"2021","journal-title":"Curr. Neuropharmacol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"5616","DOI":"10.33263\/BRIAC103.616623","article-title":"Caftaric Acid: An Overview on Its Structure, Daily Consumption, Bioavailability and Pharmacological Effects","volume":"10","author":"Khaled","year":"2020","journal-title":"Biointerface Res. Appl. Chem."},{"key":"ref_193","unstructured":"Gezer, C. (2017). Potential Health Effects of the Popular Compound of Artichoke: Cynarin (CYN). Prog. Nutr., 19."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"3654","DOI":"10.3390\/molecules19033654","article-title":"Artichoke, Cynarin and Cyanidin Downregulate the Expression of Inducible Nitric Oxide Synthase in Human Coronary Smooth Muscle Cells","volume":"19","author":"Xia","year":"2014","journal-title":"Molecules"},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Sebastiani, G., Almeida-Toledano, L., Serra-Delgado, M., Navarro-Tapia, E., Sailer, S., Valverde, O., Garcia-Algar, O., and Andreu-Fern\u00e1ndez, V. (2021). Therapeutic Effects of Catechins in Less Common Neurological and Neurodegenerative Disorders. Nutrients, 13.","DOI":"10.3390\/nu13072232"},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Jakubek, P., Raji\u0107, J., Kuczy\u0144ska, M., Suliborska, K., Heldt, M., Dziedziul, K., Vidakovi\u0107, M., Namie\u015bnik, J., and Bartoszek, A. (2023). Beyond Antioxidant Activity: Redox Properties of Catechins May Affect Changes in the DNA Methylation Profile\u2014The Example of SRXN1 Gene. Antioxidants, 12.","DOI":"10.3390\/antiox12030754"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.fitote.2017.03.002","article-title":"Flavan-3-Ols and Proanthocyanidins from Limonium brasiliense Inhibit the Adhesion of Porphyromonas gingivalis to Epithelial Host Cells by Interaction with Gingipains","volume":"118","author":"Hensel","year":"2017","journal-title":"Fitoterapia"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s41702-020-0057-8","article-title":"Activity of Catechins and Their Applications","volume":"4","author":"Bae","year":"2020","journal-title":"Biomed. Dermatol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1159\/000491755","article-title":"Antioxidant Properties of Ferulic Acid and Its Possible Application","volume":"31","author":"Dana","year":"2018","journal-title":"Skin Pharmacol. Physiol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"e00717","DOI":"10.1016\/j.btre.2022.e00717","article-title":"Ferulic Acid Derivatives Inhibiting Staphylococcus aureus TetK and MsrA Efflux Pumps","volume":"34","author":"Pinheiro","year":"2022","journal-title":"Biotechnol. Rep."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s13273-021-00219-5","article-title":"Ferulic Acid Exhibits Anti-Inflammatory Effects by Inducing Autophagy and Blocking NLRP3 Inflammasome Activation","volume":"18","author":"Liu","year":"2022","journal-title":"Mol. Cell. Toxicol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.3892\/ijmm.2017.3127","article-title":"Ferulic Acid Exerts Neuroprotective Effects against Cerebral Ischemia\/Reperfusion-Induced Injury via Antioxidant and Anti-Apoptotic Mechanisms in Vitro and in Vivo","volume":"40","author":"Ren","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"777576","DOI":"10.3389\/fnut.2021.777576","article-title":"Ferulic Acid From Plant Biomass: A Phytochemical With Promising Antiviral Properties","volume":"8","author":"Antonopoulou","year":"2021","journal-title":"Front. Nutr."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"678487","DOI":"10.1155\/2015\/678487","article-title":"Ferulic Acid Induces Th1 Responses by Modulating the Function of Dendritic Cells and Ameliorates Th2-Mediated Allergic Airway Inflammation in Mice","volume":"2015","author":"Lee","year":"2015","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"9603271221136204","DOI":"10.1177\/09603271221136205","article-title":"Hepatoprotective Effect of Ferulic Acid and\/or Low Doses of \u03b3-Irradiation against Cisplatin-Induced Liver Injury in Rats","volume":"41","author":"Esmat","year":"2022","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12935-018-0595-y","article-title":"The Anticancer Effects of Ferulic Acid Is Associated with Induction of Cell Cycle Arrest and Autophagy in Cervical Cancer Cells","volume":"18","author":"Gao","year":"2018","journal-title":"Cancer Cell Int."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"e22004","DOI":"10.1002\/jbt.22004","article-title":"In Vitro and in Vivo Antithrombotic and Cytotoxicity Effects of Ferulic Acid","volume":"32","author":"Choi","year":"2018","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1139\/apnm-2015-0002","article-title":"Ferulic Acid Exerts Its Antidiabetic Effect by Modulating Insulin-Signalling Molecules in the Liver of High-Fat Diet and Fructose-Induced Type-2 Diabetic Adult Male Rat","volume":"40","author":"Narasimhan","year":"2015","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1055\/s-2006-961535","article-title":"Anti-Inflammatory Activity of Gallic Acid","volume":"58","author":"Kroes","year":"1992","journal-title":"Planta Med."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.toxrep.2021.01.001","article-title":"Hepatoprotective, Antioxidant and, Anti-Inflammatory Potentials of Gallic Acid in Carbon Tetrachloride-Induced Hepatic Damage in Wistar Rats","volume":"8","author":"Ojeaburu","year":"2021","journal-title":"Toxicol. Rep."