{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:32:40Z","timestamp":1791405160577,"version":"4.3.3"},"reference-count":69,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T00:00:00Z","timestamp":1706400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ANID\/FONDECYT Project","award":["1230587"],"award-info":[{"award-number":["1230587"]}]},{"name":"ANID\/FONDECYT Project","award":["FRO-19101"],"award-info":[{"award-number":["FRO-19101"]}]},{"name":"ANID\/FONDECYT Project","award":["3906\/2023"],"award-info":[{"award-number":["3906\/2023"]}]},{"name":"ANID\/FONDECYT Project","award":["FRO-1999"],"award-info":[{"award-number":["FRO-1999"]}]},{"name":"Ministry of Education","award":["1230587"],"award-info":[{"award-number":["1230587"]}]},{"name":"Ministry of Education","award":["FRO-19101"],"award-info":[{"award-number":["FRO-19101"]}]},{"name":"Ministry of Education","award":["3906\/2023"],"award-info":[{"award-number":["3906\/2023"]}]},{"name":"Ministry of Education","award":["FRO-1999"],"award-info":[{"award-number":["FRO-1999"]}]},{"name":"ANID national PhD grant","award":["1230587"],"award-info":[{"award-number":["1230587"]}]},{"name":"ANID national PhD grant","award":["FRO-19101"],"award-info":[{"award-number":["FRO-19101"]}]},{"name":"ANID national PhD grant","award":["3906\/2023"],"award-info":[{"award-number":["3906\/2023"]}]},{"name":"ANID national PhD grant","award":["FRO-1999"],"award-info":[{"award-number":["FRO-1999"]}]},{"name":"Scholarship to Promote Internationalization doctoral programs in double degree or short internship abroad","award":["1230587"],"award-info":[{"award-number":["1230587"]}]},{"name":"Scholarship to Promote Internationalization doctoral programs in double degree or short internship abroad","award":["FRO-19101"],"award-info":[{"award-number":["FRO-19101"]}]},{"name":"Scholarship to Promote Internationalization doctoral programs in double degree or short internship abroad","award":["3906\/2023"],"award-info":[{"award-number":["3906\/2023"]}]},{"name":"Scholarship to Promote Internationalization doctoral programs in double degree or short internship abroad","award":["FRO-1999"],"award-info":[{"award-number":["FRO-1999"]}]},{"name":"Universidad de La Frontera","award":["1230587"],"award-info":[{"award-number":["1230587"]}]},{"name":"Universidad de La Frontera","award":["FRO-19101"],"award-info":[{"award-number":["FRO-19101"]}]},{"name":"Universidad de La Frontera","award":["3906\/2023"],"award-info":[{"award-number":["3906\/2023"]}]},{"name":"Universidad de La Frontera","award":["FRO-1999"],"award-info":[{"award-number":["FRO-1999"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Lettuce is a vegetable that contributes vitamins, minerals, fibre, phenolic compounds and antioxidants to the human diet. In the search for improving production conditions and crop health, the use of microorganisms with plant growth-promoting capabilities, such as soil yeasts (PGPY), in conjunction with nanotechnology could offer sustainable development of agroecosystems. This study evaluated the synthesis of health-promoting bioactive compounds in lettuce under the application of soil yeast and an iron nanoparticle (NP-Fe2O3) encapsulated in alginate beads. Two yeast strains, Candida guillermondii and Rhodotorula mucilaginosa, and a consortium of both yeasts were used in the presence and absence of Fe2O3-NPs. Phenolic compounds were identified and quantified via HPLC-ESI-Q-ToF and antioxidant activity. Ten phenolic compounds were identified, highlighting the chicoric acid isomer and two quercetin glycosides with high concentrations of up to 100 \u00b5g g\u22121 in treatments with C. guillermondii. Treatments with R. mucilaginosa and NPs-Fe2O3 presented an increase in antioxidant activity, mainly in TEAC, CUPRAC and DPPH activities in leaves, with significant differences between treatments. Therefore, the use of encapsulated soil yeasts is a viable alternative for application in vegetables to improve the biosynthesis and accumulation of phenolic compounds in lettuce and other crops.