{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:42:14Z","timestamp":1790286134157,"version":"4.1.0"},"reference-count":88,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005703","name":"The Scientific Research Project Coordination Unit of Akdeniz University","doi-asserted-by":"publisher","award":["2012.01.0115.008"],"award-info":[{"award-number":["2012.01.0115.008"]}],"id":[{"id":"10.13039\/501100005703","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Since Astragalus is a genus with many important medicinal plant species, the present work aimed to investigate the phytochemical composition and some biological activities of Astragalus gymnolobus. The methanolic fractions of four organs (stems, flowers, leaves, root and whole plant) were quantified and identified by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry (LC\u2013ESI\u2013MS\/MS) analysis. Hesperidin, hyperoside, p-hydroxybenzoic acid, protocatechuic acid and p-coumaric acid were identified as main compounds among the extracts. Among all cells, leaf methanol (Lm) extract had the highest cytotoxic effect on HeLa cells (IC50 = 0.069 \u03bcg\/mL). Hesperidin, the most abundant compound in A. gymnolobus extract, was found to show a strong negative correlation with the cytotoxic effect observed in HeLa cells according to Pearson correlation test results and to have the best binding affinity to targeted proteins by docking studies. The antimicrobial activity results indicated that the most susceptible bacterium against all extracts was identified as Streptococcus pyogenes with 9\u201311 mm inhibition zone and 8192 mg\/mL MIC value. As a result of the research, it was suggested that A. gymnolobus could be considered as a promising source that contributes to the fight against cancer.<\/jats:p>","DOI":"10.3390\/plants13050658","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T03:37:57Z","timestamp":1709091477000},"page":"658","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Phenolic Compound Profiles, Cytotoxic, Antioxidant, Antimicrobial Potentials and Molecular Docking Studies of Astragalus gymnolobus Methanolic Extracts"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5206-7333","authenticated-orcid":false,"given":"Esra","family":"Aydemir","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Science, Akdeniz University, Antalya TR-07058, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3943-571X","authenticated-orcid":false,"given":"Elif","family":"Odaba\u015f K\u00f6se","sequence":"additional","affiliation":[{"name":"Medical Laboratory Program, Vocational School of Health Services, Akdeniz University, Antalya TR-07058, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Yavuz","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Akdeniz University, Antalya TR-07058, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Cansu","family":"Kilit","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Akdeniz University, Antalya TR-07058, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2115-4856","authenticated-orcid":false,"given":"Alaaddin","family":"Korkut","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Akdeniz University, Antalya TR-07058, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serap","family":"\u00d6zkaya G\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Akdeniz University, Antalya TR-07058, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cengiz","family":"Sarikurkcu","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Pharmacy, Afyonkarahisar Health Sciences University, Afyonkarahisar TR-03100, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Engin","family":"Celep","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Yeditepe University, Atasehir, Istanbul TR-34755, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. S\u00fcleyman","family":"G\u00f6kt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Akdeniz University, Antalya TR-07058, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"ref_1","first-page":"4103","article-title":"Medicinal Plants: Their Use in Anticancer Treatment","volume":"6","author":"Greenwell","year":"2015","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"ref_2","unstructured":"Podlech, D., and Zarre, S.H. (2013). Taxonomic Revision of the Genus Astragalus L. (Leguminosae) in the Old World, Vienna Natural History Museum."},{"key":"ref_3","unstructured":"G\u00fcner, A., Aslan, S., Ekim, T., Vural, M., and Baba\u00e7, M. (2012). Astragalus L. T\u00fcrkiye Bitkileri Listesi (Damarl\u0131 Bitkiler), Nezahat G\u00f6kyi\u011fit Botanik Bah\u00e7esi ve Flora Ara\u015ft\u0131rmalar\u0131 Derne\u011fi Yay\u0131nlar\u0131. 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