},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Dludla, P.V., Nkambule, B.B., Jack, B., Mkandla, Z., Mutize, T., Silvestri, S., Orlando, P., Tiano, L., Louw, J., and Mazibuko-Mbeje, S.E. (2018). Inflammation and Oxidative Stress in an Obese State and the Protective Effects of Gallic Acid. Nutrients, 11.","DOI":"10.3390\/nu11010023"},{"key":"ref_212","first-page":"1779","article-title":"Gallic Acid Has Anticancer Activity and Enhances the Anticancer Effects of Cisplatin in Non-small Cell Lung Cancer A549 Cells via the JAK\/STAT3 Signaling Pathway","volume":"41","author":"Zhang","year":"2019","journal-title":"Oncol. Rep."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/ptr.5823","article-title":"Antifungal Activity of Gallic Acid In Vitro and In Vivo","volume":"31","author":"Li","year":"2017","journal-title":"Phytother. Res."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1055\/s-2002-32070","article-title":"Inhibition of HIV-1 Integrase by Galloyl Glucoses from Terminalia chebula and Flavonol Glycoside Gallates from Euphorbia pekinensis","volume":"68","author":"Ahn","year":"2002","journal-title":"Planta Med."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.2174\/1389557522666220513150907","article-title":"A Short Review on Glucogallin and Its Pharmacological Activities","volume":"22","author":"Khan","year":"2022","journal-title":"Mini-Rev. Med. Chem."},{"key":"ref_216","first-page":"44","article-title":"In Vitro Evaluation of Antioxidant Potential of Isolated Compounds and Various Extracts of Peel of Punica Granatum L.","volume":"10","author":"Jacob","year":"2018","journal-title":"Pharmacogn. Res."},{"key":"ref_217","first-page":"1934578X1100600","article-title":"\u03b1-Glucosidase Inhibitory Activity of Kaempferol-3-O-Rutinoside","volume":"6","author":"Habtemariam","year":"2011","journal-title":"Nat. Prod. Commun."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"565700","DOI":"10.3389\/fphar.2020.565700","article-title":"The Pharmacological Action of Kaempferol in Central Nervous System Diseases: A Review","volume":"11","author":"Ortega","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.sajb.2020.10.022","article-title":"Investigation of the Anti-Inflammatory and Antioxidant Activities of Luteolin, Kaempferol, Apigenin and Quercetin","volume":"137","author":"Tian","year":"2021","journal-title":"S. Afr. J. Bot."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"5854","DOI":"10.1002\/fsn3.2513","article-title":"Myricetin: A Comprehensive Review on Its Biological Potentials","volume":"9","author":"Imran","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1039\/C6FO00445H","article-title":"Bioavailability Studies and Anticancer Properties of Malvidin Based Anthocyanins, Pyranoanthocyanins and Non-Oxonium Derivatives","volume":"7","author":"Oliveira","year":"2016","journal-title":"Food Funct."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1021\/jf103822h","article-title":"Protective Effects of Anthocyanins against Amyloid \u03b2-Peptide-Induced Damage in Neuro-2A Cells","volume":"59","author":"Shih","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.bcp.2013.06.010","article-title":"Malvidin-3-O-\u03b2 Glucoside, Major Grape Anthocyanin, Inhibits Human Macrophage-Derived Inflammatory Mediators and Decreases Clinical Scores in Arthritic Rats","volume":"86","author":"Decendit","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0003-9861(02)00561-1","article-title":"Synergistic Antioxidant Effect of Catechin and Malvidin 3-Glucoside on Free Radical-Initiated Peroxidation of Linoleic Acid in Micelles","volume":"408","author":"Rossetto","year":"2002","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_225","doi-asserted-by":"crossref","unstructured":"Kim, M., Yin, J., Hwang, I.H., Park, D.H., Lee, E.K., Kim, M.J., and Lee, M.W. (2020). Anti-Acne Vulgaris Effects of Pedunculagin from the Leaves of Quercus mongolica by Anti-Inflammatory Activity and 5\u03b1-Reductase Inhibition. Molecules., 25.","DOI":"10.3390\/molecules25092154"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/BF02976342","article-title":"Antitumor Activity of Pedunculagin, One of the Ellagitannin","volume":"18","author":"Chang","year":"1995","journal-title":"Arch. Pharm. Res."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1080\/15287394.2021.2009947","article-title":"Pedunculagin Isolated from Plinia cauliflora Seeds Exhibits Genotoxic, Antigenotoxic and Cytotoxic Effects in Bacteria and Human Lymphocytes","volume":"85","author":"Silva","year":"2022","journal-title":"J. Toxicol. Environ. Health A"},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Mattioli, R., Francioso, A., Mosca, L., and Silva, P. (2020). Anthocyanins: A Comprehensive Review of Their Chemical Properties and Health Effects on Cardiovascular and Neurodegenerative Diseases. Molecules, 25.","DOI":"10.3390\/molecules25173809"},{"key":"ref_229","doi-asserted-by":"crossref","unstructured":"Ma, Z., Du, B., Li, J., Yang, Y., and Zhu, F. (2021). An Insight into Anti-Inflammatory Activities and Inflammation Related Diseases of Anthocyanins: A Review of Both In Vivo and In Vitro Investigations. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222011076"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1111\/1750-3841.15153","article-title":"Synergistic Antioxidant Effects of Petunidin and Lycopene in H9c2 Cells Submitted to Hydrogen Peroxide: Role of Akt\/Nrf2 Pathway","volume":"85","author":"Zheng","year":"2020","journal-title":"J. Food Sci."