<\/jats:p>","DOI":"10.3390\/plants13030388","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T08:54:03Z","timestamp":1706518443000},"page":"388","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The Biosynthesis, Accumulation of Phenolic Compounds and Antioxidant Response in Lactuca sativa L. Plants Inoculated with a Biofertilizer Based on Soil Yeast and Iron Nanoparticles"],"prefix":"10.3390","volume":"13","author":[{"given":"Daniela","family":"Berr\u00edos","sequence":"first","affiliation":[{"name":"Departamento de Ciencias Qu\u00edmicas y Recursos Naturales, Scientific and Technological Bioresource Nucleus BIOREN-UFRO, Universidad de La Frontera, Temuco 4811230, Chile"},{"name":"Programa de Doctorado en Ciencias Agroalimentarias y Medioambiente, Facultad de Ciencias Agropecuarias y Forestales, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javiera","family":"Nahuelcura","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Qu\u00edmicas y Recursos Naturales, Scientific and Technological Bioresource Nucleus BIOREN-UFRO, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Programa de Doctorado en Ciencias Menci\u00f3n Biolog\u00eda Celular y Molecular Aplicada, Facultad de Ciencias Agropecuarias y Forestales, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Qu\u00edmicas y Recursos Naturales, Scientific and Technological Bioresource Nucleus BIOREN-UFRO, Universidad de La Frontera, Temuco 4811230, Chile"},{"name":"Programa de Doctorado en Ciencias Agroalimentarias y Medioambiente, Facultad de Ciencias Agropecuarias y Forestales, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2124-3100","authenticated-orcid":false,"given":"Pablo","family":"Cornejo","sequence":"additional","affiliation":[{"name":"Escuela de Agronom\u00eda, Facultad de Ciencias Agron\u00f3mica y de los Alimentos, Pontificia Universidad Cat\u00f3lica de Valpara\u00edso, Quillota 2260000, Chile"},{"name":"Centro Regional de Investigaci\u00f3n e Innovaci\u00f3n para la Sostenibilidad de la Agricultura y los Territorios Rurales, CERES, La Palma, Quillota 2260000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1614-0633","authenticated-orcid":false,"given":"Jos\u00e9","family":"P\u00e9rez-Navarro","sequence":"additional","affiliation":[{"name":"Instituto Regional de Investigaci\u00f3n Cient\u00edfica Aplicada, Universidad de Castilla-La Mancha, 13001 Ciudad Real, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2358-6636","authenticated-orcid":false,"given":"Sergio","family":"G\u00f3mez-Alonso","sequence":"additional","affiliation":[{"name":"Instituto Regional de Investigaci\u00f3n Cient\u00edfica Aplicada, Universidad de Castilla-La Mancha, 13001 Ciudad Real, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8578-3475","authenticated-orcid":false,"given":"Antonieta","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Qu\u00edmicas y Recursos Naturales, Scientific and Technological Bioresource Nucleus BIOREN-UFRO, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,28]]},"reference":[{"key":"ref_1","unstructured":"(2023, August 31). Food and Agriculture Organization of the United Nations. FAOSTAT-Vegetables Production. Available online: https:\/\/www.fao.org\/documents\/card\/en\/c\/cc3751en."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.envpol.2017.08.092","article-title":"Cadmium accumulation in edible flowering cabbages in the Pearl River Delta, China: Critical soil factors and enrichment models","volume":"233","author":"Liu","year":"2018","journal-title":"Environ. Pollut."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"104906","DOI":"10.1016\/j.envexpbot.2022.104906","article-title":"Root cell wall remodeling mediates copper oxide nanoparticles phytotoxicity on lettuce (Lactuca sativa L.)","volume":"200","author":"Guo","year":"2022","journal-title":"Environ. Exp. Bot."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.fshw.2022.09.002","article-title":"Roles of fermented plant-, dairy- and meat-based foods in the modulation of allergic responses","volume":"12","author":"Sukor","year":"2023","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jfca.2016.03.004","article-title":"Nutritional value, bioactive compounds and health benefits of lettuce (Lactuca sativa L.)","volume":"49","author":"Kim","year":"2016","journal-title":"J. Food Compos. Anal."},{"key":"ref_6","first-page":"27","article-title":"Growth, mineral content and antioxidant activity of romaine lettuce in relation to development stage in soilless system","volume":"1","author":"Altuntas","year":"2021","journal-title":"Int. J. Agric. Sci. Technol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.sajb.2023.01.034","article-title":"Effect of foliar application of amino acid biostimulants on growth, macronutrient, total phenol contents and antioxidant activity of soilless grown lettuce cultivars","volume":"154","author":"Othman","year":"2023","journal-title":"S. Afr. J. Bot."},{"key":"ref_8","unstructured":"(2023, September 02). Statistics, Food and Agriculture Organization of the United Nations. FAOSTAT-Lettuce Production. Available online: http:\/\/www.fao.org\/faostat\/es\/#data\/QC."