{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T16:17:03Z","timestamp":1785946623920,"version":"3.56.0"},"reference-count":214,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T00:00:00Z","timestamp":1698883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UNAM-PAPIIT","award":["No. IN221221"],"award-info":[{"award-number":["No. IN221221"]}]},{"name":"UNAM-PAPIIT","award":["52151"],"award-info":[{"award-number":["52151"]}]},{"name":"UNAM-PAPIIT","award":["55788"],"award-info":[{"award-number":["55788"]}]},{"name":"National System of Researchers","award":["No. IN221221"],"award-info":[{"award-number":["No. IN221221"]}]},{"name":"National System of Researchers","award":["52151"],"award-info":[{"award-number":["52151"]}]},{"name":"National System of Researchers","award":["55788"],"award-info":[{"award-number":["55788"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Nepetoideae is the most diverse subfamily of Lamiaceae, and some species are well known for their culinary and medicinal uses. In recent years, there has been growing interest in the therapeutic properties of the species of this group regarding inflammatory illnesses. This study aims to collect information on traditional uses through ethnobotanical, pharmacological, and phytochemical information of the subfamily Nepetoideae related to inflammatory diseases. UNAM electronic resources were used to obtain the information. The analysis of the most relevant literature was compiled and organised in tables. From this, about 106 species of the subfamily are traditionally recognised to alleviate chronic pain associated with inflammation. Pharmacological studies have been carried out in vitro and in vivo on approximately 308 species belonging to the genera Salvia, Ocimum, Thymus, Mentha, Origanum, Lavandula, and Melissa. Phytochemical and pharmacological evaluations have been performed and mostly prepared as essential oil or high polarity extracts, whose secondary metabolites are mainly of a phenolic nature. Other interesting and explored metabolites are diterpenes from the abietane, clerodane, and kaurane type; however, they have only been described in some species of the genera Salvia and Isodon. This review reveals that the Nepetoideae subfamily is an important source for therapeutics of the inflammatory process.<\/jats:p>","DOI":"10.3390\/plants12213752","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T09:16:21Z","timestamp":1698916581000},"page":"3752","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Ethnobotanical, Phytochemical, and Pharmacological Properties of the Subfamily Nepetoideae (Lamiaceae) in Inflammatory Diseases"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6354-4916","authenticated-orcid":false,"given":"Nancy","family":"Ortiz-Mendoza","sequence":"first","affiliation":[{"name":"Laboratorio de Productos Naturales, Departamento de Ecolog\u00eda y Recursos Naturales, Facultad de Ciencias, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"},{"name":"Posgrado en Ciencias Biol\u00f3gicas, Unidad de Posgrado, Ciudad Universitaria Coyoac\u00e1n, Edificio D, 1\u00b0 Piso, Circuito de Posgrados, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3636-7416","authenticated-orcid":false,"given":"Martha Juana","family":"Mart\u00ednez-Gordillo","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Comparada, Herbario de la Facultad de Ciencias, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4770-4174","authenticated-orcid":false,"given":"Emmanuel","family":"Mart\u00ednez-Ambriz","sequence":"additional","affiliation":[{"name":"Instituto de Ecolog\u00eda, A.C., Red de Biodiversidad y Sistem\u00e1tica, Xalapa 91073, Veracruz, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Alberto","family":"Basurto-Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Jard\u00edn Bot\u00e1nico, Instituto de Biolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4399-1508","authenticated-orcid":false,"given":"Mar\u00eda Eva","family":"Gonz\u00e1lez-Trujano","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda de Productos Naturales, Direcci\u00f3n de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Mexico City 14370, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Aguirre-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratorio de Productos Naturales, Departamento de Ecolog\u00eda y Recursos Naturales, Facultad de Ciencias, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1002\/jemt.23249","article-title":"Taxonomic study of subfamily Nepetoideae (Lamiaceae) by polynomorphological approach","volume":"82","author":"Gul","year":"2019","journal-title":"Microsc. 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