},{"key":"ref_231","doi-asserted-by":"crossref","unstructured":"Wang, Q.-Q., Gao, H., Yuan, R., Han, S., Li, X.-X., Tang, M., Dong, B., Li, J.-X., Zhao, L.-C., and Feng, J. (2020). Procyanidin A2, a Polyphenolic Compound, Exerts Anti-Inflammatory and Anti-Oxidative Activity in Lipopolysaccharide-Stimulated RAW264.7 Cells. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0237017"},{"key":"ref_232","doi-asserted-by":"crossref","unstructured":"Nawrot-Hadzik, I., Matkowski, A., Hadzik, J., Dobrowolska-Czopor, B., Olchowy, C., Dominiak, M., and Kubasiewicz-Ross, P. (2021). Proanthocyanidins and Flavan-3-Ols in the Prevention and Treatment of Periodontitis-Antibacterial Effects. Nutrients, 13.","DOI":"10.3390\/nu13010165"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1002\/mc.22461","article-title":"The PI3K\/Akt Pathway Is Involved in Procyanidin-Mediated Suppression of Human Colorectal Cancer Cell Growth","volume":"55","author":"Choy","year":"2016","journal-title":"Mol. Carcinog."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.3389\/fimmu.2019.01895","article-title":"Procyanidin B2 Activates PPAR\u03b3 to Induce M2 Polarization in Mouse Macrophages","volume":"10","author":"Tian","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s12272-016-0852-3","article-title":"Prunin Is a Highly Potent Flavonoid from Prunus davidiana Stems That Inhibits Protein Tyrosine Phosphatase 1B and Stimulates Glucose Uptake in Insulin-Resistant HepG2 Cells","volume":"40","author":"Jung","year":"2017","journal-title":"Arch. Pharm. Res."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"148","DOI":"10.22270\/jddt.v12i2.5377","article-title":"Pharmacological Activities of Punicalagin: A Review","volume":"12","author":"Rozadi","year":"2022","journal-title":"J. Drug Deliv. Ther."},{"key":"ref_237","first-page":"856","article-title":"Quercetin and Its Role in Biological Functions: An Updated Review","volume":"17","author":"Kim","year":"2018","journal-title":"EXCLI J."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1021\/np060015w","article-title":"Quercetin as the Active Principle of Hypericum hircinum Exerts a Selective Inhibitory Activity against MAO-A: Extraction, Biological Analysis, and Computational Study","volume":"69","author":"Chimenti","year":"2006","journal-title":"J. Nat. Prod."},{"key":"ref_239","doi-asserted-by":"crossref","unstructured":"Nguyen, T.L.A., and Bhattacharya, D. (2022). Antimicrobial Activity of Quercetin: An Approach to Its Mechanistic Principle. Molecules, 27.","DOI":"10.3390\/molecules27082494"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1080\/08927014.2019.1604948","article-title":"de A.; de Aguiar Cordeiro, R.; Castelo-Branco, D. de S.C.M.; Sidrim, J.J.C.; Brilhante, R.S.N. Antifungal Effects of the Flavonoids Kaempferol and Quercetin: A Possible Alternative for the Control of Fungal Biofilms","volume":"35","author":"Rocha","year":"2019","journal-title":"Biofouling"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/sj.bjp.0706246","article-title":"Flavonols Inhibit Proinflammatory Mediator Release, Intracellular Calcium Ion Levels and Protein Kinase C Theta Phosphorylation in Human Mast Cells","volume":"145","author":"Kempuraj","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1039\/C7FO01383C","article-title":"A Combination of Quercetin and Resveratrol Reduces Obesity in High-Fat Diet-Fed Rats by Modulation of Gut Microbiota","volume":"8","author":"Zhao","year":"2017","journal-title":"Food Funct."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.fct.2012.12.008","article-title":"Radioprotection by Two Phenolic Compounds: Chlorogenic and Quinic Acid, on X-Ray Induced DNA Damage in Human Blood Lymphocytes in Vitro","volume":"53","author":"Cinkilic","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1248\/bpb.24.921","article-title":"Neuroprotective and Neurotrophic Effects of Quinic Acids from Aster scaber in PC12 Cells","volume":"24","author":"Hur","year":"2001","journal-title":"Biol. Pharm. Bull."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.biopha.2017.10.021","article-title":"Quinic Acid Inhibits Vascular Inflammation in TNF-\u03b1-Stimulated Vascular Smooth Muscle Cells. Biomed. Pharmacother","volume":"96","author":"Jang","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/s12985-015-0443-9","article-title":"Quinic Acid Derivatives Inhibit Dengue Virus Replication in Vitro","volume":"12","author":"Zanello","year":"2015","journal-title":"Virol. J."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1111\/tpj.15390","article-title":"Caffeoylquinic Acids: Chemistry, Biosynthesis, Occurrence, Analytical Challenges, and Bioactivity","volume":"107","author":"Kamimura","year":"2021","journal-title":"Plant J."},{"key":"ref_248","doi-asserted-by":"crossref","unstructured":"Hou, X., Yu, T., Han, S., Chen, X., Wang, K., Gao, P., and Li, L. (2023). Caffeoylquinic Acids Protect against Alcoholic Liver Injury and Rare C10 Acetylenic Acids from Erigeron Breviscapus. Nat. Prod. Res., 1\u20136.","DOI":"10.1080\/14786419.2023.2201886"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"110301","DOI":"10.1016\/j.biopha.2020.110301","article-title":"Isorhamnetin: A Review of Pharmacological Effects","volume":"128","author":"Gong","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1021\/acs.jnatprod.5b01033","article-title":"Antituberculosis Activity of a Naturally Occurring Flavonoid, Isorhamnetin","volume":"79","author":"Jnawali","year":"2016","journal-title":"J. Nat. Prod."