{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T17:09:33Z","timestamp":1788628173067,"version":"build-2803163510"},"reference-count":248,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Hair loss (alopecia) has a multitude of causes, and the problem is still poorly defined. For curing alopecia, therapies are available in both natural and synthetic forms; however, natural remedies are gaining popularity due to the multiple effects of complex phytoconstituents on the scalp with fewer side effects. Evidence-based hair growth promotion by some plants has been reported for both traditional and advanced treatment approaches. Nanoarchitectonics may have the ability to evolve in the field of hair- and scalp-altering products and treatments, giving new qualities to hair that can be an effective protective layer or a technique to recover lost hair. This review will provide insights into several plant and herbal formulations that have been reported for the prevention of hair loss and stimulation of new hair growth. This review also focuses on the molecular mechanisms of hair growth\/loss, several isolated phytoconstituents with hair growth-promoting properties, patents, in vivo evaluation of hair growth-promoting activity, and recent nanoarchitectonic technologies that have been explored for hair growth.<\/jats:p>","DOI":"10.3390\/plants12213739","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T12:48:31Z","timestamp":1698756511000},"page":"3739","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Bioactive Compound-Loaded Nanocarriers for Hair Growth Promotion: Current Status and Future Perspectives"],"prefix":"10.3390","volume":"12","author":[{"given":"Arvind","family":"Sharma","sequence":"first","affiliation":[{"name":"School of Pharmaceutical and Health Sciences, Bhoranj (Tikker\u2013Kharwarian), Hamirpur 176041, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harapriya","family":"Mohapatra","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanika","family":"Arora","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritchu","family":"Babbar","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Arora","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonam","family":"Arora","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8640-4350","authenticated-orcid":false,"given":"Pradeep","family":"Kumar","sequence":"additional","affiliation":[{"name":"Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, 7 York Road, Parktown, Johannesburg 2193, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evren","family":"Alg\u0131n Yapar","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Sivas Cumhuriyet University, Sivas 58140, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailash","family":"Rani","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0272-2096","authenticated-orcid":false,"given":"Maninder","family":"Meenu","sequence":"additional","affiliation":[{"name":"Department of Agri-Biotechnology, National Agri-Food Biotechnology Institute, Mohali 143005, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianesan Arockia","family":"Babu","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Research, GLA University, Mathura 281406, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1557-1183","authenticated-orcid":false,"given":"Maninderjit","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2619-4643","authenticated-orcid":false,"given":"Rakesh K.","family":"Sindhu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Sharda University, Greater Noida 201306, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/j.1749-6632.1951.tb31971.x","article-title":"Patterned loss of hair in man: Types and incidence","volume":"53","author":"Hamilton","year":"1951","journal-title":"Ann. 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