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.sajb.2022.01.001","article-title":"The effect of plant biostimulants on the macronutrient content and ion ratio of several lettuce (Lactuca sativa L.) cultivars grown in a plastic house","volume":"147","author":"Yaseen","year":"2022","journal-title":"S. Afr. J. Bot."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Santander, C., Vidal, G., Ruiz, A., Vidal, C., and Cornejo, P. (2022). Salinity Eustress Increases the Biosynthesis and Accumulation of Phenolic Compounds That Improve the Functional and Antioxidant Quality of Red Lettuce. Agronomy, 12.","DOI":"10.3390\/agronomy12030598"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Yang, X., Lu, M., Wang, Y., Wang, Y., Liu, Z., and Chen, S. (2021). Response Mechanism of Plants to Drought Stress. Horticulturae, 7.","DOI":"10.20944\/preprints202102.0466.v1"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4632","DOI":"10.1002\/jsfa.11106","article-title":"Combined effects of cations in fertilizer solution on antioxidant content in red lettuce (Lactuca sativa L.)","volume":"101","author":"Sawatdee","year":"2021","journal-title":"J. Sci. Food Agric."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00217-018-3195-0","article-title":"Polyphenolic profiles in lettuce (Lactuca sativa L.) after CaCl2 treatment and cold storage","volume":"245","author":"Materska","year":"2019","journal-title":"Eur. Food Res. Technol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Mohd Yusof, F.F., Yaacob, J.S., Osman, N., Ibrahim, M.H., Wan-Mohtar, W.A.A.Q.I., Berahim, Z., and Mohd Zain, N.A. (2021). Shading. Effects on Leaf Gas Exchange, Leaf Pigments and Secondary Metabolites of Polygonum minus Huds., an Aromatic Medicinal Herb. Plants, 10.","DOI":"10.3390\/plants10030608"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/pbr.12004","article-title":"Drought stress adaptation: Metabolic adjustment and regulation of gene expression","volume":"132","author":"Bhargava","year":"2013","journal-title":"Plant Breed."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Govindasamy, V., George, P., Kumar, M., Aher, L., Raina, S., Rane, J., Annapurna, K., and Minhas, P. (2020). Multi-trait PGP rhizobacterial endophytes alleviate drought stress in a senescent genotype of sorghum (Sorghum bicolor (L.) Moench). 3 Biotech, 10.","DOI":"10.1007\/s13205-019-2001-4"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.3389\/fpls.2017.01617","article-title":"The Role of Soil Microorganisms in Plant Mineral Nutrition\u2014Current Knowledge and Future Directions","volume":"8","author":"Jacoby","year":"2017","journal-title":"Front. Plant Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ecoenv.2019.05.006","article-title":"Simultaneous mitigation of aluminum, salinity and drought stress in Lactuca sativa growth via formulated plant growth promoting Rhodotorula mucilaginosa CAM4","volume":"180","author":"Silambarasan","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ijbiomac.2018.10.016","article-title":"Evaluation of the production of exopolysaccharide by plant growth promoting yeast Rhodotorula sp. strain CAH2 under abiotic stress conditions","volume":"121","author":"Silambarasan","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Alzandi, A.A., and Naguib, D.M. (2022). Effect of yeast application on soil health and root metabolic status of corn seedlings under drought stress. Arch. Microbiol., 204.","DOI":"10.1007\/s00203-022-02843-8"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1002\/jsfa.10166","article-title":"Efficiency of two arbuscular mycorrhizal fungal inocula to improve saline stress tolerance in lettuce plants by changes of antioxidant defense mechanisms","volume":"100","author":"Santander","year":"2020","journal-title":"J. Sci. Food Agric."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1007\/s42729-021-00591-0","article-title":"Rhizosphere Management for Phytoremediation of Copper Mine Tailings","volume":"21","author":"Tapia","year":"2021","journal-title":"J. Soil Sci. Plant Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.plaphy.2016.05.038","article-title":"Role of nanomaterials in plants under challenging environments","volume":"110","author":"Mobin","year":"2017","journal-title":"Plant Physiol. Biochem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.scienta.2018.03.060","article-title":"A general overview of the benefits and possible negative effects of the nanotechnology in horticulture","volume":"238","author":"Esquivel","year":"2018","journal-title":"Sci. Hortic."