},{"key":"ref_251","doi-asserted-by":"crossref","unstructured":"Guan, H., Luo, W., Bao, B., Cao, Y., Cheng, F., Yu, S., Fan, Q., Zhang, L., Wu, Q., and Shan, M. (2022). A Comprehensive Review of Rosmarinic Acid: From Phytochemistry to Pharmacology and Its New Insight. Molecules, 27.","DOI":"10.3390\/molecules27103292"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1007\/s12010-008-8440-8","article-title":"Monopalmityloxy Shikimic Acid: Enzymatic Synthesis and Anticoagulation Activity Evaluation","volume":"158","author":"Tang","year":"2009","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1039\/C6FO00927A","article-title":"Anti-Platelet and Anti-Thrombogenic Effects of Shikimic Acid in Sedentary Population","volume":"7","author":"Veach","year":"2016","journal-title":"Food Funct."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0367-326X(00)00127-1","article-title":"An Antioxidant Sinapic Acid Ester Isolated from Iberis Amara","volume":"71","author":"Fabre","year":"2000","journal-title":"Fitoterapia"},{"key":"ref_255","doi-asserted-by":"crossref","unstructured":"Legrum, W. (2011). Riechstoffe, Zwischen Gestank und Duft: Vorkommen, Eigenschaften und Anwendung von Riechstoffen und deren Gemischen, Vieweg + Teubner. Studienb\u00fccher Chemie; 1. Aufl.","DOI":"10.1007\/978-3-8348-8276-9_1"},{"key":"ref_256","unstructured":"(2003). Ullmann\u2019s Encyclopedia of Industrial Chemistry, Wiley-VCH Verlag GmbH & Co. KGaA."},{"key":"ref_257","unstructured":"Fenaroli, G., and Burdock, G.A. (2002). Fenaroli\u2019s Handbook of Flavor Ingredients, CRC Press. [4th ed.]."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1438-8677.2009.00246.x","article-title":"Loss of Flower Bud Vigour in the Mediterranean Shrub, Cistus albidus L. at Advanced Developmental Stages","volume":"12","year":"2010","journal-title":"Plant Biol."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/jxb\/ern274","article-title":"Hydrogen Peroxide Is Involved in the Acclimation of the Mediterranean Shrub, Cistus albidus L., to Summer Drought","volume":"60","author":"Alegre","year":"2008","journal-title":"J. Exp. Bot."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0308-8146(00)00099-6","article-title":"Epimerisation of Catechins in Green Tea Infusions","volume":"70","author":"Wang","year":"2000","journal-title":"Food Chem."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1021\/jf0730338","article-title":"Reaction Kinetics of Degradation and Epimerization of Epigallocatechin Gallate (EGCG) in Aqueous System over a Wide Temperature Range","volume":"56","author":"Wang","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"6639","DOI":"10.1007\/s13197-015-1746-y","article-title":"Effects of Different Brewing Conditions on Catechin Content and Sensory Acceptance in Turkish Green Tea Infusions","volume":"52","author":"Saklar","year":"2015","journal-title":"J. Food Sci. Technol."},{"key":"ref_263","first-page":"1","article-title":"Ethnobotanical Profile of Medicinal Plants Used by People of North-Eastern Morocco: Cross-Cultural and Historical Approach (Part I)","volume":"21","author":"Kharchoufa","year":"2021","journal-title":"Ethnobot. Res. Appl."},{"key":"ref_264","unstructured":"Fajardo, J., Verde, A., Rivera, D., and Ob\u00f3n, C. (2000). Las Plantas En La Cultura Popular de La Provincia de Albacete, Diputacio\u0144 de Albacete. Serie I\u2014Estudios; Instituto de Estudios Albacetenses \u201cDon Juan Manuel\u201d de la Excma."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"115532","DOI":"10.1016\/j.jep.2022.115532","article-title":"Moroccan Medicinal Plants Traditionally Used for the Treatment of Skin Diseases: From Ethnobotany to Clinical Trials","volume":"297","author":"Ajjoun","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_266","unstructured":"Fern\u00e1ndez Oca\u00f1a, A.M. (2000). Estudio Etnobot\u00e1nico En El Parque Natural de Las Sierras de Cazorla, Segura y Las Villas, Investigaci\u00f3n Qu\u00edmica de Un Grupo de Especies Interesantes, Departamento de Biolog\u00eda Animal, Vegetal y Ecolog\u00eda, Facultad de Ciencias Experimentales, Universidad de Ja\u00e9n."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.indcrop.2018.10.045","article-title":"Valorizing Industrial Hemp (Cannabis sativa L.) by-Products: Cannabidiol Enrichment in the Inflorescence Essential Oil Optimizing Sample Pre-Treatment Prior to Distillation","volume":"128","author":"Fiorini","year":"2019","journal-title":"Ind. Crops Prod."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1021\/np960004a","article-title":"The Volatile Oil Composition of Fresh and Air-Dried Buds of Cannabis sativa","volume":"59","author":"Ross","year":"1996","journal-title":"J. Nat. Prod."},{"key":"ref_269","doi-asserted-by":"crossref","unstructured":"Antony, A., and Farid, M. (2022). Effect of Temperatures on Polyphenols during Extraction. Appl. Sci., 12.","DOI":"10.3390\/app12042107"},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s13197-017-2895-y","article-title":"The Effect of Drying Temperatures on Antioxidant Activity, Phenolic Compounds, Fatty Acid Composition and Tocopherol Contents in Citrus Seed and Oils","volume":"55","author":"Uslu","year":"2018","journal-title":"J. Food Sci. Technol."