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The present study expands its actions on the cardiovascular system by evaluating its vasorelaxant and blood pressure-lowering effects in spontaneously hypertensive rats (SHRs). Aortic endothelium-intact (E+) preparations of SHRs pre-contracted by phenylephrine and exposed to cumulative concentrations of G.\u00a0achachairu extract, fractions, and DGP exhibited a significant relaxation compared to vehicle-only exposed rings. The non-selective muscarinic receptor antagonist (atropine), the non-selective inhibitor of nitric oxide synthase (L-NAME), as well as the inhibitor of soluble guanylate cyclase (ODQ) altogether avoided DGP-induced relaxation. Tetraethylammonium (small conductance Ca2+-activated K+ channel blocker), 4-aminopyridine (a voltage-dependent K+ channel blocker), and barium chloride (an influx-rectifying K+ channel blocker) significantly reduced DGP capacity to induce relaxation without the interference of glibenclamide (an ATP-sensitive inward rectifier 6.1 and 6.2 K+ channel blocker). Additionally, administration of DGP, 1 mg\/kg i.v., decreased the mean, systolic, and diastolic arterial pressures, and the heart rate of SHRs. The natural xanthone DGP showed promising potential as an endothelium-dependent vasorelaxant, operating through the nitric oxide pathway and potassium channels, ultimately significantly reducing blood pressure in hypertensive rats.<\/jats:p>","DOI":"10.3390\/plants13040528","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T05:55:59Z","timestamp":1707976559000},"page":"528","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Vasodilation and Blood Pressure-Lowering Effect of 3-Demethyl-2-Geranyl-4-Prenylbellidifoline, a Xanthone Obtained from Garcinia achachairu, in Hypertensive Rats"],"prefix":"10.3390","volume":"13","author":[{"given":"Lu\u00edsa Nath\u00e1lia Bolda","family":"Mariano","sequence":"first","affiliation":[{"name":"Laboratory of Cardiovascular Biology, Department of Pharmacology, Universidade Federal de Santa Catarina (UFSC), Florian\u00f3polis 88040-900, SC, Brazil"},{"name":"Postgraduate Program in Pharmaceutical Sciences, N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR), Universidade do Vale do Itaja\u00ed (UNIVALI), Rua Uruguai, 458, Centro, Itaja\u00ed 88302-901, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita de C\u00e1ssia Vilhena","family":"da Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR), Universidade do Vale do Itaja\u00ed (UNIVALI), Rua Uruguai, 458, Centro, Itaja\u00ed 88302-901, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rivaldo","family":"Niero","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR), Universidade do Vale do Itaja\u00ed (UNIVALI), Rua Uruguai, 458, Centro, Itaja\u00ed 88302-901, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valdir","family":"Cechinel Filho","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR), Universidade do Vale do Itaja\u00ed (UNIVALI), Rua Uruguai, 458, Centro, Itaja\u00ed 88302-901, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5971-226X","authenticated-orcid":false,"given":"Jos\u00e9 Eduardo","family":"da Silva-Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Biology, Department of Pharmacology, Universidade Federal de Santa Catarina (UFSC), Florian\u00f3polis 88040-900, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5251-5642","authenticated-orcid":false,"given":"Priscila","family":"de Souza","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico-Farmac\u00eauticas (NIQFAR), Universidade do Vale do Itaja\u00ed (UNIVALI), Rua Uruguai, 458, Centro, Itaja\u00ed 88302-901, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"key":"ref_1","first-page":"787","article-title":"Updated Cardiovascular Prevention Guideline of the Brazilian Society of Cardiology\u20142019","volume":"113","author":"Dutra","year":"2019","journal-title":"Arq. 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