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.dib.2018.02.002","article-title":"Data on rhizosphere pH, phosphorus uptake and wheat growth responses upon TiO2 nanoparticles application","volume":"17","author":"Rafique","year":"2018","journal-title":"Data Brief"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1007\/s11356-020-11218-9","article-title":"Efficacy of nanoparticles as nanofertilizer production: A review","volume":"28","author":"Fatima","year":"2021","journal-title":"Environ. Sci. Pollut."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"123385","DOI":"10.1016\/j.jhazmat.2020.123385","article-title":"Effects of nano-enabled agricultural strategies on food quality: Current knowledge and future research needs","volume":"401","author":"Gomez","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"124148","DOI":"10.1016\/j.jhazmat.2020.124148","article-title":"Ecotoxicological and regulatory aspects of environmental sustainability of nanopesticides","volume":"404","author":"Grillo","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Fincheira, P., Hoffmann, N., Tortella, G., Ruiz, A., Cornejo, P., Diez, M.C., Seabra, A.B., Benavides-Mendoza, A., and Rubilar, O. (2023). Eco-Efficient Systems Based on Nanocarriers for the Controlled Release of Fertilizers and Pesticides: Toward Smart Agriculture. Nanomaterials, 13.","DOI":"10.3390\/nano13131978"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.taap.2017.05.025","article-title":"Nanotechnology in agriculture: Opportunities, toxicological implications, and occupational risks","volume":"329","author":"Lavicoli","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"101658","DOI":"10.1016\/j.eti.2021.101658","article-title":"Nanofertilizers towards sustainable agriculture and environment","volume":"23","author":"Hasan","year":"2021","journal-title":"Environ. Technol. Innov."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1080\/01904167.2016.1270320","article-title":"Morpho-physiological and biochemical response of maize (Zea mays L.) plants fertilized with nano-iron (Fe3O4) micronutrient","volume":"40","author":"Elanchezhian","year":"2017","journal-title":"J. Plant Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"127445","DOI":"10.1016\/j.chemosphere.2020.127445","article-title":"Uptake of iron oxide nanoparticles inhibits the photosynthesis of the wheat after foliar exposure","volume":"259","author":"Lu","year":"2020","journal-title":"Chemosphere"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.sjbs.2016.06.004","article-title":"Effects of hematite and ferrihydrite nanoparticles on germination and growth of maize seedlings","volume":"24","author":"Pariona","year":"2017","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.chemosphere.2019.03.168","article-title":"Comparison study of zinc nanoparticles and zinc sulphate on wheat growth: From toxicity and zinc biofortification","volume":"227","author":"Du","year":"2019","journal-title":"Chemosphere"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e04595","DOI":"10.1016\/j.heliyon.2020.e04595","article-title":"Physiological and anti-oxidative response of biologically and chemically synthesized iron oxide: Zea mays a case study","volume":"6","author":"Hasan","year":"2020","journal-title":"Heliyon"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Pallavi, C.M.M., Srivastava, R., Arora, S., and Sharma, A.K. (2016). Impact assessment of silver nanoparticles on plant growth and soil bacterial diversity. 3 Biotech, 6.","DOI":"10.1007\/s13205-016-0567-7"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Nimsi, K.A., Manjusha, K., Kathiresan, K., and Arya, H. (2023). Plant growth-promoting yeasts (PGPY), the latest entrant for use in sustainable agriculture: A review. J. Appl. Microbiol., 134.","DOI":"10.1093\/jambio\/lxac088"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00374-005-0008-y","article-title":"Promotion of plant growth by an auxin producing isolate of the yeast Williopsis saturnus endophytic in maize (Zea mays L.) roots","volume":"42","author":"Nassar","year":"2005","journal-title":"Biol. Fertil. Soils"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.funbio.2014.04.010","article-title":"Plant growth-promoting traits of epiphytic and endophytic yeasts isolated from rice and sugar cane leaves in Thailand","volume":"118","author":"Nutaratat","year":"2014","journal-title":"Fungal Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.apsoil.2011.11.009","article-title":"Plant growth promoting characteristics of soil yeast (Candida tropicalis HY) and its effectiveness for promoting rice