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1021\/jf980017p","article-title":"Effect of Temperature on the Free Radical Scavenging Capacity of Extracts from Red and White Grape Pomace Peels","volume":"46","author":"Larrauri","year":"1998","journal-title":"J. Agric. Food Chem."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.crfs.2021.03.011","article-title":"Extraction of Phenolic Compounds: A Review","volume":"4","author":"Alara","year":"2021","journal-title":"Curr. Res. Food Sci."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13020-018-0177-x","article-title":"Techniques for Extraction and Isolation of Natural Products: A Comprehensive Review","volume":"13","author":"Zhang","year":"2018","journal-title":"Chin. Med."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4172\/2157-7471.1000342","article-title":"Determination of Phenol Content and Antibacterial Activity of Five Medicinal Plants Ethanolic Extracts from North-West of Morocco","volume":"7","author":"Bouyahya","year":"2016","journal-title":"J. Plant Pathol. Microbiol."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/ffj.2730070411","article-title":"Isolation of Rosemary Oil: Comparison between Hydrodistillation and Supercritical CO2 Extraction","volume":"7","author":"Reverchon","year":"1992","journal-title":"Flavour Fragr. J."},{"key":"ref_276","doi-asserted-by":"crossref","unstructured":"He, X., Yang, J., Huang, Y., Zhang, Y., Wan, H., and Li, C. (2019). Green and Efficient Ultrasonic-Assisted Extraction of Bioactive Components from Salvia miltiorrhiza by Natural Deep Eutectic Solvents. Molecules, 25.","DOI":"10.3390\/molecules25010140"},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"230S","DOI":"10.1093\/ajcn\/81.1.230S","article-title":"Bioavailability and Bioefficacy of Polyphenols in Humans. I. Review of 97 Bioavailability Studies","volume":"81","author":"Manach","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0753-3322(02)00205-6","article-title":"Absorption and Metabolism of Polyphenols in the Gut and Impact on Health","volume":"56","author":"Scalbert","year":"2002","journal-title":"Biomed. Pharmacother."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.3390\/nu5093367","article-title":"Flavonoid Bioavailability and Attempts for Bioavailability Enhancement","volume":"5","author":"Thilakarathna","year":"2013","journal-title":"Nutrients"},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1039\/C3FO60599J","article-title":"Unsaturated Fatty Acids Promote Bioaccessibility and Basolateral Secretion of Carotenoids and \u03b1-Tocopherol by Caco-2 Cells","volume":"5","author":"Failla","year":"2014","journal-title":"Food Funct."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1039\/C4FO00817K","article-title":"Enhancement of Flavonoid Ability to Cross the Blood\u2013Brain Barrier of Rats by Co-Administration with \u03b1-Tocopherol","volume":"6","author":"Ferri","year":"2015","journal-title":"Food Funct."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ijpharm.2013.08.017","article-title":"Influence of Borneol and Muscone on Geniposide Transport through MDCK and MDCK-MDR1 Cells as Blood\u2013Brain Barrier in Vitro Model","volume":"456","author":"Chen","year":"2013","journal-title":"Int. J. Pharm."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1097\/WNR.0000000000000792","article-title":"L-Borneol Induces Transient Opening of the Blood\u2013Brain Barrier and Enhances the Therapeutic Effect of Cisplatin","volume":"28","author":"Yin","year":"2017","journal-title":"NeuroReport"},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.jep.2013.10.028","article-title":"The Mechanism of the Opening of the Blood\u2013Brain Barrier by Borneol: A Pharmacodynamics and Pharmacokinetics Combination Study","volume":"150","author":"Yu","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.etap.2010.01.004","article-title":"Enhancement of Intestinal Absorption of Akebia Saponin D by Borneol and Probenecid in Situ and in Vitro","volume":"29","author":"Zhou","year":"2010","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_286","unstructured":"Alcaraz Ariza, F.J., and Le Hou\u00e9rou, H.-N. (2002). Flora B\u00e1sica de la Regi\u00f3n de Murcia, Sociedad Cooperativa de Ense\u00f1anza Severo Ochoa."},{"key":"ref_287","unstructured":"St\u00fcbing, G., and Peris, J.B. (1998). Plantas Medicinales de la Comunidad Valenciana, Generalitat Valenciana, Conselleria de Medio Ambiete."},{"key":"ref_288","unstructured":"Segarra i Dur\u00e0, E. (2008). Etnobot\u00e0nica Farmac\u00e8utica de G\u00e0tova, Universitat de Val\u00e8ncia."},{"key":"ref_289","unstructured":"Ledesma, J. (2004). Estudio Del Uso Tradicional de Las Plantas Silvestres En La Sierra de Montsant, Trabajo Fin de Carrera, Escuela de Ingenier\u00eda Forestal de Lleida."},{"key":"ref_290","unstructured":"Carri\u00f3 Cabrer, M.E. (2013). Contribuci\u00f3 a l\u2019etnobot\u00e0nica de Mallorca, La Biodiversitat Vegetal i La Seva Gesti\u00f3 En Una Illa Mediterr\u00e0nia, Universidad de Barcelona."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.jep.2012.03.049","article-title":"Ethnobotany of Medicinal Plants Used in Eastern Mallorca (Balearic Islands, Mediterranean Sea)","volume":"141","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_292","first-page":"299","article-title":"Traditional Knowledge of Medicinal Plants in the Serra de Mariola Natural Park, South-Eastern Spain","volume":"10","author":"Belda","year":"2013","journal-title":"Afr. J. Tradit. Complement. Altern. Med."