{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T16:03:41Z","timestamp":1782489821795,"version":"3.54.5"},"reference-count":69,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science, Technological Development and Innovation of The Republic of Serbia","award":["451-03-47\/2023-01\/200088"],"award-info":[{"award-number":["451-03-47\/2023-01\/200088"]}]},{"name":"Serbian Academy of Science and Arts","award":["451-03-47\/2023-01\/200088"],"award-info":[{"award-number":["451-03-47\/2023-01\/200088"]}]},{"name":"University of Kragujevac","award":["451-03-47\/2023-01\/200088"],"award-info":[{"award-number":["451-03-47\/2023-01\/200088"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>The goal of the present research was to screen the antimicrobial activity of an ethanolic extract of Kitaibelia vitifolia against 30 multidrug-resistant (MDR) bacterial strains isolated from healthcare-associated infections. Minimum inhibitory concentrations (MICs) of the samples against the tested bacteria were determined using the microdilution method. MDR bacterial strains were characterized using standard biochemical tests and the commercial identification systems API 20 NE and API 20 E as: Klebsiella spp. (18 isolates\u2014I); methicillin-resistant Staphylococcus aureus (MRSA)\u20143; Acinetobacter spp.\u20143; Pseudomonas aeruginosa\u20145; vancomycin-resistant Enterococcus (VRE)\u20141. The sensitivity of isolated bacterial strains was determined using the disc diffusion method against 25 commonly used antibiotics. The highest level of sensitivity to K. vitifolia extract was confirmed in 88.89% of Klebsiella spp. isolates, E.\u00a0coli ATCC 25922, two strains of MRSA (1726, 1063), Acinetobacter spp. strain 1578, and VRE strain 30, like Enterococcus faecalis ATCC 29212 (MIC =&lt; 2.44 \u03bcg\/mL). The lowest sensitivity was exhibited by 75.00% of Acinetobacter spp. (strains 1577 and 6401), where the highest values for MICs were noted (1250 \u03bcg\/mL). The results indicate that the extract of K. vitifolia could be a possible source for creating new, efficient, and effective natural medicines for combat against MDR strains of bacteria.<\/jats:p>","DOI":"10.3390\/plants12183236","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T21:34:12Z","timestamp":1694554452000},"page":"3236","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of Antimicrobial Activity of Kitaibelia vitifolia Extract against Proven Antibiotic-Susceptible and Multidrug-Resistant (MDR) Strains of Bacteria of Clinical Origin"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2016-7345","authenticated-orcid":false,"given":"Vladimir S.","family":"Kur\u0107ubi\u0107","sequence":"first","affiliation":[{"name":"Department of Food Technology, Faculty of Agronomy, University of Kragujevac, Cara Du\u0161ana 34, 32000 \u010ca\u010dak, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana V.","family":"Raketi\u0107","sequence":"additional","affiliation":[{"name":"Microbiology Laboratory for Food and Water, Public Health Institute \u010ca\u010dak, Veselina Miliki\u0107a 7, 32000 \u010ca\u010dak, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena M.","family":"Ma\u0161kovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Engineering, Faculty of Agronomy, University of Kragujevac, Cara Du\u0161ana 34, 32000 \u010ca\u010dak, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavle Z.","family":"Ma\u0161kovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Engineering, Faculty of Agronomy, University of Kragujevac, Cara Du\u0161ana 34, 32000 \u010ca\u010dak, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luka V.","family":"Kur\u0107ubi\u0107","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University Clinical Center of Serbia, Pasterova 2, 11000 Beograd, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Heinz","sequence":"additional","affiliation":[{"name":"DIL German Institute of Food Technology, Prof.-von-Klitzing-Str. 7, D-49610 Quakenbr\u00fcck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1611-2264","authenticated-orcid":false,"given":"Igor B.","family":"Tomasevic","sequence":"additional","affiliation":[{"name":"DIL German Institute of Food Technology, Prof.-von-Klitzing-Str. 7, D-49610 Quakenbr\u00fcck, Germany"},{"name":"Department of Animal Source Food Technology, Faculty of Agriculture, University of Belgrade, Nemanjina 6, 11080 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/10495390600957092","article-title":"Genetics of Antimicrobial Resistance","volume":"17","author":"Harbottle","year":"2006","journal-title":"Anim. 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