{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:08:12Z","timestamp":1787170092228,"version":"build-2736575974"},"reference-count":173,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T00:00:00Z","timestamp":1702684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018992","name":"Serbian Academy of Sciences and Arts","doi-asserted-by":"publisher","award":["01-2022"],"award-info":[{"award-number":["01-2022"]}],"id":[{"id":"10.13039\/501100018992","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018992","name":"Serbian Academy of Sciences and Arts","doi-asserted-by":"publisher","award":["451-03-47\/2023-01\/200007"],"award-info":[{"award-number":["451-03-47\/2023-01\/200007"]}],"id":[{"id":"10.13039\/501100018992","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018992","name":"Serbian Academy of Sciences and Arts","doi-asserted-by":"publisher","award":["451-03-47\/2023-01\/200026"],"award-info":[{"award-number":["451-03-47\/2023-01\/200026"]}],"id":[{"id":"10.13039\/501100018992","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018992","name":"Serbian Academy of Sciences and Arts","doi-asserted-by":"publisher","award":["451-03-47\/2023-01\/200168"],"award-info":[{"award-number":["451-03-47\/2023-01\/200168"]}],"id":[{"id":"10.13039\/501100018992","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Science, Technological Development and Innovation of the Republic of Serbia","award":["01-2022"],"award-info":[{"award-number":["01-2022"]}]},{"name":"Ministry of Science, Technological Development and Innovation of the Republic of Serbia","award":["451-03-47\/2023-01\/200007"],"award-info":[{"award-number":["451-03-47\/2023-01\/200007"]}]},{"name":"Ministry of Science, Technological Development and Innovation of the Republic of Serbia","award":["451-03-47\/2023-01\/200026"],"award-info":[{"award-number":["451-03-47\/2023-01\/200026"]}]},{"name":"Ministry of Science, Technological Development and Innovation of the Republic of Serbia","award":["451-03-47\/2023-01\/200168"],"award-info":[{"award-number":["451-03-47\/2023-01\/200168"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Euphorbia seguieriana ssp. seguieriana Necker (ES) and Euphorbia cyparissias (EC) with a habitat in the Deliblato Sands were the subject of this examination. The latexes of these so far insufficiently investigated species of the Euphorbia genus are used in traditional medicine for the treatment of wounds and warts on the skin. To determine their chemical composition, non-targeted screening of the latexes\u2019 chloroform extracts was performed using liquid chromatography coupled with quadrupole time-of-flight mass spectrometry employing an electrospray ionization source (LC-ESI QTOF MS). The analysis of the obtained results showed that the latexes of ES and EC represent rich sources of diterpenes, tentatively identified as jatrophanes, ingenanes, tiglianes, myrsinanes, premyrsinanes, and others. Examination of the anticancer activity of the ES and EC latex extracts showed that both extracts significantly inhibited the growth of the non-small cell lung carcinoma NCI-H460 and glioblastoma U87 cell lines as well as of their corresponding multi-drug resistant (MDR) cell lines, NCI-H460\/R and U87-TxR. The obtained results also revealed that the ES and EC extracts inhibited the function of P-glycoprotein (P-gp) in MDR cancer cells, whose overexpression is one of the main mechanisms underlying MDR.<\/jats:p>","DOI":"10.3390\/plants12244181","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T08:55:29Z","timestamp":1702889729000},"page":"4181","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["LC-ESI QToF MS Non-Targeted Screening of Latex Extracts of Euphorbia seguieriana ssp. seguieriana Necker and Euphorbia cyparissias and Determination of Their Potential Anticancer Activity"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4235-3504","authenticated-orcid":false,"given":"Milka","family":"Jadranin","sequence":"first","affiliation":[{"name":"University of Belgrade\u2014Institute of Chemistry, Technology and Metallurgy, Department of Chemistry, Njego\u0161eva 12, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danica","family":"Savi\u0107","sequence":"additional","affiliation":[{"name":"University of Belgrade\u2014Institute of Chemistry, Technology and Metallurgy, Department of Chemistry, Njego\u0161eva 12, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ema","family":"Lup\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Institute for Biological Research \u201cSini\u0161a Stankovi\u0107\u201d\u2014National Institute of the Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11108 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7412-3685","authenticated-orcid":false,"given":"Ana","family":"Podolski-Reni\u0107","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Institute for Biological Research \u201cSini\u0161a Stankovi\u0107\u201d\u2014National Institute of the Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11108 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9045-8239","authenticated-orcid":false,"given":"Milica","family":"Pe\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Institute for Biological Research \u201cSini\u0161a Stankovi\u0107\u201d\u2014National Institute of the Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11108 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vele","family":"Te\u0161evi\u0107","sequence":"additional","affiliation":[{"name":"University of Belgrade\u2014Faculty of Chemistry, Studentski trg 12\u201316, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slobodan","family":"Milosavljevi\u0107","sequence":"additional","affiliation":[{"name":"University of Belgrade\u2014Faculty of Chemistry, Studentski trg 12\u201316, 11000 Belgrade, Serbia"},{"name":"Serbian Academy of Science and Arts, Kneza Mihaila 35, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordana","family":"Krsti\u0107","sequence":"additional","affiliation":[{"name":"University of Belgrade\u2014Faculty of Chemistry, Studentski trg 12\u201316, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1146\/annurev-pharmtox-010611-134529","article-title":"Drug transporters in drug efficacy and toxicity","volume":"52","author":"DeGorter","year":"2012","journal-title":"Annu. 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