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/BF02862112","article-title":"Ethnobotanical Resources in the Province of Almeria, Spain: Campos de Nijar","volume":"50","year":"1996","journal-title":"Econ. Bot."},{"key":"ref_294","unstructured":"Torres-Montes, F. (2004). Nombres y Usos Tradicionales de Las Plantas Silvestres En Almer\u00eda (Estudio Linguistico y Etnografico), Diputaci\u00f3n de Almer\u00eda e Instituto de Estudios Almerienses."},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jep.2015.10.022","article-title":"Medicinal and Local Food Plants in the South of Alava (Basque Country, Spain)","volume":"176","author":"Priestley","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"ref_296","unstructured":"Ortu\u00f1o Moya, I.M. (2004). Etnobot\u00e1nica de Los Villares y Valdepe\u00f1as de Ja\u00e9n (Sur de La Pen\u00ednsula Ib\u00e9rica), Universidad de Ja\u00e9n\u2014Departamento de Biolog\u00eda Animal, Vegetal y Ecolog\u00eda, Facultad de Ciencias Experimentales."},{"key":"ref_297","unstructured":"Goicoetxea Marcaida, A. (2017). Etnobot\u00e1nica y Medicina Popular en el Pa\u00eds Vasco, Pastor."},{"key":"ref_298","unstructured":"Gonz\u00e1lez-Tejero Garc\u00eda, M.R. (1989). Investigaciones Etnobot\u00e1nicas En La Provincia de Granada, Departamento de Biolog\u00eda Vegetal, Facultad de Farmacia, Universidad de Granada."},{"key":"ref_299","unstructured":"Rivera, D., Alcaraz, F., Verde, A., Fajardo, J., and Ob\u00f3n, C. (2008). Las Plantas en la Cultura Popular, SOMEHN (Sociedad Mediterr\u00e1nea de Historia Natural)."},{"key":"ref_300","unstructured":"Guzm\u00e1n, A. (1997). Aproximaci\u00f3n a La Etnobot\u00e1nica de La Provincia de Ja\u00e9n, Departamento de Biolog\u00eda Vegetal, Universidad de Granada."},{"key":"ref_301","unstructured":"Atzei, A.D. (2003). Le Piante Nella Tradizione Popolare Della Sardegna: Documentazione Sugli Usi Alimentari, Aromatizzanti, Profumieri, Artigianali, Cosmetici, Medicinali, Veterinari, Magici, Ornamentali, Rituali, Religiosi, Tintori, Antiparassitari e Vari, Delle Piante, C. Delfino."},{"key":"ref_302","unstructured":"Rivera, D., Robleda, A., Ob\u00f3n, C., and Cano, F. (1994). Introducci\u00f3n al Mundo de Las Plantas Medicinales En Murcia, Ayuntamiento de Murcia. [1st ed.]."},{"key":"ref_303","unstructured":"Pellicer, J. (2000). Costumari Bot\u00e0nic: Recerques Etnobot\u00e0niques a Les Comarques Centrals Valencianes; Farga monogr\u00e0fica, Edicions del Bullent. [2nd ed.]."},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2019.01.005","article-title":"Chemical Composition, Antioxidant and Anti-Inflammatory Activities of the Essential Oils from Male and Female Specimens of Baccharis punctulata (Asteraceae)","volume":"234","author":"Ascari","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2174\/1872213X12666180115153635","article-title":"Anti-Inflammatory Drugs and Herbs with Special Emphasis on Herbal Medicines for Countering Inflammatory Diseases and Disorders\u2014A Review","volume":"12","author":"Yatoo","year":"2018","journal-title":"Recent Pat. Inflamm. Allergy Drug Discov."},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"9099","DOI":"10.1073\/pnas.0803601105","article-title":"Beta-Caryophyllene Is a Dietary Cannabinoid","volume":"105","author":"Gertsch","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1055\/s-2006-958058","article-title":"Apigenin, a Component of Matricaria recutita Flowers, Is a Central Benzodiazepine Receptors-Ligand with Anxiolytic Effects","volume":"61","author":"Viola","year":"1995","journal-title":"Planta Med."},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.jnutbio.2011.03.017","article-title":"Route of Administration Determines the Anxiolytic Activity of the Flavonols Kaempferol, Quercetin and Myricetin\u2014Are They Prodrugs?","volume":"23","author":"Vissiennon","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1211\/0022357001774075","article-title":"Identification of Kaempferol as a Monoamine Oxidase Inhibitor and Potential Neuroprotectant in Extracts of Ginkgo biloba Leaves","volume":"52","author":"Sloley","year":"2000","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1016\/j.jff.2013.09.010","article-title":"Determination of Flavonoids by LC\/MS and Anti-Inflammatory Activity in Moringa oleifera","volume":"5","author":"Coppin","year":"2013","journal-title":"J. Funct. Foods"},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"112316","DOI":"10.1016\/j.jep.2019.112316","article-title":"The Old Pharmaceutical Oleoresin Labdanum of Cistus creticus L. Exerts Pronounced in Vitro Anti-Dengue Virus Activity","volume":"257","author":"Kuchta","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0145-2126(98)00134-9","article-title":"The Effect of Sclareol on Growth and Cell Cycle Progression of Human Leukemic Cell Lines","volume":"23","author":"Dimas","year":"1999","journal-title":"Leuk. Res."},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1055\/s-2006-957410","article-title":"Cytotoxic Activity of Labdane Type Diterpenes against Human Leukemic Cell Lines in Vitro","volume":"64","author":"Dimas","year":"1998","journal-title":"Planta Med."},{"key":"ref_314","first-page":"4065","article-title":"Cytotoxic Activity and Antiproliferative Effects of a New Semi-Synthetic Derivative of Ent-3 Beta-Hydroxy-13-Epi-Manoyl Oxide on Human Leukemic Cell Lines","volume":"19","author":"Dimas","year":"1999","journal-title":"Anticancer Res."