{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:20:36Z","timestamp":1792153236116,"version":"4.4.0"},"reference-count":99,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:00:00Z","timestamp":1702857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"BSMRSTU Research Center (BSMRSTU-RC)","award":["2023-33"],"award-info":[{"award-number":["2023-33"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Quercetin (QUA), a flavonoid compound, is ubiquitously found in plants and has demonstrated a diverse range of biological activities. The primary objective of the current study is to assess the potential antiemetic properties of QUA using an in vivo and in silico approach. In this experiment, 4-day-old chicks were purchased to induce emesis by orally administering copper sulfate pentahydrate (CuSO4\u00b75H2O) at a dose of 50 mg\/kg (orally). Domperidone (DOM) (6 mg\/kg), Hyoscine (HYS) (21 mg\/kg), and Ondansetron (OND) (5 mg\/kg) were treated as positive controls (PCs), and distilled water and a trace amount of Tween 80 mixture was employed as a negative control (NC). QUA was given orally at two distinct doses (25 and 50 mg\/kg). Additionally, QUA (50 mg\/kg) and PCs were administered separately or in combination to assess their antagonistic or synergistic effects on the chicks. The binding affinity of QUA and referral ligands towards the serotonin receptor (5HT3), dopamine receptors (D2 and D3), and muscarinic acetylcholine receptors (M1\u2013M5) were estimated, and ligand\u2013receptor interactions were visualized through various computational tools. In vivo findings indicate that QUA (25 and 50 mg\/kg) has a significant effect on reducing the number of retches (16.50 \u00b1 4.65 and 10.00 \u00b1 4.19 times) and increasing the chick latency period (59.25 \u00b1 4.75 and 94.25 \u00b1 4.01 s), respectively. Additionally, QUA (50 mg\/kg) in combination with Domperidone and Ondansetron exhibited superior antiemetic effects, reducing the number of retches and increasing the onset of emesis-inducing time. Furthermore, it is worth noting that QUA exhibited the strongest binding affinity against the D2 receptor with a value of \u22129.7 kcal\/mol through the formation of hydrogen and hydrophobic bonds. In summary, the study found that QUA exhibited antiemetic activity in chicks, potentially by interacting with the D2 receptor pathway.<\/jats:p>","DOI":"10.3390\/plants12244189","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T08:55:29Z","timestamp":1702889729000},"page":"4189","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Assessment of Quercetin Antiemetic Properties: In Vivo and In Silico Investigations on Receptor Binding Affinity and Synergistic Effects"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0672-6581","authenticated-orcid":false,"given":"Raihan","family":"Chowdhury","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6179-9720","authenticated-orcid":false,"given":"Md. Shimul","family":"Bhuia","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3180-6372","authenticated-orcid":false,"given":"Asraful Islam","family":"Rakib","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubel","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6634-4207","authenticated-orcid":false,"given":"Henrique Douglas Melo","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, Regional University of Cariri\u2014URCA, Crato 63105-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac Moura","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, Regional University of Cariri\u2014URCA, Crato 63105-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1065-9581","authenticated-orcid":false,"given":"Irwin Rose Alencar","family":"de Menezes","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, Regional University of Cariri\u2014URCA, Crato 63105-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0034-8202","authenticated-orcid":false,"given":"Muhammad Torequl","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zhong, W., Shahbaz, O., Teskey, G., Beever, A., Kachour, N., Venketaraman, V., and Darmani, N.A. 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