{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T21:24:42Z","timestamp":1791753882576,"version":"4.3.4"},"reference-count":140,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:00:00Z","timestamp":1703030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Moringa oleifera (M. oleifera) is a tropical tree native to Pakistan, India, Bangladesh, and Afghanistan; it is cultivated for its nutritious leaves, pods, and seeds. This scientific study was conducted to outline the anti-inflammatory properties and mechanisms of action of bioactive compounds from M. oleifera. The existing research has found that the plant is used in traditional medicine due to its bioactive compounds, including phytochemicals: flavonoids and polyphenols. The compounds are thought to exert their anti-inflammatory effects due to: (1) inhibition of pro-inflammatory enzymes: quercetin and kaempferol inhibit the pro-inflammatory enzymes (cyclooxygenase and lipoxygenase); (2) regulation of cytokine production: isothiocyanates modulate signaling pathways involved in inflammation, such as the nuclear factor-kappa B (NF-kappa B) pathway; isothiocyanates inhibit the production of pro-inflammatory cytokines such as TNF-\u03b1 (tumor necrosis factor \u03b1) and IL-1\u03b2 (interleukin-1\u03b2); and (3) antioxidant activity: M. oleifera contains flavonoids, polyphenols, known to reduce oxidative stress and inflammation. The review includes M. oleifera\u2019s effects on cardiovascular protection, anti-hypertensive activities, type 2 diabetes, inflammatory bowel disease, and non-alcoholic fatty liver disease (NAFLD). This research could prove valuable for exploring the pharmacological potential of M. oleifera and contributing to the prospects of developing effective medicines for the benefit of human health.<\/jats:p>","DOI":"10.3390\/plants13010020","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T07:20:31Z","timestamp":1703056831000},"page":"20","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":124,"title":["Bioactive Compounds in Moringa oleifera: Mechanisms of Action, Focus on Their Anti-Inflammatory Properties"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1651-0860","authenticated-orcid":false,"given":"Adina","family":"Chi\u0219","sequence":"first","affiliation":[{"name":"Department of Molecular Sciences, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 6 Louis Pasteur St, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7938-4443","authenticated-orcid":false,"given":"Paul Aim\u00e9","family":"Noubissi","sequence":"additional","affiliation":[{"name":"Department of Animal Biology and Conservation, Faculty of Science, University of Buea, Buea P.O. Box 63, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8939-7267","authenticated-orcid":false,"given":"Oana-Lelia","family":"Pop","sequence":"additional","affiliation":[{"name":"Department of Food Science, University of Agricultural Science and Veterinary Medicine, 3-5 Calea M\u0103n\u0103\u0219tur, 400372 Cluj-Napoca, Romania"},{"name":"Molecular Nutrition and Proteomics Lab, CDS3, Life Science Institute, University of Agricultural Science and Veterinary Medicine, 3-5 Calea M\u0103n\u0103\u0219tur, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2410-6582","authenticated-orcid":false,"given":"Carmen Ioana","family":"Mure\u0219an","sequence":"additional","affiliation":[{"name":"Department of Food Science, University of Agricultural Science and Veterinary Medicine, 3-5 Calea M\u0103n\u0103\u0219tur, 400372 Cluj-Napoca, Romania"},{"name":"Molecular Nutrition and Proteomics Lab, CDS3, Life Science Institute, University of Agricultural Science and Veterinary Medicine, 3-5 Calea M\u0103n\u0103\u0219tur, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4145-9788","authenticated-orcid":false,"given":"Michel Archange","family":"Fokam Tagne","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, University of Ngaound\u00e9r\u00e9, Ngaound\u00e9r\u00e9 P.O. 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