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"7188","DOI":"10.1016\/j.tetlet.2013.10.113","article-title":"Syntheses of Prodelphinidin B1, B2, and B4 and Their Antitumor Activities against Human PC-3 Prostate Cancer Cell Lines","volume":"54","author":"Fujii","year":"2013","journal-title":"Tetrahedron Lett."},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"e02610","DOI":"10.1016\/j.heliyon.2019.e02610","article-title":"Identification and Characterization of Oligomeric Proanthocyanidins with Significant Anti-Cancer Activity in Adzuki Beans (Vigna angularis)","volume":"5","author":"Kawahara","year":"2019","journal-title":"Heliyon"},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/1040869059096","article-title":"Dietary Polyphenols and the Prevention of Diseases","volume":"45","author":"Scalbert","year":"2005","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"8114","DOI":"10.1523\/JNEUROSCI.19-18-08114.1999","article-title":"Reversals of Age-Related Declines in Neuronal Signal Transduction, Cognitive, and Motor Behavioral Deficits with Blueberry, Spinach, or Strawberry Dietary Supplementation","volume":"19","author":"Joseph","year":"1999","journal-title":"J. Neurosci."},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"S215","DOI":"10.1097\/00005344-200606001-00018","article-title":"The Effect of Flavanol-Rich Cocoa on the FMRI Response to a Cognitive Task in Healthy Young People","volume":"47","author":"Francis","year":"2006","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_320","first-page":"433","article-title":"Cerebral Blood Flow Response to Flavanol-Rich Cocoa in Healthy Elderly Humans","volume":"4","author":"Sorond","year":"2008","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1126\/science.aav6885","article-title":"Adult Neurogenesis in Mammals","volume":"364","author":"Gage","year":"2019","journal-title":"Science"},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.stem.2018.03.015","article-title":"Human Hippocampal Neurogenesis Persists throughout Aging","volume":"22","author":"Boldrini","year":"2018","journal-title":"Cell Stem Cell"},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"226","DOI":"10.14393\/BJ-v32n1a2016-30208","article-title":"Comparison of Antioxidant and Antimicrobial Activities of Two Cultivated Cistus Species from Tunisia","volume":"32","author":"Mahmoudi","year":"2016","journal-title":"Biosci. J."},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/0006-2952(93)90476-D","article-title":"Effects of Flavonoids on the Release of Reactive Oxygen Species by Stimulated Human Neutrophils. Multivariate Analysis of Structure-Activity Relationships (SAR)","volume":"46","author":"Limasset","year":"1993","journal-title":"Biochem. Pharmacol."},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/10286020500209087","article-title":"Elevated Levels of DNA Repair Enzymes and Antioxidative Enzymes by (+)-Catechin in Murine Microglia Cells after Oxidative Stress","volume":"8","author":"Huang","year":"2006","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"104172","DOI":"10.1016\/j.jff.2020.104172","article-title":"A Review on Anti-Cancer Effect of Green Tea Catechins","volume":"74","author":"Cheng","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1469-0691.2010.03432.x","article-title":"Evolving Epidemiology of Hepatitis C Virus","volume":"17","author":"Lavanchy","year":"2011","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s12035-019-01759-7","article-title":"Gallic Acid Attenuated LPS-Induced Neuroinflammation: Protein Aggregation and Necroptosis","volume":"57","author":"Liu","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/sj.bjp.0707505","article-title":"Cannabinoid CB2 Receptors in Human Brain Inflammation","volume":"153","author":"Benito","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1523\/JNEUROSCI.23-04-01398.2003","article-title":"Nonpsychotropic Cannabinoid Receptors Regulate Microglial Cell Migration","volume":"23","author":"Walter","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"5319","DOI":"10.2174\/092986712803833335","article-title":"Terpene Compounds in Nature: A Review of Their Potential Antioxidant Activity","volume":"19","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"ref_332","doi-asserted-by":"crossref","unstructured":"Kim, T., Song, B., Cho, K.S., and Lee, I.-S. (2020). Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21062187"},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1159\/000186049","article-title":"Antioxidant Activity of Bisabolol: Inhibitory Effects on Chemiluminescence of Human Neutrophil Bursts and Cell-Free Systems","volume":"83","author":"Braga","year":"2009","journal-title":"Pharmacology"},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1089\/rej.2013.1515","article-title":"Anti-Stress Effects of d-Limonene and Its Metabolite Perillyl Alcohol","volume":"17","author":"Bisson","year":"2014","journal-title":"Rejuvenation Res."},{"key":"ref_335","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.jpain.2010.02.022","article-title":"The Antinociceptive Effect of (-)-Linalool in Models of Chronic Inflammatory and Neuropathic Hypersensitivity in Mice","volume":"11","author":"Batista","year":"2010","journal-title":"J. Pain"},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1007\/s11064-015-1629-7","article-title":"Linalool Inhibits LPS-Induced Inflammation in BV2 Microglia Cells by Activating Nrf2","volume":"40","author":"Li","year":"2015","journal-title":"Neurochem. Res."