growth","volume":"61","author":"Amprayn","year":"2012","journal-title":"Appl. Soil Ecol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4014\/jmb.1006.06045","article-title":"Molecular genetic identification of yeast strains isolated from Egyptian soils for solubilization of inorganic phosphates and growth promotion of corn plants","volume":"21","author":"Hesham","year":"2011","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Bright, J.P., Karunanadham, K., Maheshwari, H.S., Karuppiah, E.A.A., Thankappan, S., Nataraj, R., Pandian, D., Ameen, F., Poczai, P., and Sayyed, R.Z. (2022). Seed-Borne Probiotic Yeasts Foster Plant Growth and Elicit Health Protection in Black Gram (Vigna mungo L.). Sustainability, 14.","DOI":"10.3390\/su14084618"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"785","DOI":"10.2135\/cropsci2013.07.0488","article-title":"Yeasts as a biofertilizer alters plant growth and morphology","volume":"54","author":"Lonhienne","year":"2014","journal-title":"Crop Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41438-018-0050-1","article-title":"A novel integrated non-targeted metabolomic analysis reveals significant metabolite variations between different lettuce (Lactuca sativa. L) varieties","volume":"5","author":"Yang","year":"2018","journal-title":"Hortic. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"111994","DOI":"10.1016\/j.scienta.2023.111994","article-title":"Quantification of total polyphenols, antioxidants, anthocyanins and secondary metabolites by UPLC VION IMS QTOF MS\/MS analysis in green and red lettuce cultivars","volume":"315","author":"Hameed","year":"2023","journal-title":"Sci. Hortic."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.foodchem.2007.11.032","article-title":"Characterisation of polyphenols and antioxidant properties of five lettuce varieties and escarole","volume":"108","author":"Llorach","year":"2008","journal-title":"Food Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jfca.2013.10.001","article-title":"Chemical composition and antioxidant capacity of lettuce: Comparative study of regular-sized (Romaine) and baby-sized (Little Gem and Mini Romaine) types","volume":"33","author":"Fenoll","year":"2014","journal-title":"J. Food Compos. Anal."},{"key":"ref_49","first-page":"11110","article-title":"Influence of cultivar and season on carotenoids and phenolic compounds from red lettuce influence of cultivar and season on lettuce","volume":"155","author":"Pagno","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Fincheira, P., Espinoza, J., Vera, J., Berrios, D., Nahuelcura, J., Ruiz, A., Quiroz, A., Bustamante, L., Cornejo, P., and Tortella, G. (2023). The Impact of 2-Ketones Released from Solid Lipid Nanoparticles on Growth Modulation and Antioxidant System of Lactuca sativa. Plants, 12.","DOI":"10.3390\/plants12173094"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez, F., Santander, C., Ruiz, A., P\u00e9rez, R., Moreira, J., Vidal, G., Aroca, R., Santos, C., and Cornejo, P. (2023). Inoculation with Actinobacteria spp. Isolated from a Hyper-Arid Environment Enhances Tolerance to Salinity in Lettuce Plants (Lactuca sativa L.). Plants, 12.","DOI":"10.3390\/plants12102018"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"5122","DOI":"10.1021\/jf904274v","article-title":"The Impact of Genotype and Salinity on Physiological Function, Secondary Metabolite Accumulation, and Antioxidative Responses in Lettuce","volume":"58","author":"Mahmoudi","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.foodchem.2013.02.120","article-title":"Comparative study of the antioxidant capacity and polyphenol content of Douro wines by chemical and electrochemical methods","volume":"141","author":"Rebelo","year":"2013","journal-title":"Food Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"101550","DOI":"10.1016\/j.pmpp.2020.101550","article-title":"Plant, pathogen and biocontrol agent interaction effects on bioactive compounds and antioxidant activity in garlic","volume":"112","author":"Cavalcanti","year":"2020","journal-title":"Physiol. Mol. Plant Pathol."},{"key":"ref_55","first-page":"854","article-title":"Effect of phenolic acids on the antioxidant system of tomato plants (Solanum lycopersicum Mill.)","volume":"32","year":"2021","journal-title":"Agron. Mesoam."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.scienta.2017.06.022","article-title":"Arbuscular mycorrhizal fungi affect total phenolics content and antioxidant activity in leaves of oak leaf lettuce varieties","volume":"224","author":"Avio","year":"2017","journal-title":"Sci. Hortic."