{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:07:13Z","timestamp":1788984433029,"version":"build-2803163510"},"reference-count":74,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation (NRF)"},{"name":"Health and Welfare Sector Education and Training Authority (HWSETA)"},{"name":"StEP up University of KwaZulu-Natal (UKZN)"},{"name":"Mangosuthu University of Technology (MUT)"},{"name":"University College London (UCL)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>The treatment and management of diabetes mellitus (DM) with conventional therapies, such as insulin injections and oral hypoglycemic agents, present significant challenges due to their side effects and burdensome administration. Therapies often manage symptoms rather than addressing insulin regulation, akin to medications like thiazolidinediones and glinides, which resemble many medicinal plants. Medicinal plants offer potential alternative treatments due to bioactive compounds targeting diabetes causes. We aimed to explore the antidiabetic potential of two medicinal plants, Psidium guajava and Seriphium plumosum L., by investigating their phytochemical constituents, medicinal uses, pharmacological actions, and mechanisms. This review followed specific guidelines and searched databases including PubMed, Scopus, ScienceDirect, and Web of Science for studies on medicinal plants and DM. Eligible studies underwent quality assessment and were categorized based on their design and interventions for data synthesis. This review identified the phytochemical constituents in Psidium guajava and Seriphium plumosum L., including tannins, flavonoids, phenols, and steroids, exerting antidiabetic effects through various mechanisms like antioxidant activity, anti-inflammatory effects, stimulation of insulin secretion, glucose regulation, and inhibition of carbohydrate-digesting enzymes. Psidium guajava and Seriphium plumosum L. exhibit promising antidiabetic potential, offering alternative approaches to diabetes management. Polyherbalism, combining multiple plant extracts, may enhance therapeutic efficacy in diabetes treatment. Comprehensive research is needed to explore the combined therapeutic effects of these plants and develop more effective antidiabetic treatments. This review highlights the importance of harnessing natural resources to combat the global burden of DM. Further research is warranted to fully explore the combined therapeutic effects of these plants and develop novel treatments.<\/jats:p>","DOI":"10.3390\/plants13121608","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T11:58:58Z","timestamp":1718107138000},"page":"1608","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Review on the Anti-Hyperglycemic Potential of Psidium guajava and Seriphium plumosum L."],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9146-3809","authenticated-orcid":false,"given":"Nokukhanya","family":"Thembane","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Mangosuthu University of Technology, Durban 4026, South Africa"},{"name":"Traditional Medicine Laboratory, University of KwaZulu-Natal, Durban 4041, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sphamandla","family":"Hlatshwayo","sequence":"additional","affiliation":[{"name":"Traditional Medicine Laboratory, University of KwaZulu-Natal, Durban 4041, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mlungisi","family":"Ngcobo","sequence":"additional","affiliation":[{"name":"Traditional Medicine Laboratory, University of KwaZulu-Natal, Durban 4041, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phikelelani","family":"Ngubane","sequence":"additional","affiliation":[{"name":"Discipline of Medical Microbiology, University of KwaZulu-Natal, Durban 4041, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1946-3120","authenticated-orcid":false,"given":"Nceba","family":"Gqaleni","sequence":"additional","affiliation":[{"name":"Traditional Medicine Laboratory, University of KwaZulu-Natal, Durban 4041, South Africa"},{"name":"Africa Health Research Institute, Durban 4013, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"119632","DOI":"10.1016\/j.lfs.2021.119632","article-title":"Overview of Key Molecular and Pharmacological Targets for Diabetes and Associated Diseases","volume":"278","author":"Shahcheraghi","year":"2021","journal-title":"Life Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/dom.13614","article-title":"Comparative Effectiveness and Harms of Long-Acting Insulins for Type 1 and Type 2 Diabetes: A Systematic Review and Meta-Analysis","volume":"21","author":"Holmes","year":"2019","journal-title":"Diabetes Obes. 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