},{"key":"ref_337","doi-asserted-by":"crossref","first-page":"704197","DOI":"10.3389\/fphar.2021.704197","article-title":"Therapeutic Applications of Terpenes on Inflammatory Diseases","volume":"12","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.envres.2017.07.048","article-title":"Metals and Neurodegenerative Diseases. A Systematic Review","volume":"159","author":"Cicero","year":"2017","journal-title":"Environ. Res."},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.3233\/JAD-200282","article-title":"Heavy Metals Exposure and Alzheimer\u2019s Disease and Related Dementias","volume":"76","author":"Bakulski","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"ref_340","doi-asserted-by":"crossref","unstructured":"Pyatha, S., Kim, H., Lee, D., and Kim, K. (2022). Association between Heavy Metal Exposure and Parkinson\u2019s Disease: A Review of the Mechanisms Related to Oxidative Stress. Antioxidants, 11.","DOI":"10.3390\/antiox11122467"},{"key":"ref_341","doi-asserted-by":"crossref","first-page":"532640","DOI":"10.1155\/2009\/532640","article-title":"The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels","volume":"2009","author":"Adams","year":"2009","journal-title":"J. Toxicol."},{"key":"ref_342","doi-asserted-by":"crossref","first-page":"15493","DOI":"10.1038\/ncomms15493","article-title":"Fetal and Postnatal Metal Dysregulation in Autism","volume":"8","author":"Arora","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_343","unstructured":"Grove, J., Ripke, S., Als, T.D., Mattheisen, M., Walters, R., Won, H., Pallesen, J., Agerbo, E., Andreassen, O.A., and Anney, R. (2017). Common Risk Variants Identified in Autism Spectrum Disorder; Common Risk Variants Identified in Autism Spectrum Disorder. bioRXiv."},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"106468","DOI":"10.1016\/j.envint.2021.106468","article-title":"Metal and Essential Element Concentrations during Pregnancy and Associations with Autism Spectrum Disorder and Attention-Deficit\/Hyperactivity Disorder in Children","volume":"152","author":"Skogheim","year":"2021","journal-title":"Environ. Int."},{"key":"ref_345","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0076-6879(01)35243-6","article-title":"Metal Chelation of Polyphenols","volume":"Volume 335","author":"Hider","year":"2001","journal-title":"Methods in Enzymology"},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.mam.2010.09.006","article-title":"Basic Biochemical Mechanisms behind the Health Benefits of Polyphenols","volume":"31","author":"Fraga","year":"2010","journal-title":"Mol. Aspects Med."},{"key":"ref_347","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.fct.2017.10.042","article-title":"Protective Role of Quercetin against Copper(II)-Induced Oxidative Stress: A Spectroscopic, Theoretical and DNA Damage Study","volume":"110","author":"Jomova","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"S335","DOI":"10.3233\/JAD-200185","article-title":"Polyphenols as Potential Metal Chelation Compounds Against Alzheimer\u2019s Disease","volume":"82","author":"Burillo","year":"2021","journal-title":"J. Alzheimers Dis."},{"key":"ref_349","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1021\/ar500152x","article-title":"The Ongoing Search for Small Molecules to Study Metal-Associated Amyloid-\u03b2 Species in Alzheimer\u2019s Disease","volume":"47","author":"Savelieff","year":"2014","journal-title":"Acc. Chem. Res."},{"key":"ref_350","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0162-0134(02)00511-1","article-title":"Iron and Copper Chelation by Flavonoids: An Electrospray Mass Spectrometry Study","volume":"92","author":"Fernandez","year":"2002","journal-title":"J. Inorg. Biochem."},{"key":"ref_351","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1177\/0300985819880346","article-title":"Cistus salviifolius Toxicity in Cattle","volume":"57","author":"Mignacca","year":"2020","journal-title":"Vet. Pathol."},{"key":"ref_352","first-page":"627","article-title":"A Urinary Retention Syndrome in Beef Cows Probably Caused by Ingestion of Cistus","volume":"153","author":"Yeruham","year":"2002","journal-title":"Rev. M\u00e9d V\u00e9t"},{"key":"ref_353","doi-asserted-by":"crossref","unstructured":"Acamovic, T., Stewart, C.S., and Pennycott, T.W. (2004). Poisonous Plants and Related Toxins, CABI.","DOI":"10.1079\/9780851996141.0000"},{"key":"ref_354","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.sajb.2022.11.009","article-title":"Ethnoveterinary Practices of Medicinal Plants among the Zemmour and Zayane Tribes, Middle Atlas, Morocco","volume":"151","author":"Chaachouay","year":"2022","journal-title":"S. Afr. J. Bot."}],"container-title":["Plants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2223-7747\/12\/16\/2988\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:37:13Z","timestamp":1760128633000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2223-7747\/12\/16\/2988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,18]]},"references-count":354,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["plants12162988"],"URL":"https:\/\/doi.org\/10.3390\/plants12162988","relation":{},"ISSN":["2223-7747"],"issn-type":[{"value":"2223-7747","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,18]]}}}