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"4958","DOI":"10.1007\/s11356-019-06673-y","article-title":"Effects of silicon nanoparticles on growth and physiology of wheat in cadmium contaminated soil under different soil moisture levels","volume":"27","author":"Khan","year":"2020","journal-title":"Environ. Sci. Pollut."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-L\u00f3pez, J.I., Ni\u00f1o-Medina, G., Olivares-S\u00e1enz, E., Lira-Saldivar, R.H., Barriga-Castro, E.D., V\u00e1zquez-Alvarado, R., Rodr\u00edguez-Salinas, P.A., and Zavala-Garc\u00eda, F. (2019). Foliar application of zinc oxide nanoparticles and zinc sulfate boosts the content of bioactive compounds in habanero peppers. Plants, 8.","DOI":"10.3390\/plants8080254"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/j.jhazmat.2011.06.081","article-title":"Low toxicity of HfO2, SiO2, Al2O3 and CeO2 nanoparticles to the yeast, Saccharomyces cerevisiae","volume":"192","author":"Field","year":"2011","journal-title":"J. Hazard. Mater."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.chemosphere.2013.06.075","article-title":"Toxicity of TiO2, ZrO2, Fe0, Fe2O3, and Mn2O3 nanoparticles to the yeast, Saccharomyces cerevisiae","volume":"93","author":"Field","year":"2013","journal-title":"Chemosphere"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"112027","DOI":"10.1016\/j.ecoenv.2021.112027","article-title":"A review on metal-based nanoparticles and their toxicity to beneficial soil bacteria and fungi","volume":"213","author":"Ameen","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"P\u00e9rez, R., Tapia, Y., Antil\u00e9n, M., Ruiz, A., Pimentel, P., Santander, C., Aponte, H., Gonz\u00e1lez, F., and Cornejo, P. (2023). Beneficial Interactive Effects Provided by an Arbuscular Mycorrhizal Fungi and Yeast on the Growth of Oenothera picensis Established on Cu Mine Tailings. Plants, 12.","DOI":"10.3390\/plants12234012"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Dasgan, H.Y., Yilmaz, D., Zikaria, K., Ikiz, B., and Gruda, N.S. (2023). Enhancing the Yield, Quality and Antioxidant Content of Lettuce through Innovative and Eco-Friendly Biofertilizer Practices in Hydroponics. Horticulturae, 9.","DOI":"10.3390\/horticulturae9121274"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.59188\/eduvest.v3i7.887","article-title":"Growth and yields of bima brebes shallot variety planted using a floating hydroponics system","volume":"3","author":"Harsela","year":"2023","journal-title":"Eduvest-J. Univers. Stud."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/s41565-018-0131-1","article-title":"A critical evaluation of nanopesticides and nanofertilizers against their conventional analogues","volume":"13","author":"Kah","year":"2018","journal-title":"Nat. Nanotechnol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"606454","DOI":"10.3389\/fsufs.2021.606454","article-title":"Successful Plant Growth-Promoting Microbes: Inoculation Methods and Abiotic","volume":"5","author":"Lopes","year":"2021","journal-title":"Front. Sustain. Food Syst."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"106632","DOI":"10.1016\/j.microc.2021.106632","article-title":"Evaluation of the effect of organic pollutants exposure on the antioxidant activity, total phenolic and total flavonoid content of lettuce (Lactuca sativa L.) using UV\u2013Vis spectrophotometry and chemometrics","volume":"170","author":"Niksad","year":"2021","journal-title":"Microchem. J."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.foodres.2018.06.019","article-title":"New acylated flavonols identified in Vitis vinifera grapes and wines","volume":"112","author":"Favre","year":"2018","journal-title":"Food Res. Int."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.5740\/jaoacint.13-175","article-title":"Determination of Total Antioxidant Capacity by Oxygen Radical Absorbance Capacity (ORAC) Using Fluorescein as the Fluorescence Probe: First Action","volume":"96","author":"Ou","year":"2013","journal-title":"J. AOAC Int."}],"container-title":["Plants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2223-7747\/13\/3\/388\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:50:43Z","timestamp":1760104243000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2223-7747\/13\/3\/388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,28]]},"references-count":69,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["plants13030388"],"URL":"https:\/\/doi.org\/10.3390\/plants13030388","relation":{},"ISSN":["2223-7747"],"issn-type":[{"value":"2223-7747","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,28]]}}}